The impact of oral health and 0.2% chlorhexidine oral gel on the prevalence of nosocomial infections in surgical intensive-care Patients: A randomized placebo-controlled study

Wiener Klinische Wochenschrift

Volumn 122, Issue 13-14, 2010, Pages 397-404

  Ćabov, Tomislav ^a   MacAn, Darko ^b   Husedžinović, Ino ^b   Škrlin Šubić, Jasenka ^b   Bošnjak, Danica ^b   Šestan Crnek, Sandra ^a,b   Perić, Berislav ^b   Kovač, Zoran ^c   Golubović, Vesna ^a  

^a UNIVERSITY OF RIJEKA   (Croatia)

^b University of Zagreb School of Medicine   (Croatia)

^c KBC RIJEKA   (Croatia)

Author keywords

Chlorhexidine; Dental plaque; Intensive care patients; Nosocomial infection; Oral decontamination

Indexed keywords

CHLORHEXIDINE; PLACEBO;

ADULT; AGED; ARTICLE; ASEPSIS; BACTERIAL COLONIZATION; BACTERIUM CULTURE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HEALTH STATUS; HOSPITAL INFECTION; HUMAN; HUMAN TISSUE; INCIDENCE; INFECTION PREVENTION; INFECTION RATE; INTENSIVE CARE UNIT; LENGTH OF STAY; MAJOR CLINICAL STUDY; MALE; MORTALITY; MOUTH HYGIENE; MOUTH INFECTION; MOUTH MUCOSA; PREVALENCE; RANDOMIZED CONTROLLED TRIAL; SURGICAL PATIENT; TOOTH PLAQUE; TRACHEAL ASPIRATION PROCEDURE;

ADMINISTRATION, ORAL; ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BACTERIAL INFECTIONS; BRAIN INJURIES; CHLORHEXIDINE; CROATIA; CROSS INFECTION; CROSS-SECTIONAL STUDIES; DENTAL PLAQUE INDEX; DMF INDEX; FEMALE; GELS; HUMANS; INTENSIVE CARE; INTUBATION, INTRATRACHEAL; MALE; MIDDLE AGED; MULTIPLE TRAUMA; NEOPLASMS; ORAL HYGIENE; RESPIRATION, ARTIFICIAL; YOUNG ADULT;

EID: 77957793331     PISSN: 00435325     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00508-010-1397-y     Document Type: Article

References (29)

