Reactivation of human acetylcholinesterase and butyrylcholinesterase inhibited by Leptophos-Oxon with different oxime reactivators in vitro

International Journal of Molecular Sciences

Volumn 11, Issue 8, 2010, Pages 2856-2863

  Jun, Daniel ^a,b   Musilova, Lucie ^c   Pohanka, Miroslav ^a   Jung, Young Sik ^d   Bostik, Pavel ^a   Kuca, Kamil ^a  

^a UNIVERSITY OF DEFENCE   (Czech Republic)

^b CZECH UNIVERSITY OF LIFE SCIENCES PRAGUE   (Czech Republic)

^c Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^d Korea Research Institute of Chemical Technology   (South Korea)

Author keywords

Acetylcholinesterase; Butyrylcholinesterase; Leptophos oxon; Nerve agent; Oxime; Pesticide; Reactivator; Scavenger

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; ACETYLCHOLINESTERASE; CHOLINESTERASE; CHOLINESTERASE REACTIVATOR; K 005; K 027; K 033; K 048; K 074; K 075; K 099; K 101; K 117; K 127; K 203; K 252; K 252A; K 252B; K 269; LEPTOPHOS; OBIDOXIME; OXIME DERIVATIVE; PESTICIDE; PRALIDOXIME; TIPINDOLE METHIODIDE; TRIMEDOXIME; UNCLASSIFIED DRUG; LEPTOPHOS OXON; OXIME;

ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; ENZYME REACTIVATION; ERYTHROCYTE; HUMAN; HUMAN CELL; IN VITRO STUDY; STRUCTURE ACTIVITY RELATION; ANALOGS AND DERIVATIVES; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY;

ACETYLCHOLINESTERASE; BUTYRYLCHOLINESTERASE; ERYTHROCYTES; HUMANS; LEPTOPHOS; OXIMES; PESTICIDES;

EID: 77957915931     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms11082856     Document Type: Article

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