Combined blockade of Β-and α1-adrenoceptors in left ventricular remodeling induced by hypertension: Beneficial or not

Hypertension Research

Volumn 33, Issue 10, 2010, Pages 984-985

  O Uchi, Jin ^a   Lopes, Coeli M B ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CARVEDILOL; CATECHOLAMINE; DOXAZOSIN; GUANINE NUCLEOTIDE BINDING PROTEIN; PRAZOSIN; RECEPTOR SUBTYPE;

ADRENERGIC STIMULATION; ADRENERGIC SYSTEM; CONCEPTUAL FRAMEWORK; DRUG RECEPTOR BINDING; HEART FAILURE; HEART VENTRICLE REMODELING; HUMAN; HYPERTENSION; NONHUMAN; NOTE; PATHOPHYSIOLOGY;

ADRENERGIC ANTAGONISTS; ANIMALS; BISOPROLOL; CARBAZOLES; DISEASE MODELS, ANIMAL; HUMANS; HYPERTENSION; PROPANOLAMINES; PROPRANOLOL; RATS; RATS, INBRED SHR; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, BETA; VENTRICULAR REMODELING;

EID: 77957695022     PISSN: 09169636     EISSN: 13484214     Source Type: Journal    
DOI: 10.1038/hr.2010.157     Document Type: Note

References (15)

1. Brodde OE, Michel MC. Adrenergic and muscarinic receptors in the human heart. Pharmacol Rev 1999; 51: 651-690.
2. Triposkiadis F, Karayannis G, Giamouzis G, Skoularigis J, Louridas G, Butler J. The sympathetic nervous system in heart failure physiology, pathophysiology, and clinical implications. J Am Coll Cardiol 2009; 54: 1747-1762.
3. 2+ mediated through alpha-and beta-adrenoceptors. Circ Res 1988; 62: 247-265.
4. Bers DM. Cardiac excitation-contraction coupling. Nature 2002; 415: 198-205.
5. Woodcock EA, Du XJ, Reichelt ME, Graham RM. Cardiac alpha 1-adrenergic drive in pathological remodelling. Cardiovasc Res 2008; 77: 452-462.
6. Xiao RP. Beta-adrenergic signaling in the heart: dual coupling of the beta2-adrenergic receptor to G(s) and G(i) proteins. Sci STKE 2001; 2001: re15.
7. Houser SR, Piacentino III V, Weisser J. Abnormalities of calcium cycling in the hypertrophied and failing heart. J Mol Cell Cardiol 2000; 32: 1595-1607.
8. Osadchii OE. Cardiac hypertrophy induced by sustained beta-adrenoreceptor activation: pathophysiological aspects. Heart Fail Rev 2007; 12: 66-86.
9. Frigerio M, Roubina E. Drugs for left ventricular remodeling in heart failure. Am J Cardiol 2005; 96: 10L-18L.
10. Chen WQ, Cai H, Zhang C, Ji XP, Zhang Y. Is overall blockade superior to selective blockade of adrenergic receptor subtypes in suppressing left ventricular remodeling in spontaneously hypertensive rats? Hypertens Res 2010; 33: 1071-1081.
11. Yaoita H, Sakabe A, Maehara K, Maruyama Y. Different effects of carvedilol, metoprolol, and propranolol on left ventricular remodeling after coronary stenosis or after permanent coronary occlusion in rats. Circulation 2002; 105: 975-980.
12. Bristow MR. beta-adrenergic receptor blockade in chronic heart failure. Circulation 2000; 101: 558-569.
13. 2+ channel. Circ Res 2008; 102: 1378-1388.
14. Palaniyandi SS, Sun L, Ferreira JC, Mochly-Rosen D. Protein kinase C in heart failure: a therapeutic target? Cardiovasc Res 2009; 82: 229-239.
15. Frishman WH. Carvedilol. N Engl J Med 1998; 339: 1759-1765.