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Volumn 37, Issue 5, 2010, Pages 1143-1152

Mechanisms behind COX-1 and COX-2 inhibition of tumor growth in vivo

Author keywords

COX 1; COX 2; EGF R; Prostanoids

Indexed keywords

CYCLINE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR; GROWTH FACTOR; INDOMETACIN; JANUS KINASE 1; K RAS PROTEIN; MESSENGER RNA; NONSTEROID ANTIINFLAMMATORY AGENT; NUCLEOSIDE DIPHOSPHATE KINASE NM23; PHOSPHATIDYLINOSITOL 3 KINASE; PROSTAGLANDIN E2; PROTEIN BAX; PROTEIN BCL 2; PROTEIN C JUN; PROTEIN P21; PROTEIN P27; PROTEIN P53; STAT3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA3;

EID: 77957868679     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo_00000766     Document Type: Article
Times cited : (23)

References (58)
  • 1
    • 0022627338 scopus 로고
    • Tumor angiogenesis inhibition by prostaglandin synthetase inhibitors
    • Peterson HI: Tumor angiogenesis inhibition by prostaglandin synthetase inhibitors. Anticancer Res 6: 251-253, 1986.
    • (1986) Anticancer Res , vol.6 , pp. 251-253
    • Peterson, H.I.1
  • 2
    • 2942591962 scopus 로고    scopus 로고
    • Reduction of tumor progression and paraneoplastic syndrome development in murine lung adenocarcinoma by nonsteroidal antiinflammatory drugs
    • DOI 10.1002/ijc.20226
    • Peluffo GD, Stillitani I, Rodriguez VA, Diament MJ and Klein SM: Reduction of tumor progression and paraneoplastic syndrome development in murine lung adenocarcinoma by nonsteroidal antiinflammatory drugs. Int J Cancer 110: 825-830, 2004. (Pubitemid 38758507)
    • (2004) International Journal of Cancer , vol.110 , Issue.6 , pp. 825-830
    • Peluffo, G.D.1    Stillitani, I.2    Rodriguez, V.A.3    Diament, M.J.4    Klein, S.M.5
  • 3
    • 0026083223 scopus 로고
    • Effects of indomethacin, cytokines, and cyclosporin a on tumor growth and the subsequent development of cancer cachexia
    • Gelin J, Andersson C and Lundholm K: Effects of indomethacin, cytokines, and cyclosporin A on tumor growth and the subsequent development of cancer cachexia. Cancer Res 51: 880-885, 1991.
    • (1991) Cancer Res , vol.51 , pp. 880-885
    • Gelin, J.1    Andersson, C.2    Lundholm, K.3
  • 4
    • 0025048510 scopus 로고
    • The effect of indomethacin on food and water intake, motor activity and survival in tumour-bearing rats
    • DOI 10.1016/0277-5379(90)90158-P
    • Sandstrom R, Gelin J and Lundholm K: The effect of indomethacin on food and water intake, motor activity and survival in tumour-bearing rats. Eur J Cancer 26: 811-814, 1990. (Pubitemid 20328554)
    • (1990) European Journal of Cancer , vol.26 , Issue.7 , pp. 811-814
    • Sandstrom, R.1    Gelin, J.2    Lundholm, K.3
  • 6
    • 3042665905 scopus 로고    scopus 로고
    • Cyclooxygenase as a target in lung cancer
    • Brown JR and DuBois RN: Cyclooxygenase as a target in lung cancer. Clin Cancer Res 10: S4266-S4269, 2004.
    • (2004) Clin Cancer Res , vol.10
    • Brown, J.R.1    DuBois, R.N.2
  • 7
    • 0034307162 scopus 로고    scopus 로고
    • Experimental cancer cachexia: The role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 Bl background and eicosanoid-dependent cachexia
    • Cahlin C, Korner A, Axelsson H, Wang W, Lundholm K and Svanberg E: Experimental cancer cachexia: the role of host-derived cytokines interleukin (IL)-6, IL-12, interferon-gamma, and tumor necrosis factor alpha evaluated in gene knockout, tumor-bearing mice on C57 Bl background and eicosanoid-dependent cachexia. Cancer Res 60: 5488-5493, 2000.
