메뉴 건너뛰기




Volumn 26, Issue 4, 2010, Pages 193-202

Iloperidone - A second-generation antipsychotic for the treatment of acute schizophrenia

Author keywords

[No Author keywords available]

Indexed keywords

CHLORPROMAZINE; CYTOCHROME P450 2D6; CYTOCHROME P450 3A4; FLUOXETINE; HALOPERIDOL; ILOPERIDONE; ITRACONAZOLE; KETOCONAZOLE; METHADONE; MOXIFLOXACIN; O DEMETHYLASE; PAROXETINE; QUINIDINE; RISPERIDONE; ZIPRASIDONE;

EID: 77957359401     PISSN: 87551225     EISSN: None     Source Type: Journal    
DOI: 10.1177/875512251002600404     Document Type: Review
Times cited : (3)

References (34)
  • 1
    • 0004050325 scopus 로고    scopus 로고
    • American Psychiatric Association. 2nd edition, (accessed 2010 Jan 11). DOI 10.1176/appi.books.9780890423363.45859
    • American Psychiatric Association. Practice guideline for the treatment of patients with schizophrenia. 2nd edition, 2004. www.psychiatryonline.com/ pracGuide/pracGuideChapToc-6.aspx (accessed 2010 Jan 11). DOI 10.1176/appi.books.9780890423363.45859
    • (2004) Practice Guideline for the Treatment of Patients with Schizophrenia
  • 3
    • 33645739107 scopus 로고    scopus 로고
    • Schizophrenia and other psychotic disorders
    • Sadock BJ, Sadock VA, eds. 8th ed. Philadelphia: Lippincott Williams & Wilkins
    • Buchanan RW, Carpenter WT, Lauriello J, et al. Schizophrenia and other psychotic disorders. In: Sadock BJ, Sadock VA, eds. Comprehensive textbook of psychiatry. 8th ed. Philadelphia: Lippincott Williams & Wilkins, 2005:1329-1558.
    • (2005) Comprehensive Textbook of Psychiatry , pp. 1329-1558
    • Buchanan, R.W.1    Carpenter, W.T.2    Lauriello, J.3
  • 4
    • 0032965694 scopus 로고    scopus 로고
    • The economic impact of schizophrenia
    • Rice DP. The economic impact of schizophrenia. J Clin Psychiatry 1999;60(supp 1):4-6.
    • (1999) J Clin Psychiatry , vol.60 , Issue.SUPPL. 1 , pp. 4-6
    • Rice, D.P.1
  • 6
    • 0032987267 scopus 로고    scopus 로고
    • Increased dopamine transmission in schizophrenia: Relationship to illness phases
    • DOI 10.1016/S0006 = 3223(99)00067-0
    • Laruelle M, Abi-Dargham A, Gil R, Kegeles L, Innis R. Increased dopamine transmission in schizophrenia: relationship to illness phases. Biol Psychiatry 1999;46:56-72. DOI 10.1016/S0006 = 3223(99)00067-0
    • (1999) Biol Psychiatry , vol.46 , pp. 56-72
    • Laruelle, M.1    Abi-Dargham, A.2    Gil, R.3    Kegeles, L.4    Innis, R.5
  • 7
    • 0029988896 scopus 로고    scopus 로고
    • Serotonin-dopamine interaction and its relevance to schizophrenia
    • Kapur S, Remington G. Serotonin-dopamine interaction and its relevance to schizophrenia. Am J Psychiatry 1996;153:466-76.
    • (1996) Am J Psychiatry , vol.153 , pp. 466-476
    • Kapur, S.1    Remington, G.2
  • 8
    • 0034678029 scopus 로고    scopus 로고
    • Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation
    • DOI 10.1126/science.287.5460.2020
    • Castner SA, Williams GV, Goldman-Rakic PS. Reversal of antipsychotic-induced working memory deficits by short-term dopamine D1 receptor stimulation. Science 2000;287:2020-2. DOI 10.1126/science.287.5460.2020
    • (2000) Science , vol.287 , pp. 2020-2022
    • Castner, S.A.1    Williams, G.V.2    Goldman-Rakic, P.S.3
  • 9
    • 55049106809 scopus 로고    scopus 로고
    • Upcoming agents for the treatment of schizophrenia: Mechanism of action, efficacy, and tolerability
    • DOI 10.2165/0003495-200868160-00002
