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The role of activins and follistatins in the skin and hair follicle development and function
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Hashimoto O, Nakamura T, Shoji H, Shimasaki S, Hayashi Y, Sugino H: A novel role of follistatin, an activin-binding protein, in the inhibition of activin action in rat pituitary cells. Endocytotic degradation of activin and its acceleration by follistatin associated with cell-surface heparin sulfate. J. Biol. Chem. 272, 13835-13842 (2007).
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The structure of FSTL3 activin A complex
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Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenic proteins
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Sidis Y, Mukherjee A, Keutmann H, Delbaere A, Sadatsuki M, Schneyer A: Biological activity of follistatin isoforms and follistatin-like-3 is dependent on differential cell surface binding and specificity for activin, myostatin, and bone morphogenic proteins. Endocrinology 147, 3586-3597 (2006).
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□ Excellent current review on the emerging role of activin in inflammation
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Activin A: A novel player and inflammatory marker of in inflammatory bowed disease?
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Activin A is an acute allergen-responsive cytokine and provides a link to TGF-β-mediated airway remodeling in asthma
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Temporal expression of activin in acute burn wounds from inflammatory cells to fibroblasts
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McLean CA, Cleland H, Monerieff NJ, Barton RJ, De Kretser DM, Phillips DJ: Temporal expression of activin in acute burn wounds from inflammatory cells to fibroblasts. Burns 34, 50-55 (2008).
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Potential anti-inflammatory role of activin A in acute coronary syndromes
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Evidence for activin A and follistatin involvement in the systemic inflammatory response
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17
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33846838410
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Activin A release into cerebrospinal fluid in a subset of patients with severe traumatic brain injury
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Phillips DJ, Nguyen P, Adamides AA et al.: Activin A release into cerebrospinal fluid in a subset of patients with severe traumatic brain injury. J. Neurotrauma 23, 1283-1294 (2006).
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Serum follistatin concentrations are increased in patients with septicaemia
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Serum concentrations of activin and follistatin are elevated and run in parallel in patients with septicemia
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Michel U, Ebert S, Phillips D, Nau R: Serum concentrations of activin and follistatin are elevated and run in parallel in patients with septicemia. Eur. J. Endocrinol. 148, 559-564 (2003).
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TGF-β superfamiliy members promote survival of midbrain dopaminergic neurons and protect them against MPP+ toxicity
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Activin A concentrations in human cerebrospinal fluid are age-dependent and elevated in meningitis
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Ebert S, Phillips DJ, Jenzewski P, Nau R, O'Connor AE, Michel U: Activin A concentrations in human cerebrospinal fluid are age-dependent and elevated in meningitis. J. Neurol. Sci. 250, 50-57 (2006).
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Regulation of activin A synthesis in microglial cells: Pathophysiological implications or bacterial meningitis
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Increased activin levels in cerebrospinal fluid of rabbits with bacterial meningitis are associated with activation of microglia
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Activin A release into the circulation is an early event in systemic inflammation and precedes the release of follistatin
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Jones KL, Braumann JN, Groome NP, De Kretser DM, Phillips DJ: Activin A release into the circulation is an early event in systemic inflammation and precedes the release of follistatin. Endocrinology 141, 1905-1908 (2000).
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Characterisation of the rapid release of activin A following acute lipopolysaccharide challenge in the ewe
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□ Key article describing the potential of follistatin FS to reduce mortality in a mouse model of acute systemic inflammation
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Jones KL, De Kretser DM, Clarke IJ, Scheerlinck J-PY, Phillips DJ: Characterisation of the rapid release of activin A following acute lipopolysaccharide challenge in the ewe. J. Endocrinol. 182, 69-80 (2004). □ Key article describing the potential of follistatin (FS) to reduce mortality in a mouse model of acute systemic inflammation.
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Effects of age and pregnancy on the circulatory activin response of sheep to acute inflammatory challenge by lipopolysaccharide
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McClure L, O'Connor AE, Hayward S, Jenkin G, Walker DW, Phillips DJ: Effects of age and pregnancy on the circulatory activin response of sheep to acute inflammatory challenge by lipopolysaccharide. J. Endocrinol. 185, 139-149 (2005).
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Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia
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Jones KL, Mansell A, Patella S, Scott BJ, Hedger MP, De Kretser DM, Phillips DJ: Activin A is a critical component of the inflammatory response, and its binding protein, follistatin, reduces mortality in endotoxemia. Proc. Natl Acad. Sci. USA 104, 16239-16244 (2007).
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Follistatin concentrations in male sheep increase following sham castration/castration or injection of interleukin-1β
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Follistatin has a biphasic response but follicle-stimulating hormone is unchanged during an inflammatory episode in growing lambs
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Activin-A: A novel dendritic cell-derived cytokine that potently attenuates CD40 ligand-specific cytokine and chemokine production
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Contrasting effects of inflammatory cytokines and glucocorticoids on the production of activin A in human marrow stromal cells and their implications
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