메뉴 건너뛰기




Volumn 14, Issue 3, 2009, Pages 276-283

Myeloma bone disease: Recent advances in biology, diagnosis, and treatment

Author keywords

Biochemical markers; Bone; DKK 1; ICTP; MIP 1; Multiple myeloma; Osteoblast; Osteoclast; Osteoprotegerin; RANKL

Indexed keywords

BHQ 880; BIOCHEMICAL MARKER; BISPHOSPHONIC ACID DERIVATIVE; BORTEZOMIB; DENOSUMAB; DICKKOPF 1 PROTEIN; DICKKOPF 1 PROTEIN ANTIBODY; MACROPHAGE INFLAMMATORY PROTEIN 1; NEUTRALIZING ANTIBODY; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN; PAMIDRONIC ACID; POLY(METHYL METHACRYLATE); PROTEASOME INHIBITOR; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

EID: 63849093676     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2009-0003     Document Type: Article
Times cited : (68)

References (92)
  • 1
    • 21344434846 scopus 로고    scopus 로고
    • Advances in biology and treatment of multiple myeloma
    • Ludwig H. Advances in biology and treatment of multiple myeloma. Ann Oncol 2005;16(suppl 2):ii106-ii12.
    • (2005) Ann Oncol , vol.16 , Issue.SUPPL. 2
    • Ludwig, H.1
  • 4
    • 0038509089 scopus 로고    scopus 로고
    • Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: A report of the International Myeloma Working Group
    • International Myeloma Working Group
    • International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: A report of the International Myeloma Working Group. Br J Haematol 2003; 121:749-757.
    • (2003) Br J Haematol , vol.121 , pp. 749-757
  • 5
    • 0037216353 scopus 로고    scopus 로고
    • Review of 1027 patients with newly diagnosed multiple myeloma
    • Kyle RA, Gertz MA, Witzig TE et al. Review of 1027 patients with newly diagnosed multiple myeloma. Mayo Clin Proc 2003;78:21-33.
    • (2003) Mayo Clin Proc , vol.78 , pp. 21-33
    • Kyle, R.A.1    Gertz, M.A.2    Witzig, T.E.3
  • 6
    • 34447266200 scopus 로고    scopus 로고
    • An international field study of the reliability and validity of a disease-specific questionnaire module (the QLQ- MY20) in assessing the quality of life of patients with multiple myeloma
    • Cocks K, Cohen D, Wisff F et al. An international field study of the reliability and validity of a disease-specific questionnaire module (the QLQ- MY20) in assessing the quality of life of patients with multiple myeloma. Eur J Cancer 2007;43:1670-1678.
    • (2007) Eur J Cancer , vol.43 , pp. 1670-1678
    • Cocks, K.1    Cohen, D.2    Wisff, F.3
  • 7
    • 51649090583 scopus 로고    scopus 로고
    • Incorporation of the bone marker car- boxy-terminal telopeptide of type-1 collagen improves prognostic information of the International Staging System in newly diagnosed symptomatic multiple myeloma
    • Jakob C, Sterz J, Liebisch P et al. Incorporation of the bone marker car- boxy-terminal telopeptide of type-1 collagen improves prognostic information of the International Staging System in newly diagnosed symptomatic multiple myeloma. Leukemia 2008;22:1767-1772.
    • (2008) Leukemia , vol.22 , pp. 1767-1772
    • Jakob, C.1    Sterz, J.2    Liebisch, P.3
  • 8
    • 14344250737 scopus 로고    scopus 로고
    • Fracture risk with multiple myeloma: A population-based study
    • Melton LJ 3rd, Kyle RA, Achenbach SJ et al. Fracture risk with multiple myeloma: A population-based study. J Bone Miner Res 2005;20:487-493.
    • (2005) J Bone Miner Res , vol.20 , pp. 487-493
    • Melton 3rd, L.J.1    Kyle, R.A.2    Achenbach, S.J.3
  • 9
    • 0032956189 scopus 로고    scopus 로고
    • Economic impact of using clodronate in the management of patients withmultiple myeloma
    • Bruce NJ, McCloskey EV, Kanis JA et al. Economic impact of using clodronate in the management of patients withmultiple myeloma. Br J Haematol 1999;104:358-364.
    • (1999) Br J Haematol , vol.104 , pp. 358-364
    • Bruce, N.J.1    McCloskey, E.V.2    Kanis, J.A.3
  • 10
    • 0025783336 scopus 로고
    • Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma
    • Bataille R, Chappard D, Marcelli C et al. Recruitment of new osteoblasts and osteoclasts is the earliest critical event in the pathogenesis of human multiple myeloma. J Clin Invest 1991;88:62-66.
    • (1991) J Clin Invest , vol.88 , pp. 62-66
    • Bataille, R.1    Chappard, D.2    Marcelli, C.3
  • 11
    • 1542720384 scopus 로고    scopus 로고
    • Cancer and the microenvi-ronment: Myeloma-osteoclast interactions as a model
    • Yaccoby S, Wezeman MJ, Henderson A et al. Cancer and the microenvi-ronment: Myeloma-osteoclast interactions as a model. Cancer Res 2004; 64:2016-2023.
