-
2
-
-
1542618316
-
Improving second-line therapy in aggressive non-Hodgkin's lymphoma
-
Gisselbrecht C., Mounier N. Improving second-line therapy in aggressive non-Hodgkin's lymphoma. Semin. Oncol. 2004, 31:12-16.
-
(2004)
Semin. Oncol.
, vol.31
, pp. 12-16
-
-
Gisselbrecht, C.1
Mounier, N.2
-
3
-
-
34347220473
-
Defining the role of mTOR in cancer
-
Guertin D.A., Sabatini D.M. Defining the role of mTOR in cancer. Cancer Cell 2007, 12:9-22.
-
(2007)
Cancer Cell
, vol.12
, pp. 9-22
-
-
Guertin, D.A.1
Sabatini, D.M.2
-
4
-
-
68249093818
-
Targeting the phosphoinositide 3-kinase pathway in cancer
-
Liu P., Cheng H., Roberts T.M., Zhao J.J. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat. Rev. Drug Discov. 2009, 8:627-644.
-
(2009)
Nat. Rev. Drug Discov.
, vol.8
, pp. 627-644
-
-
Liu, P.1
Cheng, H.2
Roberts, T.M.3
Zhao, J.J.4
-
5
-
-
43049131769
-
Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations
-
LoPiccolo J., Blumenthal G.M., Bernstein W.B., Dennis P.A. Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations. Drug Resist. Updates 2008, 11:32-50.
-
(2008)
Drug Resist. Updates
, vol.11
, pp. 32-50
-
-
LoPiccolo, J.1
Blumenthal, G.M.2
Bernstein, W.B.3
Dennis, P.A.4
-
6
-
-
33747846726
-
Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma
-
Rudelius M., Pittaluga S., Nishizuka S., Pham T.H.T., Fend F., Jaffe E.S., Quintanilla-Martinez L., Raffeld M. Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphoma. Blood 2006, 108:1668-1676.
-
(2006)
Blood
, vol.108
, pp. 1668-1676
-
-
Rudelius, M.1
Pittaluga, S.2
Nishizuka, S.3
Pham, T.H.T.4
Fend, F.5
Jaffe, E.S.6
Quintanilla-Martinez, L.7
Raffeld, M.8
-
7
-
-
33845501828
-
Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival
-
Uddin S., Hussain A.R., Siraj A.K., Manogaran P.S., Al-Jomah N.A., Moorji A., Atizado V., Al-Dayel F., Belgaumi A., El-Solh H., Ezzat A., Bavi P., Al-Kuraya K.S. Role of phosphatidylinositol 3'-kinase/AKT pathway in diffuse large B-cell lymphoma survival. Blood 2006, 108:4178-4186.
-
(2006)
Blood
, vol.108
, pp. 4178-4186
-
-
Uddin, S.1
Hussain, A.R.2
Siraj, A.K.3
Manogaran, P.S.4
Al-Jomah, N.A.5
Moorji, A.6
Atizado, V.7
Al-Dayel, F.8
Belgaumi, A.9
El-Solh, H.10
Ezzat, A.11
Bavi, P.12
Al-Kuraya, K.S.13
-
8
-
-
33746118057
-
Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma
-
Vega F., Medeiros L.J., Leventaki V., Atwell C., Cho-Vega J.H., Tian L., Claret F.-X., Rassidakis G.Z. Activation of mammalian target of rapamycin signaling pathway contributes to tumor cell survival in anaplastic lymphoma kinase-positive anaplastic large cell lymphoma. Cancer Res. 2006, 66:6589-6597.
-
(2006)
Cancer Res.
, vol.66
, pp. 6589-6597
-
-
Vega, F.1
Medeiros, L.J.2
Leventaki, V.3
Atwell, C.4
Cho-Vega, J.H.5
Tian, L.6
Claret, F.-X.7
Rassidakis, G.Z.8
-
9
-
-
49049087320
-
Low-dose, single-agent temsirolimus for relapsed mantle cell lymphoma: a phase 2 trial in the north central cancer treatment group
-
Ansell S.M., Inwards D.J., Rowland K.M., Flynn P.J., Morton R.F., Moore D.F., Kaufmann S.H., Ghobrial I., Kurtin P.J., Maurer M., Allmer C., Witzig T.E. Low-dose, single-agent temsirolimus for relapsed mantle cell lymphoma: a phase 2 trial in the north central cancer treatment group. Cancer 2008, 113:508-514.
