Splenectomy changes the pattern of cytokine production in β-thalassemic patients

Cytokine

Volumn 35, Issue 5-6, 2006, Pages 253-257

  Moshtaghi Kashanian, Ghollam Reza ^a   Gholamhoseinian, Ahmad ^a   Hoseinimoghadam, Afrooz ^a   Rajabalian, Saeeid ^a  

^a KERMAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

thalassemic; IL 10; IL 2; Splenectomized; TGF 1

Indexed keywords

CYTOKINE; HEPARIN; INTERLEUKIN 10; INTERLEUKIN 2; LIPOPOLYSACCHARIDE; PHYTOHEMAGGLUTININ; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; BETA THALASSEMIA; BLOOD CELL; BLOOD SAMPLING; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOKINE PRODUCTION; EVALUATION; FEMALE; HEPARINIZATION; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNOSTIMULATION; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE SUBPOPULATION; MALE; PLASMA; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; SCHOOL CHILD; SPLENECTOMY; STATISTICAL SIGNIFICANCE; SURGICAL PATIENT; TIME; TRANSFUSION;

BETA-THALASSEMIA; CELLS, CULTURED; CHILD; CYTOKINES; FEMALE; HUMANS; LIPOPOLYSACCHARIDES; LYMPHOCYTES; MALE; PHYTOHEMAGGLUTININS; SPLENECTOMY;

EID: 37849185984     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2006.09.003     Document Type: Article

References (19)

1. Farmakis D., Giakoumis A., Polymeropoulos E., and Aessopos A. Pathogenetic aspects of immune deficiency associated with beta-thalassemia. Med Sci Monit 9 (2003) RA19-RA22
2. Ezer U., Gulderen F., Culha V.K., Akgul N., and Gurbuz O. Immunological status of thalassemia syndrome. Pediatr Hematol Oncol 19 (2002) 51-58
3. Pattanapanyasat K., Thepthai C., Lamchiagdhase P., Tachavanich S., Thanomsuk K., et al. Lymphocyte subsets and specific T-cell immune response in thalassemia. Cytometry 42 (2000) 11-17
4. Gordeuk V.R., Delanghe J.R., Langlois M.R., and Boelaert J.R. Iron status and the outcome of HIV infection: an overview. J Clin Virol 20 (2001) 111-115
5. Archararit N., Chuncharunee S., Pornvoranunt A., Atamasirikul K., Rachakom B., and Atichartakarn V. Serum C-reactive protein level in postsplenectomized thalassemic patients. J Med Assoc Thai 83 Suppl 1 (2000) S63-S69
6. Butthep P., Rummavas S., Wisedpanichkij R., Jindadamrongwech S., Fucharoen S., and Bunyaratvej A. Increased circulating activated endothelial cells, vascular endothelial growth factor, and tumor necrosis factor in thalassemia. Am J Hematol 70 (2002) 100-106
7. Salsaa B., and Zoumbos N.C. A distinct pattern of cytokine production from blood mononuclear cells in multitransfused patients with beta-thalassaemia. Clin Exp Immunol 107 (1997) 589-592
8. Wanachiwanawin W., Wiener E., Siripanyaphinyo U., Chinprasertsuk S., Mawas F., Fucharoen S., et al. Serum levels of tumor necrosis factor-alpha, interleukin-1, and interferon-gamma in beta(o)-thalassemia/HbE and their clinical significance. J Interferon Cytokine Res 19 (1999) 105-111
9. Lombardi G., Matera R., Minervini M.M., Cascavilla N., D'Arcangelo P., Carotenuto M., et al. Serum levels of cytokines and soluble antigens in polytransfused patients with beta-thalassemia major: relationship to immune status. Haematologica 79 (1994) 406-412
10. Aggeli C., Antoniades C., Cosma C., Chrysohoou C., Tousoulis D., Ladis V., et al. Endothelial dysfunction and inflammatory process in transfusion-dependent patients with beta-thalassemia major. Int J Cardiol 105 (2005) 80-84
11. Giron-Gonzalez J.A., Moral F.J., Elvira J., Garcia-Gil D., Guerrero F., Gavilan I., et al. Consistent production of a higher TH1:TH2 cytokine ratio by stimulated T cells in men compared with women. Eur J Endocrinol 143 (2000) 31-36
12. Cohen A.R., Galanello R., Pennell D.J., Cunningham M.J., and Vichinsky E. Thalassemia. Hematology (Am Soc Hematol Educ Program) (2004) 14-34
13. Del Vecchio G.C., Schettini F., Piacente L., De Santis A., Giordano P., and De Mattia D. Effects of deferiprone on immune status and cytokine pattern in thalassaemia major. Acta Haematol 108 (2002) 144-149
14. Sritippayawan S., Lekhanont P., Harnruthakorn C., Samransamruajkit R., Deerojanawong J., Seksarn P., et al. Restrictive lung disease and serum TGF-beta1 in thalassemia major children. Asian Pac J Allergy Immunol 23 (2005) 121-126
15. Nelson B.H. IL-2, regulatory T cells, and tolerance. J Immunol 172 (2004) 3983-3988
16. Trinchieri G. Regulatory role of T cells producing both interferon-gamma and interleukin 10 in persistent infection. J Exp Med 194 (2001) F53-F57
17. Miyazono K. Positive and negative regulation of TGF-beta signaling. J Cell Sci 113 Pt 7 (2000) 1101-1109
18. Liew F.Y., and McInnes I.B. Role of interleukin 15 and interleukin 18 in inflammatory response. Ann Rheum Dis 61 Suppl 2 (2002) ii100-ii102
19. Caligiuri G., Kaveri S., and Nicoletti A. When interleukin-18 conducts, the Preludio sounds the same no matter who plays. Arterioscler Thromb Vasc Biol 25 (2005) 655-657