    • (2004) Cancer Res , vol.64 , pp. 2016-2023
    • Yaccoby, S.1    Wezeman, M.J.2    Henderson, A.3
  • 12
    • 0020436606 scopus 로고
    • Quantitative histology of myeloma-induced bone changes
    • Valentin-Opran A, Charhon SA, Meunier PJ et al. Quantitative histology of myeloma-induced bone changes. Br J Haematol 1982;52:601-610.
    • (1982) Br J Haematol , vol.52 , pp. 601-610
    • Valentin-Opran, A.1    Charhon, S.A.2    Meunier, P.J.3
  • 13
    • 39449098165 scopus 로고    scopus 로고
    • Interactions of myeloma cells with osteoclasts promote tumour expansion and bone degradation through activation of a complex signalling network and upregulation of cathepsin K, matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA)
    • Hecht M, von Metzler I, Sack K et al. Interactions of myeloma cells with osteoclasts promote tumour expansion and bone degradation through activation of a complex signalling network and upregulation of cathepsin K, matrix metalloproteinases (MMPs) and urokinase plasminogen activator (uPA). Exp Cell Res 2008;314:1082-1093.
    • (2008) Exp Cell Res , vol.314 , pp. 1082-1093
    • Hecht, M.1    von Metzler, I.2    Sack, K.3
  • 14
    • 0016262579 scopus 로고
    • Evidence for the secretion of an osteoclast stimulating factor in myeloma
    • Mundy GR, Raisz LG, Cooper RA et al. Evidence for the secretion of an osteoclast stimulating factor in myeloma. N Engl J Med 1974;291:1041-1046.
    • (1974) N Engl J Med , vol.291 , pp. 1041-1046
    • Mundy, G.R.1    Raisz, L.G.2    Cooper, R.A.3
  • 15
    • 0030714605 scopus 로고    scopus 로고
    • A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function
    • Anderson DM, Maraskovsky E, Billingsley WL et al. A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature 1997;390:175-179.
    • (1997) Nature , vol.390 , pp. 175-179
    • Anderson, D.M.1    Maraskovsky, E.2    Billingsley, W.L.3
  • 16
    • 0032540319 scopus 로고    scopus 로고
    • Lacey DL, Timms E, Tan HL et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998;93:165-176. 17 Simonet WS, Lacey DL, Dunstan CR et al. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 1997;89: 309 -319.
    • Lacey DL, Timms E, Tan HL et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998;93:165-176. 17 Simonet WS, Lacey DL, Dunstan CR et al. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 1997;89: 309 -319.
  • 17
    • 0033611467 scopus 로고    scopus 로고
    • OPGL is a key regulator of osteoclas-togenesis, lymphocyte development and lymph-node organogenesis
    • Kong YY, Yoshida H, Sarosi I et al. OPGL is a key regulator of osteoclas-togenesis, lymphocyte development and lymph-node organogenesis. Nature 1999;397:315-323.
    • (1999) Nature , vol.397 , pp. 315-323
    • Kong, Y.Y.1    Yoshida, H.2    Sarosi, I.3
  • 18
    • 0032079445 scopus 로고    scopus 로고
    • Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification
    • Bucay N, Sarosi I, Dunstan CR et al. Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 1998; 12:1260 -1268.
    • (1998) Genes Dev , vol.12 , pp. 1260-1268
    • Bucay, N.1    Sarosi, I.2    Dunstan, C.R.3
  • 19
    • 0033984313 scopus 로고    scopus 로고
    • The roles ofosteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption
    • HofbauerLC, Khosla S, Dunstan CR et al. The roles ofosteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption. J Bone Miner Res 2000;15:2-12.
    • (2000) J Bone Miner Res , vol.15 , pp. 2-12
    • Hofbauer, L.C.1    Khosla, S.2    Dunstan, C.R.3
  • 20
    • 0035949510 scopus 로고    scopus 로고
    • Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression
    • Pearse RN, Sordillo EM, Yaccoby S et al. Multiple myeloma disrupts the TRANCE/osteoprotegerin cytokine axis to trigger bone destruction and promote tumor progression. Proc Natl Acad SciUSA 2001;98:11581-11586.
    • (2001) Proc Natl Acad SciUSA , vol.98 , pp. 11581-11586
    • Pearse, R.N.1    Sordillo, E.M.2    Yaccoby, S.3
  • 21
    • 0035895083 scopus 로고    scopus 로고
    • Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment
    • Giuliani N, Bataille R, Mancini C et al. Myeloma cells induce imbalance in the osteoprotegerin/osteoprotegerin ligand system in the human bone marrow environment. Blood 2001;98:3527-3533.
    • (2001) Blood , vol.98 , pp. 3527-3533
    • Giuliani, N.1    Bataille, R.2    Mancini, C.3
  • 22
    • 0037443533 scopus 로고    scopus 로고
    • RANK ligand and osteoprotegerin in myeloma bone disease
    • Sezer O, Heider U, Zavrski I et al. RANK ligand and osteoprotegerin in myeloma bone disease. Blood 2003;101:2094-2098.
