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Volumn 403, Issue 3, 2010, Pages 386-404

Mechanism of Dephosphorylation of the SR Protein ASF/SF2 by Protein Phosphatase 1

Author keywords

Phosphorylation; Protein kinase; Protein phosphatase; Splicing; SR protein

Indexed keywords

ARGININE; CELL PROTEIN; PHOSPHOPROTEIN PHOSPHATASE 1; PROTEIN ASF; PROTEIN CLK; PROTEIN KINASE; PROTEIN SR; PROTEIN SRPK1; SERINE; UNCLASSIFIED DRUG; CLK DUAL-SPECIFICITY KINASES; HYBRID PROTEIN; NUCLEAR PROTEIN; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; RNA; RNA BINDING PROTEIN; SERINE-ARGININE-RICH SPLICING PROTEINS; SRPK1 PROTEIN, HUMAN;

EID: 77957754590     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2010.08.024     Document Type: Article
Times cited : (30)

References (34)
  • 1
    • 0042671357 scopus 로고    scopus 로고
    • Pre-mRNA splicing: awash in a sea of proteins
    • Jurica M.S., Moore M.J. Pre-mRNA splicing: awash in a sea of proteins. Mol. Cell 2003, 12:5-14.
    • (2003) Mol. Cell , vol.12 , pp. 5-14
    • Jurica, M.S.1    Moore, M.J.2
  • 3
    • 0027137934 scopus 로고
    • Specific interactions between proteins implicated in splice site selection and regulated alternative splicing
    • Wu J.Y., Maniatis T. Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. Cell 1993, 75:1061-1070.
    • (1993) Cell , vol.75 , pp. 1061-1070
    • Wu, J.Y.1    Maniatis, T.2
  • 4
    • 0029377886 scopus 로고
    • SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome
    • Roscigno R.F., Garcia-Blanco M.A. SR proteins escort the U4/U6.U5 tri-snRNP to the spliceosome. RNA 1995, 1:692-706.
    • (1995) RNA , vol.1 , pp. 692-706
    • Roscigno, R.F.1    Garcia-Blanco, M.A.2
  • 5
    • 0032873673 scopus 로고    scopus 로고
    • Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing
    • Chew S.L., Liu H.X., Mayeda A., Krainer A.R. Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing. Proc. Natl Acad. Sci. USA 1999, 96:10655-10660.
    • (1999) Proc. Natl Acad. Sci. USA , vol.96 , pp. 10655-10660
    • Chew, S.L.1    Liu, H.X.2    Mayeda, A.3    Krainer, A.R.4
  • 6
    • 0032737702 scopus 로고    scopus 로고
    • SR protein kinases: the splice of life
    • Stojdl D.F., Bell J.C. SR protein kinases: the splice of life. Biochem. Cell Biol. 1999, 77:293-298.
    • (1999) Biochem. Cell Biol. , vol.77 , pp. 293-298
    • Stojdl, D.F.1    Bell, J.C.2
  • 7
    • 0034161419 scopus 로고    scopus 로고
    • Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases
    • Blencowe B.J. Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases. Trends Biochem. Sci. 2000, 25:106-110.
    • (2000) Trends Biochem. Sci. , vol.25 , pp. 106-110
    • Blencowe, B.J.1
  • 8
    • 25844491145 scopus 로고    scopus 로고
    • Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2
    • Ngo J.C., Chakrabarti S., Ding J.H., Velazquez-Dones A., Nolen B., Aubol B.E., et al. Interplay between SRPK and Clk/Sty kinases in phosphorylation of the splicing factor ASF/SF2 is regulated by a docking motif in ASF/SF2. Mol. Cell 2005, 20:77-89.
    • (2005) Mol. Cell , vol.20 , pp. 77-89
    • Ngo, J.C.1    Chakrabarti, S.2    Ding, J.H.3    Velazquez-Dones, A.4    Nolen, B.5    Aubol, B.E.6
