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Volumn 24, Issue 10, 2010, Pages 1700-1712

The use of biochemical markers of bone remodeling in multiple myeloma: A report of the International Myeloma Working Group

(16)  Terpos, E a   Dimopoulos, M A a   Sezer, O b   Roodman, D c   Abildgaard, N d   Vescio, R e   Tosi, P f   Garcia Sanz, R g   Davies, F h   Chanan Khan, A i   Palumbo, A j   Sonneveld, P k   Drake, M T l   Harousseau, J L m   Anderson, K C n   Durie, B G M e  


Author keywords

bone markers; CTX; ICTP; myeloma; NTX

Indexed keywords

AMINO TERMINAL TELOPEPTIDE; BIOCHEMICAL MARKER; CARBOXY TERMINAL TELOPEPTIDE; MATRIX METALLOPROTEINASE;

EID: 77957991625     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2010.173     Document Type: Review
Times cited : (78)

References (97)
  • 1
    • 5444262558 scopus 로고    scopus 로고
    • Bisphosphonates: Clinical experience
    • Coleman RE. Bisphosphonates: clinical experience. Oncologist 2004; 9 (Suppl 4): 14-27.
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 4 , pp. 14-27
    • Coleman, R.E.1
  • 2
    • 23844551832 scopus 로고    scopus 로고
    • Myeloma bone disease: Pathophysio-logy and management
    • Terpos E, Dimopoulos MA. Myeloma bone disease: pathophysio-logy and management. Ann Oncol 2005; 16: 1223-1231.
    • (2005) Ann Oncol , vol.16 , pp. 1223-1231
    • Terpos, E.1    Dimopoulos, M.A.2
  • 3
    • 62549117773 scopus 로고    scopus 로고
    • Pathogenesis of myeloma bone disease
    • Roodman GD. Pathogenesis of myeloma bone disease. Leukemia 2009; 23: 435-441.
    • (2009) Leukemia , vol.23 , pp. 435-441
    • Roodman, G.D.1
  • 4
    • 63849093676 scopus 로고    scopus 로고
    • Myeloma bone disease: Recent advances in biology, diagnosis and treatment
    • Sezer O. Myeloma bone disease: Recent advances in biology, diagnosis and treatment. Oncologist 2009; 14: 276-283.
    • (2009) Oncologist , vol.14 , pp. 276-283
    • Sezer, O.1
  • 5
    • 0742269486 scopus 로고    scopus 로고
    • A comparison of fluorine-18 fluoro-deoxyglucose PET and technetium-99m sestamibi in assessing patients with multiple myeloma
    • Mileshkin L, Blum R, Seymour JF, Patrikeos A, Hicks RJ, Prince HM. A comparison of fluorine-18 fluoro-deoxyglucose PET and technetium-99m sestamibi in assessing patients with multiple myeloma. Eur J Haematol 2004; 72: 32-37.
    • (2004) Eur J Haematol , vol.72 , pp. 32-37
    • Mileshkin, L.1    Blum, R.2    Seymour, J.F.3    Patrikeos, A.4    Hicks, R.J.5    Prince, H.M.6
  • 6
    • 70349303765 scopus 로고    scopus 로고
    • International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple Myeloma
    • Dimopoulos M, Terpos E, Comenzo RL, Tosi P, Beksac M, Sezer O et al. International myeloma working group consensus statement and guidelines regarding the current role of imaging techniques in the diagnosis and monitoring of multiple Myeloma. Leukemia 2009; 23: 1545-1556.
    • (2009) Leukemia , vol.23 , pp. 1545-1556
    • Dimopoulos, M.1    Terpos, E.2    Comenzo, R.L.3    Tosi, P.4    Beksac, M.5    Sezer, O.6
  • 8
    • 69449108135 scopus 로고    scopus 로고
    • The use of bisphosphonates in multiple myeloma: Recommendations of an expert panel on behalf of the European Myeloma Network
    • Terpos E, Sezer O, Croucher PI, García-Sanz R, Boccadoro M, San Miguel J et al. The use of bisphosphonates in multiple myeloma: recommendations of an expert panel on behalf of the European Myeloma Network. Ann Oncol 2009; 20: 1303-1317.
    • (2009) Ann Oncol , vol.20 , pp. 1303-1317
    • Terpos, E.1    Sezer, O.2    Croucher, P.I.3    García-Sanz, R.4    Boccadoro, M.5    San Miguel, J.6
  • 9
    • 34548128339 scopus 로고    scopus 로고
    • The effect of novel anti-myeloma agents on bone metabolism of patients with multiple myeloma
    • Terpos E, Dimopoulos MA, Sezer O. The effect of novel anti-myeloma agents on bone metabolism of patients with multiple myeloma. Leukemia 2007; 21: 1875-1884.
    • (2007) Leukemia , vol.21 , pp. 1875-1884
    • Terpos, E.1    Dimopoulos, M.A.2    Sezer, O.3
  • 11
    • 0029799613 scopus 로고    scopus 로고
    • Molecular basis and clinical application of biological markers of bone turnover
    • Calvo MS, Eyre DR, Gundberg CM. Molecular basis and clinical application of biological markers of bone turnover. Endocrine Rev 1996; 17: 333-368.
    • (1996) Endocrine Rev , vol.17 , pp. 333-368
    • Calvo, M.S.1    Eyre, D.R.2    Gundberg, C.M.3
  • 12
    • 0037345003 scopus 로고    scopus 로고
    • Biochemical markers of bone turnover and fracture prediction
    • Hannon RA, Eastell R. Biochemical markers of bone turnover and fracture prediction. J Br Menopause Soc 2003; 9: 10-15.
    • (2003) J Br Menopause Soc , vol.9 , pp. 10-15
    • Hannon, R.A.1    Eastell, R.2
  • 13
    • 0942300651 scopus 로고    scopus 로고
    • Clinical performance of immunoreactive tartrate-resistant acid phosphatase isoform 5b as a marker of bone resorption
    • Hannon RA, Clowes JA, Eagleton AC, Al Hadari A, Eastell R, Blumsohn A. Clinical performance of immunoreactive tartrate-resistant acid phosphatase isoform 5b as a marker of bone resorption. Bone 2004; 34: 187-194.
    • (2004) Bone , vol.34 , pp. 187-194
    • Hannon, R.A.1    Clowes, J.A.2    Eagleton, A.C.3    Al Hadari, A.4    Eastell, R.5    Blumsohn, A.6
  • 14
    • 0035125338 scopus 로고    scopus 로고
    • Serum bone sialoprotein as a marker of tumour burden and neoplastic bone involvement and as a prognostic factor in multiple myeloma
    • Woitge HW, Pecherstorfer M, Horn E, Keck AV, Diel IJ, Bayer P et al. Serum bone sialoprotein as a marker of tumour burden and neoplastic bone involvement and as a prognostic factor in multiple myeloma. Br J Cancer 2001; 84: 344-351.
