Blood GHB concentrations and results of medical examinations in 25 car drivers in Norway

European Journal of Clinical Pharmacology

Volumn 66, Issue 10, 2010, Pages 987-998

  Al Samarraie, Muhammad S ^a   Karinen, Ritva ^a   Mørland, Jørg ^a   Stokke Opdal, Mimi ^a,b  

^a NORWEGIAN INSTITUTE OF PUBLIC HEALTH   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Blood concentrations; Clinical test of impairment; Drug driving; GHB

Indexed keywords

4 HYDROXYBUTYRIC ACID;

ABNORMAL BEHAVIOR; ADULT; AGGRESSION; ARTICLE; BALANCE IMPAIRMENT; CAR DRIVER; CAR DRIVING; CENTRAL NERVOUS SYSTEM DEPRESSION; CLINICAL ARTICLE; CONCENTRATION RESPONSE; CONSCIOUSNESS LEVEL; CONTROLLED STUDY; DRIVING ABILITY; DRUG ABUSE; DRUG BLOOD LEVEL; DRUG SCREENING; ENZYME ANALYSIS; FEMALE; FORENSIC TOXICOLOGY; GAS CHROMATOGRAPHY; HEALTH PROGRAM; HUMAN; MALE; MEDICAL EXAMINATION; MEMORY DISORDER; NORWAY; NYSTAGMUS; PRIORITY JOURNAL; PUPIL; PUPIL REFLEX; SHORT TERM MEMORY; SOMNOLENCE; TRAFFIC ACCIDENT; TRAFFIC SAFETY;

ACCIDENTS, TRAFFIC; ADULT; AUTOMOBILE DRIVING; BIOLOGICAL MARKERS; CONSCIOUSNESS; FEMALE; FORENSIC TOXICOLOGY; HUMANS; MALE; NORWAY; POLICE; SAFETY; SODIUM OXYBATE; SUBSTANCE ABUSE DETECTION;

EID: 77957669528     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00228-010-0870-x     Document Type: Article

References (29)