1. J Chastre JY Fagon 2002 Ventilator-associated pneumonia Am J Respir Crit Care Med 165 867 903 11934711 (Pubitemid 34774654)
2. FA Scannapieco GD Papandonatos RG Dunford 1998 Associations between oral conditions and respiratory disease in a national sample survey population Ann Periodontol 3 251 256 1:STN:280:DyaK1czovF2gsA%3D%3D 9722708
3. Megan DW, Chow AW (1986) Bacterial aspiration and anaerobic pleuro-pulmonary infections. In: Sande MA, Hudson LD, Root RK (eds) Respiratory infections. Churchill & Livingstone, New York, pp 269-92
4. GB Toews 1986 Nosocomial pneumonia Am J Med Sci 291 355 367 10.1097/00000441-198605000-00013 1:STN:280:DyaL283ht1elsA%3D%3D 3518453 (Pubitemid 17035509)
5. R Fiddian-Green S Baker 1991 Nosocomial pneumonia in the critically ill: Product of aspiration or translocation? Crit Care Med 19 763 769 1:STN:280:DyaK3M3nsFGitQ%3D%3D 2055052
6. Mayhall CG (1996) Hospital epidemiology and infection control. Williams & Wilkins, Baltimore
7. B Gipe D Donnelly S Harris 1995 A survey of dental health in patients with respiratory failure (abstract) Am J Respir Crit Care Med 151 A340
8. F Fourrier B Duviver H Boutigny M Roussel-Delvallez C Chopin 1998 Colonization of dental plaque: a source of nosocomial infection in intensive care unit patients Crit Care Med 26 301 308 10.1097/00003246-199802000-00032 1:STN:280:DyaK1c7islKrtQ%3D%3D 9468169 (Pubitemid 28082693)
9. FA Scannapieco EM Stewart JM Mylotte 1992 Colonization of dental plaque by respiratory pathogens in medical intensive care patients Crit Care Med 20 740 745 10.1097/00003246-199206000-00007 1:STN:280:DyaK383ot1yqtg%3D%3D 1597025
10. Jr. Le Gall S Lemeshow F Saulnier 1993 A new simplified acute physiology score based on a European/North American multicenter study JAMA 270 2957 2963 10.1001/jama.270.24.2957 1:STN:280:DyaK2c%2Fns1GmtA%3D%3D 8254858 (Pubitemid 24000804)
11. H Klein C Palmer 1940 Studies on dental caries. A procedure for the recording and statistical processing of dental examination findings J Dent Res 19 243 256
12. J Silness H Löe 1964 Periodontal disease in pregnancy II: correlation between oral hygiene and periodontal condition Acta Odontol Scand 22 121 135 10.3109/00016356408993968 1:STN:280:DyaF2c7hs1CgsA%3D%3D 14158464
13. F Fourrier E Cau-Pottier H Boutigny M Roussel-Delvallez M Jourdain C Chopin 2000 Effects of dental plaque antiseptic decontamination on bacterial colonization and nosocomial infections in critically ill patients Intensive Care Med 26 1239 1247 10.1007/s001340000585 1:STN:280:DC%2BD3MzgsFWisA%3D%3D 11089748
14. F Fourrier D Dubois P Pronnier P Herbecq O Leroy T Desmettre, et al. 2005 Effect of gingival and dental plaque antiseptic decontamination on nosocomial infections acquired in the intensive care unit: a double-blind placebo-controlled multicenter study Crit Care Med 33 1728 1735 10.1097/01.CCM.0000171537.03493.B0 16096449 (Pubitemid 41153697)
15. DC Bergmans MJ Bonten CA Gaillard JC Paling S van der Geest FH van Tiel, et al. 2001 Prevention of ventilator-associated pneumonia by oral decontamination: a prospective, randomized, double-blind, placebo-controlled study Am J Respir Crit Care Med 164 382 388 1:STN:280:DC%2BD3MrhsFyrsA%3D%3D 11500337 (Pubitemid 32778203)
16. MA de La Cal E Cerdá P García-Hierro HK van Saene D Gómez-Santos E Negro, et al. 2005 Survival benefit in critically ill burned patients receiving selective decontamination of the digestive tract: a randomized, placebo-controlled, double-blind trial Ann Surg 241 424 430 10.1097/01.sla.0000154148.58154.d5 15729064 (Pubitemid 40299718)
17. WA Krueger FP Lenhart G Neeser G Ruckdeschel H Schreckhase HJ Eissner, et al. 2002 Influence of combined intravenous and topical antibiotic prophylaxis on the incidence of infections, organ dysfunctions, and mortality in critically ill surgical Patients: a prospective, stratified, randomized, double-blind, placebo-controlled clinical trial Am J Respir Crit Care Med 166 1029 1037 10.1164/rccm.2105141 12379544 (Pubitemid 35178699)
18. E de Jonge MJ Schultz L Spanjaard PM Bossuyt MB Vroom J Dankert, et al. 2003 Effects of selective decontamination of digestive tract on mortality and acquisition of resistant bacteria in intensive care: a randomised controlled trial Lancet 362 1011 1016 10.1016/S0140-6736(03)14409-1 1:CAS:528: DC%2BD3sXns1ehsbs%3D 14522530 (Pubitemid 37186877)
19. AM de Smet JA Kluytmans BS Cooper EM Mascini RF Benus TS van der Werf, et al. 2009 Decontamination of the digestive tract and oropharynx in ICU patients N Engl J Med 360 20 31 10.1056/NEJMoa0800394 1:CAS:528:DC%2BD1MXhvFOitA%3D%3D 19118302
20. AN Laggner M Tryba A Georgopoulos K Lenz G Grimm W Graninger, et al. 1994 Oropharyngeal decontamination with gentamicin for long-term ventilated patients on stress ulcer prophylaxis with sucralfate? Wien Klin Wochenschr 106 15 19 1:STN:280:DyaK2c7ot1emtg%3D%3D 8135026 (Pubitemid 24037460)
21. AM Milstone CL Passaretti TM Perl 2008 Chlorhexidine: expanding the armamentarium for infection control and prevention Clin Infect Dis 46 274 281 10.1086/524736 18171263 (Pubitemid 351269170)
22. AJ DeRiso II JS Ladowski TA Dillon JW Justice AC Peterson 1996 Chlorhexidine gluconate 0.12% oral rinse reduces the incidence of total nosocomial respiratory infection and nonprophylactic systemic antibiotic use in patients undergoing heart surgery Chest 109 1556 1561 10.1378/chest.109.6.1556 1:CAS:528:DyaK2sXit1aktL8%3D 8769511
23. S Houston P Hougland JJ Anderson M LaRocco V Kennedy LO Gentry 2002 Effectiveness of 0.12% chlorhexidine gluconate oral rinse in reducing prevalence of nosocomial pneumonia in patients undergoing heart surgery Am J Crit Care 11 567 570 12425407
24. LA Pineda RG Saliba AA El Solh 2006 Effect of oral decontamination with chlorhexidine on the incidence of nosocomial pneumonia: a meta-analysis Crit Care 10 R35 10.1186/cc4837 16507165 (Pubitemid 47079786)
25. H Mori H Hirasawa S Oda H Shiga K Matsuda M Nakamura 2006 Oral care reduces incidence of ventilator-associated pneumonia in ICU populations Intensive Care Med 32 230 236 10.1007/s00134-005-0014-4 16435104 (Pubitemid 43251143)
26. MP Chlebicki N Safdar 2007 Topical chlorhexidine for prevention of ventilator-associated pneumonia: a meta-analysis Crit Care Med 35 595 602 10.1097/01.CCM.0000253395.70708.AC 1:CAS:528:DC%2BD2sXhtFKis7c%3D 17205028 (Pubitemid 46148554)
27. EY Chan A Ruest MO Meade DJ Cook 2007 Oral decontamination for prevention of pneumonia in mechanically ventilated adults: systematic review and meta-analysis BMJ 334 889 10.1136/bmj.39136.528160.BE 17387118 (Pubitemid 46724331)
28. A Kola P Gastmeier 2007 Efficacy of oral chlorhexidine in preventing lower respiratory tract infections. Meta-analysis of randomized controlled trials J Hosp Infect 66 207 216 10.1016/j.jhin.2007.03.025 1:STN:280: DC%2BD2szoslOmtg%3D%3D 17544168 (Pubitemid 46979844)
29. H Tantipong C Morkchareonpong S Jaiyindee V Thamlikitkul 2008 Randomized controlled trial and meta-analysis of oral decontamination with 2% chlorhexidine solution for the prevention of ventilator-associated pneumonia Infect Control Hosp Epidemiol 29 131 136 10.1086/526438 18179368 (Pubitemid 351269208)