Is there an ideal animal model to study hypertrophic scarring?

Journal of Burn Care and Research

Volumn 29, Issue 2, 2008, Pages 363-368

  Ramos, Maria Luiza Christovão ^a   Gragnani, Alfredo ^a   Ferreira, Lydia M ^a  

^a FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL MODEL; ARTICLE; CHEMICAL INJURY; FULL THICKNESS SKIN GRAFT; GUINEA PIG; HISTOLOGY; HYPERTROPHIC SCAR; IMMUNE DEFICIENCY; KELOID; MEDICAL RESEARCH; NONHUMAN; PATHOPHYSIOLOGY; PROPHYLAXIS; RABBIT; SKIN TOXICITY; SWINE; VALIDATION STUDY; WOUND HEALING;

ANIMALS; CICATRIX, HYPERTROPHIC; MODELS, ANIMAL; RABBITS; RISK FACTORS; SWINE; WOUND HEALING;

EID: 41849124209     PISSN: 1559047X     EISSN: 15590488     Source Type: Journal    
DOI: 10.1097/BCR.0b013e3181667557     Document Type: Article

References (41)

1. Atiyeh BS, Costagliola M, Hayek SN. Keloid or hypertrophic scar: the controversy: review of the literature. Ann Plast Surg 2005;54:676-80.
2. Hillmer MP, MacLeod SM, Experimental keloid scar models: a review of methodological issues. J Cutan Med Surg 2002;6:354-9.
3. Campaner AB, Ferreira LM, Gragnani A, Bruder JM, Cusick JL, Morgan JR. Upregulation of TGF-beta1 expression may be necessary but is not sufficient for excessive scarring. J Invest Dermatol 2006;126:1168-76.
4. Hochman B, Vilas Boas FC, Mariano M, Ferreiras LM. Keloid heterograft in the hamster (Mesocricetus auratus) cheek pouch, Brazil. Acta Cir Bras 2005;20:200-12.
5. Greenhalgh DG, Models of wound healing. J Burn Care Rehabil 2005;26:293-305.
6. Dorsett-Martin WA. Rat models of skin wound healing: a review. Wound Repair Regen 2004;12:591-9.
7. Ferreira LM, Hochman B, Barbosa MVJ. Experimental models in research. Acta Cir Bras 2005;20:28-34.
8. Shetlar MR, Shetlar CL, Hendricks L, Kischer JW. The use of athymic nude mice for the study of human keloids. Proc Soc Exp Biol Med 1985;179:549-52.
9. Kischer CW, Pindur J, Shetlar MR, Shetlar CL. Implants of hypertrophic scars and keloids into the nude (athymic) mouse: viability and morphology. J Trauma 1989;29:672-7.
10. Kischer CW, Sheridan D, Pindur J. Use of nude (athymic) mice for the study of hypertrophic scars and keloids: vascular continuity between mouse and implants. Anat Rec 1989;225:189-96.
11. Polo M, Kim YJ, Kucukcelebi A, Hayward PG, Ko F, Robson MC. An in vivo model of human proliferative scar. J Surg Res 1998;74:187-95.
12. Escamez MJ, Garcia M, Larcher F, et al. An in vivo model of wound healing in genetically modified skin-humanized mice. J Invest Dermatol 2004;123:1182-91.
13. Yang DY, Li SR, Li G, et al. [Establishment of an animal model of human hyperplastic scar in nude mice.] Zhonghua Shao Shang Za Zhi 2004;20:82-4.
14. Aksoy MH, Vargel I, Canter IH, et al. A new experimental hypertrophic scar model in guinea pigs. Aesthetic Plast Surg 2002;26:388-96.
15. Morris DE, Whu L, Zhao LL, et al. Acute and chronic animal models for excessive dermal scarring: quantitative studies. Plast Reconstr Surg 1997;100:674-81.
16. Marcus JR, Tyrone JW, Bonoma S, Xia Y, Mustoe TA. Cellular mechanisms for diminished scarring with aging. Plast Reconstr Surg 2000;105:1591-9.
17. Saulis AS, Mogford JH, Mustoe TA. Effect of mederma on hypertrophic scarring in the rabbit ear model. Plast Reconst Surg 2002;110:177-183.
18. Kim I, Mogford JE, Witschi C, Nafissi M, Mustoe TA. Inhibition of prolyl 4-hydroxylase reduces scar hypertrophy in a rabbit model of cutaneous scarring. Wound Repair Regen 2003;11:368-72.
19. Reid RR, Mogford JE, Butt R, deGiorgio-Miller A, Mustoe TA. Inhibition of procollagen C-proteinase reduces scar hypertrophy in a rabbit model of cutaneous scarring. Wound Repair Regen 2006;14:138-41.
20. Reid RR, Roy N, Mogford JE, Zimmerman H, Lee C, Mustoe TA. Reduction of hypertrophic scar via retroviral delivery of a dominant negative TGF-beta receptor II. J Plast Reconstr Aesthet Surg 2007;60:64-72, discussion 73-4.
