Effectiveness of topical zinc oxide application on hypertrophic scar development in rabbits

Burns

Volumn 36, Issue 7, 2010, Pages 1027-1035

  Aksoy, Berna ^a,b   Atakan, Nilgün ^a   Aksoy, H Mete ^b   Tezel, Gaye Güler ^a   Renda, Nurten ^a   Özkara, H Asuman ^a   Önder, Evren ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

^b Private Konak Hospital   (Turkey)

Author keywords

Animal study; Hypertrophic scar; Prophylaxis; Zinc oxide

Indexed keywords

PLACEBO; ZINC OXIDE;

ANIMAL EXPERIMENT; CONFERENCE PAPER; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; HISTOPATHOLOGY; HYPERTROPHIC SCAR; NONHUMAN; RABBIT; SCAR FORMATION; SKINFOLD THICKNESS;

ADMINISTRATION, TOPICAL; ANIMALS; CICATRIX, HYPERTROPHIC; DERMATOLOGIC AGENTS; DISEASE MODELS, ANIMAL; EAR, EXTERNAL; HYDROXYPROLINE; RABBITS; WOUND HEALING; WOUNDS AND INJURIES; ZINC; ZINC OXIDE;

EID: 77957557956     PISSN: 03054179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.burns.2010.01.020     Document Type: Conference Paper

References (41)

