Involvement of regulatory T cells in the immunosuppression characteristic of patients with paracoccidioidomycosis

Infection and Immunity

Volumn 78, Issue 10, 2010, Pages 4392-4401

  Ferreira, Maria Carolina ^a   Dias De Oliveira, Rômulo Tadeu ^a   Da Silva, Rosiane Maria ^a   Lima Blotta, Maria Heloisa Souza ^a   Mamoni, Ronei Luciano ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

CD38 ANTIGEN; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; FAS LIGAND; GLUCOCORTICOID INDUCED TUMOR NECROSIS FACTOR RECEPTOR; TRANSCRIPTION FACTOR FOXP3;

ARTICLE; CD4+ CD25+ T LYMPHOCYTE; CELL CONTACT; CLINICAL ARTICLE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; LYMPHOCYTE COUNT; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SOUTH AMERICAN BLASTOMYCOSIS;

ANTIFUNGAL AGENTS; COCULTURE TECHNIQUES; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; IMMUNITY, CELLULAR; IMMUNOCOMPROMISED HOST; PARACOCCIDIOIDOMYCOSIS; RNA, MESSENGER; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 77957733793     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00487-10     Document Type: Article

References (44)

1. Agostini, M., E. Cenci, E. Pericolini, G. Nocentini, G. Bistoni, A. Vecchiarelli, and C. Riccardi. 2005. The glucocorticoid-induced tumor necrosis factor receptor-related gene modulates the response to Candida albicans infection. Infect. Immun. 73:7502-7508.
2. Andersson, J., D. Q. Tran, M. Pesu, T. S. Davidson, H. Ramsey, J. J. O'Shea, and E. M. Shevach. 2008. CD4+ FoxP3+ regulatory T cells confer infectious tolerance in a TGF-beta-dependent manner. J. Exp. Med. 205:1975-1981.
3. Baecher-Allan, C., and D. A. Hafler. 2004. Suppressor T cells in human diseases. J. Exp. Med. 200:273-276.
4. Belkaid, Y., and B. T. Rouse. 2005. Natural regulatory T cells in infectious disease. Nat. Immunol. 6:353-360.
5. Benard, G., M. A. Hong, G. M. Del Negro, L. Batista, M. A. Shikanai-Yasuda, and A. J. Duarte. 1996. Antigen-specific immunosuppression in paracoccidioidomycosis. Am. J. Trop. Med. Hyg. 54:7-12.
6. Benard, G., M. J. Mendes-Giannini, M. Juvenale, E. T. Miranda, and A. J. Duarte. 1997. Immunosuppression in paracoccidioidomycosis: T cell hyporesponsiveness to two Paracoccidioides brasiliensis glycoproteins that elicit strong humoral immune response. J. Infect. Dis. 175:1263-1267.
7. Benard, G., C. C. Romano, C. R. Cacere, M. Juvenale, M. J. Mendes-Giannini, and A. J. Duarte. 2001. Imbalance of IL-2, IFN-gamma and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis. Cytokine 13:248-252.
8. Brummer, E., E. Castaneda, and A. Restrepo. 1993. Paracoccidioidomycosis: an update. Clin. Microbiol. Rev. 6:89-117.
9. Calich, V. L., T. A. da Costa, M. Felonato, C. Arruda, S. Bernardino, F. V. Loures, L. R. Ribeiro, R. de Cassia Valente-Ferreira, and A. Pina. 2008. Innate immunity to Paracoccidioides brasiliensis infection. Mycopathologia 165:223-236.
10. Calich, V. L., C. A. Vaz, and E. Burger. 1998. Immunity to Paracoccidioides brasiliensis infection. Res. Immunol. 149:407-417, 499-500.
11. Campanelli, A. P., G. A. Martins, J. T. Souto, M. S. Pereira, M. C. Livonesi, R. Martinez, and J. S. Silva. 2003. Fas-Fas ligand (CD95-CD95L) and cytotoxic T lymphocyte antigen-4 engagement mediate T cell unresponsiveness in patients with paracoccidioidomycosis. J. Infect. Dis. 187:1496-1505.
12. Campanelli, A. P., A. M. Roselino, K. A. Cavassani, M. S. Pereira, R. A. Mortara, C. I. Brodskyn, H. S. Goncalves, Y. Belkaid, M. Barral-Netto, A. Barral, and J. S. Silva. 2006. CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. J. Infect. Dis. 193:1313-1322.