    • (2001) Br J Cancer , vol.84 , pp. 344-351
    • Woitge, H.W.1    Pecherstorfer, M.2    Horn, E.3    Keck, A.V.4    Diel, I.J.5    Bayer, P.6
  • 15
    • 33646827389 scopus 로고    scopus 로고
    • Biochemical markers of bone turnover: Part I: Biochemistry and variability
    • Seibel MJ. Biochemical markers of bone turnover: part I: biochemistry and variability. Clin Biochem Rev 2005; 26: 97-122.
    • (2005) Clin Biochem Rev , vol.26 , pp. 97-122
    • Seibel, M.J.1
  • 16
    • 0034972607 scopus 로고    scopus 로고
    • Bone marker nomenclature
    • Delmas PD. Bone marker nomenclature. Bone 2001; 28: 575-576.
    • (2001) Bone , vol.28 , pp. 575-576
    • Delmas, P.D.1
  • 17
    • 0001638603 scopus 로고
    • Gastrointestinal absorption and renal excretion of hydroxyproline peptides
    • Prockop DJ, Keiser HR, Sjoerdsma A. Gastrointestinal absorption and renal excretion of hydroxyproline peptides. Lancet 1962; 2: 527-528.
    • (1962) Lancet , vol.2 , pp. 527-528
    • Prockop, D.J.1    Keiser, H.R.2    Sjoerdsma, A.3
  • 18
    • 0032895152 scopus 로고    scopus 로고
    • Serum galactosyl hydroxylysine as a biochemical marker of bone resorption
    • Al-Dehaimi AW, Blumsohn A, Eastell R. Serum galactosyl hydroxylysine as a biochemical marker of bone resorption. Clin Chem 1999; 45: 676-681.
    • (1999) Clin Chem , vol.45 , pp. 676-681
    • Al-Dehaimi, A.W.1    Blumsohn, A.2    Eastell, R.3
  • 21
    • 0032032089 scopus 로고    scopus 로고
    • Collagen cross-links in mineralizing tissues: A review of their chemistry, function, and clinical relevance
    • Knott L, Bailey AJ. Collagen cross-links in mineralizing tissues: a review of their chemistry, function, and clinical relevance. Bone 1998; 22: 181-187.
    • (1998) Bone , vol.22 , pp. 181-187
    • Knott, L.1    Bailey, A.J.2
  • 22
    • 10744225319 scopus 로고    scopus 로고
    • The type i collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation
    • Garnero P, Ferreras M, Karsdal MA, Nicamhlaoibh R, Risteli J, Borel O et al. The type I collagen fragments ICTP and CTX reveal distinct enzymatic pathways of bone collagen degradation. J Bone Miner Res 2003; 18: 859-867.
    • (2003) J Bone Miner Res , vol.18 , pp. 859-867
    • Garnero, P.1    Ferreras, M.2    Karsdal, M.A.3    Nicamhlaoibh, R.4    Risteli, J.5    Borel, O.6
  • 23
    • 0026676875 scopus 로고
    • A specific immunoassay for monitoring human bone resorption: Quantitation of type i collagen cross-linked N-telopeptides in urine
    • Hanson DA, Weis MA, Bollen AM, Maslan SL, Singer FR, Eyre DR. A specific immunoassay for monitoring human bone resorption: quantitation of type I collagen cross-linked N-telopeptides in urine. J Bone Miner Res 1992; 7: 1251-1258.
    • (1992) J Bone Miner Res , vol.7 , pp. 1251-1258
    • Hanson, D.A.1    Weis, M.A.2    Bollen, A.M.3    Maslan, S.L.4    Singer, F.R.5    Eyre, D.R.6
  • 24
    • 0030772533 scopus 로고    scopus 로고
    • Osteoclasts generate cross-linked collagen N-telopeptides (NTx) but not free pyridinolines when cultured on human bone
    • Apone S, Lee MY, Eyre DR. Osteoclasts generate cross-linked collagen N-telopeptides (NTx) but not free pyridinolines when cultured on human bone. Bone 1997; 21: 129-136.
    • (1997) Bone , vol.21 , pp. 129-136
    • Apone, S.1    Lee, M.Y.2    Eyre, D.R.3
  • 25
    • 0030904548 scopus 로고    scopus 로고
    • Measurement of bone degradation products in serum using antibodies reactive with an isomerized form of an 8 amino acid sequence of the C-telopeptide of type i collagen
    • Bonde M, Garnero P, Fledelius C, Qvist P, Delmas PD, Christiansen C. Measurement of bone degradation products in serum using antibodies reactive with an isomerized form of an 8 amino acid sequence of the C-telopeptide of type I collagen. J Bone Miner Res 1997; 12: 1028-1034.
    • (1997) J Bone Miner Res , vol.12 , pp. 1028-1034
    • Bonde, M.1    Garnero, P.2    Fledelius, C.3    Qvist, P.4    Delmas, P.D.5    Christiansen, C.6
  • 26
    • 0031786307 scopus 로고    scopus 로고
    • Serum crosslaps one step ELISA. First application of monoclonal antibodies for measurement in serum of bone-related degradation products from C-terminal telopeptides of type i collagen
    • Rosenquist C, Fledelius C, Christgau S, Pedersen BJ, Bonde M, Qvist P et al. Serum crosslaps one step ELISA. First application of monoclonal antibodies for measurement in serum of bone-related degradation products from C-terminal telopeptides of type I collagen. Clin Chem 1998; 44: 2281-2289.
    • (1998) Clin Chem , vol.44 , pp. 2281-2289
    • Rosenquist, C.1    Fledelius, C.2    Christgau, S.3    Pedersen, B.J.4    Bonde, M.5    Qvist, P.6
  • 27
    • 0027417926 scopus 로고
    • Radio-immunoassay for the pyridinoline cross-linked carboxy-terminal telopeptide of type i collagen: A new serum marker of bone collagen degradation
    • Risteli J, Elomaa I, Niemi S, Novamo A, Risteli L. Radio-immunoassay for the pyridinoline cross-linked carboxy-terminal telopeptide of type I collagen: a new serum marker of bone collagen degradation. Clin Chem 1993; 39: 635-640.
    • (1993) Clin Chem , vol.39 , pp. 635-640
    • Risteli, J.1    Elomaa, I.2    Niemi, S.3    Novamo, A.4    Risteli, L.5
  • 28
    • 0034012685 scopus 로고    scopus 로고
    • Immunochemical characterization of assay for carboxyterminal telopeptide of human type i collagen: Loss of antigenicity by treatment with cathepsin K
    • Sassi ML, Eriksen H, Risteli L, Niemi S, Mansell J, Gowen M et al. Immunochemical characterization of assay for carboxyterminal telopeptide of human type I collagen: loss of antigenicity by treatment with cathepsin K. Bone 2000; 26: 367-373.