    • Bishara D, Taylor D. Upcoming agents for the treatment of schizophrenia: mechanism of action, efficacy, and tolerability. Drugs 2008;68:2269-92. DOI 10.2165/0003495-200868160-00002
    • (2008) Drugs , vol.68 , pp. 2269-2292
    • Bishara, D.1    Taylor, D.2
  • 10
    • 12344326514 scopus 로고    scopus 로고
    • Treatments for schizophrenia: A critical review of pharmacology and mechanisms of action of antipsychotic drugs
    • DOI 10.1038/sj.mp.4001556
    • Miyamoto S, Duncan GE, Marx CE, Lieberman JA. Treatments for schizophrenia: a critical review of pharmacology and mechanisms of action of antipsychotic drugs. Mol Psychiatry 2005;10:79-104. DOI 10.1038/sj.mp.4001556
    • (2005) Mol Psychiatry , vol.10 , pp. 79-104
    • Miyamoto, S.1    Duncan, G.E.2    Marx, C.E.3    Lieberman, J.A.4
  • 11
    • 33646818313 scopus 로고    scopus 로고
    • Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia
    • DOI 10.2165/00023210-200620050-00004
    • Horacek J, Bubenikova-Valesova V, Kopecek M, et al. Mechanism of action of atypical antipsychotic drugs and the neurobiology of schizophrenia. CNS Drugs 2006;20:389-409. DOI 10.2165/00023210-200620050-00004
    • (2006) CNS Drugs , vol.20 , pp. 389-409
    • Horacek, J.1    Bubenikova-Valesova, V.2    Kopecek, M.3
  • 12
    • 25144456112 scopus 로고    scopus 로고
    • Effectiveness of antipsychotic drugs in patients with chronic schizophrenia
    • DOI 10.1056/NEJMoa051688
    • Lieberman JA, Stroup TS, McEvoy JP, et al. Effectiveness of antipsychotic drugs in patients with chronic schizophrenia. N Engl J Med 2005;353:1209-23. DOI 10.1056/NEJMoa051688
    • (2005) N Engl J Med , vol.353 , pp. 1209-1223
    • Lieberman, J.A.1    Stroup, T.S.2    McEvoy, J.P.3
  • 14
    • 19944429395 scopus 로고    scopus 로고
    • Glucose metabolism in patients with schizophrenia treated with atypical antipsychotic agents: A frequently sampled intravenous glucose tolerance test and minimal model analysis
    • DOI 10.1001/archpsyc.62.1.19
    • Henderson DC, Cagliero E, Copeland PM, et al. Glucose metabolism in patients with schizophrenia treated with atypical antipsychotic agents: a frequently sampled intravenous glucose tolerance test and minimal model analysis. Arch Gen Psychiatry 2005;62:19-28. DOI 10.1001/archpsyc.62.1.19
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 19-28
    • Henderson, D.C.1    Cagliero, E.2    Copeland, P.M.3
  • 15
    • 0036840804 scopus 로고    scopus 로고
    • An assessment of the independent effects of olanzapine and risperidone exposure and the risk of hyperlipidemia in schizophrenic patients
    • DOI 10.1001/archpsyc.59.11.1021
    • Koro CE, Fedder DO, L'Italien GJ, et al. An assessment of the independent effects of olanzapine and risperidone exposure and the risk of hyperlipidemia in schizophrenic patients. Arch Gen Psychiatry 2002;59:1021-6. DOI 10.1001/archpsyc.59.11.1021
    • (2002) Arch Gen Psychiatry , vol.59 , pp. 1021-1026
    • Koro, C.E.1    Fedder, D.O.2    L'Italien, G.J.3
  • 16
    • 85036748709 scopus 로고    scopus 로고
    • Rockville, MD: Vanda Pharmaceuticals, Inc.
    • Package insert. Fanapt (iloperidone). Rockville, MD: Vanda Pharmaceuticals, Inc., 2009.
    • (2009) Package Insert. Fanapt (Iloperidone)
  • 17
    • 0029050942 scopus 로고
    • The pharmacological profile of iloperidone, a novel atypical antipsychotic agent
    • Szewczak MR, Corbett R, Rush DK, et al. The pharmacological profile of iloperidone, a novel atypical antipsychotic agent. J Pharmacol Exp Ther 1995;274:1404-13.
    • (1995) J Pharmacol Exp Ther , vol.274 , pp. 1404-1413
