Cigarette smoke extract induces HO-1 expression in mouse cerebral vascular endothelial cells: Involvement of c-Src/NADPH oxidase/PDGFR/JAK2/STAT3 pathway

Journal of Cellular Physiology

Volumn 225, Issue 3, 2010, Pages 741-750

  Shih, Ruey Horng ^a   Lee, I Ta ^a   Hsieh, Hsi Lung ^b   Kou, Yu Ru ^c   Yang, Chuen Mao ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

^b CHANG GUNG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ACTIN; CIGARETTE SMOKE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; HEME OXYGENASE 1; JANUS KINASE 2; PLATELET DERIVED GROWTH FACTOR RECEPTOR; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SHORT HAIRPIN RNA; STAT3 PROTEIN; ENZYME INHIBITOR; HMOX1 PROTEIN, MOUSE; JAK2 PROTEIN, MOUSE; MEMBRANE PROTEIN; MESSENGER RNA; PROTEIN TYROSINE KINASE; SCAVENGER; STAT3 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; BRAIN BLOOD VESSEL; CELL PROTECTION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; GENETIC TRANSFECTION; MOUSE; NONHUMAN; PERIPHERAL VASCULAR SYSTEM; PRIORITY JOURNAL; PROTEIN EXPRESSION; STRESS; VASCULAR ENDOTHELIUM; ANIMAL; BINDING SITE; BIOSYNTHESIS; BRAIN; CELL CULTURE; DRUG EFFECT; ENDOTHELIUM CELL; ENZYMOLOGY; GENETICS; METABOLISM; PROMOTER REGION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SMOKE; SMOKING; TIME; VASCULARIZATION;

ANIMALS; BINDING SITES; BRAIN; CELLS, CULTURED; ENDOTHELIAL CELLS; ENZYME INDUCTION; ENZYME INHIBITORS; FREE RADICAL SCAVENGERS; HEME OXYGENASE-1; JANUS KINASE 2; MEMBRANE PROTEINS; MICE; NADPH OXIDASE; PROMOTER REGIONS, GENETIC; REACTIVE OXYGEN SPECIES; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; RNA INTERFERENCE; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMOKE; SMOKING; SRC-FAMILY KINASES; STAT3 TRANSCRIPTION FACTOR; TIME FACTORS;

EID: 77957850108     PISSN: 00219541     EISSN: 10974652     Source Type: Journal    
DOI: 10.1002/jcp.22270     Document Type: Article

References (42)

