Fused tricyclic pyrrolizinones that exhibit pseudo-irreversible blockade of the NK1 receptor

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 19, 2010, Pages 5925-5932

  Morriello, Gregori J ^a   Chicchi, Gary ^a   Johnson, Tricia ^a   Mills, Sander G ^a   Demartino, Julie ^a   Kurtz, Marc ^a   Tsao, K L C ^a   Zheng, Song ^a   Tong, Xinchun ^a   Carlson, Emma ^a   Townson, Karen ^a   Wheeldon, Alan ^a   Boyce, Susan ^a   Collinson, Neil ^a   Rupniak, Nadia ^a   Devita, Robert J ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Functional IP; Neurokinin; Neurokinin 1 antagonists

Indexed keywords

NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; PYRROLIDINE DERIVATIVE; TRICYCLIC PYRROLIZINONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG SYNTHESIS; HUMAN; IC 50; NONHUMAN; RAT; RECEPTOR BLOCKING;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; DOGS; HUMANS; MACACA MULATTA; MICROSOMES; PYRROLIDINES; RATS; RECEPTORS, NEUROKININ-1; STRUCTURE-ACTIVITY RELATIONSHIP;

GERBILLINAE;

EID: 77957577496     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.07.058     Document Type: Article

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