    • Szewczak, M.R.1    Corbett, R.2    Rush, D.K.3
  • 19
    • 0035673012 scopus 로고    scopus 로고
    • Extended radioligand binding profile of iloperidone: A broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders
    • DOI 10.1016/S0893-133X(01)00285-8
    • Kalkman HO, Subramanian N, Hoyer D. Extended radioligand binding profile of iloperidone: a broad spectrum dopamine/serotonin/norepinephrine receptor antagonist for the management of psychotic disorders. Neuropsychopharmacology 2001;25:904-14. DOI 10.1016/S0893-133X(01)00285-8
    • (2001) Neuropsychopharmacology , vol.25 , pp. 904-914
    • Kalkman, H.O.1    Subramanian, N.2    Hoyer, D.3
  • 20
    • 0036199878 scopus 로고    scopus 로고
    • Receptor profile of P88-8991 and P95-12113, metabolites of the novel antipsychotic iloperidone
    • DOI 10.1016/S0278-5846(01)00307-4
    • Subramanian K, Kalkman HO. Receptor profile of P88-8991 and P95-12113, metabolites of the novel antipsychotic iloperidone. Prog Neuropsychopharmacol Biol Psychiatry 2002;26:553-63. DOI 10.1016/S0278-5846(01)00307-4
    • (2002) Prog Neuropsychopharmacol Biol Psychiatry , vol.26 , pp. 553-563
    • Subramanian, K.1    Kalkman, H.O.2
  • 21
    • 0029011364 scopus 로고
    • Safety, tolerability, and effect of food on the pharmacokinetics of iloperidone (HP 873), a potential atypical antipsychotic
    • Erratum. J Clin Pharmacol 1996;36:92
    • Sainati SM, Hubbard JW, Chi E, Grasing K, Brecher MB. Safety, tolerability, and effect of food on the pharmacokinetics of iloperidone (HP 873), a potential atypical antipsychotic. J Clin Pharmacol 1995;35:713-20. Erratum. J Clin Pharmacol 1996;36:92.
    • (1995) J Clin Pharmacol , vol.35 , pp. 713-720
    • Sainati, S.M.1    Hubbard, J.W.2    Chi, E.3    Grasing, K.4    Brecher, M.B.5
  • 22
    • 67649216860 scopus 로고    scopus 로고
    • Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia
    • DOI 10.4088/JCP.08m04391
    • Volpi S, Potkin SG, Malhotra AK, Licamele L, Lavedan C. Applicability of a genetic signature for enhanced iloperidone efficacy in the treatment of schizophrenia. J Clin Psychiatry 2009;70:801-9. DOI 10.4088/JCP.08m04391
    • (2009) J Clin Psychiatry , vol.70 , pp. 801-809
    • Volpi, S.1    Potkin, S.G.2    Malhotra, A.K.3    Licamele, L.4    Lavedan, C.5
  • 23
    • 40849089245 scopus 로고    scopus 로고
    • Efficacy of iloperidone in the treatment of schizophrenia: Initial phase 3 studies
    • DOI 10.1097/JCP.0b013e3181692787
    • Potkin SG, Litman RE, Torres R, Wolfgang CD. Efficacy of iloperidone in the treatment of schizophrenia: initial phase 3 studies. J Clin Psychopharmacol 2008;28:S4-11. DOI 10.1097/JCP.0b013e3181692787
    • (2008) J Clin Psychopharmacol , vol.28
    • Potkin, S.G.1    Litman, R.E.2    Torres, R.3    Wolfgang, C.D.4
  • 24
    • 40849111788 scopus 로고    scopus 로고
    • Four-week, double-blind, placebo- And ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia
    • DOI 10.1097/JCP.0b013e318169d4ce, PII 0000471420080400100004
    • Cutler AJ, Kalali AH, Weiden PJ, Hamilton J, Wolfgang CD. Four-week, double-blind, placebo- and ziprasidone-controlled trial of iloperidone in patients with acute exacerbations of schizophrenia. J Clin Psychopharmacol 2008;28:S20-8. DOI 10.1097/JCP.0b013e318169d4ce (Pubitemid 351397673)
    • (2008) Journal of Clinical Psychopharmacology , vol.28 , Issue.7 SUPPL. 1
    • Cutler, A.J.1    Kalali, A.H.2    Weiden, P.J.3    Hamilton, J.4    Wolfgang, C.D.5
  • 26
    • 0023606101 scopus 로고