-
(2008)
Cancer
, vol.113
, pp. 508-514
-
-
Ansell, S.M.1
Inwards, D.J.2
Rowland, K.M.3
Flynn, P.J.4
Morton, R.F.5
Moore, D.F.6
Kaufmann, S.H.7
Ghobrial, I.8
Kurtin, P.J.9
Maurer, M.10
Allmer, C.11
Witzig, T.E.12
-
10
-
-
51449092399
-
Phase III study of patients with relapsed, refractory mantle cell lymphoma treated with temsirolimus compared with investigator's choice therapy
-
Hess G., Romaguera J.E., Verhoef G., Herbrecht R., Crump M., Strahs A., Clancy J., Hewes B., Coiffier B. Phase III study of patients with relapsed, refractory mantle cell lymphoma treated with temsirolimus compared with investigator's choice therapy. J. Clin. Oncol. (Meeting Abstracts) 2008, 26:8513.
-
(2008)
J. Clin. Oncol. (Meeting Abstracts)
, vol.26
, pp. 8513
-
-
Hess, G.1
Romaguera, J.E.2
Verhoef, G.3
Herbrecht, R.4
Crump, M.5
Strahs, A.6
Clancy, J.7
Hewes, B.8
Coiffier, B.9
-
11
-
-
51449096670
-
A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies
-
Rizzieri D.A., Feldman E., DiPersio J.F., Gabrail N., Stock W., Strair R., Rivera V.M., Albitar M., Bedrosian C.L., Giles F.J. A phase 2 clinical trial of deforolimus (AP23573, MK-8669), a novel mammalian target of rapamycin inhibitor, in patients with relapsed or refractory hematologic malignancies. Clin. Cancer Res. 2008, 14:2756-2762.
-
(2008)
Clin. Cancer Res.
, vol.14
, pp. 2756-2762
-
-
Rizzieri, D.A.1
Feldman, E.2
DiPersio, J.F.3
Gabrail, N.4
Stock, W.5
Strair, R.6
Rivera, V.M.7
Albitar, M.8
Bedrosian, C.L.9
Giles, F.J.10
-
12
-
-
61649117233
-
Activity of single agent temsirolimus (CCI-779) in non-mantle cell non-Hodgkin lymphoma subtypes
-
Smith S.M., Pro B., Cisneros A., Smith S., Stiff P., Lester E., Modi S., Dancey J.E., Vokes E.E., van Besien K. Activity of single agent temsirolimus (CCI-779) in non-mantle cell non-Hodgkin lymphoma subtypes. J. Clin. Oncol. (Meeting Abstracts) 2008, 26:8514.
-
(2008)
J. Clin. Oncol. (Meeting Abstracts)
, vol.26
, pp. 8514
-
-
Smith, S.M.1
Pro, B.2
Cisneros, A.3
Smith, S.4
Stiff, P.5
Lester, E.6
Modi, S.7
Dancey, J.E.8
Vokes, E.E.9
van Besien, K.10
-
13
-
-
23944481410
-
Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma
-
Witzig T.E., Geyer S.M., Ghobrial I., Inwards D.J., Fonseca R., Kurtin P., Ansell S.M., Luyun R., Flynn P.J., Morton R.F., Dakhil S.R., Gross H., Kaufmann S.H. Phase II trial of single-agent temsirolimus (CCI-779) for relapsed mantle cell lymphoma. J. Clin. Oncol. 2005, 23:5347-5356.
-
(2005)