    • (2003) Blood , vol.101 , pp. 2094-2098
    • Sezer, O.1    Heider, U.2    Zavrski, I.3
  • 23
    • 0035895055 scopus 로고    scopus 로고
    • Osteoprotegerin inhibits the development ofosteolytic bone disease in multiple myeloma
    • Croucher PI, Shipman CM, Lippitt J et al. Osteoprotegerin inhibits the development ofosteolytic bone disease in multiple myeloma. Blood 2001;98: 3534-3540.
    • (2001) Blood , vol.98 , pp. 3534-3540
    • Croucher, P.I.1    Shipman, C.M.2    Lippitt, J.3
  • 24
    • 0037389602 scopus 로고    scopus 로고
    • Expression of receptor activator of nuclear factor kappaB ligand on bone marrow plasma cells correlates with osteolytic bone disease in patients with multiple myeloma
    • Heider U, Langelotz C, Jakob C et al. Expression of receptor activator of nuclear factor kappaB ligand on bone marrow plasma cells correlates with osteolytic bone disease in patients with multiple myeloma. Clin Cancer Res 2003;9:1436-1440.
    • (2003) Clin Cancer Res , vol.9 , pp. 1436-1440
    • Heider, U.1    Langelotz, C.2    Jakob, C.3
  • 25
    • 0141482103 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor- kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo
    • Farrugia AN, Atkins GJ, To LB et al. Receptor activator of nuclear factor- kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo. Cancer Res 2003;63:5438-5445.
    • (2003) Cancer Res , vol.63 , pp. 5438-5445
    • Farrugia, A.N.1    Atkins, G.J.2    To, L.B.3
  • 26
    • 47249140444 scopus 로고    scopus 로고
    • Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteo- blasts: A potential mechanism underlying osteolytic bone lesions in multiple myeloma
    • Qiang YW, Chen Y, Stephens O et al. Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteo- blasts: A potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood 2008;112:196-207.
    • (2008) Blood , vol.112 , pp. 196-207
    • Qiang, Y.W.1    Chen, Y.2    Stephens, O.3
  • 27
    • 0037108435 scopus 로고    scopus 로고
    • Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells
    • Standal T, Seidel C, Hjertner 0 et al. Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells. Blood 2002;100:3002-3007.
    • (2002) Blood , vol.100 , pp. 3002-3007
    • Standal, T.1    Seidel, C.2    Hjertner 03
  • 28
    • 0043245842 scopus 로고    scopus 로고
    • Soluble receptor activator ofnuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: Proposal for a novel prognostic index
    • Terpos E, Szydlo R, Apperley JF et al. Soluble receptor activator ofnuclear factor kappaB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: Proposal for a novel prognostic index. Blood 2003;102:1064-1069.
    • (2003) Blood , vol.102 , pp. 1064-1069
    • Terpos, E.1    Szydlo, R.2    Apperley, J.F.3
  • 29
    • 0342322717 scopus 로고    scopus 로고
    • Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma
    • Choi SJ, Cruz JC, Craig F et al. Macrophage inflammatory protein 1-alpha is a potential osteoclast stimulatory factor in multiple myeloma. Blood 2000;96:671-675.
    • (2000) Blood , vol.96 , pp. 671-675
    • Choi, S.J.1    Cruz, J.C.2    Craig, F.3
  • 30
    • 0035664488 scopus 로고    scopus 로고
    • Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease
    • Choi SJ, Oba Y, Gazitt Y et al. Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease. J Clin Invest 2001;108:1833-1841.
    • (2001) J Clin Invest , vol.108 , pp. 1833-1841
    • Choi, S.J.1    Oba, Y.2    Gazitt, Y.3
  • 31
    • 0037105599 scopus 로고    scopus 로고
    • Role for macrophage inflammatory protein (MIP)-1α and MIP-1β in the development of osteolytic lesions in multiple myeloma
    • Abe M, Hiura K, Wilde J et al. Role for macrophage inflammatory protein (MIP)-1α and MIP-1β in the development of osteolytic lesions in multiple myeloma. Blood 2002;100:2195-2202.
    • (2002) Blood , vol.100 , pp. 2195-2202
    • Abe, M.1    Hiura, K.2    Wilde, J.3
  • 32
    • 0038579121 scopus 로고    scopus 로고
    • Dual effects of macrophage inflammatory protein-1α on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease
    • Oyajobi BO, Franchin G, Williams PJ et al. Dual effects of macrophage inflammatory protein-1α on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone disease. Blood 2003;102:311-319.
    • (2003) Blood , vol.102 , pp. 311-319
    • Oyajobi, B.O.1    Franchin, G.2    Williams, P.J.3
  • 33
    • 63849323647 scopus 로고    scopus 로고
    • Lentzsch S, Gries M, Janz M et al. Macrophage inflammatory protein 1-alpha (MIP-1 alpha) triggers migration and signaling cascades mediating sur
    • Lentzsch S, Gries M, Janz M et al. Macrophage inflammatory protein 1-alpha (MIP-1 alpha) triggers migration and signaling cascades mediating sur
  • 34
    • 63849185320 scopus 로고    scopus 로고
    • vival and proliferation in multiple myeloma (MM) cells. Blood 2003;101: 3568-3573.
