Increased pretransplantation plasma kynurenine levels do not protect from but predict acute kidney allograft rejection

Human Immunology

Volumn 71, Issue 11, 2010, Pages 1067-1072

  Lahdou, Imad ^a   Sadeghi, Mahmoud ^a   Daniel, Volker ^a   Schenk, Martin ^b   Renner, Fabrice ^c   Weimer, Rolf ^c   Löb, Stefan ^b   Schmidt, Jan ^a   Mehrabi, Arianeb ^a   Schnitzler, Paul ^a   Königsrainer, Alfred ^b   Döhler, Bernd ^a   Opelz, Gerhard ^a   Terness, Peter ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^c JUSTUS LIEBIG UNIVERSITY   (Germany)

Author keywords

Early acute rejection; IDO; Kynurenine; Renal transplantation; Tryptophan

Indexed keywords

CYCLOSPORIN A; KYNURENINE; METHYLPREDNISOLONE; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; TACROLIMUS; TRYPTOPHAN;

ACUTE GRAFT REJECTION; ACUTE KIDNEY TUBULE NECROSIS; ADULT; AMINO ACID BLOOD LEVEL; ARTICLE; CONTROLLED STUDY; FEMALE; HEMODIALYSIS PATIENT; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY ALLOGRAFT REJECTION; KIDNEY BIOPSY; KIDNEY FAILURE; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL;

ACUTE DISEASE; ADULT; AGED; BIOPSY; FEMALE; GRAFT REJECTION; HUMANS; KIDNEY CORTEX NECROSIS; KIDNEY FAILURE, CHRONIC; KIDNEY TRANSPLANTATION; KYNURENINE; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; PROGNOSIS; TRANSPLANTATION, HOMOLOGOUS; TRYPTOPHAN;

EID: 77957754665     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humimm.2010.08.013     Document Type: Article

References (30)

