Trypanosoma cruzi-induced activation of functionally distinct αβ and γδ CD4- CD8- T cells in individuals with polar forms of Chagas' disease

Infection and Immunity

Volumn 78, Issue 10, 2010, Pages 4421-4430

  Amaral Villani, Fernanda Nobre ^a   Da Costa Rocha, Manoel Otávio ^a   Pereira Nunes, Maria Do Carmo ^a   Do Valle Antonelli, Lis Ribeiro ^b   Dias Magalhães, Luisa Mourão ^a   Coelho Dos Santos, Janete Soares ^a   Gollob, Kenneth J ^c,d,e   Dutra, Walderez O ^a,e  

^a FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^b INSTITUTO OSWALDO CRUZ   (Brazil)

^c SRI INTERNATIONAL   (United States)

^d Santa Casa Hospital   (Brazil)

^e Santa Casa Hospital ^*  (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10;

ADULT; AGED; ARTICLE; CD4 CD8 RATIO; CELL FUNCTION; CHAGAS DISEASE; CLINICAL ARTICLE; CYTOKINE PRODUCTION; FEMALE; HEART FUNCTION; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRYPANOSOMA CRUZI;

ADULT; AGED; CHAGAS DISEASE; CROSS-SECTIONAL STUDIES; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTERLEUKIN-10; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; TRYPANOSOMA CRUZI; YOUNG ADULT;

EID: 77957734477     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00179-10     Document Type: Article

References (53)