    • vival and proliferation in multiple myeloma (MM) cells. Blood 2003;101: 3568-3573.
  • 36
    • 20144388592 scopus 로고    scopus 로고
    • Elevated serum levels of stromal-derived factor-1α are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients
    • Zannettino AC, Farrugia AN, Kortesidis A et al. Elevated serum levels of stromal-derived factor-1α are associated with increased osteoclast activity and osteolytic bone disease in multiple myeloma patients. Cancer Res 2005;65:1700-1709.
    • (2005) Cancer Res , vol.65 , pp. 1700-1709
    • Zannettino, A.C.1    Farrugia, A.N.2    Kortesidis, A.3
  • 37
    • 63849262026 scopus 로고    scopus 로고
    • Bone-resorbing cells in multiple myeloma: Osteoclasts, myeloma cell polykaryons, or both?
    • Silvestris F, Ciavarella S, De Matteo M et al. Bone-resorbing cells in multiple myeloma: Osteoclasts, myeloma cell polykaryons, or both? The Oncologist 2009;14:264-275.
    • (2009) The Oncologist , vol.14 , pp. 264-275
    • Silvestris, F.1    Ciavarella, S.2    De Matteo, M.3
  • 38
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature 2003;423:337-342.
    • (2003) Nature , vol.423 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 39
    • 0026558465 scopus 로고
    • Myeloma affects both the growth and function of human osteoblast-like cells
    • Evans CE, Ward C, Rathour L et al. Myeloma affects both the growth and function of human osteoblast-like cells. Clin Exp Metastasis 1992; 10:33-38.
    • (1992) Clin Exp Metastasis , vol.10 , pp. 33-38
    • Evans, C.E.1    Ward, C.2    Rathour, L.3
  • 40
    • 5044228112 scopus 로고    scopus 로고
    • Wnt signaling inosteoblasts and bone diseases
    • Westendorf JJ, Kahler RA, Schroeder TM. Wnt signaling inosteoblasts and bone diseases. Gene 2004;341:19-39.
    • (2004) Gene , vol.341 , pp. 19-39
    • Westendorf, J.J.1    Kahler, R.A.2    Schroeder, T.M.3
  • 41
    • 18044386744 scopus 로고    scopus 로고
    • Osteoporosis-Pseudoglioma Syndrome Collaborative Group. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development
    • Gong Y, Slee RB, Fukai N et al.; Osteoporosis-Pseudoglioma Syndrome Collaborative Group. LDL receptor-related protein 5 (LRP5) affects bone accrual and eye development. Cell 2001;107:513-523.
    • (2001) Cell , vol.107 , pp. 513-523
    • Gong, Y.1    Slee, R.B.2    Fukai, N.3
  • 42
    • 0038783316 scopus 로고    scopus 로고
    • Secreted antagonists of the Wnt signalling pathway
    • Kawano Y, Kypta R. Secreted antagonists of the Wnt signalling pathway. J Cell Sci 2003;116:2627-2634.
    • (2003) J Cell Sci , vol.116 , pp. 2627-2634
    • Kawano, Y.1    Kypta, R.2
  • 43
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003;349:2483-2494.
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3
  • 44
    • 33747468221 scopus 로고    scopus 로고
    • Serum concentrations of Dick- kopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation
    • Politou MC, Heath DJ, Rahemtulla A et al. Serum concentrations of Dick- kopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation. Int J Cancer 2006;119:1728-1731.
    • (2006) Int J Cancer , vol.119 , pp. 1728-1731
    • Politou, M.C.1    Heath, D.J.2    Rahemtulla, A.3
  • 45
    • 43549108372 scopus 로고    scopus 로고
    • Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma
    • Kaiser M, Mieth M, Liebisch P et al. Serum concentrations of DKK-1 correlate with the extent of bone disease in patients with multiple myeloma. Eur J Haematol 2008;80:490-494.
    • (2008) Eur J Haematol , vol.80 , pp. 490-494
    • Kaiser, M.1    Mieth, M.2    Liebisch, P.3
  • 46
    • 57649158485 scopus 로고    scopus 로고
    • Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment
    • Heider U, Kaiser M, Mieth M et al. Serum concentrations of DKK-1 decrease in patients with multiple myeloma responding to anti-myeloma treatment. Eur J Haematol 2009;82:31-38.
    • (2009) Eur J Haematol , vol.82 , pp. 31-38
    • Heider, U.1    Kaiser, M.2    Mieth, M.3
  • 47
    • 40849083276 scopus 로고    scopus 로고
    • Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma
    • Qiang YW, Barlogie B, Rudikoff S et al. Dkk1-induced inhibition of Wnt signaling in osteoblast differentiation is an underlying mechanism of bone loss in multiple myeloma. Bone 2008;42:669-680.