    • (2000) Cancer Res , vol.60 , pp. 5488-5493
    • Cahlin, C.1    Korner, A.2    Axelsson, H.3    Wang, W.4    Lundholm, K.5    Svanberg, E.6
  • 8
    • 0028875743 scopus 로고
    • Effect of extended ibuprofen administration on the acute phase protein response in colorectal cancer patients
    • McMillan DC, Leen E, Smith J, Sturgeon C, Preston T, Cooke TG and McArdle CS: Effect of extended ibuprofen administration on the acute phase protein response in colorectal cancer patients. Eur J Surg Oncol 21: 531-534, 1995.
    • (1995) Eur J Surg Oncol , vol.21 , pp. 531-534
    • McMillan, D.C.1    Leen, E.2    Smith, J.3    Sturgeon, C.4    Preston, T.5    Cooke, T.G.6    McArdle, C.S.7
  • 10
    • 0034654126 scopus 로고    scopus 로고
    • Effect of cyclooxygenase and nitric oxide synthase inhibitors on tumor growth in mouse tumor models with and without cancer cachexia related to prostanoids
    • Cahlin C, Gelin J, Delbro D, Lonnroth C, Doi C and Lundholm K: Effect of cyclooxygenase and nitric oxide synthase inhibitors on tumor growth in mouse tumor models with and without cancer cachexia related to prostanoids. Cancer Res 60: 1742-1749, 2000.
    • (2000) Cancer Res , vol.60 , pp. 1742-1749
    • Cahlin, C.1    Gelin, J.2    Delbro, D.3    Lonnroth, C.4    Doi, C.5    Lundholm, K.6
  • 12
    • 1942428953 scopus 로고    scopus 로고
    • Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia
    • Lundholm K, Daneryd P, Korner U, Hyltander A and Bosaeus I: Evidence that long-term COX-treatment improves energy homeostasis and body composition in cancer patients with progressive cachexia. Int J Oncol 24: 505-512, 2004.
    • (2004) Int J Oncol , vol.24 , pp. 505-512
    • Lundholm, K.1    Daneryd, P.2    Korner, U.3    Hyltander, A.4    Bosaeus, I.5
  • 13
    • 70049107784 scopus 로고    scopus 로고
    • Regression of recurrent respiratory papillomatosis with celecoxib and erlotinib combination therapy
    • Limsukon A, Susanto I, Hoo GW, Dubinett SM and Batra RK: Regression of recurrent respiratory papillomatosis with celecoxib and erlotinib combination therapy. Chest 136: 924-926, 2009.
    • (2009) Chest , vol.136 , pp. 924-926
    • Limsukon, A.1    Susanto, I.2    Hoo, G.W.3    Dubinett, S.M.4    Batra, R.K.5
  • 14
    • 24344477064 scopus 로고    scopus 로고
    • Epidermal growth factor-induced cyclooxygenase-2 expression is mediated through phosphatidylinositol-3 kinase, not mitogen-activated protein/extracellular signal-regulated kinase kinase, in recurrent respiratory papillomas
    • DOI 10.1158/1078-0432.CCR-04-2664
    • Wu R, Abramson AL, Shikowitz MJ, Dannenberg AJ and Steinberg BM: Epidermal growth factor-induced cyclooxygenase-2 expression is mediated through phosphatidylinositol-3 kinase, not mitogen-activated protein/extracellular signal-regulated kinase kinase, in recurrent respiratory papillomas. Clin Cancer Res 11: 6155-6161, 2005. (Pubitemid 41262942)
    • (2005) Clinical Cancer Research , vol.11 , Issue.17 , pp. 6155-6161
    • Wu, R.1    Abramson, A.L.2    Shikowitz, M.J.3    Dannenberg, A.J.4    Steinberg, B.M.5
  • 15
    • 57649108802 scopus 로고    scopus 로고
    • Combination of an EGFR blocker and a COX-2 inhibitor for the treatment of advanced cutaneous squamous cell carcinoma
    • Jalili A, Pinc A, Pieczkowski F, Karlhofer FM, Stingl G and Wagner SN: Combination of an EGFR blocker and a COX-2 inhibitor for the treatment of advanced cutaneous squamous cell carcinoma. J Dtsch Dermatol Ges 6: 1066-1069, 2008.