J. Clin. Oncol.
, vol.23
, pp. 5347-5356
-
-
Witzig, T.E.1
Geyer, S.M.2
Ghobrial, I.3
Inwards, D.J.4
Fonseca, R.5
Kurtin, P.6
Ansell, S.M.7
Luyun, R.8
Flynn, P.J.9
Morton, R.F.10
Dakhil, S.R.11
Gross, H.12
Kaufmann, S.H.13
-
14
-
-
33749002279
-
Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies
-
Yee K.W.L., Zeng Z., Konopleva M., Verstovsek S., Ravandi F., Ferrajoli A., Thomas D., Wierda W., Apostolidou E., Albitar M., O'Brien S., Andreeff M., Giles F.J. Phase I/II study of the mammalian target of rapamycin inhibitor everolimus (RAD001) in patients with relapsed or refractory hematologic malignancies. Clin. Cancer Res. 2006, 12:5165-5173.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 5165-5173
-
-
Yee, K.W.L.1
Zeng, Z.2
Konopleva, M.3
Verstovsek, S.4
Ravandi, F.5
Ferrajoli, A.6
Thomas, D.7
Wierda, W.8
Apostolidou, E.9
Albitar, M.10
O'Brien, S.11
Andreeff, M.12
Giles, F.J.13
-
15
-
-
1642586272
-
Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy
-
Wendel H.-G., Stanchina E.D., Fridman J.S., Malina A., Ray S., Kogan S., Cordon-Cardo C., Pelletier J., Lowe S.W. Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy. Nature 2004, 428:332-337.
-
(2004)
Nature
, vol.428
, pp. 332-337
-
-
Wendel, H.-G.1
Stanchina, E.D.2
Fridman, J.S.3
Malina, A.4
Ray, S.5
Kogan, S.6
Cordon-Cardo, C.7
Pelletier, J.8
Lowe, S.W.9
-
16
-
-
33846516354
-
Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma
-
Haritunians T., Mori A., O'Kelly J., Luong Q.T., Giles F.J., Koeffler H.P. Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphoma. Leukemia 2006, 21:333-339.
-
(2006)
Leukemia
, vol.21
, pp. 333-339
-
-
Haritunians, T.1
Mori, A.2
O'Kelly, J.3
Luong, Q.T.4
Giles, F.J.5
Koeffler, H.P.6
-
17
-
-
52649149525
-
MTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia
-
Teachey D.T., Sheen C., Hall J., Ryan T., Brown V.I., Fish J., Reid G.S., Seif A.E., Norris R., Chang Y.J., Carroll M., Grupp S.A. mTOR inhibitors are synergistic with methotrexate: an effective combination to treat acute lymphoblastic leukemia. Blood 2008, 112:2020-2023.
-
(2008)
Blood
, vol.112
, pp. 2020-2023
-
-
Teachey, D.T.1
Sheen, C.2
Hall, J.3
Ryan, T.4
Brown, V.I.5
Fish, J.6
Reid, G.S.7
Seif, A.E.8
Norris, R.9
Chang, Y.J.10
Carroll, M.11
Grupp, S.A.12
-
18
-
-
0036928350
-
Rituximab-mediated sensitization of B-non-Hodgkin's lymphoma (NHL) to cytotoxicity induced by paclitaxel, gemcitabine, and vinorelbine
-
Emmanouilides C., Jazirehi A.R., Bonavida B. Rituximab-mediated sensitization of B-non-Hodgkin's lymphoma (NHL) to cytotoxicity induced by paclitaxel, gemcitabine, and vinorelbine. Cancer Biother. Radiopharm. 2002, 17:621-630.
-
(2002)
Cancer Biother. Radiopharm.
, vol.17
, pp. 621-630
-
-
Emmanouilides, C.1
Jazirehi, A.R.2
Bonavida, B.3
-
19
-
-
0034989302
-
Gemcitabine as a single agent in the treatment of relapsed or refractory low-grade non-Hodgkin's lymphoma
-
Dumontet C., Morschhauser F., Solal-Celigny P., Bouafia F., Bourgeois E., Thieblemont C., Leleu X., Hequet O., Salles G., Coiffier B. Gemcitabine as a single agent in the treatment of relapsed or refractory low-grade non-Hodgkin's lymphoma. Br. J. Haematol. 2001, 113:772-778.
-
(2001)
Br. J. Haematol.
, vol.113
, pp. 772-778
-
-
Dumontet, C.1
Morschhauser, F.2
Solal-Celigny, P.3
Bouafia, F.4
Bourgeois, E.5
Thieblemont, C.6
Leleu, X.7
Hequet, O.8
Salles, G.9
Coiffier, B.10
-
20
-
-
0032784782
-
Gemcitabine as a single agent in the treatment of relapsed or refractory aggressive non-Hodgkin's lymphoma
-
Fossa A., Santoro A., Hiddemann W., Truemper L., Niederle N., Buksmaui S., Bonadonna G., Seeber S., Nowrousian M.R. Gemcitabine as a single agent in the treatment of relapsed or refractory aggressive non-Hodgkin's lymphoma. J. Clin. Oncol. 1999, 17:3786-3792.