1. + T cells in chronic Chagas' disease patients. Int. Immunol. 18:465-471.
2. + T cells to immune senescence. J. Immunol. 183:4103-4108.
3. Antonelli, L. R., W. O. Dutra, R. P. Almeida, O. Bacellar, E. M. Carvalho, and K. J. Gollob. 2005. Activated inflammatory T cells correlate with lesion size in human cutaneous leishmaniasis. Immunol. Lett. 101:226-230.
4. -) αβ and γδ T cells from human patients with cutaneous leishmaniasis. Infect. Immun. 74:6317-6323.
5. HIGH regulatory T cells in morbidity in Chagas disease. Front Biosci. 12:2797-2806.
6. Aufderheide, A. C., W. Salo, M. Madden, J. Streitz, J. Buikstra, F. Guhl, B. Arriaza, C. Renier, L. E. Wittmers, Jr., G. Fornaciari, and M. Allison. 2004. A 9,000-year record of Chagas' disease. Proc. Natl. Acad. Sci. U. S. A. 101:2034-2039.
7. Bacellar, O., H. Lessa, A. Schriefer, P. Machado, A. Ribeiro de Jesus, W. O. Dutra, K. J. Gollob, and E. M. Carvalho. 2002. Up-regulation of Th1-type responses in mucosal leishmaniasis patients. Infect. Immun. 70:6734-6740.
8. - T cells in humans with the autoimmune lymphoproliferative syndrome express a novel CD45 isoform that is analogous to murine B220 and represents a marker of altered O-glycan biosynthesis. Clin. Immunol. 100:314-324.
9. Bottrel, R. L., W. O. Dutra, F. A. Martins, B. Gontijo, E. Carvalho, M. Barral-Netto, A. Barral, R. P. Almeida, W. Mayrink, R. Locksley, and K. J. Gollob. 2001. Flow cytometric determination of cellular sources and frequencies of key cytokine-producing lymphocytes directed against recombinant LACK and soluble Leishmania antigen in human cutaneous leishmaniasis. Infect. Immun. 69:3232-3239.
10. β-gene families, and phenotypically resemble memory T cells. Proc. Natl. Acad. Sci. U. S. A. 90:11787-11791.
11. Buscaglia, C. A., and J. M. Di Noia. 2003. Trypanosoma cruzi clonal diversity and the epidemiology of Chagas' disease. Microbes Infect. 5:419-427.
12. Costa, G. C., M. O. da Costa Rocha, P. R. Moreira, C. A. Menezes, M. R. Silva, K. J. Gollob, and W. O. Dutra. 2009. Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy. J. Infect. Dis. 199:451-454.
13. Cunha-Neto, E., V. J. Dzau, P. D. Allen, D. Stamatiou, L. Benvenutti, M. L. Higuchi, N. S. Koyama, J. S. Silva, J. Kalil, and C. C. Liew. 2005. Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy. Am. J. Pathol. 167:305-313.
14. Duthie, M. S., M. Kahn, M. White, R. P. Kapur, and S. J. Kahn. 2005. Both CD1d antigen presentation and interleukin-12 are required to activate natural killer T cells during Trypanosoma cruzi infection. Infect. Immun. 73:1890-1894.
15. Duthie, M. S., M. Kahn, M. White, R. P. Kapur, and S. J. Kahn. 2005. Critical proinflammatory and anti-inflammatory functions of different subsets of CD1d-restricted natural killer T cells during Trypanosoma cruzi infection. Infect. Immun. 73:181-192.
16. Dutra, W. O., Z. M. da Luz, J. R. Cancado, M. E. Pereira, R. M. Brigido-Nunes, L. M. Galvao, D. G. Colley, Z. Brener, G. Gazzinelli, and J. F. Carvalho-Parra. 1996. Influence of parasite presence on the immunologic profile of peripheral blood mononuclear cells from chagasic patients after specific drug therapy. Parasite Immunol. 18:579-585.
17. Dutra, W. O., and K. J. Gollob. 2008. Current concepts in immunoregulation and pathology of human Chagas disease. Curr. Opin. Infect. Dis. 21:287-292.
18. Dutra, W. O., O. A. Martins-Filho, J. R. Cancado, J. C. Pinto-Dias, Z. Brener, G. L. Freeman Junior, D. G. Colley, G. Gazzinelli, and J. C. Parra. 1994. Activated T and B lymphocytes in peripheral blood of patients with Chagas' disease. Int. Immunol. 6:499-506.
19. Dutra, W. O., O. A. Martins-Filho, J. R. Cancado, J. C. Pinto-Dias, Z. Brener, G. Gazzinelli, J. F. Carvalho, and D. G. Colley. 1996. Chagasic patients lack CD28 expression on many of their circulating T lymphocytes. Scand. J. Immunol. 43:88-93.
20. Dutra, W. O., C. A. Menezes, F. N. Villani, G. C. da Costa, A. B. da Silveira, D. Reis, and K. J. Gollob. 2009. Cellular and genetic mechanisms involved in the generation of protective and pathogenic immune responses in human Chagas disease. Mem. Inst. Oswaldo Cruz 104(Suppl 1):208-218.
21. Dutra, W. O., M. O. Rocha, and M. M. Teixeira. 2005. The clinical immunology of human Chagas disease. Trends Parasitol. 21:581-587.
22. Faria, D. R., K. J. Gollob, J. Barbosa, Jr., A. Schriefer, P. R. Machado, H. Lessa, L. P. Carvalho, M. A. Romano-Silva, A. R. de Jesus, E. M. Carvalho, and W. O. Dutra. 2005. Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis. Infect. Immun. 73:7853-7859.
23. Fiuza, J. A., R. T. Fujiwara, J. A. Gomes, M. O. Rocha, A. T. Chaves, F. F. de Araujo, R. C. Fares, A. Teixeira-Carvalho, A. Martins-Filho Ode, G. G. Cancado, and R. Correa-Oliveira. 2009. Profile of central and effector memory T cells in the progression of chronic human Chagas disease. PLoS Negl. Trop. Dis. 3:e512.
24. + T cells at heart lesions of human chronic Chagas disease cardiomyopathy. Scand. J. Immunol. 66:362-371.
25. - (double negative) T cell subpopulations in human cutaneous leishmaniasis: a balancing act between protection and pathology. Int. Immunopharmacol. 8:1338-1343.
26. Reference deleted.
27. -) alpha beta T-cell receptor positive cells from an immunodeficient patient. Scand. J. Immunol. 34:635-645.
