Purkinje cell death after uptake of anti-yo antibodies in cerebellar slice cultures

Journal of Neuropathology and Experimental Neurology

Volumn 69, Issue 10, 2010, Pages 997-1007

  Greenlee, John E ^a,d,f   Clawson, Susan A ^d   Hill, Kenneth E ^d   Wood, Blair L ^d   Tsunoda, Ikuo ^g   Carlson, Noel G ^b,c,d,e,f  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b Research Service   (United States)

^c GRECC   (United States)

^d Department of Neurology ^*  (United States)

^e Center on Aging   (United States)

^f UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^g LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Anti Yo antibody; Autoantibodies; Cerebellar slice cultures; Paraneoplastic syndromes; Purkinje cells

Indexed keywords

CELL ANTIBODY; IMMUNOGLOBULIN G; UNCLASSIFIED DRUG; YO ANTIBODY; CDR2 PROTEIN, HUMAN; DIAGNOSTIC AGENT; NERVE PROTEIN; ORGANIC COMPOUND; SYTOX GREEN;

ANIMAL TISSUE; ANTIBODY TITER; APOPTOSIS; ARTICLE; CELL DEATH; CELL VIABILITY; CEREBELLUM; CEREBROSPINAL FLUID; CLINICAL ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; PURKINJE CELL; RAT; ANIMAL; BLOOD; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG EFFECT; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; METHODOLOGY; NEWBORN; NICK END LABELING; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; TIME;

ANIMALS; ANIMALS, NEWBORN; CELL DEATH; CEREBELLUM; HUMANS; IMMUNOGLOBULIN G; IN SITU NICK-END LABELING; MICROSCOPY, CONFOCAL; NERVE TISSUE PROTEINS; ORGAN CULTURE TECHNIQUES; ORGANIC CHEMICALS; PURKINJE CELLS; RATS; TIME FACTORS;

EID: 77957963965     PISSN: 00223069     EISSN: None     Source Type: Journal    
DOI: 10.1097/NEN.0b013e3181f0c82b     Document Type: Article

References (40)