-
(1999)
J. Clin. Oncol.
, vol.17
, pp. 3786-3792
-
-
Fossa, A.1
Santoro, A.2
Hiddemann, W.3
Truemper, L.4
Niederle, N.5
Buksmaui, S.6
Bonadonna, G.7
Seeber, S.8
Nowrousian, M.R.9
-
21
-
-
0344577907
-
Phase II study of paclitaxel in combination with mitoxantrone and ifosfamide/mesna for patients with relapsed or refractory non-Hodgkin's lymphoma after failure to cytarabine/cisplatin combination
-
Romaguera J.E., Rodriguez M.A., Hagemeister F.B., McLaughlin P., Rodriguez J., Preti A., Younes A., Sarris A.H., Cabanillas F. Phase II study of paclitaxel in combination with mitoxantrone and ifosfamide/mesna for patients with relapsed or refractory non-Hodgkin's lymphoma after failure to cytarabine/cisplatin combination. Invest. New Drugs 1999, 17:187-192.
-
(1999)
Invest. New Drugs
, vol.17
, pp. 187-192
-
-
Romaguera, J.E.1
Rodriguez, M.A.2
Hagemeister, F.B.3
McLaughlin, P.4
Rodriguez, J.5
Preti, A.6
Younes, A.7
Sarris, A.H.8
Cabanillas, F.9
-
22
-
-
8544262941
-
Phase I study of fludarabine and paclitaxel for the treatment of low-grade non-Hodgkin's lymphoma
-
Younes A., Rodriguez M.A., McLaughlin P., North L., Sarris A.H., Pate O., Hagemeister F.B., Romaguera J., Preti A., Bachier C., Cabanillas F. Phase I study of fludarabine and paclitaxel for the treatment of low-grade non-Hodgkin's lymphoma. Leukemia Lymphoma 1997, 26:77-82.
-
(1997)
Leukemia Lymphoma
, vol.26
, pp. 77-82
-
-
Younes, A.1
Rodriguez, M.A.2
McLaughlin, P.3
North, L.4
Sarris, A.H.5
Pate, O.6
Hagemeister, F.B.7
Romaguera, J.8
Preti, A.9
Bachier, C.10
Cabanillas, F.11
-
23
-
-
0030468310
-
Activity of single agent vinorelbine in pretreated non-Hodgkin's lymphoma
-
Balzarotti M., Santoro A., Tondini C., Fornier M., Bonadonna G. Activity of single agent vinorelbine in pretreated non-Hodgkin's lymphoma. Ann. Oncol. 1996, 7:970-972.
-
(1996)
Ann. Oncol.
, vol.7
, pp. 970-972
-
-
Balzarotti, M.1
Santoro, A.2
Tondini, C.3
Fornier, M.4
Bonadonna, G.5
-
24
-
-
34447338028
-
Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21WAF1/CIP1 expression with rapamycin
-
Chiang C.-T., Way T.-D., Lin J.-K. Sensitizing HER2-overexpressing cancer cells to luteolin-induced apoptosis through suppressing p21WAF1/CIP1 expression with rapamycin. Mol. Cancer Ther. 2007, 6:2127-2138.
-
(2007)
Mol. Cancer Ther.
, vol.6
, pp. 2127-2138
-
-
Chiang, C.-T.1
Way, T.-D.2
Lin, J.-K.3
-
25
-
-
76549129820
-
Drug combination studies and their synergy quantification using the Chou-Talalay method
-
Chou T.C. Drug combination studies and their synergy quantification using the Chou-Talalay method. Cancer Res. 2010, 70:440-446.
-
(2010)
Cancer Res.
, vol.70
, pp. 440-446
-
-
Chou, T.C.1
-
26
-
-
67649695550
-
Gemcitabine-based combination chemotherapy as salvage treatment for refractory or relapsing aggressive non-Hodgkin's lymphoma
-
Yang S.H., Lin Z.Z., Kuo S.H., Cheng A.L. Gemcitabine-based combination chemotherapy as salvage treatment for refractory or relapsing aggressive non-Hodgkin's lymphoma. Am. J. Hematol. 2009, 84:457-459.