  • 9
    • 0033574564 scopus 로고    scopus 로고
    • The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs)
    • Koizumi J., Okamoto Y., Onogi H., Mayeda A., Krainer A.R., Hagiwara M. The subcellular localization of SF2/ASF is regulated by direct interaction with SR protein kinases (SRPKs). J. Biol. Chem. 1999, 274:11125-11131.
    • (1999) J. Biol. Chem. , vol.274 , pp. 11125-11131
    • Koizumi, J.1    Okamoto, Y.2    Onogi, H.3    Mayeda, A.4    Krainer, A.R.5    Hagiwara, M.6
  • 10
    • 0032827418 scopus 로고    scopus 로고
    • The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing
    • Prasad J., Colwill K., Pawson T., Manley J.L. The protein kinase Clk/Sty directly modulates SR protein activity: both hyper- and hypophosphorylation inhibit splicing. Mol. Cell. Biol. 1999, 19:6991-7000.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6991-7000
    • Prasad, J.1    Colwill, K.2    Pawson, T.3    Manley, J.L.4
  • 11
    • 33746339533 scopus 로고    scopus 로고
    • Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growth
    • Patwardhan P., Shen Y., Goldberg G.S., Miller W.T. Individual Cas phosphorylation sites are dispensable for processive phosphorylation by Src and anchorage-independent cell growth. J. Biol. Chem. 2006, 281:20689-20697.
    • (2006) J. Biol. Chem. , vol.281 , pp. 20689-20697
    • Patwardhan, P.1    Shen, Y.2    Goldberg, G.S.3    Miller, W.T.4
  • 12
    • 0035830965 scopus 로고    scopus 로고
    • Multi-site phosphorylation of Pho4 by the cyclin-CDK Pho80-Pho85 is semi-processive with site preference
    • Jeffery D.A., Springer M., King D.S., O'Shea E.K. Multi-site phosphorylation of Pho4 by the cyclin-CDK Pho80-Pho85 is semi-processive with site preference. J. Mol. Biol. 2001, 306:997-1010.
    • (2001) J. Mol. Biol. , vol.306 , pp. 997-1010
    • Jeffery, D.A.1    Springer, M.2    King, D.S.3    O'Shea, E.K.4
  • 13
    • 0030746219 scopus 로고    scopus 로고
    • Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase
    • Ferrell J.E., Bhatt R.R. Mechanistic studies of the dual phosphorylation of mitogen-activated protein kinase. J. Biol. Chem. 1997, 272:19008-19016.
    • (1997) J. Biol. Chem. , vol.272 , pp. 19008-19016
    • Ferrell, J.E.1    Bhatt, R.R.2
  • 14
    • 0027075932 scopus 로고
    • Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping
    • Robbins D.J., Cobb M.H. Extracellular signal-regulated kinases 2 autophosphorylates on a subset of peptides phosphorylated in intact cells in response to insulin and nerve growth factor: analysis by peptide mapping. Mol. Biol. Cell 1992, 3:299-308.
    • (1992) Mol. Biol. Cell , vol.3 , pp. 299-308
    • Robbins, D.J.1    Cobb, M.H.2
  • 16
    • 0035943595 scopus 로고    scopus 로고
    • The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3
    • Zhao Y., Zhang Z.Y. The mechanism of dephosphorylation of extracellular signal-regulated kinase 2 by mitogen-activated protein kinase phosphatase 3. J. Biol. Chem. 2001, 276:32382-32391.
    • (2001) J. Biol. Chem. , vol.276 , pp. 32382-32391
    • Zhao, Y.1    Zhang, Z.Y.2
  • 19
    • 29244449634 scopus 로고    scopus 로고
    • Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty
