Synthesis and biological evaluation of fluorinated deoxynucleotide analogs based on bis-(difluoromethylene)triphosphoric acid

Proceedings of the National Academy of Sciences of the United States of America

Volumn 107, Issue 36, 2010, Pages 15693-15698

  Prakash, G K Surya ^a   Zibinsky, Mikhail ^a   Upton, Thomas G ^a   Kashemirov, Boris A ^a   McKenna, Charles E ^a   Oertell, Keriann ^a   Goodman, Myron F ^a   Batra, Vinod K ^b   Pedersen, Lars C ^b   Beard, William A ^b   Shock, David D ^b   Wilson, Samuel H ^b   Olah, George A ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

DNA polymerase beta; Fluorinated triphosphate; Isopolarity and bioisotericity; Nonhydrolyzable nucleotides; Pentabasic acid

Indexed keywords

DEOXYRIBONUCLEOTIDE; DNA POLYMERASE; FLUORINE DERIVATIVE; OXYGEN; PHOSPHORUS DERIVATIVE; POLYANION; PURINE NUCLEOTIDE; DNA; FLUORINE; PHOSPHONIC ACID DERIVATIVE; RNA;

ARTICLE; ATOM; CELL POLARITY; CRYSTAL STRUCTURE; ENZYME CONFORMATION; HYDROGEN BOND; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SYNTHESIS; CHEMICAL STRUCTURE; CHEMISTRY; NUCLEAR MAGNETIC RESONANCE; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DNA; FLUORINE; HYDROGEN BONDING; MODELS, MOLECULAR; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHONIC ACIDS; RNA;

EID: 77957653336     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1007430107     Document Type: Article

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