1. Greenlee JE, Brashear HR. Antibodies to cerebellar Purkinje cells in patients with paraneoplastic cerebellar degeneration and ovarian carcinoma. Ann Neurol 1983;14:609-13
2. Jaeckle KA, Graus F, Houghton A, et al. Autoimmune response of patients with paraneoplastic cerebellar degeneration to a Purkinje cell cytoplasmic antigen. Ann Neurol 1985;18:592-600
3. Anderson NE, Rosenblum MK, Posner JB. Paraneoplastic cerebellar degeneration: Clinical immunological correlations. Ann Neurol 1988;24: 559-67
4. Cunningham J, Graus F, Anderson N, et al. Partial characterization of the Purkinje cell antigens in paraneoplastic cerebellar degeneration. Neurology 1986;36:1163-68
5. Furneaux HM, Reich L, Posner JB. Autoantibody synthesis in the central nervous system of patients with paraneoplastic syndromes. Neurology 1990;40:1085-91
6. Moll JW, Antoine JC, Brashear HR, et al. Guidelines on the detection of paraneoplastic antiYneuronal-specific antibodies: Report from the Workshop to the Fourth Meeting of the International Society of Neuro-Immunology on paraneoplastic neurological disease, held October 22-23, 1994, in Rotterdam, The Netherlands. Neurology 1995;45:1937-41
7. Rodriguez M, Truh LI, O'Neill BP, et al. Autoimmune paraneoplastic cerebellar degeneration: Ultrastructural localization of antibody-binding sites in Purkinje cells. Neurology 1988;38:1380-86
8. Hida C, Tsukamoto T, Awano H, et al. Ultrastructural localization of antiYPurkinje cell antibody-binding sites in paraneoplastic cerebellar degeneration. Arch Neurol 1994;51:555-58
9. Furneaux HM, Rosenblum MK, Dalmau J, et al. Selective expression of Purkinje cell antigens in tumor tissue from patients with paraneoplastic cerebellar degeneration. N Engl J Med 1990;322:1844-51
10. Tanaka K, Tanaka M, Onodera O, et al. Passive transfer and active immunization with the recombinant leucine-zipper (Yo) protein as an attempt to establish an animal model of paraneoplastic cerebellar degeneration. J Neurol Sci 1994;127:153-58
11. Tanaka K, Tanaka M, Igarashi S, et al. Trial to establish an animal model of paraneoplastic cerebellar degeneration with anti-Yo antibody, 2. Passive transfer of murine mononuclear cells activated with recombinant Yo protein to paraneoplastic cerebellar degeneration lymphocytes in severe combined immunodeficiency mice. Clin Neurol Neurosurg 1995; 97:101-5
12. Tanaka M, Tanaka K, Tsuji S. No ataxia and no Purkinje cell loss in newborn young of SJL mice with anti-Yo antibody [letter to editor]. Exp Neurol 1998;149:200
13. Tanaka M, Tanaka K, Onodera O, et al. Trial to establish an animal model of paraneoplastic cerebellar degeneration with anti-Yo antibody, 1. Mouse strains bearing different MHC molecules produce antibodies on immunization with recombinant Yo protein but do not cause Purkinje cell loss. Clin Neurol Neurosurg 1995;97:95-100
14. Graus F, Illa I, Agusta M, et al. Effect of intraventricular injection of antiYPurkinje cell antibody (anti-Yo) in a guinea pig model. J Neurol Sci 1991;106:82-87
15. Greenlee JE, Burns JB, Rose JW, et al. Uptake of systemically administered human anticerebellar antibody by rat Purkinje cells following blood-brain barrier disruption. Acta Neuropathol Berl 1995;89:341-45
16. Sakai K, Gofuku M, Kitagawa Y, et al. Induction of antiYPurkinje cell antibodies in vivo by immunizing with a recombinant 52-kDa paraneo-plastic cerebellar degenerationYassociated protein. J Neuroimmunol 1995;60:135-41
17. Graus F, Seguardo OG, Tolosa E. Selective concentration of antiY Purkinje cell antibody in the CSF of two patients with paraneoplastic cerebellar degeneration. Acta Neurol Scand 1988;78:210-13
18. Hill KE, Clawson SA, Rose JW, et al. Cerebellar Purkinje cells incorporate immunoglobulins and immunotoxins in vitro: Implications for human neurological disease and immunotherapeutics. J Neuroinflammation 2009;6:31
19. Sakai K, Ogasawara T, Hirose G, et al. Analysis of autoantibody binding to 52 kd paraneoplastic cerebellar degenerationYassociated antigen expressed in recombinant proteins. Ann Neurol 1993;33:373-80
20. Greenlee JE, Parks TN, Jaeckle KA. Type IIa (Banti-Hu[) antineuronal antibodies produce destruction of rat cerebellar granule neurons in vitro. Neurology 1993;43:2049-54
21. Gincel D, Regan MR, Jin L, et al. Analysis of cerebellar Purkinje cells using EAAT4 glutamate transporter promoter reporter in mice generated via bacterial artificial chromosomeYmediated transgenesis. Exp Neurol 2007;203:205-12
22. Tauer U, Volk B, Heimrich B. Differentiation of Purkinje cells in cere-bellar slice cultures: An immunocytochemical and Golgi EM study. Neuropathol Appl Neurobiol 1996;22:361-69
23. Nag TC, Wadhwa S. Calbindin immunoreactivity in the developing and adult human cerebellum. J Chem Neuroanat 1999;17:1-12
24. King MA. Detection of dead cells and measurement of cell killing by flow cytometry. J Immunol Methods 2000;243:155-66
25. Borges LF, Elliott PJ, Gill R, et al. Selective extraction of small and large molecules from the cerebrospinal fluid by Purkinje neurons. Science 1985;228:346-48
26. Chen S, Su HS. Selective labeling by propidium iodide injected into the lateral cerebral ventricle of the rat. Brain Res 1989;483:379-83
27. Jones LJ, Singer VL. Fluorescence microplateYbased assay for tumor necrosis factor activity using SYTOX Green stain. Anal Biochem 2001; 293:8-15
28. Cheung NS, Beart PM, Pascoe CJ, et al. Human Bcl-2 protects against AMPA receptorYmediated apoptosis. J Neurochem 2000;74: 1613-20
29. Krassioukov AV, Ackery A, Schwartz G, et al. An in vitro model of neurotrauma in organotypic spinal cord cultures from adult mice. Brain Res Brain Res Protoc 2002;10:60-68
30. Moldrich RX, Beart PM, Pascoe CJ, et al. Low-affinity kainate receptor agonists induce insult-dependent apoptosis and necrosis in cultured murine cortical neurons. J Neurosci Res 2000;59:788-96
31. Roth BL, Poot M, Yue ST, et al. Bacterial viability and antibiotic susceptibility testing with SYTOX green nucleic acid stain. Appl Environ Microbiol 1997;63:2421-31
32. Mori S, Sternberger NH, Herman MM, et al. Leakage and neuronal uptake of serum protein in aged and Alzheimer brains. A postmortem phenomenon with antemortem etiology. Lab Invest 1991;64:345-51
33. Dropcho EJ, Chen YT, Posner JB, et al. Cloning of a brain protein identified by autoantibodies from a patient with paraneoplastic cerebellar degeneration. Proc Natl Acad Sci U S A 1987;84:4552-56
34. Furneaux HM, Dropcho EJ, Barbut D, et al. Characterization of a cDNA encoding a 34-kDa Purkinje neuron protein recognized by sera from patients with paraneoplastic cerebellar degeneration. Proc Natl Acad Sci U S A 1989;86:2873-77
35. Dropcho EJ, Furneaux H, Chen YT, et al. Expression of the CDR brain protein by tumors from patients with paraneoplastic cerebellar degeneration. Ann Neurol 1988;24:121-22
36. Peterson K, Rosenblum MK, Kotanides H, et al. Paraneoplastic cerebel-lar degeneration. I. A clinical analysis of 55 anti-Yo antibodyYpositive patients. Neurology 1992;42:1931-37
37. Albert ML, Austin LM, Darnell RB. Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration. Ann Neurol 2000;47:9-17
38. Dalmau J, Rosenfeld MR. Paraneoplastic syndromes of the CNS. Lancet Neurol 2008;7:327-40
39. Borges LF, Busis NA. Intraneuronal accumulation of myeloma proteins. Arch Neurol 1985;42:690-95
40. Fathallah-Shaykh H, Wolf S, Wong E, et al. Cloning of a leucine-zipper protein recognized by the sera of patients with antibody-associated paraneoplastic cerebellar degeneration. Proc Natl Acad Sci U S A 1991; 88:3451-54