Enantioselective synthesis of α-methyl carboxylic acids from readily available starting materials via chemoenzymatic dynamic kinetic resolution

Journal of Organic Chemistry

Volumn 75, Issue 20, 2010, Pages 6842-6847

  Thalén, Lisa K ^a   Sumic, Anna ^a   Bogár, Krisztián ^a,b   Norinder, Jakob ^a   Persson, Andreas K Ä ^a   Bäckvall, Jan E ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ENANTIOSELECTIVITY; SUBSTITUTION REACTIONS;

ALLYLIC SUBSTITUTION; C-C DOUBLE BONDS; COPPER CATALYZED; DYNAMIC KINETIC RESOLUTION; ENANTIOSELECTIVE; ENANTIOSELECTIVE SYNTHESIS; GRIGNARD ADDITION; RUTHENIUM CATALYSTS;

CARBOXYLIC ACIDS;

4 PHENYL 3 BUTEN 2 YLBUTANOAIC ACID; ALPHA METHYLCARBOXYLIC ACID DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; CINNAMALDEHYDE; COPPER; RUTHENIUM; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CHEMICAL MODIFICATION; DYNAMIC KINETIC RESOLUTION; ENANTIOSELECTIVITY; GRIGNARD REACTION; OXIDATION; STEREOCHEMISTRY; SUBSTITUTION REACTION; SYNTHESIS;

EID: 77957902243     PISSN: 00223263     EISSN: 15206904     Source Type: Journal    
DOI: 10.1021/jo1011653     Document Type: Article

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