Caspase 8 and menin expressions are not correlated in human parathyroid tumors

Endocrine Journal

Volumn 57, Issue 9, 2010, Pages 825-832

  Yu, Dong ^a   Nagamura, Yuko ^a   Shimazu, Satoko ^a   Naito, Junko ^b   Kaji, Hiroshi ^b   Wada, Seiki ^c   Honda, Munehiro ^d   Xue, Lian ^e   Tsukada, Toshihiko ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b KOBE UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Institute of Endocrine and Metabolic Disorders   (Japan)

^d Mishuku Hospital   (Japan)

^e MEDICAL COLLEGE OF SOOCHOW UNIVERSITY   (China)

Author keywords

Caspase 8; MEN1; Menin; siRNA

Indexed keywords

CASPASE 8; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN DEPENDENT KINASE INHIBITOR 2B; METHIONINE; MULTIPLE ENDOCRINE NEOPLASIA 1 PROTEIN; SMALL INTERFERING RNA; TUMOR PROTEIN; UNCLASSIFIED DRUG;

CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA DETERMINATION; DOWN REGULATION; GENE EXPRESSION REGULATION; GENE MUTATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; MULTIPLE ENDOCRINE NEOPLASIA; NOTE; PARATHYROID TUMOR; PRIMARY HYPERPARATHYROIDISM; WESTERN BLOTTING;

CASPASE 8; CYCLIN-DEPENDENT KINASE INHIBITOR P15; CYCLIN-DEPENDENT KINASE INHIBITOR P27; HEK293 CELLS; HUMANS; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; PARATHYROID NEOPLASMS; PROTO-ONCOGENE PROTEINS;

EID: 77957737536     PISSN: 09188959     EISSN: 13484540     Source Type: Journal    
DOI: 10.1507/endocrj.K10E-085     Document Type: Note

References (21)

1. Chandrasekharappa SC, Guru SC, Manickam P, Olufemi SE, Collins FS, Emmert-Buck MR, Debelenko LV, Zhuang Z, Lubensky IA, Liotta LA, Crabtree JS, Wang Y, Roe BA, Weisemann J, Boguski MS, Agarwal SK, Kester MB, Kim YS, Heppner C, Dong Q, Spiegel AM, Burns AL, Marx SJ (1997) Positional cloning of the gene for multiple endocrine neoplasia-type 1. Science 276: 404-407.
2. Tsukada T, Nagamura Y, Ohkura N (2009) MEN1 gene and its mutations: Basic and clinical implications. Cancer Sci 100: 209-215.
3. Heppner C, Kester MB, Agarwal SK, Debelenko LV, Emmert-Buck MR, Guru SC, Manickam P, Olufemi SE, Skarulis MC, Doppman JL, Alexander RH, Kim YS, Saggar SK, Lubensky IA, Zhuang Z, Liotta LA, Chandrasekharappa SC, Collins FS, Spiegel AM, Burns AL, Marx SJ (1997) Somatic mutation of the MEN1 gene in parathyroid tumours. Nat Genet 16: 375-378.
4. Guru SC, Goldsmith PK, Burns AL, Marx SJ, Spiegel AM, Collins FS, Chandrasekharappa SC (1998) Menin, the product of the MEN1 gene, is a nuclear protein. Proc Natl Acad Sci USA 95: 1630-1634.
5. Maruyama K, Tsukada T, Hosono T, Ohkura N, Kishi M, Honda M, Nara-Ashizawa N, Nagasaki K, Yamaguchi K (1999) Structure and distribution of rat menin mRNA. Mol Cell Endocrinol 156: 25-33.
6. Milne TA, Hughes CM, Lloyd R, Yang Z, Rozenblatt-Rosen O, Dou Y, Schnepp RW, Krankel C, Livolsi VA, Gibbs D, Hua X, Roeder RG, Meyerson M, Hess JL (2005) Menin and MLL cooperatively regulate expression of cyclin-dependent kinase inhibitors. Proc Natl Acad Sci USA 102: 749-754.
7. Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans. Proc Natl Acad Sci USA 103: 15558-15563.
8. Agarwal SK, Mateo CM, Marx SJ (2009) Rare germline mutations in cyclin-dependent kinase inhibitor genes in multiple endocrine neoplasia type 1 and related states. J Clin Endocrinol Metab 94: 1826-1834.
9. Schnepp RW, Mao H, Sykes SM, Zong WX, Silva A, La P, Hua X (2004) Menin induces apoptosis in murine embryonic fibroblasts. J Biol Chem 279: 10685-10691.
10. La P, Yang Y, Karnik SK, Silva AC, Schnepp RW, Kim SK, Hua X (2007) Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1. J Biol Chem 282: 31332-31340.
11. Fulda S (2009) Caspase-8 in cancer biology and therapy. Cancer Lett. 281: 128-133.
12. Xue L, Yu D, Furusawa Y, Cao J, Okayasu R, Fan S (2009) ATM-dependent hyper-radiosensitivity in mammalian cells irradiated by heavy ions. Int J Radiat Oncol Biol Phys 75: 235-243.
13. Xue L, Yu D, Furusawa Y, Okayasu R, Tong J, Cao J, Fan S (2009) Regulation of ATM in DNA double strand break repair accounts for the radiosensitivity in human cells exposed to high linear energy transfer ionizing radiation. Mutat Res 670: 15-23.
14. Shimizu S, Tsukada T, Futami H, Ui K, Kameya T, Kawanaka M, Uchiyama S, Aoki A, Yasuda H, Kawano S, Ito Y, Kanbe M, Obara T, Yamaguchi K (1997) Germline mutations of the MEN1 gene in Japanese kindred with multiple endocrine neoplasia type 1. Jpn J Cancer Res 88: 1029-1032.
15. Kishi M, Tsukada T, Shimizu S, Futami H, Ito Y, Kanbe M, Obara T, Yamaguchi K (1998) A large germline deletion of the MEN1 gene in a family with multiple endocrine neoplasia type 1. Jpn J Cancer Res 89: 1-5.
16. Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm FG, Look AT, Lahti JM, Kidd VJ (2000) Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med 6: 529-535.
17. INK4c. Proc Natl Acad Sci USA 102: 14659-14664.
18. Lindberg D, Akerström G, Westin G (2008) Evaluation of CDKN2C/p18, CDKN1B/p27 and CDKN2B/p15 mRNA expression, and CpG methylation status in sporadic and MEN1-associated pancreatic endocrine tumours. Clin Endocrinol 68: 271-277.
19. den Dunnen JT, Antonarakis SE (2000) Mutation nomenclature extensions and suggestions to describe complex mutations: a discussion. Hum Mutat 15: 7-12.
20. Wada S, Watanabe M, Tsukada T, Yasuda S, Yamaguchi K, Kitahama S, Iitaka M, Katayama S (2001) A germline mutation, 1001delC, of the multiple endocrine neoplasia type 1 (MEN 1) gene in a Japanese family. Intern Med 40: 499-505.
21. Naito J, Kaji H, Sowa H, Kitazawa R, Kitazawa S, Tsukada T, Hendy GN, Sugimoto T, Chihara K (2006) Expression and functional analysis of menin in a multiple endocrine neoplasia type 1 (MEN1) patient with somatic loss of heterozygosity in chromosome 11q13 and unidentified germline mutation of the MEN1 gene. Endocrine 29: 485-490.