Quantifying solubility enhancement due to particle size reduction and crystal habit modification: Case study of acetyl salicylic acid

Journal of Pharmaceutical Sciences

Volumn 96, Issue 8, 2007, Pages 1967-1973

  Hammond, Robert B ^a   Pencheva, Klimentina ^a   Roberts, Kevin J ^c   Auffret, Tony ^b  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

^c NONE

Author keywords

Aspirin; Crystal morphology; Drug formulation; Gibbs Thompson effect; Interfacial tension; Molecular modeling; Nano crystal technology; Solubility enhancement; Solvent selection

Indexed keywords

ACETYLSALICYLIC ACID; ALCOHOL;

ARTICLE; CRYSTAL STRUCTURE; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STRUCTURE; HYDROPHILICITY; HYDROPHOBICITY; MATHEMATICAL MODEL; MOLECULAR MODEL; PARTICLE SIZE; SOLVENT EFFECT;

EID: 34548016063     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.20869     Document Type: Article

References (17)

1. Ostwald W. 1897. Studien uber die Bildung und Umwandlung fester Korper. Zeitschrift fur Physikalische Chemie (Leipzig) 22:289-329.
2. Ostwald W. 1900. Uber die vermeintliche Isomeriw des roten und gelben Quecksilberoxyds und die Oberflachenspannung fester Korper. Zeitschrift fur Physikalische Chemie (Leipzig) 34:493-503.
3. Mullin J. 2001. Crystallization (4th edition). London: Btterworth Heinemann.
4. Hulett G. 1905. The solubility of gypsum as affected by size of particles and by different crystallographic surfaces. J Am Chem Soc 27:49-56.
5. Dundon M, Mack E. 1923. The solubility and surface energy of calcium sulfate. J Am Chem Soc 45:2479-2485.
6. Sokolova E. 1990. Chemical thermodynamics. Sofia: Nauka i Izkustvo.
7. Hammond R, Pencheva K, Roberts K. 2006. A structural-kinetic approach to model face-specific solution/crystal surface energy associated with the crystallization of acetyl salicylic acid from supersaturated aqueous/ethanol solution. Cryst Growth Des 6:1324.
8. Hammond R, Ma C, Roberts K, Ghi P, Harris R. 2003. Application of systematic search methods to studies of the structures urea-dihydroxy benzene co-crystals. J Phys Chem B 107:11820-11826.
9. Roberts K, Walker E, Clydesdale G. 1996. The crystal habit of molecular materials: A structural perspective. Chapter 7. In: Gavezzotti A, editor. Theoretical aspects and computer modelling. New York: John Wiley & Sons, Inc. pp 203.
10. Watanabe A, Yamaoka Y, Takada K. 1982. Crystal habit and dissolution behavior of aspirin. Chem Pharm Bull 30:2958.
11. Meenan P. 1997. Crystal morphology predictive techniques to cheracterize crystal habit: Application to aspirin. ACS Symp Ser 667:2.
12. Ullmann F, Elvers B, Buchhalz H, Gerhartz W. 1990. Ullmanns encyclopedia of industrial chemistry. Weinheim: Wiley-VCH.
13. Parsons G, Buckton G, Chatham S. 1992. The use of surface energy and polarity determinations to predict physical stability of non-polar, non-aqueous suspensions. Int J Pharm 83:163.
14. Kashchiev D. 2000. Nucleation - basic theory with applications. Oxford: Butterworth Heinemann.
15. Walton A, Whitman D. 1963. Calculation of the surface energy for some orthorombic sulfates. J Chem Phys 40:2722.
16. Samsonov V, Sdobnyakov N, Bazulev A. 2004. Size dependance of the surface tension and the problem of Gibbs thermodynamics extension to nanosystems. Colloids Surf A 239:113.
17. Knapp L. 1922. The solubility of small particles and the stability of colloids. Trans Faraday Soc 17:457-465.