1. O. Kloeters, A. Tandara, and T.A. Mustoe Hypertrophic scar model in the rabbit ear: a reproducible model for studying scar tissue behavior with new observations on silicone gel sheeting for scar reduction Wound Repair Regen 15 2007 S40 S45
2. D. Wolfram, A. Tzankov, P. Pülzl, and H. Piza-Katzer Hypertrophic scar and keloids - a review of their pathophysiology, risk factors, and therapeutic management Dermatol Surg 35 2009 171 181
3. F.B. Niessen, P.H.M. Spauwen, J. Schalkwijk, and M. Kon On the nature of hypertrophic scars and keloids: a review Plast Reconstr Surg 104 1999 1435 1458
4. M.C.T. Bloemen, W.M. van der Veer, M.M.W. Ulrich, P.P.M. van Zuijlen, F.B. Niessen, and E. Middelkoop Prevention and curative management of hypertrophic scar formation Burns 35 2009 463 475
5. C.W. Su, K. Alizadeh, A. Boddie, and R.C. Lee The problem scar Clin Plast Surg 25 1998 451 465
6. D. Elliot, R. Cory-Pearce, and G.M. Rees The behaviour of presternal scars in a fair skinned population Ann R Coll Surg Engl 67 1985 238 240
7. E.A. Deitch, T.M. Wheelahan, M.P. Rose, J. Clothier, and J. Cotter Hypertrophic burn scars: analysis of variables J Trauma 23 1983 895 898
8. W.M. van der Veer, M.C.T. Bloemen, M.M.W. Ulrich, G. Molema, P.P. van Zuijlen, and E. Middelkoop Potential cellular and molecular causes of hypertrophic scar formation Burns 35 2009 15 29
9. S. Stenström, G. Hallmans, A. De Jongh, and T. De Wael Leprosy wound healing with ordinary adhesive tape: a preliminary report Scand J Plast Reconstr Surg 10 1976 241 244 (Pubitemid 8063375)
10. T. Söderberg, G. Hallmans, and L. Bartholdson Treatment of keloids and hypertrophic scars with adhesive zinc tape Scand J Plast Reconstr Surg 16 1982 261 266 (Pubitemid 13124273)
11. M.L.C. Ramos, A. Gragnani, and L.M. Ferreira Is there an ideal animal model to study hypertrophic scarring? J Burn Care Res 29 2008 363 368
12. D.E. Morris, L. Wu, L.L. Zhao, L. Bolton, S.I. Roth, and D.A. Ladin Acute and chronic animal models for excessive dermal scarring: quantitative studies Plast Reconstr Surg 100 1997 674 681
13. I. Bergman, and R. Loxley Two improved and simplified methods for the spectrophotometric determination of hydroxyproline Anal Chem 35 1963 1961 1965
14. G. Hallmans Local absorption of zinc from wounds treated with various zinc-compounds Acta Derm Venereol (Stockh) 58 1978 251 256
15. H.M. Aksoy, I. Vargel, H.I. Canter, Y. Erk, M. Sargon, and A. Pinar A new experimental hypertrophic scar model in guinea pigs Aesthetic Plast Surg 26 2002 388 396
16. M.S. Agren Studies on zinc in wound healing Acta Derm Venereol Suppl (Stoch) 154 1990 1 36
17. M.S. Agren Zinc in wound repair Arch Dermatol 135 1999 1273 1274
18. A.B.G. Lansdown, U. Mirastschijski, N. Stubbs, E. Scanlon, and M.S. Agren Zinc in wound healing: theoretical, experimental, and clinical aspects Wound Repair Regen 15 2007 2 16
19. K. Kubota, M. Kumakiri, Y. Miura, K. Hine, N. Kori, and H. Saito Clinical studies on zinc oxide ointment replacing boric acid and zinc oxide ointment (JP8) Hokkaido Igaku Zasshi 58 1983 400 405
20. G. Hallmans Healing of experimentally induced burn wounds: a comparative study of the healing of exposed burn wounds and burn wounds covered with adhesive zinc-tape and a scanning electron microscopic study of the microvasculature of wound healing in the rabbit ear Scand J Plast Reconstr Surg 12 1978 105 109
21. G. Hughes, and N.R. McLean Zinc oxide tape: a useful dressing for the recalcitrant finger-tip and soft-tissue injury Arch Emerg Med 5 1988 223 227
22. G. Hallmans Treatment of burns with zinc-tape: a study of local absorption of zinc in humans Scand J Plast Reconstr Surg 11 1977 155 161
23. G. Hallmans, L. Hanström, and E. Lundgren The effect of zinc tape upon wound healing a biochemical, histochemical and histological study in rats Scand J Plast Reconstr Surg 13 1979 251 259
24. J.L. Seltzer, J.J. Jeffrey, and A.Z. Eisen Evidence for mammalian collagenases as zinc ion metalloenzymes Biochim Biophys Acta 485 1977 179 187
25. M.S. Agren Zinc oxide increases degradation of collagen in necrotic wound tissue Br J Dermatol 129 1993 221
26. M.S. Agren, M. Chvapil, and L. Franzen Enhancement of re-epithelialization with topical zinc oxide in porcine partial-thickness wounds J Surg Res 50 1991 101 105
27. I. Tenaud, I. Sainte-Marie, O. Jumbou, P. Litoux, and B. Dreno In vitro modulation of keratinocyte wound healing integrins by zinc, copper and manganese Br J Dermatol 140 1999 26 34
28. M. Iwata, T. Takebayashi, H. Ohta, R.E. Alcalde, Y. Itano, and T. Matsumura Zinc accumulation and metallothionein gene expression in the proliferating epidermis during wound healing in mouse skin Histochem Cell Biol 112 1999 283 290
29. P. Tarnow, M. Agren, H. Steenfos, and J.O. Jansson Topical zinc oxide treatment increases endogenous gene expression of insulin-like growth factor-1 in granulation tissue from porcine wounds Scand J Plast Reconstr Surg Hand Surg 28 1994 255 259
30. M.S. Agren, U. Ostenfeld, F. Kallehave, Y. Gong, K. Raffn, and M.E. Crawford A randomized, double-blind, placebo-controlled multicenter trial evaluating topical zinc oxide for acute open wounds following pilonidal disease excision Wound Repair Regen 14 2006 526 535
31. M.S. Agren, T.A. Söderberg, C.-O. Reuterving, G. Hallmans, and I. Tengrup Effect of topical zinc oxide on bacterial growth and inflammation in full-thickness skin wounds in normal and diabetic rats Eur J Surg 157 1991 97 101
32. W.T. Lawrence Physiology of the acute wound Clin Plast Surg 25 1998 321 340
33. M.A. Kowalska, D. Juliano, M. Trybulec, W. Lu, and S. Niewiarowski Zinc ions potentiate adenosine diphosphate-induced platelet aggregation by activation of protein kinase C J Lab Clin Med 123 1994 102 109
34. P.A. Hebda, M.A. Collins, and M.D. Tharp Mast cell and myofibroblast in wound healing Dermatol Clin 11 1993 685 696
35. M.S. Agren, and L. Franzen Influence of zinc deficiency on breaking strength of 3-week-old skin incisions in the rat Acta Chir Scand 156 1990 667 670
36. N.F. Adham, M.K. Song, and H. Rinderknecht Binding of zinc to alpha-2-macroglobulin and its role in enzyme binding activity Biochim Biophys Acta 495 1977 212 219
37. L. Jin, T.H. Murakami, N.A. Janjua, and Y. Hori The effects of zinc oxide and diethyldithiocarbamate on the mitotic index of epidermal basal cells of mouse skin Acta Med Okayama 48 1994 231 236
38. A. Senapati, and R.P.H. Thompson Zinc deficiency and the prolonged accumulation of zinc in wounds Br J Surg 72 1985 583 584
39. A.R. Lee, and W.H. Huang Zinc sulphadiazines: novel topical antimicrobial agents for burns J Pharm Pharmacol 47 1995 503 509
40. Y. Sawada, and K. Sone Hydration and occlusion treatment for hypertrophic scars and keloids Br J Plast Surg 45 1992 599 603
41. J. Joseph, and F.J. Townsend The healing of defects in immobile skin in rabbits Br J Surg 48 1961 557 564