Increased Vo(2max) with right-shifted Hb-O2 dissociation curve at a constant O2 delivery in dog muscle in situ

Journal of Applied Physiology

Volumn 84, Issue 3, 1998, Pages 995-1002

  Richardson, Russell S ^a   Tagore, Kuldeep ^b   Haseler, Luke J ^b   Jordan, Maria ^b   Wagner, Peter D ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NONE

Author keywords

Diffusion; Exercise; Maximal oxygen uptake; Oxygen affinity; Oxyhemoglobin; Partial pressure of oxygen at 50 hemoglobin saturation; Skeletal muscle

Indexed keywords

HEMOGLOBIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; GASTROCNEMIUS MUSCLE; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN DISSOCIATION CURVE; OXYGEN SATURATION; OXYGEN TRANSPORT; PRIORITY JOURNAL; ACID BASE BALANCE; ANAEROBIC THRESHOLD; ANIMAL; BLOOD GAS ANALYSIS; ELECTROSTIMULATION; IN VITRO STUDY; KINETICS; METABOLISM; MUSCLE ISOMETRIC CONTRACTION; MUSCLE MITOCHONDRION; PHYSIOLOGY; SKELETAL MUSCLE;

ACID-BASE EQUILIBRIUM; ANAEROBIC THRESHOLD; ANIMALS; BLOOD GAS ANALYSIS; DOGS; ELECTRIC STIMULATION; HEMOGLOBINS; ISOMETRIC CONTRACTION; KINETICS; MITOCHONDRIA, MUSCLE; MUSCLE, SKELETAL; OXYGEN CONSUMPTION;

EID: 0031594768     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/jappl.1998.84.3.995     Document Type: Article

References (32)

