Reducing the mean size of API crystals by continuous manufacturing with product classification and recycle

Chemical Engineering Science

Volumn 65, Issue 21, 2010, Pages 5770-5780

  Griffin, Derek W ^a   Mellichamp, Duncan A ^a   Doherty, Michael F ^a  

^a University of California   (United States)

Author keywords

Continuous crystallization; Design; Particle micronization; Pharmaceuticals; Product classification; Systems engineering

Indexed keywords

ACTIVE PHARMACEUTICAL INGREDIENTS; CONTINUOUS CRYSTALLIZATION; COST SAVING; INDUSTRIAL CRYSTALLIZERS; KINETIC MODELS; LARGE CRYSTAL; LIMIT CYCLE; MEAN SIZE; MICRONIZATIONS; MOTHER LIQUOR; NARROW DISTRIBUTION; NEW PRODUCT; OPERATING STRATEGY; PARTICLE MICRONIZATION; PHARMACEUTICALS; PROCESS FLOW-SHEET; PRODUCT CLASSIFICATION; PRODUCTION RATES; SIMPLE MODIFICATIONS; SIZE REDUCTIONS; SMALL CRYSTALS;

CLASSIFIERS; CRYSTALLIZATION; DESIGN; DRUG PRODUCTS; RECYCLING; SUPERSATURATION; SYSTEMS ENGINEERING;

CRYSTALLIZERS;

EID: 77957370741     PISSN: 00092509     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ces.2010.05.026     Document Type: Article

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