Hypoxia-induced Activation of Epidermal Growth Factor Receptor (EGFR) kinase in the cerebral cortex of newborn piglets: The role of nitric oxide

Neurochemical Research

Volumn 35, Issue 9, 2010, Pages 1471-1477

  Mishra, Om Prakash ^a   Ashraf, Qazi M ^a   Delivoria Papadopoulos, Maria ^a  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

EGFR kinase activity; Hypoxia Brain; NNOS; NNOSi; Tyrosine phosphorylation

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE; INDUCIBLE NITRIC OXIDE SYNTHASE; N [4 AMINO 5 (AMINOETHYL)AMINOPENTYL N' NITROGUANIDINE]; NEURONAL NITRIC OXIDE SYNTHASE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN HYPOXIA; CONTROLLED STUDY; DENSITOMETRY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; MOLECULAR IMAGING; MOLECULAR MECHANICS; NERVE CELL MEMBRANE; NEUROPROTECTION; NEWBORN; NONHUMAN; PIGLET; PRIORITY JOURNAL; RADIOCHEMISTRY; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; CATALYTIC DOMAIN; CEREBRAL CORTEX; ENZYME ACTIVATION; HYPOXIA, BRAIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE I; PHOSPHORYLATION; RANDOM ALLOCATION; RECEPTOR, EPIDERMAL GROWTH FACTOR; SWINE; TYROSINE;

EID: 77957831547     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-010-0208-1     Document Type: Article

References (30)