    • (2008) Bone , vol.42 , pp. 669-680
    • Qiang, Y.W.1    Barlogie, B.2    Rudikoff, S.3
  • 48
    • 33847397091 scopus 로고    scopus 로고
    • Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
    • Yaccoby S, Ling W, ZhanF et al. Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 2007;109:2106-2111.
    • (2007) Blood , vol.109 , pp. 2106-2111
    • Yaccoby, S.1    Ling, W.2    ZhanF3
  • 49
    • 27644473781 scopus 로고    scopus 로고
    • Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2
    • Oshima T, Abe M, Asano J et al. Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2. Blood 2005;106:3160-3165.
    • (2005) Blood , vol.106 , pp. 3160-3165
    • Oshima, T.1    Abe, M.2    Asano, J.3
  • 50
    • 34447335316 scopus 로고    scopus 로고
    • Osteoblasts promote migration and invasion of myeloma cells through upregulation of matrix metalloproteinases, urokinase plasminogen activator, hepatocyte growth factor and activation of p38 MAPK
    • Hecht M, Heider U, Kaiser M et al. Osteoblasts promote migration and invasion of myeloma cells through upregulation of matrix metalloproteinases, urokinase plasminogen activator, hepatocyte growth factor and activation of p38 MAPK. Br J Haematol 2007;138:446-458.
    • (2007) Br J Haematol , vol.138 , pp. 446-458
    • Hecht, M.1    Heider, U.2    Kaiser, M.3
  • 51
    • 0028810948 scopus 로고
    • Myeloma cells upregulate interleu- kin-6 secretion in osteoblastic cells through cell-to-cell contact but down-regulate osteocalcin
    • Barillé S, Collette M, Bataille R et al. Myeloma cells upregulate interleu- kin-6 secretion in osteoblastic cells through cell-to-cell contact but down-regulate osteocalcin. Blood 1995;86:3151-3159.
    • (1995) Blood , vol.86 , pp. 3151-3159
    • Barillé, S.1    Collette, M.2    Bataille, R.3
  • 52
    • 23744507989 scopus 로고    scopus 로고
    • IL-3 is a potential inhibitor of osteoblastdifferentiationin multiple myeloma
    • Ehrlich LA, Chung HY, Ghobrial I et al. IL-3 is a potential inhibitor of osteoblastdifferentiationin multiple myeloma. Blood 2005;106:1407-1414.
    • (2005) Blood , vol.106 , pp. 1407-1414
    • Ehrlich, L.A.1    Chung, H.Y.2    Ghobrial, I.3
  • 53
    • 23744498205 scopus 로고    scopus 로고
    • Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteo-blast formation and differentiation
    • Giuliani N, Colla S, Morandi F et al. Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteo-blast formation and differentiation. Blood 2005;106:2472-2483.
    • (2005) Blood , vol.106 , pp. 2472-2483
    • Giuliani, N.1    Colla, S.2    Morandi, F.3
  • 54
    • 33644558753 scopus 로고    scopus 로고
    • Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model
    • Yaccoby S, WezemanMJ, Zangari M et al. Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model. Haematologica 2006;91:192-199.
    • (2006) Haematologica , vol.91 , pp. 192-199
    • Yaccoby, S.1    Wezeman, M.J.2    Zangari, M.3
  • 55
    • 0038345395 scopus 로고    scopus 로고
    • Upregulation of osteoblast apoptosis by malignant plasma cells: A role in myeloma bone disease
    • Silvestris F, Cafforio P, Tucci M et al. Upregulation of osteoblast apoptosis by malignant plasma cells: A role in myeloma bone disease. Br J Haematol 2003;122:39-52.
    • (2003) Br J Haematol , vol.122 , pp. 39-52
    • Silvestris, F.1    Cafforio, P.2    Tucci, M.3
  • 56
    • 58249101211 scopus 로고    scopus 로고
    • Bone marrow microenvironment and the identification of new targets for myeloma therapy
    • Podar K, Chauhan D, Anderson KC. Bone marrow microenvironment and the identification of new targets for myeloma therapy. Leukemia 2009;23: 10 -24.
    • (2009) Leukemia , vol.23 , pp. 10-24
    • Podar, K.1    Chauhan, D.2    Anderson, K.C.3
  • 57
    • 17144395881 scopus 로고    scopus 로고
    • Whole-body low-dose mul- tidetector row-CT in the diagnosis of multiple myeloma: An alternative to conventional radiography
    • Horger M, Claussen CD, Bross-Bach U et al. Whole-body low-dose mul- tidetector row-CT in the diagnosis of multiple myeloma: An alternative to conventional radiography. Eur J Radiol 2005;54:289-297.
    • (2005) Eur J Radiol , vol.54 , pp. 289-297
    • Horger, M.1    Claussen, C.D.2    Bross-Bach, U.3
  • 58
    • 0030761160 scopus 로고    scopus 로고
    • Magnetic resonance imaging of the bone marrow in hematologic malignancies
    • Moulopoulos LA, Dimopoulos MA. Magnetic resonance imaging of the bone marrow in hematologic malignancies. Blood 1997;90:2127-2147.