    • (2000) Bone , vol.26 , pp. 367-373
    • Sassi, M.L.1    Eriksen, H.2    Risteli, L.3    Niemi, S.4    Mansell, J.5    Gowen, M.6
  • 29
    • 0035148965 scopus 로고    scopus 로고
    • Tartrate-resistant acid phosphatase isoform 5b as serum marker for osteoclastic activity
    • Janckila AJ, Takahashi K, Sun SZ, Yam LT. Tartrate-resistant acid phosphatase isoform 5b as serum marker for osteoclastic activity. Clin Chem 2001; 47: 74-80. (Pubitemid 32064278)
    • (2001) Clinical Chemistry , vol.47 , Issue.1 , pp. 74-80
    • Janckila, A.J.1    Takahashi, K.2    Sun, S.Z.3    Yam, L.T.4
  • 31
    • 0018102984 scopus 로고
    • Biochemical properties of tartrate-resistant acid phosphatase in serum of adults and children
    • Lam WK, Eastlund DT, Li CY, Yam LT. Biochemical properties of tartrate-resistant acid phosphatase in serum of adults and children. Clin Chem 1978; 24: 1105-1108.
    • (1978) Clin Chem , vol.24 , pp. 1105-1108
    • Lam, W.K.1    Eastlund, D.T.2    Li, C.Y.3    Yam, L.T.4
  • 32
    • 0042093629 scopus 로고    scopus 로고
    • Tartrate-resistant acid phosphatase 5B circulates in human serum in complex with alpha2-macroglobulin and calcium
    • Ylipahkala H, Halleen JM, Kaija H, Vihko P, Väänänen HK. Tartrate-resistant acid phosphatase 5B circulates in human serum in complex with alpha2-macroglobulin and calcium. Biochem Biophys Res Commun 2003; 308: 320-324.
    • (2003) Biochem Biophys Res Commun , vol.308 , pp. 320-324
    • Ylipahkala, H.1    Halleen, J.M.2    Kaija, H.3    Vihko, P.4    Väänänen, H.K.5
  • 33
    • 0027080073 scopus 로고
    • Perspectives in alkaline phosphatase research
    • Moss DW. Perspectives in alkaline phosphatase research. Clin Chem 1992; 38: 2486-2492.
    • (1992) Clin Chem , vol.38 , pp. 2486-2492
    • Moss, D.W.1
  • 34
    • 0019222034 scopus 로고
    • Carboxylated calcium-binding proteins and vitamin K
    • Gallop PM, Lian JB, Hauschka PV. Carboxylated calcium-binding proteins and vitamin K. N Engl J Med 1980; 302: 1460-1466.
    • (1980) N Engl J Med , vol.302 , pp. 1460-1466
    • Gallop, P.M.1    Lian, J.B.2    Hauschka, P.V.3
  • 36
    • 0026700932 scopus 로고
    • Structure, expression, and regulation of the major noncollagenous matrix proteins of bone
    • Young MF, Kerr JM, Ibaraki K, Heegaard AM, Robey PG. Structure, expression, and regulation of the major noncollagenous matrix proteins of bone. Clin Orthop Relat Res 1992; 281: 275-294.
    • (1992) Clin Orthop Relat Res , vol.281 , pp. 275-294
    • Young, M.F.1    Kerr, J.M.2    Ibaraki, K.3    Heegaard, A.M.4    Robey, P.G.5
  • 37
    • 0037405123 scopus 로고    scopus 로고
    • Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity
    • Sierra J, Villagra A, Paredes R, Cruzat F, Gutierrez S, Javed A et al. Regulation of the bone-specific osteocalcin gene by p300 requires Runx2/Cbfa1 and the vitamin D3 receptor but not p300 intrinsic histone acetyltransferase activity. Mol Cell Biol 2003; 23: 3339-3351.
    • (2003) Mol Cell Biol , vol.23 , pp. 3339-3351
    • Sierra, J.1    Villagra, A.2    Paredes, R.3    Cruzat, F.4    Gutierrez, S.5    Javed, A.6
  • 38
    • 0034168328 scopus 로고    scopus 로고
    • Osteocalcin-directed gene therapy for prostate-cancer bone metastasis
    • Koeneman KS, Kao C, Ko SC, Yang L, Wada Y, Kallmes DF et al. Osteocalcin-directed gene therapy for prostate-cancer bone metastasis. World J Urol 2000; 18: 102-110.
    • (2000) World J Urol , vol.18 , pp. 102-110
    • Koeneman, K.S.1    Kao, C.2    Ko, S.C.3    Yang, L.4    Wada, Y.5    Kallmes, D.F.6
  • 39
    • 0031405795 scopus 로고    scopus 로고
    • Biochemical markers of bone metabolism: An overview
    • Christenson RH. Biochemical markers of bone metabolism: an overview. Clin Biochem 1997; 30: 573-593.
    • (1997) Clin Biochem , vol.30 , pp. 573-593
    • Christenson, R.H.1
  • 40
    • 0025149128 scopus 로고
    • Circulating C-terminal propeptide of type i procollagen is cleared mainly via the mannose receptor in liver endothelial cells
    • Smedsrod B, Melkko J, Risteli L, Risteli J. Circulating C-terminal propeptide of type I procollagen is cleared mainly via the mannose receptor in liver endothelial cells. Biochem J 1990; 271: 345-350.
    • (1990) Biochem J , vol.271 , pp. 345-350
    • Smedsrod, B.1    Melkko, J.2    Risteli, L.3    Risteli, J.4
  • 41
    • 0030629117 scopus 로고    scopus 로고
    • Assays of type i procollagen domains and collagen fragments: Problems to be solved and future trends
    • Risteli J, Risteli L. Assays of type I procollagen domains and collagen fragments: problems to be solved and future trends. Scand J Clin Lab Invest Suppl 1997; 227: 105-113.
    • (1997) Scand J Clin Lab Invest Suppl , vol.227 , pp. 105-113
    • Risteli, J.1    Risteli, L.2
  • 42
    • 0344011473 scopus 로고    scopus 로고
    • Clinical review 165: Markers of bone remodeling in metastatic bone disease
    • Fohr B, Dunstan CR, Seibel MJ. Clinical review 165: Markers of bone remodeling in metastatic bone disease. J Clin Endocrinol Metab 2003; 88: 5059-5075.