-
(2009)
Am. J. Hematol.
, vol.84
, pp. 457-459
-
-
Yang, S.H.1
Lin, Z.Z.2
Kuo, S.H.3
Cheng, A.L.4
-
27
-
-
2442464889
-
Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks
-
Pommier Y., Sordet O., Antony S., Hayward R.L., Kohn K.W. Apoptosis defects and chemotherapy resistance: molecular interaction maps and networks. Oncogene 2004, 23:2934-2949.
-
(2004)
Oncogene
, vol.23
, pp. 2934-2949
-
-
Pommier, Y.1
Sordet, O.2
Antony, S.3
Hayward, R.L.4
Kohn, K.W.5
-
28
-
-
34250330399
-
Rapid turnover of mcl-1 couples translation to cell survival and apoptosis
-
Adams K.W., Cooper G.M. Rapid turnover of mcl-1 couples translation to cell survival and apoptosis. J. Biol. Chem. 2007, 282:6192-6200.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 6192-6200
-
-
Adams, K.W.1
Cooper, G.M.2
-
29
-
-
20244365941
-
The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation
-
Beuvink I., Boulay A., Fumagalli S., Zilbermann F., Ruetz S., O Reilly T., Natt F., Hall J., Lane H.A., Thomas G. The mTOR inhibitor RAD001 sensitizes tumor cells to DNA-damaged induced apoptosis through inhibition of p21 translation. Cell 2005, 120:747-759.
-
(2005)
Cell
, vol.120
, pp. 747-759
-
-
Beuvink, I.1
Boulay, A.2
Fumagalli, S.3
Zilbermann, F.4
Ruetz, S.5
O Reilly, T.6
Natt, F.7
Hall, J.8
Lane, H.A.9
Thomas, G.10
-
30
-
-
49449108291
-
MTORC1 promotes survival through translational control of Mcl-1
-
Mills J.R., Hippo Y., Robert F., Chen S.M., Malina A., Lin C.J., Trojahn U., Wendel H.G., Charest A., Bronson R.T., Kogan S.C., Nadon R., Housman D.E., Lowe S.W., Pelletier J. mTORC1 promotes survival through translational control of Mcl-1. Proc. Natl. Acad. Sci. USA 2008, 105:10853-10858.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 10853-10858
-
-
Mills, J.R.1
Hippo, Y.2
Robert, F.3
Chen, S.M.4
Malina, A.5
Lin, C.J.6
Trojahn, U.7
Wendel, H.G.8
Charest, A.9
Bronson, R.T.10
Kogan, S.C.11
Nadon, R.12
Housman, D.E.13
Lowe, S.W.14
Pelletier, J.15
-
31
-
-
33749443714
-
Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance
-
Wei G., Twomey D., Lamb J., Schlis K., Agarwal J., Stam R.W., Opferman J.T., Sallan S.E., den Boer M.L., Pieters R., Golub T.R., Armstrong S.A. Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance. Cancer Cell 2006, 10:331-342.
-
(2006)
Cancer Cell
, vol.10
, pp. 331-342
-
-
Wei, G.1
Twomey, D.2
Lamb, J.3
Schlis, K.4
Agarwal, J.5
Stam, R.W.6
Opferman, J.T.7
Sallan, S.E.8
den Boer, M.L.9
Pieters, R.10
Golub, T.R.11
Armstrong, S.A.12
-
32
-
-
73349129405
-
Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition
-
Faber A.C., Li D., Song Y., Liang M.C., Yeap B.Y., Bronson R.T., Lifshits E., Chen Z., Maira S.M., Garcia-Echeverria C., Wong K.K., Engelman J.A. Differential induction of apoptosis in HER2 and EGFR addicted cancers following PI3K inhibition. Proc. Natl. Acad. Sci. USA 2009, 106:19503-19508.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 19503-19508
-
-
Faber, A.C.1
Li, D.2
Song, Y.3
Liang, M.C.4
Yeap, B.Y.5
Bronson, R.T.6
Lifshits, E.7
Chen, Z.8
Maira, S.M.9
Garcia-Echeverria, C.10
Wong, K.K.11
Engelman, J.A.12
|