    • (2008) J Dtsch Dermatol Ges , vol.6 , pp. 1066-1069
    • Jalili, A.1    Pinc, A.2    Pieczkowski, F.3    Karlhofer, F.M.4    Stingl, G.5    Wagner, S.N.6
  • 16
    • 33644604416 scopus 로고    scopus 로고
    • Cyclooxygenase inhibition in early onset of tumor growth and related angiogenesis evaluated in EP1 and EP3 knockout tumor-bearing mice
    • DOI 10.1007/s10456-005-9023-8
    • Axelsson H, Lönnroth C, Wang W, Svanberg E and Lundholm K: Cyclooxygenase inhibition in early onset of tumor growth and related angiogenesis evaluated in EP1 and EP3 knockout tumor-bearing mice. Angiogenesis 8: 339-348, 2005. (Pubitemid 43312269)
    • (2006) Angiogenesis , vol.8 , Issue.4 , pp. 339-348
    • Axelsson, H.1    Lonnroth, C.2    Wang, W.3    Svanberg, E.4    Lundholm, K.5
  • 18
    • 0035344036 scopus 로고    scopus 로고
    • Indomethacin and telomerase activity in tumor growth retardation
    • Lönnroth C, Andersson M and Lundholm K: Indomethacin and telomerase activity in tumor growth retardation. Int J Oncol 18: 929-937, 2001.
    • (2001) Int J Oncol , vol.18 , pp. 929-937
    • Lönnroth, C.1    Andersson, M.2    Lundholm, K.3
  • 20
    • 3042748129 scopus 로고    scopus 로고
    • Multiple roles of COX-2 in tumor angiogenesis: A target for antiangiogenic therapy
    • DOI 10.1016/j.seminoncol.2004.03.040, PII S0093775404001897
    • Gately S and Li WW: Multiple roles of COX-2 in tumor angiogenesis: a target for antiangiogenic therapy. Semin Oncol 31: 2-11, 2004. (Pubitemid 38879409)
    • (2004) Seminars in Oncology , vol.31 , Issue.SUPPL. 7 , pp. 2-11
    • Gately, S.1    Li, W.W.2
  • 21
    • 70350462093 scopus 로고    scopus 로고
    • TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling
    • Nishimura M, Shin MS, Singhirunnusorn P, Suzuki S, Kawanishi M, Koizumi K, Saiki I and Sakurai H: TAK1-mediated serine/threonine phosphorylation of epidermal growth factor receptor via p38/extracellular signal-regulated kinase: NF-{kappa}B-independent survival pathways in tumor necrosis factor alpha signaling. Mol Cell Biol 29: 5529-5539, 2009.
    • (2009) Mol Cell Biol , vol.29 , pp. 5529-5539
    • Nishimura, M.1    Shin, M.S.2    Singhirunnusorn, P.3    Suzuki, S.4    Kawanishi, M.5    Koizumi, K.6    Saiki, I.7    Sakurai, H.8
  • 22
    • 70349448435 scopus 로고    scopus 로고
    • PKC-delta binds to E-cadherin and mediates EGF-induced cell scattering
    • Singh R, Lei P and Andreadis ST: PKC-delta binds to E-cadherin and mediates EGF-induced cell scattering. Exp Cell Res 315: 2899-2913, 2009.
    • (2009) Exp Cell Res , vol.315 , pp. 2899-2913
    • Singh, R.1    Lei, P.2    Andreadis, S.T.3
  • 25
    • 48049110545 scopus 로고    scopus 로고
    • Selective COX-2 inhibitor celecoxib combined with EGFR-TKI ZD1839 on nonsmall cell lung cancer cell lines: In vitro toxicity and mechanism study
    • Chen L, He Y, Huang H, Liao H and Wei W: Selective COX-2 inhibitor celecoxib combined with EGFR-TKI ZD1839 on nonsmall cell lung cancer cell lines: in vitro toxicity and mechanism study. Med Oncol 25: 161-171, 2008.
    • (2008) Med Oncol , vol.25 , pp. 161-171
    • Chen, L.1    He, Y.2    Huang, H.3    Liao, H.4    Wei, W.5
  • 26
    • 37049032690 scopus 로고    scopus 로고
    • Response to dual blockade of epidermal growth factor receptor (EGFR) and cycloxygenase-2 in nonsmall cell lung cancer may be dependent on the EGFR mutational status of the tumor
    • Gadgeel SM, Ali S, Philip PA, Ahmed F, Wozniak A and Sarkar FH: Response to dual blockade of epidermal growth factor receptor (EGFR) and cycloxygenase-2 in nonsmall cell lung cancer may be dependent on the EGFR mutational status of the tumor. Cancer 110: 2775-2784, 2007.