    • (2003) J Clin Endocrinol Metab , vol.88 , pp. 5059-5075
    • Fohr, B.1    Dunstan, C.R.2    Seibel, M.J.3
  • 43
    • 0030607122 scopus 로고    scopus 로고
    • Biochemical bone markers in patients with multiple myeloma
    • Nawawi H, Samson D, Apperley J, Girgis S. Biochemical bone markers in patients with multiple myeloma. Clin Chim Acta 1996; 253: 61-77.
    • (1996) Clin Chim Acta , vol.253 , pp. 61-77
    • Nawawi, H.1    Samson, D.2    Apperley, J.3    Girgis, S.4
  • 44
    • 0031027328 scopus 로고    scopus 로고
    • Serum markers of bone metabolism in multiple myeloma: Prognostic value of the carboxy-terminal telopeptide of type i collagen (ICTP)
    • Abildgaard N, Bentzen SM, Nielsen JL, Heickendorff L. Serum markers of bone metabolism in multiple myeloma: prognostic value of the carboxy-terminal telopeptide of type I collagen (ICTP). Br J Haematol 1997; 96: 103-110.
    • (1997) Br J Haematol , vol.96 , pp. 103-110
    • Abildgaard, N.1    Bentzen, S.M.2    Nielsen, J.L.3    Heickendorff, L.4
  • 45
    • 0032509826 scopus 로고    scopus 로고
    • Monitoring of multiple myeloma patients by simultaneously measuring marker substances of bone resorption and formation
    • Withold W, Arning M, Schwarz M, Wolf HH, Schneider W. Monitoring of multiple myeloma patients by simultaneously measuring marker substances of bone resorption and formation. Clin Chim Acta 1998; 269: 21-30.
    • (1998) Clin Chim Acta , vol.269 , pp. 21-30
    • Withold, W.1    Arning, M.2    Schwarz, M.3    Wolf, H.H.4    Schneider, W.5
  • 46
    • 0032902720 scopus 로고    scopus 로고
    • Evaluation of bone disease in multiple myeloma: A comparison between the resorption markers urinary deoxypyridinoline/creati-nine (DPD) and serum ICTP, and an evaluation of the DPD/ osteocalcin and ICTP/osteocalcin ratios
    • Carlson K, Larsson A, Simonsson B, Turesson I, Westin J, Ljunghall S. Evaluation of bone disease in multiple myeloma: a comparison between the resorption markers urinary deoxypyridinoline/creati-nine (DPD) and serum ICTP, and an evaluation of the DPD/ osteocalcin and ICTP/osteocalcin ratios. Eur J Haematol 1999; 62: 300-306.
    • (1999) Eur J Haematol , vol.62 , pp. 300-306
    • Carlson, K.1    Larsson, A.2    Simonsson, B.3    Turesson, I.4    Westin, J.5    Ljunghall, S.6
  • 47
    • 0032952132 scopus 로고    scopus 로고
    • Novel serum markers of bone resorption: Clinical assessment and comparison with established urinary indices
    • Woitge HW, Pecherstorfer M, Li Y, Keck AV, Horn E, Ziegler R et al. Novel serum markers of bone resorption: clinical assessment and comparison with established urinary indices. J Bone Miner Res 1999; 14: 792-801.
    • (1999) J Bone Miner Res , vol.14 , pp. 792-801
    • Woitge, H.W.1    Pecherstorfer, M.2    Li, Y.3    Keck, A.V.4    Horn, E.5    Ziegler, R.6
  • 48
    • 0034073082 scopus 로고    scopus 로고
    • Prognostic value of serum markers of bone metabolism in untreated multiple myeloma patients
    • Fonseca R, Trendle MC, Leong T, Kyle RA, Oken MM, Kay NE et al. Prognostic value of serum markers of bone metabolism in untreated multiple myeloma patients. Br J Haematol 2000; 109: 24-29.
    • (2000) Br J Haematol , vol.109 , pp. 24-29
    • Fonseca, R.1    Trendle, M.C.2    Leong, T.3    Kyle, R.A.4    Oken, M.M.5    Kay, N.E.6
  • 49
    • 0033744201 scopus 로고    scopus 로고
    • Effect of pamidronate administration on markers of bone turnover and disease activity in multiple myeloma
    • Terpos E, Palermos J, Tsionos K, Anargyrou K, Viniou N, Papassavas P et al. Effect of pamidronate administration on markers of bone turnover and disease activity in multiple myeloma. Eur J Haematol 2000; 65: 331-336.
    • (2000) Eur J Haematol , vol.65 , pp. 331-336
    • Terpos, E.1    Palermos, J.2    Tsionos, K.3    Anargyrou, K.4    Viniou, N.5    Papassavas, P.6
  • 50
    • 0035057590 scopus 로고    scopus 로고
    • Biochemical markers of bone formation in patients with plasma cell dyscrasias and benign osteoporosis
    • Woitge HW, Horn E, Keck AV, Auler B, Seibel MJ, Pecherstorfer M. Biochemical markers of bone formation in patients with plasma cell dyscrasias and benign osteoporosis. Clin Chem 2001; 47: 686-693.
    • (2001) Clin Chem , vol.47 , pp. 686-693
    • Woitge, H.W.1    Horn, E.2    Keck, A.V.3    Auler, B.4    Seibel, M.J.5    Pecherstorfer, M.6
  • 51
    • 0035004937 scopus 로고    scopus 로고
    • Biochemical markers of bone disease in asymptomatic early stage multiple myeloma. A study on their role in identifying high risk patients
    • Corso A, Arcaini L, Mangiacavalli S, Astori C, Orlandi E, Lorenzi A et al. Biochemical markers of bone disease in asymptomatic early stage multiple myeloma. A study on their role in identifying high risk patients. Haematologica 2001; 86: 394-398.
    • (2001) Haematologica , vol.86 , pp. 394-398
    • Corso, A.1    Arcaini, L.2    Mangiacavalli, S.3    Astori, C.4    Orlandi, E.5    Lorenzi, A.6
  • 52
    • 0036659918 scopus 로고    scopus 로고
    • Bone resorption parameters [carboxy-terminal telopeptide of type-I collagen (ICTP), amino-terminal collagen type-I telopeptide (NTx), and deoxypyridinoline (Dpd)] in MGUS and multiple myeloma
    • Jakob C, Zavrski I, Heider U, Brux B, Eucker J, Langelotz C et al. Bone resorption parameters [carboxy-terminal telopeptide of type-I collagen (ICTP), amino-terminal collagen type-I telopeptide (NTx), and deoxypyridinoline (Dpd)] in MGUS and multiple myeloma. Eur J Haematol 2002; 69: 37-42.
