Upregulation of contractile endothelin type B receptors by lipid-soluble cigarette smoking particles in rat cerebral arteries via activation of MAPK

Toxicology and Applied Pharmacology

Volumn 249, Issue 1, 2010, Pages 25-32

  Sandhu, Hardip ^a   Xu, Cang Bao ^b   Edvinsson, Lars ^a,b  

^a Glostrup Research Institute   (Denmark)

^b LUND UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Cerebral arteries; Endothelin ETB receptor; Lipid soluble cigarette smoking particles; MAPK; Organ culture; Vascular smooth muscle cells

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (2 AMINOETHYLAMINO) 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CIGARETTE SMOKE; CONTRACTILE PROTEIN; CYCLOHEXIMIDE; DACTINOMYCIN; DIMETHYL SULFOXIDE; ENDOTHELIN B RECEPTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; NICOTINE; SARAFOTOXIN S6C;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CIGARETTE SMOKING; ENZYME ACTIVATION; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE CEREBRAL ARTERY; NONHUMAN; NUCLEOTIDE SEQUENCE; ORGAN CULTURE; PROTEIN EXPRESSION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; UPREGULATION; VASCULAR SMOOTH MUSCLE; ANIMAL; BIOSYNTHESIS; COMPARATIVE STUDY; DRUG EFFECTS; LIPID METABOLISM; METABOLISM; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; SMOKING; SOLUBILITY; SPRAGUE DAWLEY RAT; VASOCONSTRICTION;

ANIMALS; DIMETHYL SULFOXIDE; ENZYME ACTIVATION; LIPID METABOLISM; MALE; MIDDLE CEREBRAL ARTERY; MITOGEN-ACTIVATED PROTEIN KINASES; ORGAN CULTURE TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, ENDOTHELIN B; SMOKING; SOLUBILITY; UP-REGULATION; VASOCONSTRICTION;

RATTUS;

EID: 77957869032     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2010.08.010     Document Type: Article

References (50)

