Alveolar nitric oxide concentration, small airways inflammation, and targeted asthma therapy: Are we there yet?

Journal of Allergy and Clinical Immunology

Volumn 126, Issue 4, 2010, Pages 736-737

  Kelly, H William ^a  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

Author keywords

air trapping; alveolar nitric oxide; Asthma; FeNO; inflammation; inhaled corticosteroids; small airways

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; BUDESONIDE; CORTICOSTEROID; MONTELUKAST; NITRIC OXIDE;

AIRWAY CONDUCTANCE; AIRWAY RESISTANCE; ASTHMA; CONCENTRATION (PARAMETERS); DRUG DELIVERY SYSTEM; EDITORIAL; HUMAN; INFLAMMATION; LUNG ALVEOLUS; LUNG FUNCTION TEST; PRIORITY JOURNAL; SMALL AIRWAY INFLAMMATION; SPIROMETRY;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; ANTI-ASTHMATIC AGENTS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BRONCHIOLES; HUMANS; INFLAMMATION; NITRIC OXIDE; PULMONARY ALVEOLI; TREATMENT OUTCOME;

EID: 77957757070     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2010.07.040     Document Type: Editorial

References (14)

1. L. Bjermer History and future perspectives of treating asthma as a systemic and small airways disease Respir Med 95 2001 703 719
2. E.W. Gelfand, and M. Kraft The importance and features of the distal airways in children and adults J Allergy Clin Immunol 124 2009 S84 S87
3. J.-M. Tunon-de-Lara, F. Laurent, V. Girard, T. Perez, B. Aguilaniu, and H. Meziane Air trapping in mild and moderate asthma: effect of inhaled corticosteroids J Allergy Clin Immunol 119 2007 583 590
4. A.F. Gelb, C.F. Taylor, C.M. Shinar, C.A. Gutierrez, and N. Zamel Effect of fluticasone 250 μg/salmeterol 50 μg and montelukast on exhaled nitric oxide in asthmatic patients Can Respir J 15 2008 193 198
5. M. Yamaguchi, A. Niimi, T. Ueda, M. Takemura, H. Matsuoka, and M. Jinnai Effect of inhaled corticosteroids on small airways in asthma: investigation using impulse oscillometry Pulm Pharmacol Ther 22 2009 326 332
6. L.G. Fritscher, M.T. Rodrigues, N. Zamel, and K.R. Chapman The effect of montelukast on exhaled nitric oxide of alveolar and bronchial origin in inhaled corticosteroid-treated asthma Respir Med 103 2009 296 300
7. C.M.H.H.T. Robroeks, K.D. van de Kant, D. van Vliet, A.D. Kester, H.J.E. Hendriks, and J.G.M.C. Damoiseaux Comparison of the anti-inflammatory effects of extra-fine hydrofluoroalkane-beclomethasone vs fluticasone dry powder inhaler on exhaled inflammatory markers in childhood asthma Ann Allergy Asthma Immunol 100 2008 601 607
8. A.F. Gelb, C.F. Taylor, E. Nussbaum, C. Guitierrez, A. Schein, and C.M. Shinar Alveolar and airway sites of nitric oxide inflammation in treated asthma Am J Respir Crit Care Med 170 2004 737 741
9. A. Van Muylem, Y. Kerckx, and A. Michils Acinar effect of inhaled steroids evidenced by exhaled nitric oxide J Allergy Clin Immunol 126 2010 730 735
10. N.M. Tsoukias, and S.C. George A two-compartment model of pulmonary nitric oxide exchange dynamics J Appl Physiol 85 1998 653 666
11. D.A. Shelly, J.L. Puckett, and S.C. George Quantifying proximal and distal sources of NO in asthma using a multicompartment model J Appl Physiol 108 2010 821 829
12. J.G. Goldin, D.P. Tashkin, E.C. Kleerup, L.E. Greaser, U.M. Haywood, and J.W. Sayre Comparative effects of hydrofluoroalkane and chlorofluorocarbon beclomethasone dipropionate inhalation on small airways: assessment with functional helical thin-section computed tomography J Allergy Clin Immunol 104 1999 S258 S267
13. D.K.C. Lee, K. Haggart, G.P. Currie, C.E. Bates, and B.J. Lipworth Effects of hydrofluoroalkane formulations of ciclesonide 400 μg once daily vs fluticasone 250 μg twice daily on methacholine hyper-responsiveness in mild-to-moderate persistent asthma Br J Clin Pharmacol 58 2004 26 33
14. M. Berry, B. Hargadon, A. Morgan, S.J. Richter, D. Shaw, and R.H. Green Alveolar nitric oxide in adults with asthma: evidence of distal lung inflammation in refractory asthma Eur Respir J 25 2005 986 991