    • (1997) Blood , vol.90 , pp. 2127-2147
    • Moulopoulos, L.A.1    Dimopoulos, M.A.2
  • 60
    • 0028873923 scopus 로고
    • Prognostic significance of magnetic resonance imaging in patients with asymptomatic multiple myeloma
    • Moulopoulos LA, Dimopoulos MA, Smith TL et al. Prognostic significance of magnetic resonance imaging in patients with asymptomatic multiple myeloma. J Clin Oncol 1995;13:251-256.
    • (1995) J Clin Oncol , vol.13 , pp. 251-256
    • Moulopoulos, L.A.1    Dimopoulos, M.A.2    Smith, T.L.3
  • 61
    • 34047195753 scopus 로고    scopus 로고
    • HaesslerJetal. Magneticresonanceimaging inmul- tiple myeloma: Diagnostic and clinical implications
    • WalkerR, BarlogieB, HaesslerJetal. Magneticresonanceimaging inmul- tiple myeloma: Diagnostic and clinical implications. J Clin Oncol 2007;25: 1121-1128.
    • (2007) J Clin Oncol , vol.25 , pp. 1121-1128
    • WalkerR1    BarlogieB2
  • 62
  • 63
    • 5444262558 scopus 로고    scopus 로고
    • Bisphosphonates: Clinical experience
    • Coleman RE. Bisphosphonates: Clinical experience. The Oncologist 2004; 9(suppl 4):14-27.
    • (2004) The Oncologist , vol.9 , Issue.SUPPL. 4 , pp. 14-27
    • Coleman, R.E.1
  • 64
    • 9044219839 scopus 로고    scopus 로고
    • Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group
    • Berenson JR, Lichtenstein A, Porter L et al. Efficacy of pamidronate in reducing skeletal events in patients with advanced multiple myeloma. Myeloma Aredia Study Group. N Engl J Med 1996;334:488-493.
    • (1996) N Engl J Med , vol.334 , pp. 488-493
    • Berenson, J.R.1    Lichtenstein, A.2    Porter, L.3
  • 65
    • 6844252283 scopus 로고    scopus 로고
    • Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group
    • Berenson JR, Lichtenstein A, Porter L et al. Long-term pamidronate treatment of advanced multiple myeloma patients reduces skeletal events. Myeloma Aredia Study Group. J Clin Oncol 1998;16:593-602.
    • (1998) J Clin Oncol , vol.16 , pp. 593-602
    • Berenson, J.R.1    Lichtenstein, A.2    Porter, L.3
  • 66
    • 0026646339 scopus 로고
    • Randomised, placebo-controlled mul- ticentre trial of clodronate in multiple myeloma. Finnish Leukaemia Group
    • Lahtinen R, Laakso M, Palva I et al. Randomised, placebo-controlled mul- ticentre trial of clodronate in multiple myeloma. Finnish Leukaemia Group. Lancet 1992;340:1049-1052.
    • (1992) Lancet , vol.340 , pp. 1049-1052
    • Lahtinen, R.1    Laakso, M.2    Palva, I.3
  • 67
    • 0034937438 scopus 로고    scopus 로고
    • Long-term follow-up of a prospective, double-blind, placebo-controlled randomized trial of clodronate in multiple myeloma
    • McCloskey EV, Dunn JA, Kanis JA et al. Long-term follow-up of a prospective, double-blind, placebo-controlled randomized trial of clodronate in multiple myeloma. Br J Haematol 2001;113:1035-1043.
    • (2001) Br J Haematol , vol.113 , pp. 1035-1043
    • McCloskey, E.V.1    Dunn, J.A.2    Kanis, J.A.3
  • 68
    • 0035863508 scopus 로고    scopus 로고
    • Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: A pooled analysis of two randomized, controlled clinical trials
    • Major P, Lortholary A, Hon J et al. Zoledronic acid is superior to pamidronate in the treatment of hypercalcemia of malignancy: A pooled analysis of two randomized, controlled clinical trials. J Clin Oncol 2001; 19:558 -567.
    • (2001) J Clin Oncol , vol.19 , pp. 558-567
    • Major, P.1    Lortholary, A.2    Hon, J.3
  • 69
    • 0035463593 scopus 로고    scopus 로고
    • Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: A phase III, double-blind, comparative trial
    • Rosen LS, Gordon D, Kaminski M et al. Zoledronic acid versus pamidronate in the treatment of skeletal metastases in patients with breast cancer or osteolytic lesions of multiple myeloma: A phase III, double-blind, comparative trial. Cancer J 2001;7:377-387.
    • (2001) Cancer J , vol.7 , pp. 377-387
    • Rosen, L.S.1    Gordon, D.2    Kaminski, M.3
  • 70
    • 2142817155 scopus 로고    scopus 로고
    • Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases
    • Ruggiero SL, Mehrotra B, Rosenberg TJ et al. Osteonecrosis of the jaws associated with the use of bisphosphonates: A review of 63 cases. J Oral Maxillofac Surg 2004;62:527-534.
