Loss of p15/Ink4b accompanies tumorigenesis triggered by complex DNA double-strand breaks

Carcinogenesis

Volumn 31, Issue 10, 2010, Pages 1889-1896

  Camacho, Cristel V ^a   Mukherjee, Bipasha ^a   McEllin, Brian ^a   Ding, Liang Hao ^a   Hu, Burong ^b,c   Habib, Amyn A ^a,d   Xie, Xian Jin ^e   Nirodi, Chaitanya S ^a   Saha, Debabrata ^a   Story, Michael D ^a   Balajee, Adayabalam S ^b   Bachoo, Robert M ^a   Boothman, David A ^a,e   Burma, Sandeep ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c INSTITUTE OF MODERN PHYSICS   (China)

^d VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYCLIN DEPENDENT KINASE INHIBITOR 2B; DOUBLE STRANDED DNA; IRON; PROTEIN P16; TUMOR SUPPRESSOR PROTEIN; CDKN2B PROTEIN, HUMAN;

ANIMAL CELL; ARTICLE; ASTROCYTE; CARCINOGENESIS; CELL SURVIVAL; CHROMOSOME NOR; DOUBLE STRANDED DNA BREAK; GAMMA RADIATION; GENE LOCUS; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; IRRADIATION; LATENT PERIOD; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; TUMOR CELL; TUMOR SUPPRESSOR GENE; ANIMAL; CELL CULTURE; CHROMOSOME ABERRATION; CHROMOSOME DELETION; DNA REPAIR; GENETICS; NEOPLASMS; PHYSIOLOGY;

ANIMALS; CELLS, CULTURED; CHROMOSOME ABERRATIONS; CHROMOSOME DELETION; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA BREAKS, DOUBLE-STRANDED; DNA REPAIR; GENOMIC INSTABILITY; HUMANS; MICE; NEOPLASMS;

EID: 77957763073     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgq153     Document Type: Article

References (36)

1. Little, J.B. (2000) Radiation carcinogenesis. Carcinogenesis, 21, 397-404.
2. Wakeford,R. (2004) The cancer epidemiology of radiation. Oncogene, 23, 6404-6428.
3. Volpato,C.B. et al. (2008) Enhanced sensitivity of the RET proto-oncogene to ionizing radiation in vitro. Cancer Res., 68, 8986-8992.
4. Hamatani,K. et al. (2008) RET/PTC rearrangements preferentially occurred in papillary thyroid cancer among atomic bomb survivors exposed to high radiation dose. Cancer Res., 68, 7176-7182.
5. O'Driscoll,M. et al. (2006) The role of double-strand break repair-insights from human genetics. Nat. Rev. Genet., 7, 45-54.
6. Hada,M. et al. (2006) Spectrum of complex DNA damages depends on the incident radiation. Radiat. Res., 165, 223-230.
7. Durante,M. et al. (2008) Heavy ion carcinogenesis and human space exploration. Nat. Rev. Cancer, 8, 465-472.
8. Cucinotta,F.A. et al. (2006) Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings. Lancet Oncol., 7, 431-435.
9. Schulz-Ertner,D. et al. (2007) Particle radiation therapy using proton and heavier ion beams. J. Clin. Oncol., 25, 953-964.
10. Mukherjee,B. et al. (2008) Modulation of the DNA-damage response to HZE particles by shielding. DNA Repair (Amst.), 7, 1717-1730.
11. Bachoo,R.M. et al. (2002) Epidermal growth factor receptor and Ink4a/Arf: convergent mechanisms governing terminal differentiation and transformation along the neural stem cell to astrocyte axis. Cancer Cell, 1, 269-277.
12. Krimpenfort,P. et al. (2007) p15Ink4b is a critical tumour suppressor in the absence of p16Ink4a. Nature, 448, 943-946.
13. Mukherjee,B. et al. (2009) EGFRvIII and DNA double-strand break repair: a molecular mechanism for radioresistance in glioblastoma. Cancer Res., 69, 4252-4259.
14. Zijlmans,J.M. et al. (1997) Telomeres in the mouse have large interchromosomal variations in the number of T2AG3 repeats. Proc. Natl Acad. Sci. USA, 94, 7423-7428.
15. Boei,J.J. et al. (1996) Classification of X-ray-induced Robertsonian fusion-like configurations in mouse splenocytes. Int. J. Radiat. Biol., 69, 421-427.
16. Altomare,D.A. et al. (2005) Perturbations of the AKT signaling pathway in human cancer. Oncogene, 24, 7455-7464.
17. Roberts,P.J. et al. (2007) Targeting the Raf-MEK-ERK mitogenactivated protein kinase cascade for the treatment of cancer. Oncogene, 26, 3291-3310.
18. Bayani,J. et al. (2004) Multi-color FISH techniques. Curr. Protoc. Cell Biol., Chapter 22, Unit 22 5.
19. Scherthan,H. (2002) Detection of chromosome ends by telomere FISH. Methods Mol. Biol., 191, 13-31.
20. Murnane,J.P. (2006) Telomeres and chromosome instability. DNA Repair (Amst.), 5, 1082-1092.
21. Serrano,M. et al. (1996) Role of the INK4a locus in tumor suppression and cell mortality. Cell, 85, 27-37.
22. Cannon-Albright,L.A. et al. (1992) Assignment of a locus for familial melanoma, MLM, to chromosome 9p13-p22. Science, 258, 1148-1152.
23. Lukas,J. et al. (1995) Retinoblastoma-protein-dependent cell-cycle inhibition by the tumour suppressor p16. Nature, 375, 503-506.
24. Nobori,T. et al. (1994) Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature, 368, 753-756.
25. Kim,W.Y. et al. (2006) The regulation of INK4/ARF in cancer and aging. Cell, 127, 265-275.
26. Borek,C. et al. (1978) Malignant transformation in cultured hamster embryo cells produced by X-rays, 460-keV monoenergetic neutrons, and heavy ions. Cancer Res., 38, 2997-3005.
27. Hei,T.K. et al. (2001) Molecular alterations in tumorigenic human bronchial and breast epithelial cells induced by high LET radiation. Adv. Space Res., 27, 411-419.
28. Li,H. et al. (2007) Malignant transformation of human benign prostate epithelial cells by high linear energy transfer alpha-particles. Int. J. Oncol., 31, 537-544.
29. Yang,T.C. et al. (1997) Initiation of oncogenic transformation in human mammary epithelial cells by charged particles. Radiat. Oncol. Investig., 5, 134-138.
30. Zhao,Y. et al. (2004) Down-regulation of Betaig-h3 gene is involved in the tumorigenesis in human bronchial epithelial cells induced by heavy-ion radiation. Radiat. Res., 162, 655-659.
31. Alpen,E.L. et al. (1993) Tumorigenic potential of high-Z, high-LET charged-particle radiations. Radiat. Res., 136, 382-391.
32. Fry,R.J. et al. (1985) High-LET radiation carcinogenesis. Radiat. Res. Suppl., 8, S188-S95.
33. Pazzaglia,S. et al. (2006) Linking DNA damage to medulloblastoma tumorigenesis in patched heterozygous knockout mice. Oncogene, 25, 1165-1173.
34. Jen,J. et al. (1994) Deletion of p16 and p15 genes in brain tumors. Cancer Res., 54, 6353-6358.
35. Shete,S. et al. (2009) Genome-wide association study identifies five susceptibility loci for glioma. Nat. Genet., 41, 899-904.
36. Li,H. et al. (2009) The Ink4/Arf locus is a barrier for iPS cell reprogramming. Nature, 460, 1136-1139.