13. Cavassani, K. A., A. P. Campanelli, A. P. Moreira, J. O. Vancim, L. H. Vitali, R. C. Mamede, R. Martinez, and J. S. Silva. 2006. Systemic and local characterization of regulatory T cells in a chronic fungal infection in humans. J. Immunol. 177:5811-5818.
14. Fallarino, F., U. Grohmann, K. W. Hwang, C. Orabona, C. Vacca, R. Bianchi, M. L. Belladonna, M. C. Fioretti, M. L. Alegre, and P. Puccetti. 2003. Modulation of tryptophan catabolism by regulatory T cells. Nat. Immunol. 4:1206-1212.
15. Franco, M., M. R. Montenegro, R. P. Mendes, S. A. Marques, N. L. Dillon, and N. G. Mota. 1987. Paracoccidioidomycosis: a recently proposed classification of its clinical forms. Rev. Soc. Bras. Med. Trop. 20:129-132.
16. Guyot-Revol, V., J. A. Innes, S. Hackforth, T. Hinks, and A. Lalvani. 2006. Regulatory T cells are expanded in blood and disease sites in patients with tuberculosis. Am. J. Respir. Crit. Care Med. 173:803-810.
17. Ju, S. T., K. Matsui, and M. Ozdemirli. 1999. Molecular and cellular mechanisms regulating T and B cell apoptosis through Fas/FasL interaction. Int. Rev. Immunol. 18:485-513.
18. Kashino, S. S., R. A. Fazioli, C. Cafalli-Favati, L. H. Meloni-Bruneri, C. A. Vaz, E. Burger, L. M. Singer, and V. L. Calich. 2000. Resistance to Paracoccidioides brasiliensis infection is linked to a preferential Th1 immune response, whereas susceptibility is associated with absence of IFN-gamma production. J. Interferon Cytokine Res. 20:89-97.
19. Livak, K. J., and T. D. Schmittgen. 2001. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods 25:402-408.
20. Loures, F. V., A. Pina, M. Felonato, E. F. Araujo, K. R. Leite, and V. L. Calich. Toll-like receptor 4 signaling leads to severe fungal infection associated with enhanced proinflammatory immunity and impaired expansion of regulatory T cells. Infect. Immun. 78:1078-1088.
21. Loures, F. V., A. Pina, M. Felonato, and V. L. Calich. 2009. TLR2 is a negative regulator of Th17 cells and tissue pathology in a pulmonary model of fungal infection. J. Immunol. 183:1279-1290.
22. Mamoni, R. L., and M. H. Blotta. 2006. Flow-cytometric analysis of cytokine production in human paracoccidioidomycosis. Cytokine 35:207-216.
23. Mamoni, R. L., and M. H. Blotta. 2005. Kinetics of cytokines and chemokines gene expression distinguishes Paracoccidioides brasiliensis infection from disease. Cytokine 32:20-29.
24. Mamoni, R. L., S. A. Nouer, S. J. Oliveira, C. C. Musatti, C. L. Rossi, Z. P. Camargo, and M. H. Blotta. 2002. Enhanced production of specific IgG4, IgE, IgA and TGF-beta in sera from patients with the juvenile form of paracoccidioidomycosis. Med. Mycol. 40:153-159.
25. Moreira, A. P., K. A. Cavassani, F. S. M. Tristao, A. P. Campanelli, R. Martinez, M. A. Rossi, and J. S. Silva. 2008. CCR5-dependent regulatory T cell migration mediates fungal survival and severe immunosuppression. J. Immunol. 180:3049-3056.
26. Mota, N. G., M. T. Rezkallah-Iwasso, M. T. Peracoli, R. C. Audi, R. P. Mendes, J. Marcondes, S. A. Marques, N. L. Dillon, and M. F. Franco. 1985. Correlation between cell-mediated immunity and clinical forms of paracoccidioidomycosis. Trans. R. Soc. Trop. Med. Hyg. 79:765-772.
27. Musatti, C. C., M. T. Rezkallah, E. Mendes, and N. F. Mendes. 1976. In vivo and in vitro evaluation of cell-mediated immunity in patients with paracoccidiodomycosis. Cell. Immunol. 24:365-378.
