Sensitivity and resistance towards isoliquiritigenin, doxorubicin and methotrexate in T cell acute lymphoblastic leukaemia cell lines by pharmacogenomics

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 382, Issue 3, 2010, Pages 221-234

  Youns, Mahmoud ^a   Fu, Yu Jie ^b   Zu, Yuan Gang ^b   Kramer, Anne ^c   Konkimalla, V Badireenath ^c   Radlwimmer, Bernhard ^c   Sültmann, Holger ^c   Efferth, Thomas ^a,c  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b NORTHEAST FORESTRY UNIVERSITY   (China)

^c GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

Chalcone flavonoid; Chemotherapy; Molecular pharmacology; Natural products; Pharmacogenomics; Tumour genetics

Indexed keywords

DOXORUBICIN; ISOLIQUIRITIGENIN; MESSENGER RNA; METHOTREXATE; TAMOXIFEN; TRANSCRIPTOME;

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CANCER RESISTANCE; COMPARATIVE GENOMIC HYBRIDIZATION; CONTROLLED STUDY; CROSS RESISTANCE; CYTOTOXICITY; DRUG MECHANISM; DRUG SENSITIVITY; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL LINE; MICROARRAY ANALYSIS; PHARMACOGENOMICS; PROTEIN EXPRESSION; T LYMPHOCYTE;

ANTIMETABOLITES, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHALCONES; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION PROFILING; HUMANS; INHIBITORY CONCENTRATION 50; JURKAT CELLS; LEUKEMIA, T-CELL; METHOTREXATE; MICROARRAY ANALYSIS; PHARMACOGENETICS; RNA, MESSENGER;

EID: 77957584403     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-010-0541-6     Document Type: Article

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