1. S Abanades M Farre M Segura S Pichini D Barral R Pacifici M Pellegrini F Fonseca K Langohr R De La Torre 2006 Gamma-hydroxybutyrate (GHB) in humans: pharmacodynamics and pharmacokinetics Ann NY Acad Sci 1074 559 576 1:CAS:528:DC%2BD28XhtFGgs7vE 10.1196/annals.1369.065 17105953
2. L Bachs G Hoiseth S Skurtveit J Morland 2006 Heroin-using drivers: importance of morphine and morphine-6-glucuronide on late clinical impairment Eur J Clin Pharmacol 62 905 912 1:CAS:528:DC%2BD28XhtFegtb7M 10.1007/s00228-006-0195-y 17021891
3. JC Barker H Karsoho 2008 Hazardous use of gamma hydroxybutyrate: driving under the influence Subst Use Misuse 43 1507 1520 10.1080/10826080802237928 18752156
4. Baselt RC (2008) Disposition of toxic drugs and chemicals in man. Biomedical Publ, Foster City
5. K Berankova K Mutnanska M Balikova 2006 Gamma-hydroxybutyric acid stability and formation in blood and urine Forensic Sci Int 161 158 162 1:CAS:528:DC%2BD28XotFWktrg%3D 10.1016/j.forsciint.2006.01.017 16857333
6. IJ Bosman KJ Lusthof 2003 Forensic cases involving the use of GHB in The Netherlands Forensic Sci Int 133 17 21 1:CAS:528:DC%2BD3sXjs1aisbY%3D 10.1016/S0379-0738(03)00044-6 12742684
7. JG Bramness S Skurtveit J Morland 2003 Testing for benzodiazepine inebriation-relationship between benzodiazepine concentration and simple clinical tests for impairment in a sample of drugged drivers Eur J Clin Pharmacol 59 593 601 1:CAS:528:DC%2BD3sXovVymsbY%3D 10.1007/s00228-003-0677-0 14504853
8. R Brenneisen MA Elsohly TP Murphy J Passarelli S Russmann SJ Salamone DE Watson 2004 Pharmacokinetics and excretion of gamma-hydroxybutyrate (GHB) in healthy subjects J Anal Toxicol 28 625 630 1:CAS:528:DC%2BD2cXptlynsrk%3D 15538955
9. LP Carter W Koek CP France 2009 Behavioral analyses of GHB: receptor mechanisms Pharmacol Ther 121 100 114 1:CAS:528:DC%2BD1cXhsFagtr3F 10.1016/j.pharmthera.2008.10.003 19010351
10. G Colombo R Agabio C Lobina R Reali F Fadda GL Gessa 1995 Cross-tolerance to ethanol and gamma-hydroxybutyric acid Eur J Pharmacol 273 235 238 1:CAS:528:DyaK2MXjsFansbk%3D 10.1016/0014-2999(94)00687-3 7737330
11. FJ Couper BK Logan 2001 GHB and driving impairment J Forensic Sci 46 919 923 1:CAS:528:DC%2BD3MXlt12htLg%3D 11451079
12. FJ Couper BK Logan 2004 Addicted to driving under the influence-a GHB/GBL case report J Anal Toxicol 28 512 515 1:CAS:528:DC%2BD2cXnsVehurk%3D 15516306
13. KR Drasbek J Christensen K Jensen 2006 Gamma-hydroxybutyrate-a drug of abuse Acta Neurol Scand 114 145 156 1:CAS:528:DC%2BD28XhtVGitLrL 10.1111/j.1600-0404.2006.00712.x 16911342
14. S Dresen J Kempf W Weinmann 2007 Prevalence of gamma-hydroxybutyrate (GHB) in serum samples of amphetamine, metamphetamine and ecstasy impaired drivers Forensic Sci Int 173 112 116 1:CAS:528:DC%2BD2sXhtF2rtrvE 10.1016/j.forsciint.2007.02.009 17383132
15. AA Elian 2002 Determination of endogenous gamma-hydroxybutyric acid (GHB) levels in antemortem urine and blood Forensic Sci Int 128 120 122 1:CAS:528:DC%2BD38Xmtlertrw%3D 10.1016/S0379-0738(02)00183-4 12175790
16. SP Elliott 2003 Gamma hydroxybutyric acid (GHB) concentrations in humans and factors affecting endogenous production Forensic Sci Int 133 9 16 1:CAS:528:DC%2BD3sXjs1aisbs%3D 10.1016/S0379-0738(03)00043-4 12742683
17. L Goldberg 1943 Quantitative studies on alcohol tolerance in man. The influence of ethyl alcohol on sensory, motor and psychological functions referred to blood alcohol in normal and habituated individuals Acta Physiol Scand 5 1 128 10.1111/j.1748-1716.1943.tb02057.x
18. N Gordon 2004 Succinic semialdehyde dehydrogenase deficiency (SSADH) (4-hydroxybutyric aciduria, gamma-hydroxybutyric aciduria) Eur J Paediatr Neurol 8 261 265 10.1016/j.ejpn.2004.06.004 15341910
19. I Gustavsen M Al-Sammurraie J Morland JG Bramness 2009 Impairment related to blood drug concentrations of zopiclone and zolpidem compared to alcohol in apprehended drivers Accid Anal Prev 41 462 466 10.1016/j.aap.2009.01.011 19393793
20. I Gustavsen J Morland JG Bramness 2006 Impairment related to blood amphetamine and/or methamphetamine concentrations in suspected drugged drivers Accid Anal Prev 38 490 495 10.1016/j.aap.2005.11.005 16343411
21. KE Hovda MA Bjornaas K Skog A Opdahl P Drottning O Ekeberg D Jacobsen 2008 Acute poisonings treated in hospitals in Oslo: a one-year prospective study (I): pattern of poisoning Clin Toxicol (Phila) 46 35 41 1:CAS:528: DC%2BD1cXos1Gg
22. AW Jones A Eklund R Kronstrand 2009 Concentration-time profiles of gamma-hydroxybutyrate in blood after recreational doses are best described by zero-order rather than first-order kinetics J Anal Toxicol 33 332 335 1:CAS:528:DC%2BD1MXpt1SjtLc%3D 19653937
23. AW Jones A Holmgren FC Kugelberg 2007 Gamma-hydroxybutyrate concentrations in the blood of impaired drivers, users of illicit drugs, and medical examiner cases J Anal Toxicol 31 566 572 1:CAS:528:DC%2BD2sXhtlCls7rF 18093415
24. AW Jones A Holmgren FC Kugelberg 2008 Driving under the influence of gamma-hydroxybutyrate (GHB) Forensic Sci Med Pathol 4 205 211 1:CAS:528:DC%2BD1MXhtVWrtrg%3D 10.1007/s12024-008-9040-1 19291440
25. FC Kugelberg A Holmgren A Eklund AW Jones 2010 Forensic toxicology findings in deaths involving gamma-hydroxybutyrate Int J Leg Med 124 1 6 10.1007/s00414-008-0299-2
26. M Mamelak MB Scharf M Woods 1986 Treatment of narcolepsy with gamma-hydroxybutyrate. A review of clinical and sleep laboratory findings Sleep 9 285 289 1:STN:280:DyaL283gslGqtg%3D%3D 3704454
27. KL Nicholson RL Balster 2001 GHB: a new and novel drug of abuse Drug Alcohol Depend 63 1 22 1:CAS:528:DC%2BD3MXisF2rsLw%3D 10.1016/S0376-8716(00) 00191-5 11297827
28. JJ Raybon KM Boje 2007 Pharmacokinetics and pharmacodynamics of gamma-hydroxybutyric acid during tolerance in rats: effects on extracellular dopamine J Pharmacol Exp Ther 320 1252 1260 1:CAS:528:DC%2BD2sXis1WgurY%3D 10.1124/jpet.106.113886 17138862
29. BG Stephens RC Baselt 1994 Driving under the influence of GHB? J Anal Toxicol 18 357 358 1:STN:280:DyaK2M7itlyrtg%3D%3D 7823545