1. Abraham, D. J., F. C. Wireko, and R. S. Randad. Allosteric modifiers of hemoglobin: 2-(4-{[(3,5-disubstituted anilino)carbonyl]-methyl}phenoxy)-2-methylpropionic acid derivatives that lower the oxygen affinity of hemoglobin in red cell suspensions, whole blood, and in vivo in rats. Biochemistry 31: 9141-9149, 1992.
2. Barclay, J. K., and W. N. Stainsby. The role of blood flow in limiting maximal metabolic rate in muscle. Med. Sci. Sports Exerc. 7: 116-119, 1975.
3. 2 uptake in canine gastrocnemius muscle in situ. J. Appl. Physiol. 70: 1105-1112 1991.
4. 2 delivery in dog muscle in situ. J. Appl. Physiol. 70: 2656-2662, 1991.
5. 2 delivery in canine gastrocnemius in situ. J. Appl. Physiol. 66: 1219-1226, 1989.
6. Honig, C. R., T. E. Gayeski, A. Clark, and P. A. A. Clark. Arteriovenous oxygen shunt is negligible in resting and working gracilis muscles. Am. J. Physiol. 261 (Heart Circ. Physiol. 30): H2031-H2043, 1991.
7. 1H MR imaging of anatomical compartments within finger flexor muscles of the human forearm. Magn. Reson. Med. 15: 491-496, 1990.
8. Jobsis, F. F., and W. N. Stainsby. Oxidation of NADH during contractions of circulated skeletal muscle. Respir. Physiol. 4: 292-300, 1968.
9. Khandelwal, S. R., R. S. Randid, P. Lin, H. Meng, R. N. Pittman, H. A. Kontos, S. C. Choi, D. J. Abraham, and R. Schmidt-Ullrich. Enhanced oxygenation in vivo by allosteric inhibitors of hemoglobin saturation. Am. J. Physiol. 265 (Heart Circ. Physiol. 34): H1450-H1453, 1993.
10. Knight, D. R., W. Schaffartzik, D. C. Poole, M. C. Hogan, D. E. Bebout, and P. D. Wagner. Hyperoxia increases leg maximal oxygen uptake. J. Appl. Physiol. 75: 2586-2594, 1993.
11. Kunert, M. P., J. F. Liard, and D. J. Abraham. RSR-13, an allosteric effector of hemoglobin, increases systemic and illiac vascular resistance in rats. Am. J. Physiol. 271 (Heart Circ. Physiol. 40): H602-H613, 1996.
12. 2 and decreases arteriolar diameter and flow in the rat cremaster muscle. Microvasc. Res. 52: 58-68, 1996.
13. Ledinham, J. M. Autoregulation in hypertension: a review. J. Hypertens. 7: S97-S104, 1989.
14. Liard, J. F., and M. P. Kunert. Hemodynamic changes induced by low blood oxygen affinity in dogs. Am. J. Physiol. 264 (Regulatory Integrative Comp. Physiol. 33): R396-R401, 1993.
15. Piiper, J. Unequal distribution of blood flow in exercising muscle of dog. Respir. Physiol. 80: 129-136, 1990.
16. 2max. J. Appl. Physiol. 66: 2491-2495, 1989.
17. Randad, R. S., M. A. Mahran, A. S. Mehanna, and D. J. Abraham. Allosteric modifiers of hemoglobin: design, synthesis, testing and structure-allosteric activity relationship of novel hemoglobin oxygen affinity decreasing agents. J. Med. Chem. 34: 752-757, 1991.
18. 2 during single leg knee extensor exercise in man. Am. J. Physiol. 268 (Heart Circ. Physiol. 37): H1453-H1461, 1995.
19. 2 transport. J. Clin. Invest. 96: 1916-1926, 1995.
20. Richardson, R. S., D. C. Poole, D. R. Knight, and P. D. Wagner. Red blood cell transit time in man: theoretical effects of capillary density. In: Advances in Experimental Medicine and Biology, edited by M. C. Hogan, O. Mathieu-Costello, D. C. Poole, and P. D. Wagner. New York: Plenum, 1995, vol. XVII, p. 517-528.
21. 2max in normal humans. J. Appl. Physiol. 67: 291-299, 1989.
22. 2 transport during normoxic and hypoxic exercise in the dog. J. Appl. Physiol. 59: 749-757, 1985.
23. Stainsby, W. N., and A. B. Otis. Blood flow, blood oxygen tension, oxygen uptake, and oxygen transport in skeletal muscle. Am. J. Physiol. 206: 858-866, 1964.
24. Stein, J. C., and M. L. Ellsworth. Microvascular oxygen transport: impact of a left-shifted dissociation curve. Am. J. Physiol. 262 (Heart Circ. Physiol. 31): H517-H522, 1992.
25. Stringer, W., K. Wasserman, R. Casaburi, J. Porszasz, K. Maehara, and W. French. Lactic acidosis as a facilitator of oxyhemoglobin dissociation during exercise. J. Appl. Physiol. 76: 1462-1467, 1994.
26. Wagner, P. D. Gas exchange and peripheral diffusion limitation. Med. Sci. Sports Exerc. 24: 54-58, 1992.
27. 2max. Respir. Physiol. 93: 221-237, 1993.
28. 2max at sea level and altitude. Respir. Physiol. 106: 329-343, 1996.
29. Wagner, P. D., J. Roca, M. C. Hogan, D. C. Poole, D. E. Debout, and P. Haab. Experimental support of the theory of diffusion limitation of maximum oxygen uptake. In: Oxygen Transport to Tissue, edited by J. Piiper, T. K. Goldstick, and M. Meyer. New York: Plenum, 1990, vol. XII, p. 825-833.
30. Weibel, E. R. The pathway for oxygen. In: Structure and Function in the Mammalian Respiratory System. London: Harvard Univ. Press, 1984.
31. Welch, H. G. Hyperoxia and human performance: a brief review. Med. Sci. Sports Exerc. 14: 253-262, 1982.
32. Woodson, R. D. Functional consequences of altered blood oxygen affinity. Acta Biol. Med. Ger. 40: 733-736, 1981.