1. Johnson GL, Lapadat R (2004) Mitogen activated protein kinase pathways mediated by ERK, JNK and p38 protein kinases. Science 298:1911-1912
2. Nobel MEM, Endicott JA, Johnson LN (2004) Protein kinase inhibitors: insights into drug design from structure. Science 303:1800-1805 (Pubitemid 38374863)
3. Alanso A, Sasin J, Bottini N, Friedberg I, Osterman A, Godzik A, Hunter T, Dixon J, Mustalin T (2002) Protein tyrosine phosphatases in human genome. Cell 117:699-711 (Pubitemid 35425239)
4. Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S (2002) The protein kinase complement of the human genome. Science 298:1912-1934 (Pubitemid 35425239)
5. Numagami Y, Zubrow AB, Mishra OP, Delivoria-Papadopoulos M (1997) Lipid free radical generation and brain cell membrane alteration following nitric oxide synthase inhibition during cerebral hypoxia in the newborn piglet. J Neurochem 69:1542-1547 (Pubitemid 27406955)
6. Mishra OP, Fritz KI, Delivoria-Papadopoulos M (2001) NMDA receptor and neonatal brain injury. Ment Retard Develop Disabil Res Rev 7:249-253 (Pubitemid 33108262)
7. Zanelli S, Numagami Y, McGowan JE, Mishra OP, Delivoria-Papadopoulos M (1999) NMDA receptor mediated calcium influx in cerebral cortical synaptosomes of hypoxic guinea pig fetus. Neurochem Res 24:437-446 (Pubitemid 29072054)
8. Mishra OP, Zanelli S, Ohnishi ST, Delivoria-Papadopoulos M (2000) Hypoxia-induced generation of nitric oxide free radicals in cerebral cortex of newborn guinea pigs. Neurochem Res 25:1559-1565 (Pubitemid 32052017)
9. Zanelli S, Ashraf QM, Mishra OP (2002) Nitration is A mechanism of regulation of the NMDA receptor function during hypoxia. Neurosci Lett 112:869-877 (Pubitemid 34667051)
10. Delivoria-Papadopoulos M, Akhter WA, Mishra OP (2003) Hypoxia-induced Ca++-influx in cerebral cortical neuronal nuclei of newborn piglets. Neurosci Lett 342:119-123 (Pubitemid 36513922)
11. Zubrow AB, Delivoria-Papadopoulos M, Ashraf QM, Fritz KI, Mishra OP (2002) Nitric oxide-mediated Ca2+/calmodulin-dependent protein kinase IV activity during hypoxia in neuronal nuclei from newborn piglets. Neurosci Lett 335:5-8 (Pubitemid 35379802)
12. Mishra OP, Ashraf QM, Delivoria-Papadopoulos M (2002) Phosphorylation of cAMP response element binding (CREB) protein during hypoxia in cerebral cortex of newborn piglets and the effect of nitric oxide synthase inhibition. Neuroscience 115:985-991 (Pubitemid 35336038)
13. Zubrow AB, Delivoria-Papadopoulos M, Ashraf QM, Ballesteros JR, Fritz KI, Mishra OP (2002) Nitric oxide-mediated expression of bax protein and DNA fragmentation during hypoxia in neuronal nuclei from newborn piglets. Brain Res 954:60-67 (Pubitemid 35223441)
14. Mishra OP, Akhter W, Ashraf QM, Delivoria-Papadopoulos M (2003) Hypoxia-induced modification of poly(ADP-ribose)poly-myrase and DNA polymyrase B activity in cerebral cortical nuclei of newborn piglets: role of nitric oxice. Neuroscience 119:1023-1032 (Pubitemid 36776452)
15. Parikh NA, Katsetos CD, Ashraf QM, Haider SH, Legido A, Delivoria-Papadopoulos M, Mishra OP (2003) Hypoxia-induced caspase-3 activation and DNA fragmentation in cortical neurons of newborn piglets. Role of nitric oxide. Neurochem Res 28:1351-1357 (Pubitemid 38113064)
16. Mishra OP, Delivoria-Papadopoulos M (2007) NO-mediated mechanisms of hypoxic brain injury in newborns. In: Mishra OP (ed) Mechanisms of hypoxic brain injury in the newborn, potential strategies for neuroprotection. Signpost Publishers, Trivandrum, pp 157-171
17. Mishra OP, Mishra R, Ashraf QM, Delivoria-Papadopoulos M (2006) NO-mediated mechanism of neuronal nitric oxide syn-thase (nNOS) expression during hypoxia in the cerebral cortex of newborn piglets. Neurosci 140:857-863 (Pubitemid 44134243)
18. Lowry O, Rosenbrough NJ, Farr A, Randall RJ (1951) Protein measurement with Folin phenol reagent. J Biol Chem 193:265-275
19. Alessi DR, Cohen P, Ashworth A, Cowley S, Leevers SJ, Marshall CJ (1995) Assay and expression of mitogen-activated protein kinase, MAP kinase kinase. Methods Enzymol 255:289
20. Lamprecht W, Stein P, Heinz F, Weissner H (1974) Creatine phosphate. In: Bergmeyer HU (ed) Methods of enzymatic analysis vol 4. Academic Press, New York, pp 1777-1781
21. Ashraf QM, Haider SH, Katsetos CD, Delivoria-Papadopoulos M, Mishra OP (2004) Nitric oxide-mediated alterations of protein tyrosine phosphatase activity and expression during hypoxia in the cerebral cortex of newborn piglets. Neurosci Lett 362:108-112 (Pubitemid 38759079)
22. Mishra OP, Delivoria-Papadopoulos M (2004) Effect of hypoxia on the expression and activity of mitogen-activated protein (MAP) kinase-phosphatase- 1(MKP-1) and MKP-3 in neuronal nuclei of newborn piglets: The role of nitric oxide. Neuroscience 19:665-673 (Pubitemid 39489876)
23. Nathoo N, Goldlust S, Vogelbaum MA (2004) Epidermal growth factor receptor antagonists: novel therapy for the treatment of high grade gliomas. Neurosurgery 54:1480-1489 (Pubitemid 38697922)
24. Liu B, Neufeld AB (2007) Activation of epidermal growth factor receptors in astrocytes: from development to neural injury. J Neuro Sci Res 85:3523-3529 (Pubitemid 350228697)
25. Delivoria-Papadopoulos M, Ashraf QM, Mishra OP (2008) Effect of hypoxia on expression of apoptotic proteins in nuclear, mito-chondrial and cytosolic fractions of the cerebral cortex of newborn piglets: the role of nuclear Ca++-influx. Neurochem Res 33:1196-1204
26. Ravishankar S, Ashraf QM, Fritz KI, Mishra OP, Delivoria-Pa-padopoulos M (2001) Expression of Bax and Bcl-2 proteinsdur-ing hypoxia in cerebral cortical neuronal nuclei of newborn piglets. Brain Res 901:23-29
27. Akhter WA, Ashraf QM, Zanelli SA, Mishra OP, Delivoria-Pa-padopoulos M (2001) Effects of graded hypoxia on cerebral cortical genomic DNA fragmentation in newborn piglets. Biol Neonate 79:187-193
28. Oltvai ZN, Milliman CM, Korsmeyer SJ (1993) Bcl-2 heterodi-merizes in vivo with A conserved homolog, Bax, that accelerates programmed cell death. Cell 74:609-619
29. Krajewski S, Mal JK, Krajewska M, Sikorska M, Mossakowski MJ (1995) Upregulation of Bax protein levels in neurons following cerebral ischemia. J Neurosci 15:6364-6376 (Pubitemid 3001286)
30. Reed JC (1996) Mechanisms of Bcl-2 family protein function and dysfunction in health and disease. Behring Inst Mitt 97:72-100