Synthesis and anti-inflammatory activity evaluation of some novel 6-alkoxy(phenoxy)-[1,2,4]triazolo[3,4-a]phthalazine-3-amine derivatives

European Journal of Medicinal Chemistry

Volumn 45, Issue 11, 2010, Pages 4807-4812

  Sun, Xian Yu ^a,c   Hu, Chuan ^a   Deng, Xian Qing ^a   Wei, Cheng Xi ^a,b   Sun, Zhi Gang ^b   Quan, Zhe Shan ^a  

^a YANBIAN UNIVERSITY   (China)

^b INNER MONGOLIA UNIVERSITY FOR NATIONALITIES   (China)

^c HEILONGJIANG BAYI AGRICULTURAL UNIVERSITY   (China)

Author keywords

3 Amine triazole; 1,2,4 Triazolo 3,4 a phthalazine 3 amine; Anti inflammatory; Phthalazine

Indexed keywords

1 HYDRAZINE 4 CHROROPHTHALAZIN; 1,4 DICHLOROPHTHALAZINE; 2,3 DIHYDRO 1,4 PHTHALAZINEDIONE; 6 (2 AMINOPHENOXY) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (2 CHLOROPHENOXY) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (2 METHYLPHENOXYL) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (2,4 DICHLOROPHENOXY) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (3 AMINOPHENOXY) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (3 CHLOROPHENOXY) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (3 METHYLPHENOXYL) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (4 AMINOPHENOXY) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (4 BROMOPHENOXY) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (4 CHLOROPHENOXY) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (4 FLUOROPHENOXY) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (4 METHOXYPHENOXY) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (4 METHYLPHENOXYL) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (CCTYLOXY) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (HEPTYLOXY) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 (HEXYLOXY) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 ALKOXY(PHENOXY) [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE DERIVATIVES; 6 BUTOXY[1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 CHLORO [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 ETHOXY [1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 ISOPROPOXY[1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 METHOXY[1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; 6 PHENOXY[1,2,4]TRIAZOLO[3,4 A]PHTHALAZINE 3 AMINE; ANTIINFLAMMATORY AGENT; IBUPROFEN; PHTHALAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DOSE RESPONSE; DRUG POTENCY; DRUG SYNTHESIS; EVALUATION; MOUSE; NONHUMAN;

ANIMALS; ANTI-INFLAMMATORY AGENTS; DRUG EVALUATION, PRECLINICAL; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; MICE; PHTHALAZINES; SPECTROPHOTOMETRY, INFRARED;

EID: 77957829686     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2010.07.049     Document Type: Article

References (22)

1. B.L. Sng, and S.A. Schug Ann. Acad. Med. Singap. 38 2009 960 966
2. H.P. Zahradnik, A. Hanjalic-Beck, and K. Groth Contraception 3 2010 185 196
3. R. Chou, G.J. Fanciullo, P.G. Fine, J.A. Adler, J.C. Ballantyne, and P. Davies J. Pain 10 2009 113 130
4. F.W. Kraemer, and J.B. Rose Anesthesiol. Clin. 2 2009 241 268
5. R. Eccles J. Clin. Pharm. Ther. 31 2006 309 319
6. P. Rathee, H. Chaudhary, S. Rathee, D. Rathee, V. Kumar, and K. Kohli Inflamm. Allergy Drug Targets 3 2009 229 235
7. D. Mukherjee, S.E. Nissen, and E.J. Topol JAMA 286 2001 954 959
8. J.R. Van, and R.M. Botting Inflamm. Res. 44 1995 1 10
9. L.J. Cui, Z.F. Xie, H.R. Piao, G. Li, K.Y. Chai, and Z.S. Quan Biol. Pharm. Bull. 7 2005 1216 1220
10. Z.F. Xie, K.Y. Chai, H.R. Piao, K.C. Kwak, and Z.S. Quan Bioorg. Med. Chem. Lett. 21 2005 4803 4805
11. X.Y. Sun, Y.Z. Jin, F.N. Li, G. Li, K.Y. Chai, and Z.S. Quan Arch. Pharm. Res. 12 2006 1080 1085
12. Y.Z. Jin, L.P. Guan, L.M. Zhao, H.R. Piao, and Z.S. Quan Chin. J. Org. Chem. 12 2007 1567 1572
13. X.Y. Sun, C.X. Wei, K.Y. Chai, H.R. Piao, and Z.S. Quan Arch. Pharm. 341 2008 288 293
14. X.S. Cui, J. Chen, K.Y. Chai, J.S. Lee, and Z.S. Quan Med. Chem. Res. 1 2009 49 58
15. L.M. Lima, and E.J. Barreiro Curr. Med. Chem. 1 2005 23 49
16. A. Burger Prog. Drug Res. 37 1991 287 371
17. J.S. Leslie, S. Francine, A.J. Richard, J.R. Austin, W.C. Robert, and W.M. Kevin J. Med. Chem. 47 2004 3642 3657
18. X.Y. Sun, L.P. Guan, L. Zhang, C.X. Wei, H.R. Piao, Z.S. Quan, and J. Braz Chem. Soc. 20 2009 826 831
19. T. Ramalingam, M.S. Murty, Y.V.D. Nageswar, and P.B.J. Sattur Heterocyclic.Chem. 27 1990 981 982
20. G.L. Chen, W. Shan, Y.L. Wu, L.X. Ren, J.H. Dong, and Z.Z. Ji Chem. Pharm. Bull. 53 2005 1587 1590
21. R.A. Kroll, and E.A. Neuwelt Neurosurgery 42 1998 1083 1099
22. W.M. Pardridge NeuroRx 2 2005 3 14