Relative biological effectiveness of pulsed and continuous 20 MeV protons for micronucleus induction in 3D human reconstructed skin tissue

Radiotherapy and Oncology

Volumn 95, Issue 1, 2010, Pages 66-72

  Schmid, Thomas E ^a   Dollinger, Günther ^b   Hable, Volker ^b   Greubel, Christoph ^b   Zlobinskaya, Olga ^a   Michalski, Dörte ^a   Molls, Michael ^a   Röper, Barbara ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b BUNDESWEHR UNIVERSITY MUNICH   (Germany)

Author keywords

In vitro tissue; Micronucleus assay; Protons; Pulsed irradiation; RBE

Indexed keywords

PROTON;

ARTICLE; CELL COMMUNICATION; CONTROLLED STUDY; GEOMETRY; HUMAN; HUMAN TISSUE; IN VIVO STUDY; IRRADIATION; KERATINOCYTE; LASER; MICRONUCLEUS; PRIORITY JOURNAL; PROTON RADIATION; PROTON THERAPY; RADIATION DOSE; RELATIVE BIOLOGIC EFFECTIVENESS; SIMULATION; SKIN CULTURE; THREE DIMENSIONAL IMAGING; X RAY;

HUMANS; MICRONUCLEI, CHROMOSOME-DEFECTIVE; PROTONS; RELATIVE BIOLOGICAL EFFECTIVENESS; SKIN;

EID: 77950339203     PISSN: 01678140     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radonc.2010.03.010     Document Type: Article

References (30)

1. Martin M. Laser accelerated radiotherapy: is it on its way to the clinic?. J Natl Cancer Inst 101 (2009) 450-451
2. Luo W., Fourkal E., Li J., and Ma C.M. Particle selection and beam collimation system for laser-accelerated proton beam therapy. Med Phys 32 (2005) 794-806
3. Salamin Y.I., Harman Z., and Keitel C.H. Direct high-power laser acceleration of ions for medical applications. Phys Rev Lett 100 (2008) 155004
4. Henig A., Kiefer D., Markey K., et al. Enhanced laser-driven ion acceleration in the relativistic transparency regime. Phys Rev Lett 103 (2009) 045002
5. Yogo A., Daido H., Bulanov S.V., et al. Laser ion acceleration via control of the near-critical density target. Phys Rev 77 (2008) 016401
6. Chiu C., Fomytskyi M., Grigsby F., Raischel F., Downer M.C., and Tajima T. Laser electron accelerators for radiation medicine: a feasibility study. Med Phys 31 (2004) 2042-2052
7. Fan J., Luo W., Fourkal E., et al. Shielding design for a laser-accelerated proton therapy system. Phys Med Biol 52 (2007) 3913-3930
8. Henig A., Kiefer D., Geissler M., et al. Laser-driven shock acceleration of ion beams from spherical mass-limited targets. Phys Rev Lett 102 (2009) 095002
9. Kreipl M.S., Friedland W., and Paretzke H.G. Interaction of ion tracks in spatial and temporal proximity. Radiat Environ Biophys 48 (2009) 349-359
10. Kreipl M.S., Friedland W., and Paretzke H.G. Time- and space-resolved Monte Carlo study of water radiolysis for photon, electron and ion irradiation. Radiat Environ Biophys 48 (2009) 11-20
11. Plante I., Filali-Mouhim A., and Jay-Gerin J. SimulRad: a Java interface for a Monte-Carlo simulation code to visualize in 3D the early stages of water radiolysis. Radiat Phys Chem 72 (2005) 173-180
12. Belyakov O.V., Mitchell S.A., Parikh D., et al. Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. PNAS 102 (2005) 14203-14208
13. Sedelnikova O.A., Nakamura A., Kovalchuk O., et al. DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models. Cancer Res 67 (2007) 4295-4302
14. Tillman C., Grafstrom G., Jonsson A.C., et al. Survival of mammalian cells exposed to ultrahigh dose rates from a laser-produced plasma X-ray source. Radiology 213 (1999) 860-865
15. Dollinger G., Bergmaier A., Hable V., et al. Nanosecond pulsed proton microbeam. Nucl Instr Meth Phys Res B 267 (2009) 2008-2012
16. Schmid T.E., Dollinger G., Hauptner A., et al. No evidence for a different RBE between pulsed and continuous 20 MeV protons. Radiat Res 172 (2009) 567-574
17. Curren R.D., Mun G.C., Gibson D.P., and Aardema M.J. Development of a method for assessing micronucleus induction in a 3D human skin model (EpiDerm). Mutat Res 607 (2006) 192-204
18. Mun G.C., Aardema M.J., Hu T., et al. Further development of the EpiDerm 3D reconstructed human skin micronucleus (RSMN) assay. Mutat Res 673 (2009) 92-99
19. Hu T., Kaluzhny Y., Mun G.C., et al. Intralaboratory and interlaboratory evaluation of the EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay. Mutat Res 673 (2009) 100-108
20. Hauptner A., Dietzel S., Drexler G.A., et al. Microirradiation of cells with energetic heavy ions. Radiat Environ Biophys 42 (2004) 237-245
21. Hauptner A., Krucken R., Greubel C., et al. DNA-repair protein distribution along the tracks of energetic ions. Radiat Prot Dosim 122 (2006) 147-149
22. Greubel C., Hable V., Drexler G.A., et al. Quantitative analysis of DNA-damage response factors after sequential ion microirradiation. Radiat Environ Biophys 47 (2008) 415-422
23. Ziegler, J, Biersack, J. The stopping and range of ions in matter. SRIM2003 2003. Available from: http://www.srim.org.
24. Jagetia G.C., and Aruna R. Correlation of micronuclei-induction with the cell survival in HeLa cells treated with a base analogue, azidothymidine (AZT) before exposure to different doses of gamma-radiation. Toxicol Lett 139 (2003) 33-43
25. International Commission on Radiological Protection (ICRP). Relative biological effectiveness (RBE), quality factor (Q), and radiation weighting factor (wR). Publication 92. New York: Elsevier Inc. Pergamon Press; 2003.
26. Nias A.H.W., Swallow A.J., Keene J.P., and Hodgson B.W. Survival of HeLa cells from 10 nanosecond pulses of electrons. Int J Radiat Biol 17 (1970) 595-598
27. Epp E.R., Weiss H., Djordjevic B., and Santomasso A. The radiosensitivity of cultured mammalian cells exposed to single high intensity pulses of electrons in various concentrations of oxygen. Radiat Res 52 (1972) 324-332
28. Tillman C., Grafström G., Jönnon A.C., et al. Survival of mammalian cells exposed to ultrahigh dose rates from a laser-produced plasma X-ray source. Radiology 213 (1999) 860-865
29. Shinohara K., Nakano H., Miyazaki N., Tago M., and Kodama R. Effects of single pulse (≤1 ps) X-rays from laser-produced plasmas on mammalian cells. J Radiat Res 45 (2004) 509-514
30. Slonina D., Spekl K., Panteleeva A., Brankovic K., Hoinkis C., and Dörr W. Induction of micronuclei in human fibroblasts and keratinocytes by 25 kV X-rays. Radiat Environ Biophys 42 (2003) 55-61