    • (2007) Cancer , vol.110 , pp. 2775-2784
    • Gadgeel, S.M.1    Ali, S.2    Philip, P.A.3    Ahmed, F.4    Wozniak, A.5    Sarkar, F.H.6
  • 27
    • 34548682769 scopus 로고    scopus 로고
    • Inhibition of COX-2 with NS-398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: Possibilities for combination therapy
    • DOI 10.1111/j.1365-2184.2007.00459.x
    • Banu N, Buda A, Chell S, Elder D, Moorghen M, Paraskeva C, Qualtrough D and Pignatelli M: Inhibition of COX-2 with NS-398 decreases colon cancer cell motility through blocking epidermal growth factor receptor transactivation: possibilities for combination therapy. Cell Prolif 40: 768-779, 2007. (Pubitemid 47416549)
    • (2007) Cell Proliferation , vol.40 , Issue.5 , pp. 768-779
    • Banu, N.1    Buda, A.2    Chell, S.3    Elder, D.4    Moorghen, M.5    Paraskeva, C.6    Qualtrough, D.7    Pignatelli, M.8
  • 28
    • 34548724059 scopus 로고    scopus 로고
    • Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells
    • DOI 10.1152/ajpgi.00182.2007
    • Sheng G, Guo J and Warner BW: Epidermal growth factor receptor signaling modulates apoptosis via p38alpha MAPK-dependent activation of Bax in intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol 293: G599-G606, 2007. (Pubitemid 47435380)
    • (2007) American Journal of Physiology - Gastrointestinal and Liver Physiology , vol.293 , Issue.3
    • Sheng, G.1    Guo, J.2    Warner, B.W.3
  • 29
    • 33750744812 scopus 로고    scopus 로고
    • Effect of simultaneous inhibition of epidermal growth factor receptor and cyclooxygenase-2 in HER-2/Neu-positive breast cancer
    • DOI 10.1158/1078-0432.CCR-06-0042
    • Lanza-Jacoby S, Burd R, Rosato FE Jr, McGuire K, Little J, Nougbilly N and Miller S: Effect of simultaneous inhibition of epidermal growth factor receptor and cyclooxygenase-2 in HER-2/neu-positive breast cancer. Clin Cancer Res 12: 6161-6169, 2006. (Pubitemid 44703782)
    • (2006) Clinical Cancer Research , vol.12 , Issue.20 PART 1 , pp. 6161-6169
    • Lanza-Jacoby, S.1    Burd, R.2    Rosato Jr., F.E.3    McGuire, K.4    Little, J.5    Nougbilly, N.6    Miller, S.7
  • 30
    • 0037984386 scopus 로고    scopus 로고
    • Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes
    • Huh YH, Kim SH, Kim SJ and Chun JS: Differentiation status-dependent regulation of cyclooxygenase-2 expression and prostaglandin E2 production by epidermal growth factor via mitogen-activated protein kinase in articular chondrocytes. J Biol Chem 278: 9691-9697, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 9691-9697
    • Huh, Y.H.1    Kim, S.H.2    Kim, S.J.3    Chun, J.S.4
  • 32
    • 4143124753 scopus 로고    scopus 로고
    • Signal transduction pathways regulating cyclooxygenase-2 expression: Potential molecular targets for chemoprevention
    • Chun KS and Surh YJ: Signal transduction pathways regulating cyclooxygenase-2 expression: potential molecular targets for chemoprevention. Biochem Pharmacol 68: 1089-1100, 2004.
    • (2004) Biochem Pharmacol , vol.68 , pp. 1089-1100
    • Chun, K.S.1    Surh, Y.J.2
  • 34
    • 18444408375 scopus 로고    scopus 로고
    • COX-2: A molecular target for colorectal cancer prevention
    • DOI 10.1200/JCO.2005.09.051
    • Brown JR and DuBois RN: COX-2: a molecular target for colorectal cancer prevention. J Clin Oncol 23: 2840-2855, 2005. (Pubitemid 46179475)
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.12 , pp. 2840-2855
    • Brown, J.R.1    DuBois, R.N.2
  • 35
    • 32644470964 scopus 로고    scopus 로고
    • Colon cancer - Understanding how NSAIDs work
    • Clevers H: Colon cancer - understanding how NSAIDs work. N Engl J Med 354: 761-763, 2006.