    • Velazquez-Dones A., Hagopian J.C., Ma C.T., Zhong X.Y., Zhou H., Ghosh G., et al. Mass spectrometric and kinetic analysis of ASF/SF2 phosphorylation by SRPK1 and Clk/Sty. J. Biol. Chem. 2005, 280:41761-41768.
    • (2005) J. Biol. Chem. , vol.280 , pp. 41761-41768
    • Velazquez-Dones, A.1    Hagopian, J.C.2    Ma, C.T.3    Zhong, X.Y.4    Zhou, H.5    Ghosh, G.6
  • 20
    • 51249104656 scopus 로고    scopus 로고
    • Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1
    • Hagopian J.C., Ma C.T., Meade B.R., Albuquerque C.P., Ngo J.C., Ghosh G., et al. Adaptable molecular interactions guide phosphorylation of the SR protein ASF/SF2 by SRPK1. J. Mol. Biol. 2008, 382:894-909.
    • (2008) J. Mol. Biol. , vol.382 , pp. 894-909
    • Hagopian, J.C.1    Ma, C.T.2    Meade, B.R.3    Albuquerque, C.P.4    Ngo, J.C.5    Ghosh, G.6
  • 21
    • 67649306195 scopus 로고    scopus 로고
    • Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1
    • Ma C.T., Hagopian J.C., Ghosh G., Fu X.D., Adams J.A. Regiospecific phosphorylation control of the SR protein ASF/SF2 by SRPK1. J. Mol. Biol. 2009, 390:618-634.
    • (2009) J. Mol. Biol. , vol.390 , pp. 618-634
    • Ma, C.T.1    Hagopian, J.C.2    Ghosh, G.3    Fu, X.D.4    Adams, J.A.5
  • 22
    • 40649092847 scopus 로고    scopus 로고
    • A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1
    • Ngo J.C., Giang K., Chakrabarti S., Ma C.T., Huynh N., Hagopian J.C., et al. A sliding docking interaction is essential for sequential and processive phosphorylation of an SR protein by SRPK1. Mol. Cell 2008, 29:563-576.
    • (2008) Mol. Cell , vol.29 , pp. 563-576
    • Ngo, J.C.1    Giang, K.2    Chakrabarti, S.3    Ma, C.T.4    Huynh, N.5    Hagopian, J.C.6
  • 23
    • 37549002103 scopus 로고    scopus 로고
    • Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing
    • Novoyatleva T., Heinrich B., Tang Y., Benderska N., Butchbach M.E., Lorson C.L., et al. Protein phosphatase 1 binds to the RNA recognition motif of several splicing factors and regulates alternative pre-mRNA processing. Hum. Mol. Genet. 2008, 17:52-70.
    • (2008) Hum. Mol. Genet. , vol.17 , pp. 52-70
    • Novoyatleva, T.1    Heinrich, B.2    Tang, Y.3    Benderska, N.4    Butchbach, M.E.5    Lorson, C.L.6
  • 24
    • 29144447982 scopus 로고    scopus 로고
    • Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene
    • Ghigna C., Giordano S., Shen H., Benvenuto F., Castiglioni F., Comoglio P.M., et al. Cell motility is controlled by SF2/ASF through alternative splicing of the Ron protooncogene. Mol. Cell 2005, 20:881-890.
    • (2005) Mol. Cell , vol.20 , pp. 881-890
    • Ghigna, C.1    Giordano, S.2    Shen, H.3    Benvenuto, F.4    Castiglioni, F.5    Comoglio, P.M.6
  • 25
    • 73149115306 scopus 로고    scopus 로고
    • Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1
    • Huynh N., Ma C.T., Giang N., Hagopian J., Ngo J., Adams J., Ghosh G. Allosteric interactions direct binding and phosphorylation of ASF/SF2 by SRPK1. Biochemistry 2009, 48:11432-11440.
    • (2009) Biochemistry , vol.48 , pp. 11432-11440
    • Huynh, N.1    Ma, C.T.2    Giang, N.3    Hagopian, J.4    Ngo, J.5    Adams, J.6    Ghosh, G.7
  • 26