    • (2002) Eur J Haematol , vol.69 , pp. 37-42
    • Jakob, C.1    Zavrski, I.2    Heider, U.3    Brux, B.4    Eucker, J.5    Langelotz, C.6
  • 53
    • 0036842343 scopus 로고    scopus 로고
    • Evaluation of bone disease in multiple myeloma: A correlation between biochemical markers of bone metabolism and other clinical parameters in untreated multiple myeloma patients
    • Alexandrakis MG, Passam FH, Malliaraki N, Katachanakis C, Kyriakou DS, Margioris AN. Evaluation of bone disease in multiple myeloma: a correlation between biochemical markers of bone metabolism and other clinical parameters in untreated multiple myeloma patients. Clin Chim Acta 2002; 325: 51-57.
    • (2002) Clin Chim Acta , vol.325 , pp. 51-57
    • Alexandrakis, M.G.1    Passam, F.H.2    Malliaraki, N.3    Katachanakis, C.4    Kyriakou, D.S.5    Margioris, A.N.6
  • 54
    • 0037278205 scopus 로고    scopus 로고
    • Comparison of five biochemical markers of bone resorption in multiple myeloma: Elevated pre-treatment levels of S-ICTP and U-Ntx are predictive for early progression of the bone disease during standard chemotherapy
    • Abildgaard N, Brixen K, Kristensen JE, Eriksen EF, Nielsen JL, Heickendorff L. Comparison of five biochemical markers of bone resorption in multiple myeloma: elevated pre-treatment levels of S-ICTP and U-Ntx are predictive for early progression of the bone disease during standard chemotherapy. Br J Haematol 2003; 120: 235-242.
    • (2003) Br J Haematol , vol.120 , pp. 235-242
    • Abildgaard, N.1    Brixen, K.2    Kristensen, J.E.3    Eriksen, E.F.4    Nielsen, J.L.5    Heickendorff, L.6
  • 55
    • 0043245842 scopus 로고    scopus 로고
    • Soluble receptor activator of nuclear factor kappaB ligand- osteoprotegerin ratio predicts survival in multiple myeloma: Proposal for a novel prognostic index
    • Terpos E, Szydlo R, Apperley JF, Hatjiharissi E, Politou M, Meletis J et al. Soluble receptor activator of nuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: proposal for a novel prognostic index. Blood 2003; 102: 1064-1069.
    • (2003) Blood , vol.102 , pp. 1064-1069
    • Terpos, E.1    Szydlo, R.2    Apperley, J.F.3    Hatjiharissi, E.4    Politou, M.5    Meletis, J.6
  • 56
    • 0038166881 scopus 로고    scopus 로고
    • Tartrate-resistant acid phosphatase isoform 5b: A novel serum marker for monitoring bone disease in multiple myeloma
    • Terpos E, de la Fuente J, Szydlo R, Hatjiharissi E, Viniou N, Meletis J et al. Tartrate-resistant acid phosphatase isoform 5b: a novel serum marker for monitoring bone disease in multiple myeloma. Int J Cancer 2003; 106: 455-457.
    • (2003) Int J Cancer , vol.106 , pp. 455-457
    • Terpos, E.1    De La Fuente, J.2    Szydlo, R.3    Hatjiharissi, E.4    Viniou, N.5    Meletis, J.6
  • 57
    • 24644479228 scopus 로고    scopus 로고
    • Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid
    • Coleman RE, Major P, Lipton A, Brown JE, Lee KA, Smith M et al. Predictive value of bone resorption and formation markers in cancer patients with bone metastases receiving the bisphosphonate zoledronic acid. J Clin Oncol 2005; 23: 4925-4935.
    • (2005) J Clin Oncol , vol.23 , pp. 4925-4935
    • Coleman, R.E.1    Major, P.2    Lipton, A.3    Brown, J.E.4    Lee, K.A.5    Smith, M.6
  • 58
    • 32144435917 scopus 로고    scopus 로고
    • The significance of carboxy-terminal telopeptide of type i collagen (ICTP) and osteocalcin (OC) in assessment of bone disease in patients with multiple myeloma
    • Kuliszkiewicz-Janus M, Ma"ecki R, Zó"taszek A, Zastawny M. The significance of carboxy-terminal telopeptide of type I collagen (ICTP) and osteocalcin (OC) in assessment of bone disease in patients with multiple myeloma. Leuk Lymphoma 2005; 46: 1749-1753.
    • (2005) Leuk Lymphoma , vol.46 , pp. 1749-1753
    • Kuliszkiewicz-Janus, M.1    Máecki, R.2    Zótaszek, A.3    Zastawny, M.4
  • 60
    • 51649090583 scopus 로고    scopus 로고
    • Incorporation of the bone marker carboxy-terminal telopep-tide of type-1 collagen improves prognostic information of the International Staging System in newly diagnosed symptomatic multiple myeloma
    • Jakob C, Sterz J, Liebisch P, Mieth M, Rademacher J, Goerke A et al. Incorporation of the bone marker carboxy-terminal telopep-tide of type-1 collagen improves prognostic information of the International Staging System in newly diagnosed symptomatic multiple myeloma. Leukemia 2008; 22: 1767-1772.
    • (2008) Leukemia , vol.22 , pp. 1767-1772
    • Jakob, C.1    Sterz, J.2    Liebisch, P.3    Mieth, M.4    Rademacher, J.5    Goerke, A.6
  • 61
    • 0034968746 scopus 로고    scopus 로고
    • Pamidronate increases markers of bone formation in patients with multiple myeloma in plateau phase under interferon-alpha treatment
    • Terpos E, Palermos J, Viniou N, Vaiopoulos G, Meletis J, Yataganas X. Pamidronate increases markers of bone formation in patients with multiple myeloma in plateau phase under interferon-alpha treatment. Calcif Tissue Int 2001; 68: 285-290.
    • (2001) Calcif Tissue Int , vol.68 , pp. 285-290
    • Terpos, E.1    Palermos, J.2    Viniou, N.3    Vaiopoulos, G.4    Meletis, J.5    Yataganas, X.6
  • 62
    • 0034667613 scopus 로고    scopus 로고
    • Biochemical markers of bone turnover following high-dose chemotherapy and autografting in multiple myeloma
    • Clark RE, Flory AJ, Ion EM, Woodcock BE, Durham BH, Fraser WD. Biochemical markers of bone turnover following high-dose chemotherapy and autografting in multiple myeloma. Blood 2000; 96: 2697-2702.
    • (2000) Blood , vol.96 , pp. 2697-2702
    • Clark, R.E.1    Flory, A.J.2    Ion, E.M.3    Woodcock, B.E.4    Durham, B.H.5    Fraser, W.D.6
  • 63
    • 4344588926 scopus 로고    scopus 로고
    • Autologous stem cell transplantation normalizes abnormal bone remodeling and sRANKL/osteoprotegerin ratio in patients with multiple myeloma
    • Terpos E, Politou M, Szydlo R, Nadal E, Avery S, Olavarria E et al. Autologous stem cell transplantation normalizes abnormal bone remodeling and sRANKL/osteoprotegerin ratio in patients with multiple myeloma. Leukemia 2004; 18: 1420-1426.