28. Nakamura, K., A. Kitani, and W. Strober. 2001. Cell contact-dependent immunosuppression by CD4(+)CD25(+) regulatory T cells is mediated by cell surface-bound transforming growth factor beta. J. Exp. Med. 194:629-644.
29. Netea, M. G., R. Sutmuller, C. Hermann, C. A. Van der Graaf, J. W. Van der Meer, J. H. van Krieken, T. Hartung, G. Adema, and B. J. Kullberg. 2004. Toll-like receptor 2 suppresses immunity against Candida albicans through induction of IL-10 and regulatory T cells. J. Immunol. 172:3712-3718.
30. Oida, T., L. Xu, H. L. Weiner, A. Kitani, and W. Strober. 2006. TGF-beta-mediated suppression by CD4+CD25+ T cells is facilitated by CTLA-4 signaling. J. Immunol. 177:2331-2339.
31. Oliveira, S. J., R. L. Mamoni, C. C. Musatti, P. M. Papaiordanou, and M. H. Blotta. 2002. Cytokines and lymphocyte proliferation in juvenile and adult forms of paracoccidioidomycosis: comparison with infected and non-infected controls. Microbes Infect. 4:139-144.
32. Restrepo, A., M. Restrepo, F. de Restrepo, L. H. Aristizabal, L. H. Moncada, and H. Velez. 1978. Immune responses in paracoccidioidomycosis. A controlled study of 16 patients before and after treatment. Sabouraudia 16:151-163.
33. Roberts, T., N. Beyers, A. Aguirre, and G. Walzl. 2007. Immunosuppression during active tuberculosis is characterized by decreased interferon-gamma production and CD25 expression with elevated forkhead box P3, transforming growth factor-beta, and interleukin-4 mRNA levels. J. Infect. Dis. 195:870-878.
34. Sakaguchi, S., T. Takahashi, and Y. Nishizuka. 1982. Study on cellular events in post-thymectomy autoimmune oophoritis in mice. II. Requirement of Lyt-1 cells in normal female mice for the prevention of oophoritis. J. Exp. Med. 156:1577-1586.
35. Sakaguchi, S., T. Takahashi, and Y. Nishizuka. 1982. Study on cellular events in postthymectomy autoimmune oophoritis in mice. I. Requirement of Lyt-1 effector cells for oocytes damage after adoptive transfer. J. Exp. Med. 156:1565-1576.
36. Sakaguchi, S., K. Wing, and M. Miyara. 2007. Regulatory T cells - a brief history and perspective. Eur. J. Immunol. 37(Suppl. 1):S116-S123.
37. Satoguina, J. S., T. Adjobimey, K. Arndts, J. Hoch, J. Oldenburg, L. E. Layland, and A. Hoerauf. 2008. Tr1 and naturally occurring regulatory T cells induce IgG4 in B cells through GITR/GITR-L interaction, IL-10 and TGF-beta. Eur. J. Immunol. 38:3101-3113.
38. Shevach, E. M., and G. L. Stephens. 2006. The GITR-GITRL interaction: co-stimulation or contrasuppression of regulatory activity? Nat. Rev. Immunol. 6:613-618.
39. Sutmuller, R. P., M. H. den Brok, M. Kramer, E. J. Bennink, L. W. Toonen, B. J. Kullberg, L. A. Joosten, S. Akira, M. G. Netea, and G. J. Adema. 2006. Toll-like receptor 2 controls expansion and function of regulatory T cells. J. Clin. Invest. 116:485-494.
40. Vignali, D. A., L. W. Collison, and C. J. Workman. 2008. How regulatory T cells work. Nat. Rev. Immunol. 8:523-532.
41. von Boehmer, H. 2005. Mechanisms of suppression by suppressor T cells. Nat. Immunol. 6:338-344.
42. Xu, G., and Y. Shi. 2007. Apoptosis signaling pathways and lymphocyte homeostasis. Cell Res. 17:759-771. (Pubitemid 47411431)
43. Yurchenko, E., M. Tritt, V. Hay, E. M. Shevach, Y. Belkaid, and C. A. Piccirillo. 2006. CCR5-dependent homing of naturally occurring CD4+ regulatory T cells to sites of Leishmania major infection favors pathogen persistence. J. Exp. Med. 203:2451-2460.
44. Ziegler, S. F. 2006. FOXP3: of mice and men. Annu. Rev. Immunol. 24:209-226.