    • (2004) J Oral Maxillofac Surg , vol.62 , pp. 527-534
    • Ruggiero, S.L.1    Mehrotra, B.2    Rosenberg, T.J.3
  • 71
    • 33644841755 scopus 로고    scopus 로고
    • Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: Incidence and risk factors
    • Bamias A, Kastritis E, Bamia C et al. Osteonecrosis of the jaw in cancer after treatment with bisphosphonates: Incidence and risk factors. J Clin Oncol 2005;23:8580-8587.
    • (2005) J Clin Oncol , vol.23 , pp. 8580-8587
    • Bamias, A.1    Kastritis, E.2    Bamia, C.3
  • 72
    • 34347260332 scopus 로고    scopus 로고
    • American Society of Clinical Oncology 2007 clinical practice guideline update on the role of bisphos- phonates in multiple myeloma
    • Kyle RA, Yee GC, Somerfield MR et al. American Society of Clinical Oncology 2007 clinical practice guideline update on the role of bisphos- phonates in multiple myeloma. J Clin Oncol 2007;25:2464-2472.
    • (2007) J Clin Oncol , vol.25 , pp. 2464-2472
    • Kyle, R.A.1    Yee, G.C.2    Somerfield, M.R.3
  • 73
    • 63849200591 scopus 로고    scopus 로고
    • Terpos E, Sezer O, Croucher P et al. Guidance for the use of bisphospho
    • Terpos E, Sezer O, Croucher P et al. Guidance for the use of bisphospho-
  • 74
    • 63849161734 scopus 로고    scopus 로고
    • nates in multiple myeloma: Recommendations of an expert panel on behalf of the European Myeloma Network. Ann Oncol 2009 (in press).
    • nates in multiple myeloma: Recommendations of an expert panel on behalf of the European Myeloma Network. Ann Oncol 2009 (in press).
  • 75
    • 58949104001 scopus 로고    scopus 로고
    • Reduction of osteonecrosis of the jaw(ONJ) after implementation of preventive measures inpatients with multiple myeloma treated with zoledronic acid
    • Dimopoulos MA, Kastritis E, Bamia C et al. Reduction of osteonecrosis of the jaw(ONJ) after implementation of preventive measures inpatients with multiple myeloma treated with zoledronic acid. Ann Oncol 2009;20:117-120.
    • (2009) Ann Oncol , vol.20 , pp. 117-120
    • Dimopoulos, M.A.1    Kastritis, E.2    Bamia, C.3
  • 76
    • 58949093771 scopus 로고    scopus 로고
    • Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. The experience of the National Cancer Institute of Milan
    • Ripamonti CI, Maniezzo M, Campa T et al. Decreased occurrence of osteonecrosis of the jaw after implementation of dental preventive measures in solid tumour patients with bone metastases treated with bisphosphonates. The experience of the National Cancer Institute of Milan. Ann Oncol 2009; 20:137-145.
    • (2009) Ann Oncol , vol.20 , pp. 137-145
    • Ripamonti, C.I.1    Maniezzo, M.2    Campa, T.3
  • 77
    • 34548133601 scopus 로고    scopus 로고
    • Bortezomib inhibits human osteoclastogenesis
    • von Metzler I, Krebbel H, Hecht M et al. Bortezomib inhibits human osteoclastogenesis. Leukemia 2007;21:2025-2034.
    • (2007) Leukemia , vol.21 , pp. 2025-2034
    • von Metzler, I.1    Krebbel, H.2    Hecht, M.3
  • 78
    • 33847365658 scopus 로고    scopus 로고
    • Proteasome as an emerging therapeutic target in cancer
    • Zavrski I, Kleeberg L, Kaiser M et al. Proteasome as an emerging therapeutic target in cancer. Curr Pharm Des 2007;13:471-485.
    • (2007) Curr Pharm Des , vol.13 , pp. 471-485
    • Zavrski, I.1    Kleeberg, L.2    Kaiser, M.3
  • 79
    • 33847380754 scopus 로고    scopus 로고
    • Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma
    • Jakob C, Egerer K, Liebisch P et al. Circulating proteasome levels are an independent prognostic factor for survival in multiple myeloma. Blood 2007;109:2100-2105.
    • (2007) Blood , vol.109 , pp. 2100-2105
    • Jakob, C.1    Egerer, K.2    Liebisch, P.3
  • 81
    • 20444441871 scopus 로고    scopus 로고
    • Proteasome inhibitors abrogate osteoclast differentiation and osteoclast function
    • Zavrski I, Krebbel H, Wildemann B et al. Proteasome inhibitors abrogate osteoclast differentiation and osteoclast function. Biochem Biophys Res Commun 2005;333:200-205.
    • (2005) Biochem Biophys Res Commun , vol.333 , pp. 200-205
    • Zavrski, I.1    Krebbel, H.2    Wildemann, B.3
  • 82
    • 48949107708 scopus 로고    scopus 로고
    • Pulse treatment with the proteasome inhibitor bortezomib inhibits osteoclast resorptive activity in clinically relevant conditions
    • Boissy P, Andersen TL, Lund T et al. Pulse treatment with the proteasome inhibitor bortezomib inhibits osteoclast resorptive activity in clinically relevant conditions. Leuk Res 2008;32:1661-1668.