    • (2004) Leukemia , vol.18 , pp. 1420-1426
    • Terpos, E.1    Politou, M.2    Szydlo, R.3    Nadal, E.4    Avery, S.5    Olavarria, E.6
  • 64
    • 0034021345 scopus 로고    scopus 로고
    • Biochemical markers of bone metabolism reflect osteoclastic and osteoblastic activity in multiple myeloma
    • Abildgaard N, Glerup H, Rungby J, Bendix-Hansen K, Kassem M, Brixen K et al. Biochemical markers of bone metabolism reflect osteoclastic and osteoblastic activity in multiple myeloma. Eur J Haematol 2000; 64: 121-129.
    • (2000) Eur J Haematol , vol.64 , pp. 121-129
    • Abildgaard, N.1    Glerup, H.2    Rungby, J.3    Bendix-Hansen, K.4    Kassem, M.5    Brixen, K.6
  • 65
    • 12444282685 scopus 로고    scopus 로고
    • Serum levels of carboxy-terminal telopeptide of type-I collagen are elevated in patients with multiple myeloma showing skeletal manifestations in magnetic resonance imaging but lacking lytic bone lesions in conventional radiography
    • Jakob C, Zavrski I, Heider U, Bollow M, Schulz CO, Fleissner C et al. Serum levels of carboxy-terminal telopeptide of type-I collagen are elevated in patients with multiple myeloma showing skeletal manifestations in magnetic resonance imaging but lacking lytic bone lesions in conventional radiography. Clin Cancer Res 2003; 9: 3047-3051.
    • (2003) Clin Cancer Res , vol.9 , pp. 3047-3051
    • Jakob, C.1    Zavrski, I.2    Heider, U.3    Bollow, M.4    Schulz, C.O.5    Fleissner, C.6
  • 66
    • 0037345794 scopus 로고    scopus 로고
    • Urinary N-telopeptide levels in multiple myeloma patients, correlation with Tc-99m-sestaMIBI scintigraphy and other biochemical markers of disease activity
    • Alexandrakis MG, Kyriakou DS, Passam FH, Malliaraki N, Vlachonikolis IG, Karkavitsas N et al. Urinary N-telopeptide levels in multiple myeloma patients, correlation with Tc-99m-sestaMIBI scintigraphy and other biochemical markers of disease activity. Hematol Oncol 2003; 21: 17-24.
    • (2003) Hematol Oncol , vol.21 , pp. 17-24
    • Alexandrakis, M.G.1    Kyriakou, D.S.2    Passam, F.H.3    Malliaraki, N.4    Vlachonikolis, I.G.5    Karkavitsas, N.6
  • 67
    • 77952423759 scopus 로고    scopus 로고
    • Prognostic variables for survival and skeletal complications in patients with multiple myeloma osteolytic bone disease
    • Terpos E, Berenson J, Cook RJ, Lipton A, Coleman RE. Prognostic variables for survival and skeletal complications in patients with multiple myeloma osteolytic bone disease. Leukemia 2010; 24: 1043-1049.
    • (2010) Leukemia , vol.24 , pp. 1043-1049
    • Terpos, E.1    Berenson, J.2    Cook, R.J.3    Lipton, A.4    Coleman, R.E.5
  • 68
    • 0032824758 scopus 로고    scopus 로고
    • Prognostic evaluation in multiple myeloma: An analysis of the impact of new prognostic factors
    • Turesson I, Abildgaard N, Ahlgren T, Dahl I, Holmberg E, Hjorth M et al. Prognostic evaluation in multiple myeloma: an analysis of the impact of new prognostic factors. Br J Haematol 1999; 106: 1005-1012.
    • (1999) Br J Haematol , vol.106 , pp. 1005-1012
    • Turesson, I.1    Abildgaard, N.2    Ahlgren, T.3    Dahl, I.4    Holmberg, E.5    Hjorth, M.6
  • 69
    • 40849094250 scopus 로고    scopus 로고
    • The clinical significance of soluble human leukocyte antigen class-I, ICTP, and RANKL molecules in multiple myeloma patients
    • Schütt P, Rebmann V, Brandhorst D, Wiefelspütz J, Ebeling P, Opalka B et al. The clinical significance of soluble human leukocyte antigen class-I, ICTP, and RANKL molecules in multiple myeloma patients. Hum Immunol 2008; 69: 79-87.
    • (2008) Hum Immunol , vol.69 , pp. 79-87
    • Schütt, P.1    Rebmann, V.2    Brandhorst, D.3    Wiefelspütz, J.4    Ebeling, P.5    Opalka, B.6
  • 70
    • 77957982168 scopus 로고    scopus 로고
    • High baseline NTX predicts for inferior survival and shorter time to first SRE in Multiple Myeloma
    • Terpos E, Berenson J, Lipton A, Coleman R, Cook R. High baseline NTX predicts for inferior survival and shorter time to first SRE in Multiple Myeloma. Clin Lymphoma Myeloma 2009; 9 (Suppl 1): 50-51.
    • (2009) Clin Lymphoma Myeloma , vol.9 , Issue.SUPPL. 1 , pp. 50-51
    • Terpos, E.1    Berenson, J.2    Lipton, A.3    Coleman, R.4    Cook, R.5
  • 71
    • 0007723637 scopus 로고    scopus 로고
    • Monitoring the action of clodronate with type i collagen metabolites in multiple myeloma
    • Elomaa I, Risteli L, Laakso M, Lahtinen R, Virkkunen P, Risteli J. Monitoring the action of clodronate with type I collagen metabolites in multiple myeloma. Eur J Cancer 1996; 32A: 1166-1170.
    • (1996) Eur J Cancer , vol.32 A , pp. 1166-1170
    • Elomaa, I.1    Risteli, L.2    Laakso, M.3    Lahtinen, R.4    Virkkunen, P.5    Risteli, J.6
  • 72
    • 0035312469 scopus 로고    scopus 로고
    • Zoledronic acid reduces skeletal-related events in patients with osteolytic metastases
    • Berenson JR, Rosen LS, Howell A, Porter L, Coleman RE, Morley W et al. Zoledronic acid reduces skeletal-related events in patients with osteolytic metastases. Cancer 2001; 91: 1191-1200.
    • (2001) Cancer , vol.91 , pp. 1191-1200
    • Berenson, J.R.1    Rosen, L.S.2    Howell, A.3    Porter, L.4    Coleman, R.E.5    Morley, W.6
  • 73
    • 0035463593 scopus 로고    scopus 로고
    • Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: A phase III, double-blind, comparative trial
    • Rosen LS, Gordon D, Kaminski M, Howell A, Belch A, Mackey J et al. Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: a phase III, double-blind, comparative trial. Cancer J 2001; 7: 377-387.
