The Goldilocks model for TCR-too much attraction might not be best for vaccine design

PLoS Biology

Volumn 8, Issue 9, 2010, Pages

  Slansky, Jill E ^a   Jordan, Kimberly R ^a  

^a UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 2; MAJOR HISTOCOMPATIBILITY ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE VACCINE; T LYMPHOCYTE RECEPTOR;

ARTICLE; BINDING AFFINITY; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CYTOKINE PRODUCTION; LISTERIA MONOCYTOGENES; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE; TUMOR IMMUNITY; VACCINATION; VACCINE PRODUCTION;

MODELS, BIOLOGICAL; MUTATION; RECEPTORS, ANTIGEN, T-CELL; VACCINES;

EID: 77957929065     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1000482     Document Type: Article

References (17)

1. Rosenberg SA, Restifo NP, Yang JC, Morgan RA, Dudley ME (2008) Adoptive cell transfer: a clinical path to effective cancer immunotherapy. Nat Rev Cancer 8: 299-308.
2. Slingluff CL, Jr., Petroni GR, Olson W, Czarkowski A, Grosh WW, et al. (2008) Helper T-cell responses and clinical activity of a melanoma vaccine with multiple peptides from MAGE and melanocytic differentiation antigens. J Clin Oncol 26: 4973-4980.
3. Market E, Papavasiliou FN (2003) V(D)J recombination and the evolution of the adaptive immune system. PLoS Biol 1: E16.
4. Bjorkman PJ, Strominger JL, Wiley DC (1985) Crystallization and X-ray diffraction studies on the histocompatibility antigens HLA-A2 and HLA-A28 from human cell membranes. J Mol Biol 186: 205-210.
5. Slansky JE (2003) Antigen-specific T cells: analyses of the needles in the haystack. PLoS Biol 1: E78.
6. Huseby ES, White J, Crawford F, Vass T, Becker D, et al. (2005) How the T cell repertoire becomes peptide and MHC specific. Cell 122: 247-260
7. Palmer E, Naeher D (2009) Affinity threshold for thymic selection through a Tcell receptor-co-receptor zipper. Nat Rev Immunol 9: 207-213.
8. Yu P, Haymaker CL, Divekar RD, Ellis JS, Hardaway J, et al. (2008) Fetal exposure to high-avidity TCR ligand enhances expansion of peripheral T regulatory cells. J Immunol 181: 73-80.
9. Seder RA, Paul WE, Davis MM, Fazekas de St Groth B (1992) The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med 176: 1091-1098.
10. Blander JM, Sant'Angelo DB, Bottomly K, Janeway CA, Jr. (2000) Alteration at a single amino acid residue in the T cell receptor alpha chain complementarity determining region 2 changes the differentiation of naive CD4 T cells in response to antigen from T helper cell type 1 (Th1) to Th2. J Exp Med 191: 2065-2074.
11. McKeithan TW (1995) Kinetic proofreading in T-cell receptor signal transduction. Proc Natl Acad Sci U S A 92: 5042-5046.
12. Valitutti S, Muller S, Cella M, Padovan E, Lanzavecchia A (1995) Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375: 148-151.
13. Kalergis AM, Boucheron N, Doucey MA, Palmieri E, Goyarts EC, et al. (2001) Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nat Immunol 2: 229-234.
14. Garcia KC, Scott CA, Brunmark A, Carbone FR, Peterson PA, et al. (1996) CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. Nature 384: 577-581.
15. Hahn M, Nicholson MJ, Pyrdol J, Wucherpfennig KW (2005) Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor. Nat Immunol 6: 490-496.
16. Huppa JB, Axmann M, Mortelmaier MA, Lillemeier BF, Newell EW, et al. TCR-peptide-MHC interactions in situ show accelerated kinetics and increased affinity. Nature 463: 963-967.
17. Davis MM, Boniface JJ, Reich Z, Lyons D, Hampl J, et al. (1998) Ligand recognition by alpha beta T cell receptors. Annu Rev Immunol 16: 523-544.