Successful combination therapy of a locally advanced squamous cell carcinoma of the skin with cetuximab and γ-irradiation;Erfolgreiche kombinationsbehandlung eines inoperablen plattenepithelkarzinoms der haut mit cetuximab und radiotherapie

JDDG - Journal of the German Society of Dermatology

Volumn 8, Issue 10, 2010, Pages 826-828

  Göppner, Daniela ^a   Nekwasil, Stephan ^a   Franke, Ingolf ^a   Gollnick, Harald ^a   Leverkus, Martin ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CETUXIMAB; CORTICOSTEROID; EPIDERMAL GROWTH FACTOR RECEPTOR;

AGED; ARTICLE; BODY SURFACE; CANCER COMBINATION CHEMOTHERAPY; CANCER INFILTRATION; CANCER RADIOTHERAPY; CANCER REGRESSION; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; CONTINUOUS INFUSION; FEMALE; FULL THICKNESS SKIN GRAFT; GAMMA IRRADIATION; HISTOLOGY; HUMAN; PTOSIS; RASH; SKIN CARCINOMA; SQUAMOUS CELL CARCINOMA; THERAPY EFFECT; TREATMENT RESPONSE; TUMOR BIOPSY;

AGED, 80 AND OVER; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CARCINOMA, SQUAMOUS CELL; CHEMOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; FEMALE; GAMMA RAYS; HUMANS; RADIOTHERAPY, ADJUVANT; SKIN NEOPLASMS; TREATMENT OUTCOME;

EID: 77957603160     PISSN: 16100379     EISSN: 16100387     Source Type: Journal    
DOI: 10.1111/j.1610-0387.2010.07526.x     Document Type: Article

References (10)

1. Brantsch KD, Meisner C, Schonfisch B, Trilling B, Wehner-Caroli J, Röcken M, Breuninger H: Analysis of risk factors determining prognosis of cutaneous squamous-cell carcinoma: a prospective study. Lancet Oncol 2008; 9: 713-20.
2. Jambusaria-Pahlajani A, Miller CJ, Quon H, Smith N, Klein RQ, Schmults CD: Surgical monotherapy versus surgery plus adjuvant radiotherapy in highrisk cutaneous squamous cell carcinoma: a systematic review of outcomes. Dermatol Surg 2009; 35: 574-85.
3. Mendelsohn J, Baselga J: Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 2003; 21: 2787-99.
4. Fogarty GB, Conus NM, Chu J, McArthur G: Characterization of the expression and activation of the epidermal growth factor receptor in squamous cell carcinoma of the skin. Br J Dermatol 2007; 156: 92-8.
5. Huang SM, Bock JM, Harari PM: Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 1999; 59: 1935-40.
6. Bonner JA, Harari PM, Giralt J, Azarnia N, Shin DM, Cohen RB, Jones CU, Sur R, Raben D, Jassem J, Ove R, Kies MS, Baselga J, Youssoufian H, Amellal N, Rowinsky EK, Ang KK: Radiotherapy plus cetuximab for squamouscell carcinoma of the head and neck. N Engl J Med 2006; 354: 567-78.
7. Bonner JA, Buchsbaum DJ, Russo SM, Fiveash JB, Trummell HQ, Curiel DT, Raisch KP: Anti-EGFR-mediated radiosensitization as a result of augmented EGFR expression. Int J Radiat Oncol Biol Phys 2004; 59: 2-10.
8. Wacker B, Nagrani T, Weinberg J, Witt K, Clark G, Cagnoni PJ: Correlation between development of rash and efficacy in patients treated with the epidermal growth factor receptor tyrosine kinase inhibitor erlotinib in two large phase III studies. Clin Cancer Res 2007; 13: 3913-3921.
9. Lacouture ME, Melosky BL: Cutaneous reactions to anticancer agents targeting the epidermal growth factor receptor: a dermatology-oncology perspective. Skin Therapy Lett 2007; 12: 1-5.
10. Bernier J, Bonner J, Vermorken JB, Bensadoun RJ, Dummer R, Giralt J, Kornek G, Hartley A, Mesia R, Robert C, Segaert S, Ang KK: Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck. Ann Oncol 2008; 19: 142-149.