    • (2001) Cancer J , vol.7 , pp. 377-387
    • Rosen, L.S.1    Gordon, D.2    Kaminski, M.3    Howell, A.4    Belch, A.5    MacKey, J.6
  • 74
    • 0036570071 scopus 로고    scopus 로고
    • Effects of long-term intravenous ibandronate therapy on skeletal-related events, survival, and bone resorption markers in patients with advanced multiple myeloma
    • Menssen HD, Sakalov A, Fontana A, Herrmann Z, Boewer C, Facon T et al. Effects of long-term intravenous ibandronate therapy on skeletal-related events, survival, and bone resorption markers in patients with advanced multiple myeloma. J Clin Oncol 2002; 20: 2353-2359.
    • (2002) J Clin Oncol , vol.20 , pp. 2353-2359
    • Menssen, H.D.1    Sakalov, A.2    Fontana, A.3    Herrmann, Z.4    Boewer, C.5    Facon, T.6
  • 75
    • 19244365106 scopus 로고    scopus 로고
    • Pamidronate is superior to ibandronate in decreasing bone resorption, interleukin-6 and beta 2-micro-globulin in multiple myeloma
    • Terpos E, Viniou N, de la Fuente J, Meletis J, Voskaridou E, Karkantaris C et al. Pamidronate is superior to ibandronate in decreasing bone resorption, interleukin-6 and beta 2-micro-globulin in multiple myeloma. Eur J Haematol 2003; 70: 34-42.
    • (2003) Eur J Haematol , vol.70 , pp. 34-42
    • Terpos, E.1    Viniou, N.2    De La Fuente, J.3    Meletis, J.4    Voskaridou, E.5    Karkantaris, C.6
  • 76
    • 27644523704 scopus 로고    scopus 로고
    • The combination of intermediate doses of thalidomide with dexamethasone is an effective treatment for patients with refractory/relapsed multiple myeloma and normalizes abnormal bone remodeling, through the reduction of sRANKL/osteo-protegerin ratio
    • Terpos E, Mihou D, Szydlo R, Tsimirika K, Karkantaris C, Politou M et al. The combination of intermediate doses of thalidomide with dexamethasone is an effective treatment for patients with refractory/relapsed multiple myeloma and normalizes abnormal bone remodeling, through the reduction of sRANKL/osteo-protegerin ratio. Leukemia 2005; 19: 1969-1976.
    • (2005) Leukemia , vol.19 , pp. 1969-1976
    • Terpos, E.1    Mihou, D.2    Szydlo, R.3    Tsimirika, K.4    Karkantaris, C.5    Politou, M.6
  • 77
    • 34248143552 scopus 로고    scopus 로고
    • Clinical utility of biochemical markers of bone metabolism for improving the management of patients with advanced multiple myeloma
    • Lipton A, Cook RJ, Coleman RE, Smith MR, Major P, Terpos E et al. Clinical utility of biochemical markers of bone metabolism for improving the management of patients with advanced multiple myeloma. Clin Lymphoma Myeloma 2007; 7: 346-353.
    • (2007) Clin Lymphoma Myeloma , vol.7 , pp. 346-353
    • Lipton, A.1    Cook, R.J.2    Coleman, R.E.3    Smith, M.R.4    Major, P.5    Terpos, E.6
  • 78
    • 77049089989 scopus 로고    scopus 로고
    • A double-blind, randomized study of denosumab versus zoledronic acid for the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma
    • (abstract 20LBA)
    • Henry D, von Moos R, Vadhan-Raj S, Hungria V, Spencer A, Hirsh V et al. A double-blind, randomized study of denosumab versus zoledronic acid for the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma. Eur J Cancer 2009: (Suppl 3): 12 (abstract 20LBA).
    • (2009) Eur J Cancer , Issue.SUPPL. 3 , pp. 12
    • Henry, D.1    Von Moos, R.2    Vadhan-Raj, S.3    Hungria, V.4    Spencer, A.5    Hirsh, V.6
  • 79
    • 0035496947 scopus 로고    scopus 로고
    • Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease
    • Seidel C, Hjertner Ø, Abildgaard N, Heickendorff L, Hjorth M, Westin J et al. Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease. Blood 2001; 98: 2269-2271.
    • (2001) Blood , vol.98 , pp. 2269-2271
    • Seidel, C.1    Hjertner Ø2    Abildgaard, N.3    Heickendorff, L.4    Hjorth, M.5    Westin, J.6
  • 81
    • 34548729630 scopus 로고    scopus 로고
    • Serum levels of OPG RANKL and RANKL/OPG ratio in newly-diagnosed patients with multiple myeloma. Clinical correlations
    • Goranova-Marinova V, Goranov S, Pavlov P, Tzvetkova T. Serum levels of OPG, RANKL and RANKL/OPG ratio in newly-diagnosed patients with multiple myeloma. Clinical correlations. Haemato-logica 2007; 92: 1000-1001.
    • (2007) Haemato-logica , vol.92 , pp. 1000-1001
    • Goranova-Marinova, V.1    Goranov, S.2    Pavlov, P.3    Tzvetkova, T.4
  • 82
    • 33845923381 scopus 로고    scopus 로고
    • The effect of zoledronic acid on serum osteoprotegerin in early stage multiple myeloma
    • Martini G, Gozzetti A, Gennari L, Avanzati A, Nuti R, Lauria F. The effect of zoledronic acid on serum osteoprotegerin in early stage multiple myeloma. Haematologica 2006; 91: 1720-1721.
    • (2006) Haematologica , vol.91 , pp. 1720-1721
    • Martini, G.1    Gozzetti, A.2    Gennari, L.3    Avanzati, A.4    Nuti, R.5    Lauria, F.6
  • 83
    • 57849161431 scopus 로고    scopus 로고
    • The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide is an effective regimen for relapsed/refractory myeloma and is associated with improvement of abnormal bone metabolism and angiogenesis
    • Terpos E, Kastritis E, Roussou M, Heath D, Christoulas D, Anagnostopoulos N et al. The combination of bortezomib, melphalan, dexamethasone and intermittent thalidomide is an effective regimen for relapsed/refractory myeloma and is associated with improvement of abnormal bone metabolism and angiogenesis. Leukemia 2008; 22: 2247-2256.