    • (2006) N Engl J Med , vol.354 , pp. 761-763
    • Clevers, H.1
  • 36
    • 0034237679 scopus 로고    scopus 로고
    • Distribution and function of prostanoid receptors: Studies from knockout mice
    • DOI 10.1016/S0163-7827(00)00008-4, PII S0163782700000084
    • Sugimoto Y, Narumiya S and Ichikawa A: Distribution and function of prostanoid receptors: studies from knockout mice. Prog Lipid Res 39: 289-314, 2000. (Pubitemid 30336470)
    • (2000) Progress in Lipid Research , vol.39 , Issue.4 , pp. 289-314
    • Sugimoto, Y.1    Narumiya, S.2    Ichikawa, A.3
  • 37
    • 0018103226 scopus 로고
    • A comparative study of the influence of malignant tumor on host metabolism in mice and man. Evaluation of an experimental model
    • Lundholm K, Edstrom S, Ekman L, Karlberg I, Bylund AC and Schersten T: A comparative study of the influence of malignant tumor on host metabolism in mice and man: evaluation of an experimental model. Cancer 42: 453-461, 1978. (Pubitemid 8405836)
    • (1978) Cancer , vol.42 , Issue.2 , pp. 453-461
    • Lundholm, K.1    Edstrom, S.2    Ekman, L.3
  • 38
    • 0019440943 scopus 로고
    • Metabolic host reaction in response to the proliferation of nonmalignant cells versus malignant cells in vivo
    • Karlberg I, Edstrom S, Ekman L, Johansson S, Schersten T and Lundholm K: Metabolic host reaction in response to the proliferation of nonmalignant cells versus malignant cells in vivo. Cancer Res 41: 4154-4161, 1981. (Pubitemid 11011212)
    • (1981) Cancer Research , vol.41 , Issue.10 , pp. 4154-4161
    • Karlberg, I.1    Edstrom, S.2    Ekman, L.3
  • 40
    • 48349099492 scopus 로고    scopus 로고
    • Celecoxib pre-treatment in human colorectal adenocarcinoma patients is associated with gene expression alterations suggestive of diminished cellular proliferation
    • Auman JT, Church R, Lee SY, Watson MA, Fleshman JW and McLeod HL: Celecoxib pre-treatment in human colorectal adenocarcinoma patients is associated with gene expression alterations suggestive of diminished cellular proliferation. Eur J Cancer 44: 1754-1760, 2008.
    • (2008) Eur J Cancer , vol.44 , pp. 1754-1760
    • Auman, J.T.1    Church, R.2    Lee, S.Y.3    Watson, M.A.4    Fleshman, J.W.5    McLeod, H.L.6
  • 41
    • 68849123400 scopus 로고    scopus 로고
    • Aspirin use and survival after diagnosis of colorectal cancer
    • Chan AT, Ogino S and Fuchs CS: Aspirin use and survival after diagnosis of colorectal cancer. JAMA 302: 649-658, 2009.