28. Leiby, D. A., R. M. Herron, Jr., E. J. Read, B. A. Lenes, and R. J. Stumpf. 2002. Trypanosoma cruzi in Los Angeles and Miami blood donors: impact of evolving donor demographics on seroprevalence and implications for transfusion transmission. Transfusion 42:549-555.
29. Macedo, A. M., and S. D. J. Pena. 1998. Genetic variability of Trypanosoma cruzi: implications for the pathogenesis of Chagas disease. Parasitol. Today 14:119-124.
30. + T cells are reliable markers of autoimmune lymphoproliferative syndrome (ALPS) associated with FAS loss of function. Blood 113:3027-3030.
31. Medeiros, M. M., J. R. Peixoto, A. C. Oliveira, L. Cardilo-Reis, V. L. Koatz, L. Van Kaer, J. O. Previato, L. Mendonca-Previato, A. Nobrega, and M. Bellio. 2007. Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi. J. Leukoc. Biol. 82:488-496.
32. - cells from chagasic patients: distinct repertoire and cytokine expression. Clin. Exp. Immunol. 137:129-138.
33. - T cells and cytokine serum levels in young and adult rats. Exp. Parasitol. 116:366-374.
34. Nakayasu, E. S., D. V. Yashunsky, L. L. Nohara, A. C. Torrecilhas, A. V. Nikolaev, and I. C. Almeida. 2009. GPIomics: global analysis of glycosylphosphatidylinositol-anchored molecules of Trypanosoma cruzi. Mol. Syst. Biol. 5:261.
35. + TCRαβ intermediate cells increase during experimental malaria infection and are able to exhibit inhibitory activity against the parasite liver stage in vitro. J. Immunol. 164:1463-1469.
36. - T lymphocytes to a microbial antigen. Nature 360:593-597.
37. - α/β T cells demonstrates preferential use of several Vβ genes and an invariant TCR α chain. J. Exp. Med. 178:1-16.
38. Priatel, J. J., O. Utting, and H. S. Teh. 2001. TCR/self-antigen interactions drive double-negative T cell peripheral expansion and differentiation into suppressor cells. J. Immunol. 167:6188-6194.
39. Procopio, D. O., I. C. Almeida, A. C. Torrecilhas, J. E. Cardoso, L. Teyton, L. R. Travassos, A. Bendelac, and R. T. Gazzinelli. 2002. Glycosylphosphatidylinositol-anchored mucin-like glycoproteins from Trypanosoma cruzi bind to CD1d but do not elicit dominant innate or adaptive immune responses via the CD1d/NKT cell pathway. J. Immunol. 169:3926-3933.
40. Rassi, A., A. O. Luquetti, A. Rassi, Jr., G. G. Rassi, S. G. Rassi, D. A. S. IG, and A. G. Rassi. 2007. Specific treatment for Trypanosoma cruzi: lack of efficacy of allopurinol in the human chronic phase of Chagas disease. Am. J. Trop. Med. Hyg. 76:58-61.
41. Reis, D. D., E. M. Jones, S. Tostes, E. R. Lopes, E. Chapadeiro, G. Gazzinelli, D. G. Colley, and T. L. McCurley. 1993. Expression of major histocompatibility complex antigens and adhesion molecules in hearts of patients with chronic Chagas' disease. Am. J. Trop. Med. Hyg. 49:192-200.
42. Rezende, J. M., and A. O. Luquetti. 1994. Chagasic megavisceras. PAHO Sci. Publ. 547:149-171.
43. Rocha, M. O., A. L. Ribeiro, and M. M. Teixeira. 2003. Clinical management of chronic Chagas cardiomyopathy. Front. Biosci. 8:e44-54.
44. Rocha, M. O., M. M. Teixeira, and A. L. Ribeiro. 2007. An update on the management of Chagas cardiomyopathy. Expert Rev. Anti Infect. Ther. 5:727-743.
45. Sardinha, L. R., R. M. Elias, T. Mosca, K. R. Bastos, C. R. Marinho, M. R. D'Imperio Lima, and J. M. Alvarez. 2006. Contribution of NK, NK T, γδ T, and αβ T cells to the gamma interferon response required for liver protection against Trypanosoma cruzi. Infect. Immun. 74:2031-2042.
46. Sardinha, L. R., T. Mosca, R. M. Elias, R. S. do Nascimento, L. A. Goncalves, D. Z. Bucci, C. R. Marinho, C. Penha-Goncalves, M. R. Lima, and J. M. Alvarez. 2010. The liver plays a major role in clearance and destruction of blood trypomastigotes in Trypanosoma cruzi chronically infected mice. PLoS Negl. Trop. Dis. 4:e578.
47. Sosa-Estani, S., and E. L. Segura. 2006. Etiological treatment in patients infected by Trypanosoma cruzi: experiences in Argentina. Curr. Opin. Infect. Dis. 19:583-587.
48. Souza, P. E., M. O. Rocha, C. A. Menezes, J. S. Coelho, A. C. Chaves, K. J. Gollob, and W. O. Dutra. 2007. Trypanosoma cruzi infection induces differential modulation of costimulatory molecules and cytokines by monocytes and T cells from patients with indeterminate and cardiac Chagas' disease. Infect. Immun. 75:1886-1894.
49. Souza, P. E., M. O. Rocha, E. Rocha-Vieira, C. A. Menezes, A. C. Chaves, K. J. Gollob, and W. O. Dutra. 2004. Monocytes from patients with indeterminate and cardiac forms of Chagas' disease display distinct phenotypic and functional characteristics associated with morbidity. Infect. Immun. 72:5283-5291.
50. Steindel, M., L. Kramer Pacheco, D. Scholl, M. Soares, M. H. de Moraes, I. Eger, C. Kosmann, T. C. Sincero, P. H. Stoco, S. M. Murta, C. J. de Carvalho-Pinto, and E. C. Grisard. 2008. Characterization of Trypanosoma cruzi isolated from humans, vectors, and animal reservoirs following an outbreak of acute human Chagas disease in Santa Catarina State, Brazil. Diagn. Microbiol. Infect. Dis. 60:25-32.
51. + T cells, the key to control Chagas' disease morbidity? Clin. Exp. Immunol. 145:81-92.
52. - peripheral blood mononuclear cells in patients with Plasmodium falciparum malaria. Eur. Cytokine Netw. 10:155-160.
53. World Health Organization. 2002. WHO Technical Report Series. Control of Chagas disease. World Health Organization, Geneva, Switzerland.