    • (2008) Leukemia , vol.22 , pp. 2247-2256
    • Terpos, E.1    Kastritis, E.2    Roussou, M.3    Heath, D.4    Christoulas, D.5    Anagnostopoulos, N.6
  • 84
    • 30944433586 scopus 로고    scopus 로고
    • Correlation of osteoprotegerin and sRANKL concentrations in serum and bone marrow of multiple myeloma patients
    • Kraj M, Owczarska K, Sokołowska U, Centkowski P, Pogłód R, Kruk B. Correlation of osteoprotegerin and sRANKL concentrations in serum and bone marrow of multiple myeloma patients. Arch Immunol Ther Exp 2005; 53: 454-464.
    • (2005) Arch Immunol Ther Exp , vol.53 , pp. 454-464
    • Kraj, M.1    Owczarska, K.2    Sokołowska, U.3    Centkowski, P.4    Pogłód, R.5    Kruk, B.6
  • 85
    • 0033617982 scopus 로고    scopus 로고
    • Content and distribution of noncollagenous matrix proteins in bone and cementum: Relationship to speed of formation and collagen packing density
    • Nanci A. Content and distribution of noncollagenous matrix proteins in bone and cementum: relationship to speed of formation and collagen packing density. J Struct Biol 1999; 126: 256-269.
    • (1999) J Struct Biol , vol.126 , pp. 256-269
    • Nanci, A.1
  • 86
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R, Rasmussen E, Ma Y, Barlogie B et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003; 349: 2483-2494.
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3    Rasmussen, E.4    Ma, Y.5    Barlogie, B.6
  • 87
    • 33747468221 scopus 로고    scopus 로고
    • Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation
    • Politou MC, Heath DJ, Rahemtulla A, Szydlo R, Anagnostopoulos A, Dimopoulos MA et al. Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation. Int J Cancer 2006; 119: 1728-1731.
    • (2006) Int J Cancer , vol.119 , pp. 1728-1731
    • Politou, M.C.1    Heath, D.J.2    Rahemtulla, A.3    Szydlo, R.4    Anagnostopoulos, A.5    Dimopoulos, M.A.6
  • 88
    • 43549108372 scopus 로고    scopus 로고
    • Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma
    • Kaiser M, Mieth M, Liebisch P, Oberländer R, Rademacher J, Jakob C et al. Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma. Eur J Hematol 2008; 80: 490-494.
    • (2008) Eur J Hematol , vol.80 , pp. 490-494
    • Kaiser, M.1    Mieth, M.2    Liebisch, P.3    Oberländer, R.4    Rademacher, J.5    Jakob, C.6
  • 89
    • 36849026690 scopus 로고    scopus 로고
    • Myeloma cell expression of 10 candidate genes for osteolytic bone disease. only overexpression of DKK1 correlates with clinical bone involvement at diagnosis
    • Haaber J, Abildgaard N, Knudsen LM, Dahl IM, Lodahl M, Thomassen M et al. Myeloma cell expression of 10 candidate genes for osteolytic bone disease. Only overexpression of DKK1 correlates with clinical bone involvement at diagnosis. Br J Haematol 2008; 140: 25-35.
    • (2008) Br J Haematol , vol.140 , pp. 25-35
    • Haaber, J.1    Abildgaard, N.2    Knudsen, L.M.3    Dahl, I.M.4    Lodahl, M.5    Thomassen, M.6
  • 90
    • 33847397091 scopus 로고    scopus 로고
    • Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
    • Yaccoby S, Ling W, Zhan F, Walker R, Barlogie B, Shaughnessy Jr JD et al. Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 2007; 109: 2106-2111.
    • (2007) Blood , vol.109 , pp. 2106-2111
    • Yaccoby, S.1    Ling, W.2    Zhan, F.3    Walker, R.4    Barlogie, B.5    Shaughnessy Jr., J.D.6
  • 91
    • 33645725851 scopus 로고    scopus 로고
    • First-line therapy with thalidomide, dexamethasone and zoledronic acid decreases bone resorption markers in patients with multiple myeloma
    • Tosi P, Zamagni E, Cellini C, Parente R, Cangini D, Tacchetti T et al. First-line therapy with thalidomide, dexamethasone and zoledronic acid decreases bone resorption markers in patients with multiple myeloma. Eur J Haematol 2006; 76: 399-404.
    • (2006) Eur J Haematol , vol.76 , pp. 399-404
    • Tosi, P.1    Zamagni, E.2    Cellini, C.3    Parente, R.4    Cangini, D.5    Tacchetti, T.6
  • 92
    • 54049156803 scopus 로고    scopus 로고
    • Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma
    • Breitkreutz I, Raab MS, Vallet S, Hideshima T, Raje N, Mitsiades C et al. Lenalidomide inhibits osteoclastogenesis, survival factors and bone-remodeling markers in multiple myeloma. Leukemia 2008; 22: 1925-1932.
    • (2008) Leukemia , vol.22 , pp. 1925-1932
    • Breitkreutz, I.1    Raab, M.S.2    Vallet, S.3    Hideshima, T.4    Raje, N.5    Mitsiades, C.6
  • 95
    • 33746786028 scopus 로고    scopus 로고
    • Bortezomib increases osteoblast activity in myeloma patients irrespective of response to treatment
    • Heider U, Kaiser M, Müller C, Jakob C, Zavrski I, Schulz CO et al. Bortezomib increases osteoblast activity in myeloma patients irrespective of response to treatment. Eur J Haematol 2006; 77: 233-238.
    • (2006) Eur J Haematol , vol.77 , pp. 233-238
    • Heider, U.1    Kaiser, M.2    Müller, C.3    Jakob, C.4    Zavrski, I.5    Schulz, C.O.6
  • 96
    • 34347400592 scopus 로고    scopus 로고
    • The proteasome inhibitor bortezomib affects osteoblast differentiation in vitro and in vivo in multiple myeloma patients
    • Giuliani N, Morandi F, Tagliaferri S, Lazzaretti M, Bonomini S, Crugnola M et al. The proteasome inhibitor bortezomib affects osteoblast differentiation in vitro and in vivo in multiple myeloma patients. Blood 2007; 110: 334-338.
    • (2007) Blood , vol.110 , pp. 334-338
    • Giuliani, N.1    Morandi, F.2    Tagliaferri, S.3    Lazzaretti, M.4    Bonomini, S.5    Crugnola, M.6
  • 97
    • 33750566914 scopus 로고    scopus 로고
    • Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand co ncentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma
    • Terpos E, Heath DJ, Rahemtulla A, Zervas K, Chantry A, Anagnostopoulos A et al. Bortezomib reduces serum dickkopf-1 and receptor activator of nuclear factor-kappaB ligand co ncentrations and normalises indices of bone remodelling in patients with relapsed multiple myeloma. Br J Haematol 2006; 135: 688-692.
    • (2006) Br J Haematol , vol.135 , pp. 688-692
    • Terpos, E.1    Heath, D.J.2    Rahemtulla, A.3    Zervas, K.4    Chantry, A.5    Anagnostopoulos, A.6


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