Optogenetic fMRI sheds light on the neural basis of the BOLD signal

Journal of Neurophysiology

Volumn 104, Issue 4, 2010, Pages 1838-1840

  Palmer, Helen S ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

OPSIN; VIRUS VECTOR;

BLOOD OXYGENATION LEVEL DEPENDENT SIGNAL; BRAIN FUNCTION; BRAIN NERVE CELL; FUNCTIONAL MAGNETIC RESONANCE IMAGING; GENETIC TRANSFECTION; HEMODYNAMICS; IMAGE ANALYSIS; NERVE CONDUCTION; NERVE PROJECTION; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; SIGNAL DETECTION; SIGNAL PROCESSING; TECHNIQUE; VISUAL STIMULATION;

ANIMALS; HUMANS; MAGNETIC RESONANCE IMAGING; NEURONS; OPTICAL PHENOMENA; OXYGEN; SIGNAL TRANSDUCTION;

EID: 77957837436     PISSN: 00223077     EISSN: 15221598     Source Type: Journal    
DOI: 10.1152/jn.00535.2010     Document Type: Short Survey

References (11)

1. Alloway K, Olson M, Smith J. Contralateral corticothalamic projections from MI whisker cortex: potential route for modulating hemispheric interactions. J Comp Neurol 510: 100-116, 2008.
2. Buxton R, Wong E, Frank L. Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magn Reson Med 39: 855-864, 1998. (Pubitemid 28237743)
3. Deisseroth K. Fiberoptic control of locomotion in ChR2 mouse. Video reference. 2008. ChR2: http://bit.ly/5w9gRP; control: http://bit.ly/bJDbMF.
4. Donahue M, Lu H, Jones C, Edden R, Pekar J, van Zijl P. Theoretical and experimental investigation of the VASO contrast mechanism. Magn Reson Med 56: 1261-1273, 2006.
5. Friston K. Causal modelling and brain connectivity in functional magnetic resonance imaging. PLoS Biol 7: e33, 2009.
6. Gradinaru V, Thompson K, Zhang F, Mogri M, Kay K, Schneider M, Deisseroth K. Targeting and readout strategies for fast optical neural control in vitro and in vivo. J Neurosci 27: 14231-14238, 2007.
7. Lee J, Durand R, Gradinaru V, Zhang F, Goshen I, Kim D, Fenno L, Ramakrishnan C, Deisseroth K. Global and local fMRI signals driven by neurons defined optogenetically by type and wiring. Nature 465: 788-792, 2010.
8. Logothetis N. What we can do and what we cannot do with fMRI. Nature 453: 869-878, 2008.
9. Logothetis N, Pauls J, Augath M, Trinath T, Oeltermann A. Neurophysiological investigation of the basis of the fMRI signal. Nature 412: 150-157, 2001.
10. Sokoloff L, Revich M, Kennedy C, Des Rosiers MH, Patlak CS, Pettigrew KD, Sakurada O, Shinohara M. The [14C]deoxyglucose method for the measurement of local cerebral glucose utilization: theory, procedure, and normal values in the conscious and anesthetized albino rat. J Neurochem 28: 897-916, 1977.
11. Zhang F, Gradinaru V, Adamantidis A, Durand R, Airan R, de Lecea L, Deisseroth K. Optogenetic interrogation of neural circuits: technology for probing mammalian brain structures. Nat Protoc 5: 439-456, 2010.