1. Adner M., Geary G.G., Edvinsson L. Appearance of contractile endothelin-B receptors in rat mesenteric arterial segments following organ culture. Acta Physiol. Scand. 1998, 163:121-129.
2. Alessandrini A., Namura S., Moskowitz M.A., Bonventre J.V. MEK1 protein kinase inhibition protects against damage resulting from focal cerebral ischemia. Proc. Natl Acad. Sci. USA 1999, 96:12866-12869.
3. Ansar S., Edvinsson L. Subtype activation and interaction of protein kinase C and mitogen-activated protein kinase controlling receptor expression in cerebral arteries and microvessels after subarachnoid hemorrhage. Stroke 2008, 39:185-190.
4. Barone F.C., Irving E.A., Ray A.M., Lee J.C., Kassis S., Kumar S., Badger A.M., White R.F., McVey M.J., Legos J.J., Erhardt J.A., Nelson A.H., Ohlstein E.H., Hunter A.J., Ward K., Smith B.R., Adams J.L., Parsons A.A. SB 239063, a second-generation p38 mitogen-activated protein kinase inhibitor, reduces brain injury and neurological deficits in cerebral focal ischemia. J. Pharmacol. Exp. Ther. 2001, 296:312-321.
5. Beg S.A., Hansen-Schwartz J.A., Vikman P.J., Xu C.B., Edvinsson L.I. ERK1/2 inhibition attenuates cerebral blood flow reduction and abolishes ET(B) and 5-HT(1B) receptor upregulation after subarachnoid hemorrhage in rat. J. Cereb. Blood Flow Metab. 2006, 26:846-856.
6. Benowitz N.L., Jacob P., Fong I., Gupta S. Nicotine metabolic profile in man: comparison of cigarette smoking and transdermal nicotine. J. Pharmacol. Exp. Ther. 1994, 268:296-303.
7. Braunwald E. Shattuck lecture-cardiovascular medicine at the turn of the millennium: triumphs, concerns, and opportunities. N Engl J. Med. 1997, 337:1360-1369.
8. Cannan C.R., Burnett J.C., Lerman A. Enhanced coronary vasoconstriction to endothelin-B-receptor activation in experimental congestive heart failure. Circulation 1996, 93:646-651.
9. Dagassan P.H., Breu V., Clozel M., Kunzli A., Vogt P., Turina M., Kiowski W., Clozel J.P. Up-regulation of endothelin-B receptors in atherosclerotic human coronary arteries. J. Cardiovasc. Pharmacol. 1996, 27:147-153.
10. De Mey G.R., Compeer M.G., Meens M.J. Endothelin-1, an endogenous irreversible agonist in search of an allosteric inhibitor. Mol. Cell. Pharmacol. 2009, 1:246-247.
11. Foulds J., Ramstrom L., Burke M., Fagerstrom K. Effect of smokeless tobacco (snus) on smoking and public health in Sweden. Tob. Control 2003, 12:349-359.
12. Hansen-Schwartz J., Hoel N.L., Zhou M., Xu C.B., Svendgaard N.A., Edvinsson L. Subarachnoid hemorrhage enhances endothelin receptor expression and function in rat cerebral arteries. Neurosurgery 2003, 52:1188-1194.
13. Hansen-Schwartz J., Svensson C.L., Xu C.B., Edvinsson L. Protein kinase mediated upregulation of endothelin A, endothelin B and 5-hydroxytryptamine 1B/1D receptors during organ culture in rat basilar artery. Br. J. Pharmacol. 2002, 137:118-126.
14. Henriksson M., Stenman E., Edvinsson L. Intracellular pathways involved in upregulation of vascular endothelin type B receptors in cerebral arteries of the rat. Stroke 2003, 34:1479-1483.
15. Henriksson M., Xu C.B., Edvinsson L. Importance of ERK1/2 in upregulation of endothelin type B receptors in cerebral arteries. Br. J. Pharmacol. 2004, 142:1155-1161.
16. Hoel N.L., Hansen-Schwartz J., Edvinsson L. Selective up-regulation of 5-HT(1B/1D) receptors during organ culture of cerebral arteries. NeuroReport 2001, 12:1605-1608.
17. Hogestatt E.D., Andersson K.E., Edvinsson L. Mechanical properties of rat cerebral arteries as studied by a sensitive device for recording of mechanical activity in isolated small blood vessels. Acta Physiol. Scand. 1983, 117:49-61.
18. Ihling C., Gobel H.R., Lippoldt A., Wessels S., Paul M., Schaefer H.E., Zeiher A.M. Endothelin-1-like immunoreactivity in human atherosclerotic coronary tissue: a detailed analysis of the cellular distribution of endothelin-1. J. Pathol. 1996, 179:303-308.
19. Iwasa S., Fan J., Shimokama T., Nagata M., Watanabe T. Increased immunoreactivity of endothelin-1 and endothelin B receptor in human atherosclerotic lesions. A possible role in atherogenesis. Atherosclerosis 1999, 146:93-100.
20. Lennmyr F., Karlsson S., Gerwins P., Ata K.A., Terent A. Activation of mitogen-activated protein kinases in experimental cerebral ischemia. Acta Neurol. Scand. 2002, 106:333-340.
21. Lewis T.S., Shapiro P.S., Ahn N.G. Signal transduction through MAP kinase cascades. Adv. Cancer Res. 1998, 74:49-139.
22. Maddahi A., Chen Q., Edvinsson L. Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat. BMC Neurosci. 2009, 10:56.
23. Maddahi A., Edvinsson L. Enhanced expressions of microvascular smooth muscle receptors after focal cerebral ischemia occur via the MAPK MEK/ERK pathway. BMC Neurosci. 2008, 9:85.
24. Moller S., Adner M., Edvinsson L. Increased levels of endothelin ETB receptor mRNA in human omental arteries after organ culture: quantification by competitive reverse transcription-polymerase chain reaction. Clin. Exp. Pharmacol. Physiol. 1998, 25:788-794.
25. Mulvany M.J., Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ. Res. 1977, 41:19-26.