    • (2009) JAMA , vol.302 , pp. 649-658
    • Chan, A.T.1    Ogino, S.2    Fuchs, C.S.3
  • 42
    • 35848967243 scopus 로고    scopus 로고
    • Prostanoid receptor expression in colorectal cancer related to tumor stage, differentiation and progression
    • DOI 10.1080/02841860701403061, PII 783088878
    • Gustafsson A, Hansson E, Kressner U, Nordgren S, Andersson M, Lonnroth C and Lundholm K: Prostanoid receptor expression in colorectal cancer related to tumor stage, differentiation and progression. Acta Oncol 46: 1107-1112, 2007. (Pubitemid 350058890)
    • (2007) Acta Oncologica , vol.46 , Issue.8 , pp. 1107-1112
    • Gustafsson, A.1    Hansson, E.2    Kressner, U.3    Nordgren, S.4    Andersson, M.5    Lonnroth, C.6    Lundholm, K.7
  • 44
    • 4444299059 scopus 로고    scopus 로고
    • Subepithelial myofibroblasts express cyclooxygenase-2 in colorectal tubular adenomas
    • DOI 10.1158/1078-0432.CCR-0431-03
    • Adegboyega PA, Ololade O, Saada J, Mifflin R, Di Mari JF and Powell DW: Subepithelial myofibroblasts express cyclooxygenase- 2 in colorectal tubular adenomas. Clin Cancer Res 10: 5870-5879, 2004. (Pubitemid 39180968)
    • (2004) Clinical Cancer Research , vol.10 , Issue.17 , pp. 5870-5879
    • Adegboyega, P.A.1    Ololade, O.2    Saada, J.3    Mifflin, R.4    Di Mari, J.F.5    Powell, D.W.6
  • 45
    • 41949113169 scopus 로고    scopus 로고
    • Preoperative treatment with a non-steroidal anti-inflammatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer
    • Lönnroth C, Andersson M, Arvidsson A, Nordgren S, Brevinge H, Lagerstedt K and Lundholm K: Preoperative treatment with a non-steroidal antiinflammaatory drug (NSAID) increases tumor tissue infiltration of seemingly activated immune cells in colorectal cancer. Cancer Immun 8: 5, 2008. (Pubitemid 351507297)
    • (2008) Cancer Immunity , vol.8
    • Lonnroth, C.1    Andersson, M.2    Arvidsson, A.3    Nordgren, S.4    Brevinge, H.5    Lagerstedt, K.6    Lundholm, K.7
  • 46
    • 33845323045 scopus 로고    scopus 로고
    • The role of cyclooxygenase-2 and prostaglandins in colon cancer
    • DOI 10.1016/j.prostaglandins.2006.05.026, PII S1098882306001006, Eicosanoid-Mediated Regulation of Vascular and Renal Function
    • Eisinger AL, Prescott SM, Jones DA and Stafforini DM: The role of cyclooxygenase-2 and prostaglandins in colon cancer. Prostaglandins Other Lipid Mediat 82: 147-154, 2007. (Pubitemid 44880176)
    • (2007) Prostaglandins and Other Lipid Mediators , vol.82 , Issue.1-4 , pp. 147-154
    • Eisinger, A.L.1    Prescott, S.M.2    Jones, D.A.3    Stafforini, D.M.4
  • 47
    • 0028845788 scopus 로고
    • Molecular mechanisms of diverse actions of prostanoid receptors
    • Negishi M, Sugimoto Y and Ichikawa A: Molecular mechanisms of diverse actions of prostanoid receptors. Biochim Biophys Acta 1259: 109-119, 1995.
    • (1995) Biochim Biophys Acta , vol.1259 , pp. 109-119
    • Negishi, M.1    Sugimoto, Y.2    Ichikawa, A.3
  • 48
    • 67651237283 scopus 로고    scopus 로고
    • Global tumor RNA expression in early establishment of experimental tumor growth and related angiogenesis following COX-inhibition evaluated by microarray analysis
    • Axelsson H, Lönnroth C, Andersson M, Wang W and Lundholm K: Global tumor RNA expression in early establishment of experimental tumor growth and related angiogenesis following COX-inhibition evaluated by microarray analysis. Cancer Inform 2: 199-213, 2007.
    • (2007) Cancer Inform , vol.2 , pp. 199-213
    • Axelsson, H.1    Lönnroth, C.2    Andersson, M.3    Wang, W.4    Lundholm, K.5
  • 49
    • 0037286547 scopus 로고    scopus 로고
    • Perils of immunohistochemistry: Variability in staining specificity of commercially available COX-2 antibodies on human colon tissue
    • DOI 10.1023/A:1021871423154
    • Garewal H, Ramsey L, Fass R, Hart NK, Payne CM, Bernstein H and Bernstein C: Perils of immunohistochemistry: variability in staining specificity of commercially available COX-2 antibodies on human colon tissue. Dig Dis Sci 48: 197-202, 2003. (Pubitemid 36232783)
    • (2003) Digestive Diseases and Sciences , vol.48 , Issue.1 , pp. 197-202
    • Garewal, H.1    Ramsey, L.2    Fass, R.3    Hart, N.K.4    Payne, C.M.5    Bernstein, H.6    Bernstein, C.7
  • 50
    • 75649095204 scopus 로고    scopus 로고
    • Receptor and enzyme expression for prostanoid metabolism in colorectal cancer as related to tumor tissue PGE2
    • Gustafsson A, Andersson M, Lagerstedt K, Lönnroth C, Nordgren S and Lundholm K: Receptor and enzyme expression for prostanoid metabolism in colorectal cancer as related to tumor tissue PGE2. Int J Oncol 36: 469-478, 2010.