1. Moffett J.R., Namboodiri M.A. Tryptophan and the immune response. Immunol Cell Biol 2003, 81:247-265.
2. Takikawa O. Biochemical and medical aspects of the indoleamine 2,3-dioxygenase-initiated L-tryptophan metabolism. Biochem Biophys Res Commun 2005, 338:12-19.
3. Yamazaki F., Kuroiwa T., Takikawa O., Kido R. Human indolylamine 2,3-dioxygenase. Its tissue distribution, and characterization of the placental enzyme. Biochem J 1985, 230:635-638.
4. Pfefferkorn E.R. Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan. Proc Natl Acad Sci U S A 1984, 81:908-912.
5. Nagineni C.N., Pardhasaradhi K., Martins M.C., Detrick B., Hooks J.J. Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells. Infect Immun 1996, 64:4188-4196.
6. Byrne G.I., Lehmann L.K., Landry G.J. Induction of tryptophan catabolism is the mechanism for gamma-interferon-mediated inhibition of intracellular Chlamydia psittaci replication in T24 cells. Infect Immun 1986, 53:347-351.
7. Hayashi T., Rao S.P., Takabayashi K., Van Uden J.H., Kornbluth R.S., Baird S.M., et al. Enhancement of innate immunity against Mycobacterium avium infection by immunostimulatory DNA is mediated by indoleamine 2,3-dioxygenase. Infect Immun 2001, 69:6156-6164.
8. Bodaghi B., Goureau O., Zipeto D., Laurent L., Virelizier J.L., Michelson S. Role of IFN-gamma-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells. J Immunol 1999, 162:957-964.
9. Heseler K., Spekker K., Schmidt S.K., MacKenzie C.R., Däubener W. Antimicrobial and immunoregulatory effects mediated by human lung cells: Role of IFN-gamma-induced tryptophan degradation. FEMS Immunol Med Microbiol 2008, 52:273-281.
10. Munn D.H., Zhou M., Attwood J.T., Bondarev I., Conway S.J., Marshall B., et al. Prevention of allogeneic fetal rejection by tryptophan catabolism. Science 1998, 281:1191-1193.
11. Terness P., Bauer T.M., Röse L., Dufter C., Watzlik A., Simon H., Opelz G. Inhibition of allogeneic T-cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: Mediation of suppression by tryptophan metabolites. J Exp Med 2002, 196:447-457.
12. Grohmann U., Orabona C., Fallarino F., Vacca C., Calcinaro F., Falorni A., et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 2002, 3:1097-1101.
13. Holmes E.W., Russell P.M., Kinzler G.J., Reckard C.R., Flanigan R.C., Thompson K.D., Bermes E.W. Oxidative tryptophan metabolism in renal allograft recipients: Increased kynurenine synthesis is associated with inflammation and OKT3 therapy. Cytokines 1992, 4:205-213.
14. Brandacher G., Cakar F., Winkler C., Schneeberger S., Obrist P., Bösmüller C., et al. Non-invasive monitoring of kidney allograft rejection through IDO metabolism evaluation. Kidney Int 2007, 71:60-67.
15. Bauer T.M., Jiga L.P., Chuang J.J., Randazzo M., Opelz G., Terness P. Studying the immunosuppressive role of indoleamine 2,3-dioxygenase: Tryptophan metabolites suppress rat allogeneic T-cell responses in vitro and in vivo. Transpl Int 2005, 18:95-100.
16. Yu G., Dai H., Chen J., Duan L., Gong M., Liu L., et al. Gene delivery of indoleamine 2,3-dioxygenase prolongs cardiac allograft survival by shaping the types of T-cell responses. J Gene Med 2008, 10:754-761.
17. Li J., Meinhardt A., Roehrich M.E., Golshayan D., Dudler J., Pagnotta M., et al. Indoleamine 2,3-dioxygenase gene transfer prolongs cardiac allograft survival. Am J Physiol Heart Circ Physiol 2007, 293:H3415-H3423.
18. Beutelspacher S.C., Pillai R., Watson M.P., Tan P.H., Tsang J., McClure M.O., et al. Function of indoleamine 2,3-dioxygenase in corneal allograft rejection and prolongation of allograft survival by over-expression. Eur J Immunol 2006, 36:690-700.
19. Saito K., Fujigaki S., Heyes M.P., Shibata K., Takemura M., Fujii H., et al. Mechanism of increases in L-kynurenine and quinolinic acid in renal insufficiency. Am J Physiol Ren Physiol 2000, 279:F565-F572.
20. Pawlak K., Domaniewski T., Mysliwiec M., Pawlak D. Kynurenines and oxidative status are independently associated with thrombomodulin and von Willebrand factor levels in patients with end-stage renal disease. Thromb Res 2009, 124:452-457.
21. Schmidt S.K., Müller A., Heseler K., Woite C., Spekker K., Mackenzie C.R., Däubener W. Antimicrobial and immunoregulatory properties of human tryptophan;2,3-dioxygenase. Eur J Immunol 2009, 39:2755-2764.
22. Holmes E.W., Russell P.M., Kinzler G.J., Bermes E.W. Inflammation-associated changes in the cellular availability of tryptophan and kynurenine in renal transplant recipients. Clin Chim Acta 1994, 227:1-15.
23. Sadeghi M., Daniel V., Weimer R., Wiesel M., Hergesell O., Opelz G. Pre-transplant Th1 and post-transplant Th2 cytokine patterns are associated with early acute rejection in renal transplant recipients. Clin Transpl 2003, 17:151-157.
24. Sun Q.H., Peng J.P., Xia H.F., Yang Y. IFN-gamma promotes apoptosis of the uterus and placenta in pregnant rat and human cytotrophoblast cells. J Interferon Cytokine Res 2007, 27:567-578.
25. Zhou Y., Weyman C.M., Liu H., Almasan A., Zhou A. IFN-gamma induces apoptosis in HL-60 cells through decreased Bcl-2 and increased Bak expression. J Interferon Cytokine Res 2008, 28:65-72.
26. Li W., Lewis-Antes A., Huang J., Balan M., Kotenko S.V. Regulation of apoptosis by type III interferons. Cell Prolif 2008, 41:960-979.
27. Fuchs D., Forsman A., Hagberg L., Larsson M., Norkrans G., Reibnegger G., et al. Immune activation and decreased tryptophan in patients with HIV-1 infection. J Interferon Res 1990, 10:599-603.
28. Baban B., Chandler P., McCool D., Marshall B., Munn D.H., Mellor A.L. Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific. J Reprod Immunol 2004, 61:67-77.
29. Laurence J.M., Wang C., Zheng M., Cunningham S., Earl J., Tay S.S., et al. Overexpression of indoleamine dioxygenase in rat liver allografts using a high-efficiency adeno-associated virus vector does not prevent acute rejection. Liver Transpl 2009, 15:233-241.
30. Serbecic N., Lahdou I., Scheuerle A., Höftberger R., Aboul-Enein F. Function of the tryptophan metabolite, L-kynurenine, in human corneal endothelial cells. Mol Vis 2009, 15:1312-1324.