Inhibitory effect of azimilide on Na+/Ca2+ exchange current in guinea-Pig cardiac myocytes

Journal of Pharmacological Sciences

Volumn 114, Issue 1, 2010, Pages 111-114

  Watanabe, Yasuhide ^a   Kimura, Junko ^b  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Antiarrhythmic drug; Azimilide

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; AZIMILIDE; SODIUM CALCIUM EXCHANGE PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG POTENCY; ELECTROSTIMULATION; GUINEA PIG; HEART MUSCLE CELL; IC 50; NONHUMAN; SODIUM CALCIUM EXCHANGE;

EID: 77957948426     PISSN: 13478613     EISSN: 13478648     Source Type: Journal    
DOI: 10.1254/jphs.10066SC     Document Type: Article

References (14)

1. Camm AJ, Karam R, Pratt CM. The azimilide post-infarct survival evaluation (ALIVE) trial. Am J Cardiol. 1998;81:35D-39D.
2. Connolly SJ, Schnell DJ, Page RL, Wilkinson WE, Marcello SR, Pritchett EL. Dose-response relations of azimilide in the management of symptomatic, recurrent, atrial fibrillation. Am J Cardiol. 2001;88:974-979.
3. Yao JA, Tseng GN. Azimilide (NE-10064) can prolong or shorten the action potential duration in canine ventricular myocytes: dependence on blockade on K, Ca, and Na channels. J Cardiovasc Electrophysiol. 1997;8:184-198.
4. Brooks RR, Pong SF, Izzo NJ, Moorehead TJ, Gopalakrishnan M, Triggle DJ. Interaction of azimilide with neurohumoral and channel receptors. Biochem Pharmacol. 2001;62:883-892.
5. Takács J, Iost N, Lengyel C, Virág L, Nesic M, Varró A, et al. Multiple cellular electrophysiological effects of azimilide in canine cardiac preparations. Eur J Pharmacol. 2003;470:163-170.
6. + current and experimental atrial fibrillation in guinea-pig hearts. J Pharmacol Sci. 2007;105:229-239.
7. 2+ exchanger inhibitors. J Pharmacol Sci. 2006;102:7-16.
8. 2+ exchange current guinea-pig cardiac myocytes. Br J Pharmacol. 2000;131:80-84.
9. 2+-exchange of nerve and muscle cells. Prog Neurobiol. 2007;82:287-347.
10. 2+ exchange current in guinea-pig cardiac ventricular myocytes. Br J Pharmacol. 2001;132:1317-1325.
11. Kass RS, Tsien RW, Weingart R. Ionic basis of transient inward current induced by strophanthidin in cardiac Purkinje fibres. J Physiol. 1978;281:209-226.
12. Nagy ZA, Virág L, Tóth A, Biliczki P, Acsai K, Bányász T, et al. Selective inhibition of sodium-calcium exchanger by SEA0400 decreases early and delayed afterdepolarization in canine heart. Br J Pharmacol. 2004;143:827-831.
13. 2+ exchange inhibitor, KB-R7943 on ouabain-induced arrhythmias in guinea-pigs. Br J Pharmacol. 1999;127:1846-1850.
14. Rosen MR, Danilo P. Effects of tetrodotoxin, lidocaine, verapamil, and AHR-2666 on ouabain-induced delayed afterdepolarizations in canine Purkinje fibers. Circ Res 1980;46:117-124.