    • (2010) Int J Oncol , vol.36 , pp. 469-478
    • Gustafsson, A.1    Andersson, M.2    Lagerstedt, K.3    Lönnroth, C.4    Nordgren, S.5    Lundholm, K.6
  • 51
    • 0032540344 scopus 로고    scopus 로고
    • Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy
    • DOI 10.1074/jbc.273.16.9886
    • Spencer AG, Woods JW, Arakawa T, Singer, II and Smith WL: Subcellular localization of prostaglandin endoperoxide H synthases-1 and -2 by immunoelectron microscopy. J Biol Chem 273: 9886-9893, 1998. (Pubitemid 28183086)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.16 , pp. 9886-9893
    • Spencer, A.G.1    Woods, J.W.2    Arakawa, T.3    Singer, I.I.4    Smith, W.L.5
  • 53
    • 41949098678 scopus 로고    scopus 로고
    • Growth associated proteins in tumor cells and stroma related to disease progression of colon cancer accounting for tumor tissue PGE2 content
    • Cahlin C, Lönnroth C, Arvidsson A, Nordgren S and Lundholm K: Growth associated proteins in tumor cells and stroma related to disease progression of colon cancer accounting for tumor tissue PGE2 content. Int J Oncol 32: 909-918, 2008.
    • (2008) Int J Oncol , vol.32 , pp. 909-918
    • Cahlin, C.1    Lönnroth, C.2    Arvidsson, A.3    Nordgren, S.4    Lundholm, K.5
  • 55
    • 34248228692 scopus 로고    scopus 로고
    • Interactive actions of prostaglandin and epidermal growth factor to enhance proliferation of granulosa cells from chicken prehierarchical follicles
    • Jin Y, Zhang C, Zeng W, Taya K and Tan TQ: Interactive actions of prostaglandin and epidermal growth factor to enhance proliferation of granulosa cells from chicken prehierarchical follicles. Prostaglandins Other Lipid Mediat 83: 285-294, 2007.
    • (2007) Prostaglandins Other Lipid Mediat , vol.83 , pp. 285-294
    • Jin, Y.1    Zhang, C.2    Zeng, W.3    Taya, K.4    Tan, T.Q.5
  • 56
    • 35148816105 scopus 로고    scopus 로고
    • Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer
    • Buchanan FG, Holla V, Katkuri S, Matta P and DuBois RN: Targeting cyclooxygenase-2 and the epidermal growth factor receptor for the prevention and treatment of intestinal cancer. Cancer Res 67: 9380-9388, 2007.
    • (2007) Cancer Res , vol.67 , pp. 9380-9388
    • Buchanan, F.G.1    Holla, V.2    Katkuri, S.3    Matta, P.4    DuBois, R.N.5
  • 57
    • 38349191618 scopus 로고    scopus 로고
    • NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts
    • Selvendiran K, Bratasz A, Tong L, Ignarro LJ and Kuppusamy P: NCX-4016, a nitro-derivative of aspirin, inhibits EGFR and STAT3 signaling and modulates Bcl-2 proteins in cisplatin-resistant human ovarian cancer cells and xenografts. Cell Cycle 7: 81-88, 2008.
    • (2008) Cell Cycle , vol.7 , pp. 81-88
    • Selvendiran, K.1    Bratasz, A.2    Tong, L.3    Ignarro, L.J.4    Kuppusamy, P.5
  • 58
    • 0037041899 scopus 로고    scopus 로고
    • Prostaglandin E2 reinforces the activation of Ras signal pathway in lung adenocarcinoma cells via EP3
    • Yano T, Zissel G, Muller-Qernheim J, Jae Shin S, Satoh H and Ichikawa T: Prostaglandin E2 reinforces the activation of Ras signal pathway in lung adenocarcinoma cells via EP3. FEBS Lett 518: 154-158, 2002.
    • (2002) FEBS Lett , vol.518 , pp. 154-158
    • Yano, T.1    Zissel, G.2    Muller-Qernheim, J.3    Jae Shin, S.4    Satoh, H.5    Ichikawa, T.6


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