    • (2008) Leuk Res , vol.32 , pp. 1661-1668
    • Boissy, P.1    Andersen, T.L.2    Lund, T.3
  • 83
    • 63849150893 scopus 로고    scopus 로고
    • KuckelkornUetal. Curcumindiminishes human osteoclastogenesis by inhibition of the signalosome-associated I-kB kinase
    • vonMetzlerI, KrebbelH, KuckelkornUetal. Curcumindiminishes human osteoclastogenesis by inhibition of the signalosome-associated I-kB kinase. J Cancer Res Clin Oncol 2009;135:173-179.
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 173-179
    • vonMetzlerI1    KrebbelH2
  • 84
    • 27744557499 scopus 로고    scopus 로고
    • Response to bortezomib is associated to osteoblastic activation in patients with multiple myeloma
    • Zangari M, Esseltine D, Lee CK et al. Response to bortezomib is associated to osteoblastic activation in patients with multiple myeloma. Br J Haematol 2005;131:71-73.
    • (2005) Br J Haematol , vol.131 , pp. 71-73
    • Zangari, M.1    Esseltine, D.2    Lee, C.K.3
  • 85
    • 33746786028 scopus 로고    scopus 로고
    • Bortezomib increases osteoblast activity in myeloma patients irrespective of response to treatment
    • Heider U, Kaiser M, Müller C et al. Bortezomib increases osteoblast activity in myeloma patients irrespective of response to treatment. Eur J Haematol 2006;77:233-238.
    • (2006) Eur J Haematol , vol.77 , pp. 233-238
    • Heider, U.1    Kaiser, M.2    Müller, C.3
  • 86
    • 34347400592 scopus 로고    scopus 로고
    • The proteasome inhibitor bort- ezomib affects osteoblast differentiation in vitro and in vivo in multiple myeloma patients
    • Giuliani N, Morandi F, Tagliaferri S et al. The proteasome inhibitor bort- ezomib affects osteoblast differentiation in vitro and in vivo in multiple myeloma patients. Blood 2007;110:334-338.
    • (2007) Blood , vol.110 , pp. 334-338
    • Giuliani, N.1    Morandi, F.2    Tagliaferri, S.3
  • 87
    • 38849130851 scopus 로고    scopus 로고
    • Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice
    • Mukherjee S, Raje N, Schoonmaker JA et al. Pharmacologic targeting of a stem/progenitor population in vivo is associated with enhanced bone regeneration in mice. J Clin Invest 2008;118:491-504.
    • (2008) J Clin Invest , vol.118 , pp. 491-504
    • Mukherjee, S.1    Raje, N.2    Schoonmaker, J.A.3
  • 88
    • 34548029349 scopus 로고    scopus 로고
    • Myeloma bone disease and proteasome inhibition therapies
    • Terpos E, Sezer O, Croucher P et al. Myeloma bone disease and proteasome inhibition therapies. Blood 2007;110:1098-1104.
    • (2007) Blood , vol.110 , pp. 1098-1104
    • Terpos, E.1    Sezer, O.2    Croucher, P.3
  • 89
    • 34548128339 scopus 로고    scopus 로고
    • The effect of novel anti-myeloma agents on bone metabolism of patients with multiple myeloma
    • Terpos E, Dimopoulos MA, Sezer O. The effect of novel anti-myeloma agents on bone metabolism of patients with multiple myeloma. Leukemia 2007;21:1875-1884.
    • (2007) Leukemia , vol.21 , pp. 1875-1884
    • Terpos, E.1    Dimopoulos, M.A.2    Sezer, O.3
  • 90
    • 61849174988 scopus 로고    scopus 로고
    • Anti-DKK1 mAb (BHQ880) as a potential therapeutic for multiple myeloma
    • Fulciniti M, Tassone P, Hideshima T et al. Anti-DKK1 mAb (BHQ880) as a potential therapeutic for multiple myeloma. Blood 2007;110(suppl 1): 169a.
    • (2007) Blood , vol.110 , Issue.SUPPL. 1
    • Fulciniti, M.1    Tassone, P.2    Hideshima, T.3
  • 91
    • 33644760436 scopus 로고    scopus 로고
    • A study of the biological receptor activator of nuclear factor-κB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer
    • Body JJ, Facon T, Coleman RE et al. A study of the biological receptor activator of nuclear factor-κB ligand inhibitor, denosumab, in patients with multiple myeloma or bone metastases from breast cancer. Clin Cancer Res 2006;12:1221-1228.
    • (2006) Clin Cancer Res , vol.12 , pp. 1221-1228
    • Body, J.J.1    Facon, T.2    Coleman, R.E.3
  • 92
    • 49449101080 scopus 로고    scopus 로고
    • The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement
    • Hussein MA, Vrionis FD, Allison R et al. The role of vertebral augmentation in multiple myeloma: International Myeloma Working Group Consensus Statement. Leukemia 2008;22:1479-1484.
    • (2008) Leukemia , vol.22 , pp. 1479-1484
    • Hussein, M.A.1    Vrionis, F.D.2    Allison, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.