Efficacy of oral chlorhexidine in preventing lower respiratory tract infections. Meta-analysis of randomized controlled trials

Journal of Hospital Infection

Volumn 66, Issue 3, 2007, Pages 207-216

  Kola, A ^a   Gastmeier, P ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

Chlorhexidine; Lower respiratory tract infections; Meta analysis; Oral decontamination

Indexed keywords

BICARBONATE; CHLORHEXIDINE; HYDROGEN PEROXIDE; LISTERINE; PLACEBO;

ARTIFICIAL VENTILATION; CLINICAL TRIAL; COCHRANE LIBRARY; CONFIDENCE INTERVAL; DRUG EFFICACY; HOSPITAL INFECTION; HUMAN; INCIDENCE; INFECTION PREVENTION; INFECTION RISK; INFORMATION RETRIEVAL; LOWER RESPIRATORY TRACT INFECTION; MEDLINE; META ANALYSIS; OUTCOME ASSESSMENT; REVIEW; RISK ASSESSMENT; RISK REDUCTION;

CHLORHEXIDINE; CROSS INFECTION; HUMANS; MOUTHWASHES; RANDOMIZED CONTROLLED TRIALS; RESPIRATORY TRACT INFECTIONS; RISK;

EID: 34250799654     PISSN: 01956701     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhin.2007.03.025     Document Type: Review

References (21)

1. Gastmeier P., Geffers C., Brandt C., et al. Effectiveness of a nationwide nosocomial infection surveillance system for reducing nosocomial infections. J Hosp Infect 64 (2006) 16-22
2. Safdar N., Dezfulian C., Collard H.R., and Saint S. Clinical and economic consequences of ventilator-associated pneumonia: a systematic review. Crit Care Med 33 (2005) 2184-2193
3. Cook D.J., and Kollef M.H. Risk factors for ICU-acquired pneumonia. J Am Med Assoc 279 (1998) 1605-1606
4. Collard H.R., Saint S., and Matthay M.A. Prevention of ventilator-associated pneumonia: an evidence-based systematic review. Ann Intern Med 138 (2003) 494-501
5. Bonten M.J., Bergmans D.C., Ambergen A.W., et al. Risk factors for pneumonia, and colonization of respiratory tract and stomach in mechanically ventilated ICU patients. Am J Respir Crit Care Med 154 (1996) 1339-1346
6. Fourrier F., Duvivier B., Boutigny H., Roussel-Delvallez M., and Chopin C. Colonization of dental plaque: a source of nosocomial infections in intensive care unit patients. Crit Care Med 26 (1998) 301-308
7. Garrouste-Orgeas M., Chevret S., Arlet G., et al. Oropharyngeal or gastric colonization and nosocomial pneumonia in adult intensive care unit patients. A prospective study based on genomic DNA analysis. Am J Respir Crit Care Med 156 (1997) 1647-1655
8. Houston S., Hougland P., Anderson J.J., LaRocco M., Kennedy V., and Gentry L.O. Effectiveness of 0.12% chlorhexidine gluconate oral rinse in reducing prevalence of nosocomial pneumonia in patients undergoing heart surgery. Am J Crit Care 11 (2002) 567-570
9. Grap M.J., Munro C.L., Elswick Jr. R.K., Sessler C.N., and Ward K.R. Duration of action of a single, early oral application of chlorhexidine on oral microbial flora in mechanically ventilated patients: a pilot study. Heart Lung 33 (2004) 83-91
10. Fourrier F., Dubois D., Pronnier P., et al. Effect of gingival and dental plaque antiseptic decontamination on nosocomial infections acquired in the intensive care unit: a double-blind placebo-controlled multicenter study. Crit Care Med 33 (2005) 1728-1735
11. Pineda L.A., Saliba R.G., and El Solh A.A. Effect of oral decontamination with chlorhexidine on the incidence of nosocomial pneumonia: a meta-analysis. Crit Care 10 (2006) R35
12. DeRiso II A.J., Ladowski J.S., Dillon T.A., Justice J.W., and Peterson A.C. Chlorhexidine gluconate 0.12% oral rinse reduces the incidence of total nosocomial respiratory infection and nonprophylactic systemic antibiotic use in patients undergoing heart surgery. Chest 109 (1996) 1556-1561
13. Fourrier F., Cau-Pottier E., Boutigny H., Roussel-Delvallez M., Jourdain M., and Chopin C. Effects of dental plaque antiseptic decontamination on bacterial colonization and nosocomial infections in critically ill patients. Intens Care Med 26 (2000) 1239-1247
14. Bopp M., Darby M., Loftin K.C., and Broscious S. Effects of daily oral care with 0.12% chlorhexidine gluconate and a standard oral care protocol on the development of nosocomial pneumonia in intubated patients: a pilot study. J Dent Hyg 80 (2006) 9
15. Koeman M., van der Ven A.J., Hak E., et al. Oral decontamination with chlorhexidine reduces the incidence of ventilator-associated pneumonia. Am J Respir Crit Care Med 173 (2006) 1348-1355
16. Segers P., Speekenbrink R.G., Ubbink D.T., van Ogtrop M.L., and de Mol B.A. Prevention of nosocomial infection in cardiac surgery by decontamination of the nasopharynx and oropharynx with chlorhexidine gluconate: a randomized controlled trial. J Am Med Assoc 296 (2006) 2460-2466
17. Chlebicki M.P., and Safdar N. Topical chlorhexidine for prevention of ventilator-associated pneumonia: a meta-analysis. Crit Care Med 35 (2007) 1-8
18. Macnaughton P., Baily J., Donlin N., Branfield P., Williams A., and Rowswell H. A randomised controlled trial assessing the efficacy of oral chlorhexidine in ventilated patients. Intens Care Med 30 Suppl. 1 (2004) S5-S18
19. Johanson Jr. W.G., Pierce A.K., Sanford J.P., and Thomas G.D. Nosocomial respiratory infections with Gram-negative bacilli. The significance of colonization of the respiratory tract. Ann Intern Med 77 (1972) 701-706
20. Bonten M.J. Strategies for prevention of hospital-acquired pneumonia: oral and selective decontamination of the gastrointestinal tract. Semin Respir Crit Care Med 23 (2002) 481-488
21. Tablan O.C., Anderson L.J., Besser R., Bridges C., and Hajjeh R. Guidelines for preventing healthcare-associated pneumonia, 2003: recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee. MMWR Recomm Rep 53 RR-3 (2004) 1-36