    • 0029583122 scopus 로고
    • Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate
    • Egloff M.P., Cohen P.T., Reinemer P., Barford D. Crystal structure of the catalytic subunit of human protein phosphatase 1 and its complex with tungstate. J. Mol. Biol. 1995, 254:942-959.
    • (1995) J. Mol. Biol. , vol.254 , pp. 942-959
    • Egloff, M.P.1    Cohen, P.T.2    Reinemer, P.3    Barford, D.4
  • 27
    • 0032526770 scopus 로고    scopus 로고
    • The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing
    • Duncan P.I., Stojdl D.F., Marius R.M., Scheit K.H., Bell J.C. The Clk2 and Clk3 dual-specificity protein kinases regulate the intranuclear distribution of SR proteins and influence pre-mRNA splicing. Exp. Cell Res. 1998, 241:300-308.
    • (1998) Exp. Cell Res. , vol.241 , pp. 300-308
    • Duncan, P.I.1    Stojdl, D.F.2    Marius, R.M.3    Scheit, K.H.4    Bell, J.C.5
  • 29
    • 0030028882 scopus 로고    scopus 로고
    • The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution
    • Colwill K., Pawson T., Andrews B., Prasad J., Manley J.L., Bell J.C., Duncan P.I. The Clk/Sty protein kinase phosphorylates SR splicing factors and regulates their intranuclear distribution. EMBO J. 1996, 15:265-275.
    • (1996) EMBO J. , vol.15 , pp. 265-275
    • Colwill, K.1    Pawson, T.2    Andrews, B.3    Prasad, J.4    Manley, J.L.5    Bell, J.C.6    Duncan, P.I.7
  • 30
    • 0344654761 scopus 로고    scopus 로고
    • Phosphorylation regulates in vivo interaction and molecular targeting of serine/arginine-rich pre-mRNA splicing factors
    • Yeakley J.M., Tronchere H., Olesen J., Dyck J.A., Wang H.Y., Fu X.D. Phosphorylation regulates in vivo interaction and molecular targeting of serine/arginine-rich pre-mRNA splicing factors. J. Cell Biol. 1999, 145:447-455.
    • (1999) J. Cell Biol. , vol.145 , pp. 447-455
    • Yeakley, J.M.1    Tronchere, H.2    Olesen, J.3    Dyck, J.A.4    Wang, H.Y.5    Fu, X.D.6
  • 31
    • 0026731973 scopus 로고
    • Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing
    • Mermoud J.E., Cohen P., Lamond A.I. Ser/Thr-specific protein phosphatases are required for both catalytic steps of pre-mRNA splicing. Nucleic Acids Res. 1992, 20:5263-5269.
    • (1992) Nucleic Acids Res. , vol.20 , pp. 5263-5269
    • Mermoud, J.E.1    Cohen, P.2    Lamond, A.I.3
  • 32
    • 0028043718 scopus 로고
    • Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism
    • Mermoud J.E., Cohen P.T., Lamond A.I. Regulation of mammalian spliceosome assembly by a protein phosphorylation mechanism. EMBO J. 1994, 13:5679-5688.
    • (1994) EMBO J. , vol.13 , pp. 5679-5688
    • Mermoud, J.E.1    Cohen, P.T.2    Lamond, A.I.3
  • 33
    • 35348998391 scopus 로고    scopus 로고
    • Structural basis for regulation of protein phosphatase 1 by inhibitor-2
    • Hurley T.D., Yang J., Zhang L., Goodwin K.D., Zou Q., Cortese M., et al. Structural basis for regulation of protein phosphatase 1 by inhibitor-2. J. Biol. Chem. 2007, 282:28874-28883.
    • (2007) J. Biol. Chem. , vol.282 , pp. 28874-28883
    • Hurley, T.D.1    Yang, J.2    Zhang, L.3    Goodwin, K.D.4    Zou, Q.5    Cortese, M.6


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