1. Basbaum C, Li D, Gensch E, Gallup M, Lemjabbar H. 2002. Mechanisms by which gram-positive bacteria and tobacco smoke stimulate mucin induction through the epidermal growth factor receptor (EGFR). Novartis Found Symp 248: 171-176.
2. Carnevali S, Petruzzelli S, Longoni B, Vanacore R, Barale R, Cipollini M, Scatena F, Paggiaro P, Celi A, Giuntini C. 2003. Cigarette smoke extract induces oxidative stress and apoptosis in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol 284: L955-L963.
3. Chang YC, Lai CC, Lin LF, Ni WF, Tsai CH. 2005. The up-regulation of heme oxygenase-1 expression in human gingival fibroblasts stimulated with nicotine. J Periodontal Res 40: 252-257.
4. Chavez J, Cano C, Souki A, Bermudez V, Medina M, Ciszek A, Amell A, Vargas ME, Reyna N, Toledo A, Cano R, Suarez G, Contreras F, Israili ZH, Hernandez-Hernandez R, Valasco M. 2007. Effect of cigarette smoking on the oxidant/antioxidant balance in healthy subjects. Am J Ther 14: 189-193.
5. Hoshino Y, Mio T, Nagai S, Miki H, Ito I, Izumi T. 2001. Cytotoxic effects of cigarette smoke extract on an alveolar type II cell-derived cell line. Am J Physiol Lung Cell Mol Physiol 281: L509-L516.
6. Iles KE, Dickinson DA, Wigley AF, Welty NE, Blank V, Forman HJ. 2005. HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells. Free Radic Biol Med 39: 355-364.
7. Jaimes EA, DeMaster EG, Tian RX, Raij L. 2004. Stable compounds of cigarette smoke induce endothelial superoxide anion production via NADPH oxidase activation. Arterioscler Thromb Vasc Biol 24: 1031-1036.
8. Kietzmann T, Samoylenko A, Immenschuh S. 2003. Transcriptional regulation of heme oxygenase-1 gene expression by MAP kinases of the JNK and p38 pathways in primary cultures of rat hepatocytes. J Biol Chem 278: 17927-17936.
9. Knorr-Wittmann C, Hengstermann A, Gebel S, Alam J, Muller T. 2005. Characterization of Nrf2 activation and heme oxygenase-1 expression in NIH3T3 cells exposed to aqueous extracts of cigarette smoke. Free Radic Biol Med 39: 1438-1448.
10. Kode A, Yang SR, Rahman I. 2006. Differential effects of cigarette smoke on oxidative stress and proinflammatory cytokine release in primary human airway epithelial cells and in a variety of transformed alveolar epithelial cells. Respir Res 7: 132.
11. Krymskaya VP, Goncharova EA, Ammit AJ, Lim PN, Goncharov DA, Eszterhas A, Panettieri RA, Jr. 2005. Src is necessary and sufficient for human airway smooth muscle cell proliferation and migration. FASEB J 19: 428-430.
12. Lagente V, Planquois JM, Leclerc O, Schmidlin F, Bertrand CP. 2008. Oxidative stress is an important component of airway inflammation in mice exposed to cigarette smoke or lipopolysaccharide. Clin Exp Pharmacol Physiol 35: 601-605.
13. Lee IT, Wang SW, Lee CW, Chang CC, Lin CC, Luo SF, Yang CM. 2008. Lipoteichoic acid induces HO-1 expression via the TLR2/MyD88/c-Src/NADPH oxidase pathway and Nrf2 in human tracheal smooth muscle cells. J Immunol 181: 5098-5110.
14. Lemjabbar H, Li D, Gallup M, Sidhu S, Drori E, Basbaum C. 2003. Tobacco smoke-induced lung cell proliferation mediated by tumor necrosis factor α-converting enzyme and amphiregulin. J Biol Chem 278: 26202-26207.
15. Lin F, Girotti AW. 1998. Hemin-enhanced resistance of human leukemia cells to oxidative killing: Antisense determination of ferritin involvement. Arch Biochem Biophys 352: 51-58.
16. Lin J, Xu Y, Zhang Z, Ni W, Chen S. 2005. Effect of cigarette smoke extract on the role of protein kinase C in the proliferation of passively sensitized human airway smooth muscle cells. J Huazhong Univ Sci Technolog Med Sci 25: 269-273.
17. Martin D, Rojo AI, Salinas M, Diaz R, Gallardo G, Alam J, De Galarreta CM, Cuadrado A. 2004. Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol. J Biol Chem 279: 8919-8929.
18. Methy D, Bertrand N, Prigent-Tessier A, Stanimirovic D, Beley A, Marie C. 2004. Differential MnSOD and HO-1 expression in cerebral endothelial cells in response to sublethal oxidative stress. Brain Res 1003: 151-158.
19. Meyers DG, Neuberger JS, He J. 2009. Cardiovascular effect of bans on smoking in public places: A systematic review and meta-analysis. J Am Coll Cardiol 54: 1249-1255.
