Characterisation of a carrier-free dry powder aerosol formulation using inertial impaction and laser diffraction

Pharmaceutical Research

Volumn 23, Issue 9, 2006, Pages 2210-2219

  Martin, Gary P ^a   MacRitchie, Helen B ^a   Marriott, Christopher ^a   Zeng, Xian Ming ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b MEDWAY SCHOOL OF PHARMACY   (United Kingdom)

Author keywords

Bricanyl turbohaler ; Dry powder aerosols; Formulations; Inertial impaction; Laser diffraction; Particle size distribution

Indexed keywords

BRONCHODILATING AGENT; DRUG CARRIER; TERBUTALINE;

AEROSOL; ARTICLE; AUDIOVISUAL EQUIPMENT; CHEMISTRY; DRUG FORMULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HISTOLOGY; INSTRUMENTATION; LASER; LUNG; METHODOLOGY; PARTICLE SIZE; PHARYNX; POWDER; ULTRAVIOLET SPECTROPHOTOMETRY;

AEROSOLS; BRONCHODILATOR AGENTS; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG CARRIERS; DRUG COMPOUNDING; LASERS; LUNG; MODELS, ANATOMIC; PARTICLE SIZE; PHARYNX; POWDERS; SPECTROPHOTOMETRY, ULTRAVIOLET; TERBUTALINE;

EID: 33750595241     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9056-8     Document Type: Article

References (23)

1. A. R. Clark. The use of laser diffraction for the evaluation of aerosol clouds generated by medical nebulisers. Int. J. Pharm. 115:69-78 (1995).
2. F. Moren. Pressurized aerosols for inhalation. Int. J. Pharm. 8:1-10 (1981).
3. B. Olsson, H. Jægfeldt, K. Hed, and H. Ludback. Correlation between laser scattering and inertial impaction for the particle distribution charactersation of Bricanyl Turbohaler. J. Aerosol Sci. 19:1107-1111 (1988).
4. M. Everard, S. G. Devadason, V. B. Sunderland, and P. N. Le Souef. An alternative aerosol delivery system for amiloride. Thorax 50:517-519 (1995).
5. J. Ziegler and H. Wachtel. Comparison of cascade impaction and laser diffraction for particle size distribution measurements. J. Aerosol Med. 18:311-324 (2005).
6. H. D. Smyth and A. J. Hickey. Multimodal particle size distributions emitted from HFA-134a solution pressurized metered-dose inhalers. AAPS PharmSciTech 4:E38 (2003).
7. X. M. Zeng, H. B. MacRitchie, C. Marriott, and G. P. Martin. Correlation between inertial impaction and laser diffraction sizing data for aerosolized carrier-based dry powder formulations. Submitted for publication.
8. K. Wetterlin. Turbuhaler: a new powder inhaler for administration of drugs to the airways. Pharm. Res. 5:506-508 (1988).
9. T. T. Yang and D. Kenyon. Use of an agglomerate formulation in a new multidose dry powder inhaler. In R. N. Dalby, P. R. Byron, and S. J. Farr (eds.), Respiratory Drug Delivery VII, Serentec, Raleigh, North Carolina, 2000, pp. 503-505.
10. S. White and N. Harper. Exubera®: development of a novel technology solution for pulmonary delivery of insulin. In Proceedings of drug delivery to the lung 15, The Aerosol Society, London, 2004, pp. 89-92.
11. Handbook of Pharmaceutical Excipients, 4th ed., American Pharmaceutical Association, Washington, District of Columbia, 2003.
12. British Pharmacopoeia. Aerodynamic Assessment of Fine Particles. HMSO, London, Appendix XII F, 2000, A194-A200.
13. H. Jægfeldt, J. A. R. Andersson, E. Trofast, and K. I. L. Wetterlin. Particle size distribution from different modifications of Turbohaler™. In S. P. Newman, F. Moren, and G. K. Compton (eds.), A New Concept in Inhalation Therapy, Medicom, Netherlands, 1987, pp. 90-99.
14. A. H. de Boer, D. Gjaltema, and P. Hageforn. Inhalation characteristics and their effect on in vitro drug delivery from dry powder inhalers. Part 2: Effect of peak flow rate (PIFR) and inspiration time on the in vitro drug release from 3 types of commercial dry powder inhalers. Int. J. Pharm. 138:45-56 (1996).
15. B. J. Meakin, J. M. Cainey, and P. M. Woodcock. Drug delivery characteristics of Bricanyl™ Turbohaler™ dry powder inhalers. Int. J. Pharm. 119:91-102 (1995).
16. D. L. Ross and R. K. Schultz. Effect of inhalation flow rate on the dosing characteristics of dry powder inhaler (DPI) and metered dose inhaler (MDI) products. J. Aerosol Med. 9:215-226 (1996).
17. E. D. Hirleman. Particle sizing by non-imaging techniques. In J. M. Tishkoff, R. D. Ingebo, and J. B. Kennedy (eds.), Liquid Particle Size Measurement Techniques ASTM STP 848, American Society for Testing and Materials, Philadelphia, 1984, pp. 35-60.
18. H. C. Van de Hulst. Light Scattering by Small Particles, Dover, New York, 1981.
19. P. Kippax. Appraisal of the laser diffraction particle-sizing technique. Pharm. Technol. 88-96 (2005).
20. A. H. de Boer, D. Gjaltema, P. Hagedoorn, and H. W. Frijlink. Characterization of inhalation aerosols: a critical evaluation of cascade impactor and laser diffraction technique. Int. J. Pharm. 249:219-231 (2002).
21. J. Swithenbank, J. M. Beer, D. S. Taylor, and G. C. MeCreath. A laser diagnostic technique for the measurement of droplet and particle size distribution. Prog. Aeronaut. 53:421 (1977).
22. A. Annapraguda and A. Adjei. An analysis of the Fraunhofer diffraction method for particle size distribution analysis and its application to aerosolized sprays. Int. J. Pharm. 127:219-227 (1996).
23. D. A. Edwards, J. Hanes, G. Caponetti, J. Hrkach, A. Ben-Jebria, M.-L. Eskew, J. Mintzes, D. Deaver, N. Lotan, and R. Langer. Large porous particles for pulmonary drug delivery. Science 276:1868-1871 (1997).