26. Namura S., Iihara K., Takami S., Nagata I., Kikuchi H., Matsushita K., Moskowitz M.A., Bonventre J.V., Alessandrini A. Intravenous administration of MEK inhibitor U0126 affords brain protection against forebrain ischemia and focal cerebral ischemia. Proc. Natl Acad. Sci. USA 2001, 98:11569-11574.
27. Nilsson D., Wackenfors A., Gustafsson L., Ugander M., Ingemansson R., Edvinsson L., Malmsjo M. PKC and MAPK signalling pathways regulate vascular endothelin receptor expression. Eur. J. Pharmacol. 2008, 580:190-200.
28. Pessah-Rasmussen H., Stavenow L., Xu C.B., Berglund A. Increased smooth muscle cell proliferation by dimethylbenzanthracene is correlated to variations in activity of ornithine decarboxylase but not arylhydrocarbonhydroxylase. Artery 1991, 18:240-255.
29. Repace J.L., Lowrey A.H. Indoor air pollution, tobacco smoke, and public health. Science 1980, 208:464-472.
30. Rosamond W., Flegal K., Furie K., Go A., Greenlund K., Haase N., Hailpern S.M., Ho M., Howard V., Kissela B., Kittner S., Lloyd-Jones D., McDermott M., Meigs J., Moy C., Nichol G., O'Donnell C., Roger V., Sorlie P., Steinberger J., Thom T., Wilson M., Hong Y. Heart disease and stroke statistics-2008 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2008, 117:e25-e146.
31. Roux S., Loffler B.M., Gray G.A., Sprecher U., Clozel M., Clozel J.P. The role of endothelin in experimental cerebral vasospasm. Neurosurgery 1995, 37:78-85.
32. Sandhu H.K.., Ansar S., Edvinsson L. Comparison of MEK/ERK pathway inhibitors on the upregulation of vascular G protein coupled receptors in rat cerebral arteries. Eur. J. Pharmacol. 2010, 644:128-137.
33. Santos N.C., Prieto M.J.E., Morna-Gomes A., Betbeder D., Castanho M.A.R.B. Structural characterization (shape and dimensions) and stability of polysaccharide/lipid nonoparticles. Biopolymers 1997, 41:511-520.
34. Stavenow L., Pessah-Rasmussen H. Effects of polycyclic aromatic hydrocarbons on proliferation, collagen secretion and viability of arterial smooth muscle cells in culture. Artery 1988, 15:94-108.
35. Stenman E., Malmsjo M., Uddman E., Gido G., Wieloch T., Edvinsson L. Cerebral ischemia upregulates vascular endothelin ET(B) receptors in rat. Stroke 2002, 33:2311-2316.
36. Strong K., Mathers C., Bonita R. Preventing stroke: saving lives around the world. Lancet Neurol. 2007, 6:182-187.
37. Szok D., Hansen-Schwartz J., Edvinsson L. In depth pharmacological characterization of endothelin B receptors in the rat middle cerebral artery. Neurosci. Lett. 2001, 314:69-72.
38. Uddman E., Henriksson M., Eskesen K., Edvinsson L. Role of mitogen-activated protein kinases in endothelin ETB receptor up-regulation after organ culture of rat mesenteric artery. Eur. J. Pharmacol. 2003, 482:39-47.
39. Wackenfors A., Emilson M., Ingemansson R., Hortobagyi T., Szok D., Tajti J., Vecsei L., Edvinsson L., Malmsjo M. Ischemic heart disease induces upregulation of endothelin receptor mRNA in human coronary arteries. Eur. J. Pharmacol. 2004, 484:103-109.
40. Winkles J.A., Alberts G.F., Brogi E., Libby P. Endothelin-1 and endothelin receptor mRNA expression in normal and atherosclerotic human arteries. Biochem. Biophys. Res. Commun. 1993, 191:1081-1088.
41. Xu C.B., Zheng J.P., Zhang W., Zhang Y., Edvinsson L. Lipid-soluble smoke particles upregulate vascular smooth muscle ETB receptors via activation of mitogen-activating protein kinases and NF-kappaB pathways. Toxicol. Sci. 2008, 106:546-555.
42. Zeiher A.M., Goebel H., Schachinger V., Ihling C. Tissue endothelin-1 immunoreactivity in the active coronary atherosclerotic plaque. A clue to the mechanism of increased vasoreactivity of the culprit lesion in unstable angina. Circulation 1995, 91:941-947.
43. Zhang J.Y., Cao L., Zheng X.H., Xu C.B., Cao Y.X. Dimethylsulfoxide-soluble smoking particles and nicotine affect vascular contractibility. Arch. Pharm. Res. 2009, 32:1475-1481.
44. Zhang J.Y., Cao Y.X., Xu C.B., Edvinsson L. Lipid-soluble smoke particles damage endothelial cells and reduce endothelium-dependent dilatation in rat and man. BMC Cardiovasc. Disord. 2006, 6:3.
45. Zhang W., Zhang Y., Edvinsson L., Xu C.B. Up-regulation of thromboxane A2 receptor expression by lipid soluble smoking particles through post-transcriptional mechanisms. Atherosclerosis 2008, 196:608-616.
46. Zhang W., Zhang Y., Edvinsson L., Xu C.B. Transcriptional down-regulation of thromboxane A(2) receptor expression via activation of MAPK ERK1/2, p38/NF-kappaB pathways. J. Vasc. Res. 2009, 46:162-174.
47. Zheng J.P., Zhang Y., Edvinsson L., Hjalt T., Xu C.B. NF-kappaB signaling mediates vascular smooth muscle endothelin type B receptor expression in resistance arteries. Eur. J. Pharmacol. 2010, 637:148-154.
48. Zia E., Hedblad B., Pessah-Rasmussen H., Berglund G., Janzon L., Engstrom G. Blood pressure in relation to the incidence of cerebral infarction and intracerebral hemorrhage. Hypertensive hemorrhage: debated nomenclature is still relevant. Stroke 2007, 38:2681-2685.
49. Ziche M., Morbidelli L., Donnini S., Ledda F. ETB receptors promote proliferation and migration of endothelial cells. J. Cardiovasc. Pharmacol. 1995, 26(Suppl 3):S284-S286.
50. Zuccarello M., Lewis A.I., Rapoport R.M. Endothelin ETA and ETB receptors in subarachnoid hemorrhage-induced cerebral vasospasm. Eur. J. Pharmacol. 1994, 259:R1-R2.