Pyrrolidine-carboxamides and oxadiazoles as potent hNK1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 19, 2007, Pages 5310-5315

  Young, Jonathan R ^a   Eid, Ronsar ^a   Turner, Cherilyn ^a   DeVita, Robert J ^a   Kurtz, Marc M ^a   Tsao, Kwei Lan C ^a   Chicchi, Gary G ^a   Wheeldon, Alan ^b   Carlson, Emma ^b   Mills, Sander G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

NK1 antagonists; Substance P

Indexed keywords

AMIDE; APREPITANT; CYTOCHROME P450; LIVER ENZYME; NEUROKININ 1 RECEPTOR ANTAGONIST; OXADIAZOLE DERIVATIVE; PYRROLIDINE DERIVATIVE;

ARTICLE; BINDING AFFINITY; DRUG ACTIVITY; DRUG DETERMINATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; NAUSEA AND VOMITING; NONHUMAN;

ALKALOIDS; ANTIVIRAL AGENTS; CELL LINE; CHROMATOGRAPHY, ION EXCHANGE; HEPATITIS B E ANTIGENS; HEPATITIS B SURFACE ANTIGENS; HEPATITIS B VIRUS; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MENISPERMACEAE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; OXADIAZOLES; PYRROLIDINES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 34548591161     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.08.028     Document Type: Article

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