Fluorocurcumins as cyclooxygenase-2 inhibitor: Molecular docking, pharmacokinetics and tissue distribution in mice

Pharmaceutical Research

Volumn 26, Issue 11, 2009, Pages 2438-2445

  Padhye, Subhash ^a   Banerjee, Sanjeev ^b   Chavan, Deepak ^a   Pandye, Shubhangini ^c   Swamy, K Venkateswara ^c   Ali, Shadan ^b   Li, Jing ^d   Dou, Q Ping ^b   Sarkar, Fazlul H ^b  

^a DR D Y PATIL INSTITUTE OF PHARMACEUTICAL SCIENCES AND RESEARCH   (India)

^b WAYNE STATE UNIVERSITY   (United States)

^c DR D Y PATIL BIOTECHNOLOGY AND BIOINFORMATICS INSTITUTE   (India)

^d WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

COX 2; Curcumin; Fluorocurcumin; Pharmacokinetics

Indexed keywords

CURCUMIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; FLUOROCURCUMIN DERIVATIVE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROSTAGLANDIN E2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AREA UNDER THE CURVE; ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DOWN REGULATION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG PROTEIN BINDING; DRUG RETENTION; DRUG TISSUE LEVEL; FEMALE; HUMAN; HUMAN CELL; HYDROGEN BOND; MAXIMUM PLASMA CONCENTRATION; MOLECULAR DOCKING; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; STEREOCHEMISTRY; TIME TO MAXIMUM PLASMA CONCENTRATION; TISSUE DISTRIBUTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CURCUMIN; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; FEMALE; HUMANS; MICE; MICE, SCID; MODELS, MOLECULAR; PANCREATIC NEOPLASMS; TISSUE DISTRIBUTION;

EID: 70350217623     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-9955-6     Document Type: Article

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