21. Lu L, Saulis AS, Liu WR, et al. The temporal effects of anti-TGF-beta1, 2, and 3 monoclonal antibody on wound healing and hypertrophic scar formation. J Am Coll Surg 2005;201:391-7.
22. Lee JP, Jalili RB, Tredget EE, Demare JA, Ghahary A. Antifibrogenic effects of liposome-encapsulated IFN-alpha2b cream on skin wounds in a fibrotic rabbit ear model. J Interferon Cytokine Res 2005;25:627-31.
23. Shoemaker J. A practical treatise on diseases of the skin. New York and London: D Appleton and Company; 1905.
24. Jackson DM. [The diagnosis of the depth of burning.] Br J Surg 1953;40:588-96.
25. Matsumura H, Engrav LH, Gibran NS, et al. Cones of skin occur where hypertrophic scar occurs. Wound Repair Regen 2001;9:269-77.
26. Silverman KJ, Lund DP, Zetter BR, et al. Angiogenic activity of adipose tissue. Biochem Biophys Res Commun 1988;153:347-52.
27. Dobson DE, Kambe A, Block E, et al. 1-Butyryl-glycerol: a novel angiogenesis factor secreted by differentiating adipocytes. Cell 1990;61:223-30.
28. Kern PA, Saghizadeh M, Ong JM, Bosch RJ, Deem R, Simsolo RB. The expression of tumor necrosis factor in human adipose tissue. Regulation by obesity, weight loss, and relationship to lipoprotein lipase. J Clin Invest 1995;95:2111-19.
29. Sullivan TP, Eaglstein WH, Davis SC, Mertz P. The pig as a model for human wound healing. Wound Repair Regen 2001;9:66-76.
30. Silverstein P, GoodwinMJr, Raulston G. Hypertrophic Scarring, etiology and control. In: Ann Res Progress Report of the US Army Institute of Surgical Research (section 37). 1972.
31. Silverstein P, Goodwin M Jr, Raulston G. Hypertrophic scar in the experimental animal. In: Longacre J, editor. The ultrastructure of collagen. Springfield, IL: Thomas; 1976.
32. Zhu KQ, Engrav LH, Gibran NS, et al. The female, red Duroc pig as an animal model of hypertrophic scarring and the potential role of the cones of skin. Burns 2003;29:649-64.
33. Zhu KQ, Engrav LH, Tamura RN, et al. Further similarities between cutaneous scarring in the female, red Duroc pig and human hypertrophic scarring. Burns 2004;30:518-30.
34. Liang Z, Enqrav LH, Muangman P, et al. Nerve quantification in female red Duroc pig (FRDP) scar compared to human hypertrophic scar. Burns 2004;30:57-64.
35. Zhu KQ, Engrav LH, Armendariz R, et al. Changes in VEGF and nitric oxide after deep dermal injury in the female, red Duroc pig-further similarities between female, Duroc scar and human hypertrophic scar. Burns 2005;31:5-10.
36. Harunari N, Zhu KQ, Armendariz RT, et al. Histology of the thick scar on the female, red Duroc pig: final similarities to human hypertrophic scar. Burns 2006;32:669-77.
37. Gallant CL, Olson ME, Hart DA. Molecular, histologic, and gross phenotype of skin wound healing in red Duroc pigs reveals an abnormal healing phenotype of hypercontracted, hyperpigmented scarring. Wound Repair Regen 2004;12:305-19.
38. Gallant-Behm CL, Olson ME, Hart DA. Cytokine and growth factor mRNA expression patterns associated with the hypercontracted, hyperpigmented healing phenotype of red duroc pigs: a model of abnormal human scar development? J Cutan Med Surg 2005;9:165-77.
39. Stewart CJ, Gallant-Behm CL, Forrester K, Tulip J, Hart DA. Kinetics of blood flow during healing of excisional full-thickness skin wounds in pigs as monitored by laser speckle perfusion imaging. Skin Res Technol 2006;12:247-53.
40. Gallant-Behm CL, Reno C, Tsao H, Hart DA. Genetic involvement in skin wound healing and scarring in domestic pigs: assessment of molecular expression patterns in (Yorkshire x Red Duroc) x Yorkshire backcross animals. J Invest Dermatol 2007;127:233-44.
41. Cuttle L, Kempf M, Phillips GE, et al. A porcine deep dermal partial thickness burn model with hypertrophic scarring. Burns 2006;32:806-20.