20. Misonou Y, Takahashi M, Park YS, Asahi M, Miyamoto Y, Sakiyama H, Cheng X, Taniguchi N. 2005. Acrolein induces Hsp72 via both PKCΔ/JNK and calcium signaling pathways in human umbilical vein endothelial cells. Free Radic Res 39: 507-512.
21. 1 secretion in rat mesangial cells. Life Sci 75: 611-621.
22. Nagaraj NS, Zacharias W. 2007. Cigarette smoke condensate increases cathepsin-mediated invasiveness of oral carcinoma cells. Toxicol Lett 170: 134-145.
23. Parfenova H, Basuroy S, Bhattacharya S, Tcheranova D, Qu Y, Regan RF, Leffler CW. 2006. Glutamate induces oxidative stress and apoptosis in cerebral vascular endothelial cells: Contributions of HO-1 and HO-2 to cytoprotection. Am J Physiol Cell Physiol 290: C1399-C1410.
24. Parinandi NL, Kleinberg MA, Usatyuk PV, Cummings RJ, Pennathur A, Cardounel AJ, Zweier JL, Garcia JG, Natarajan V. 2003. Hyperoxia-induced NAD(P)H oxidase activation and regulation by MAP kinases in human lung endothelial cells. Am J Physiol Lung Cell Mol Physiol 284: L26-L38.
25. Peto R, Lopez AD, Boreham J, Thun M, Heath C, Jr. 1992. Mortality from tobacco in developed countries: Indirect estimation from national vital statistics. Lancet 339: 1268-1278.
26. Pryor WA, Stone K. 1993. Oxidants in cigarette smoke. Radicals, hydrogen peroxide, peroxynitrate, and peroxynitrite. Ann NY Acad Sci 686: 12-27.
27. Ramage L, Jones AC, Whelan CJ. 2006. Induction of apoptosis with tobacco smoke and related products in A549 lung epithelial cells in vitro. J Inflamm (Lond) 3: 3.
28. Rustemeier K, Stabbert R, Haussmann HJ, Roemer E, Carmines EL. 2002. Evaluation of the potential effects of ingredients added to cigarettes. Part 2: Chemical composition of mainstream smoke. Food Chem Toxicol 40: 93-104.
29. Ryter SW, Choi AM. 2005. Heme oxygenase-1: Redox regulation of a stress protein in lung and cell culture models. Antioxid Redox Signal 7: 80-91.
30. Ryter SW, Alam J, Choi AM. 2006. Heme oxygenase-1/carbon monoxide: From basic science to therapeutic applications. Physiol Rev 86: 583-650.
31. 2 generation and cell proliferation in human umbilical vein endothelial cells. Endothelium 15: 175-188.
32. Sun J, Brand M, Zenke Y, Tashiro S, Groudine M, Igarashi K. 2004. Heme regulates the dynamic exchange of Bach1 and NF-E2-related factors in the Maf transcription factor network. Proc Natl Acad Sci USA 101: 1461-1466.
33. Tagawa A, Kaneko T, Shinohara T, Ueda A, Sato T, Ishigatsubo Y. 2005. Heme oxygenase-1 inhibits cigarette smoke-induced increase in the tracheal mucosal permeability in guinea pigs in vivo. Inflamm Res 54: 229-234.
34. Tenhunen R, Marver HS, Schmid R. 1970. The enzymatic catabolism of hemoglobin: Stimulation of microsomal heme oxygenase by hemin. J Lab Clin Med 75: 410-421.
35. Tyrrell R. 1999. Redox regulation and oxidant activation of heme oxygenase-1. Free Radic Res 31: 335-340.
36. van der TM, Rezayat D, Kauffman HF, Bakker SJ, Gans RO, Koeter GH, Choi AM, van Oosterhout AJ, Slebos DJ. 2009. Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol 297: L109-L114.
37. Wu CC, Hsieh CW, Lai PH, Lin JB, Liu YC, Wung BS. 2006. Upregulation of endothelial heme oxygenase-1 expression through the activation of the JNK pathway by sublethal concentrations of acrolein. Toxicol Appl Pharmacol 214: 244-252.
38. Yachie A, Niida Y, Wada T, Igarashi N, Kaneda H, Toma T, Ohta K, Kasahara Y, Koizumi S. 1999. Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency. J Clin Invest 103: 129-135.
39. Yuan X, Xu C, Pan Z, Keum YS, Kim JH, Shen G, Yu S, Oo KT, Ma J, Kong AN. 2006. Butylated hydroxyanisole regulates ARE-mediated gene expression via Nrf2 coupled with ERK and JNK signaling pathway in HepG2 cells. Mol Carcinog 45: 841-850.
40. Zang LY, Stone K, Pryor WA. 1995. Detection of free radicals in aqueous extracts of cigarette tar by electron spin resonance. Free Radic Biol Med 19: 161-167.
41. Zhang H, Forman HJ. 2008. Acrolein induces heme oxygenase-1 through PKC-δ and PI3K in human bronchial epithelial cells. Am J Respir Cell Mol Biol 38: 483-490.
42. Zhang X, Shan P, Jiang G, Zhang SS, Otterbein LE, Fu XY, Lee PJ. 2006. Endothelial STAT3 is essential for the protective effects of HO-1 in oxidant-induced lung injury. FASEB J 20: 2156-2158.