    • The positive and negative syndrome scale (PANSS) for schizophrenia
    • Kay SR, Fiszbein A, Opler LA. The positive and negative syndrome scale (PANSS) for schizophrenia. Schizophrenia Bull 1987;13:261-76. (Pubitemid 18039085)
    • (1987) Schizophrenia Bulletin , vol.13 , Issue.2 , pp. 261-276
    • Kay, S.R.1    Fiszbein, A.2    Opler, L.A.3
  • 27
    • 0028036695 scopus 로고
    • The brief psychiatric rating scale: Effect of scaling system on clinical response assessment
    • DOI 10.1097/00004717-199410000-00010
    • Thompson PA, Buckley PF, Meltzer HY. The brief psychiatric rating scale: effect of scaling system on clinical response assessment. J Clin Psychopharmacol 1994;14:344-6. DOI 10.1097/00004717-199410000-00010
    • (1994) J Clin Psychopharmacol , vol.14 , pp. 344-346
    • Thompson, P.A.1    Buckley, P.F.2    Meltzer, H.Y.3
  • 28
    • 20444376911 scopus 로고    scopus 로고
    • Manual for the Extrapyramidal Symptom Rating Scale (ESRS)
    • DOI 10.1016/j.schres.2005.02.013, PII S0920996405000782
    • Chouinard G, Margolese HC. Manual for the extrapyramidal symptom rating scale (ESRS). Schizophen Res 2005;76:247-65. DOI 10.1016/j.schres.2005.02.013 (Pubitemid 40804771)
    • (2005) Schizophrenia Research , vol.76 , Issue.2-3 , pp. 247-265
    • Chouinard, G.1    Margolese, H.C.2
  • 29
    • 40849102838 scopus 로고    scopus 로고
    • Safety profile of iloperodone: A pooled analysis of 6-week acute-phase pivotal trials
    • DOI 10.1097/JCP0b013e3181694f5a
    • Weiden PJ, Cutler AJ, Polymeropoulos MH, Wolfgang CD. Safety profile of iloperodone: a pooled analysis of 6-week acute-phase pivotal trials. J Clin Psychopharmacol 2008;28:S12-9. DOI 10.1097/JCP0b013e3181694f5a
    • (2008) J Clin Psychopharmacol , vol.28
    • Weiden, P.J.1    Cutler, A.J.2    Polymeropoulos, M.H.3    Wolfgang, C.D.4
  • 30
    • 26844538114 scopus 로고    scopus 로고
    • Risk of death with atypical antipsychotic drug treatment for dementia: Meta-analysis of randomized placebo-controlled trials
    • DOI 10.1001/jama.294.15.1934
    • Schneider LS, Dagerman KS, Insel P. Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. JAMA 2005;294:1934-43. DOI 10.1001/jama.294.15.1934 (Pubitemid 41464695)
    • (2005) Journal of the American Medical Association , vol.294 , Issue.15 , pp. 1934-1943
    • Schneider, L.S.1    Dagerman, K.S.2    Insel, P.3
  • 31
    • 28244431743 scopus 로고    scopus 로고
    • Risk of death in elderly users of conventional vs atypical antipsychotic medications
    • DOI 10.1056/NEJMoa052827
    • Wang PS, Schneeweiss S, Avom J, et al. Risk of death in elderly users of conventional vs atypical antipsychotic medications. N Engl J Med 2005;353:2335-41. DOI 10.1056/NEJMoa052827
    • (2005) N Engl J Med , vol.353 , pp. 2335-2341
    • Wang, P.S.1    Schneeweiss, S.2    Avom, J.3
  • 32
    • 58649100881 scopus 로고    scopus 로고
    • The dementia antipsychotic withdrawal trial (DART-AD): Long-term follow-up of a randomized placebo-controlled trial
    • DOI 10.1016/S1474-4422(08)70295-3
    • Ballard C, Hanney ML, Theodoulou M, et al. The dementia antipsychotic withdrawal trial (DART-AD): long-term follow-up of a randomized placebo-controlled trial. Lancet Neurol 2009;8:151-7. DOI 10.1016/S1474-4422(08) 70295-3
    • (2009) Lancet Neurol , vol.8 , pp. 151-157
    • Ballard, C.1    Hanney, M.L.2    Theodoulou, M.3
  • 33
    • 0035150202 scopus 로고    scopus 로고
    • Antipsychotic drugs: Prolonged QTc interval, torsade de pointes, and sudden death
    • DOI 10.1176/appi.ajp.158.11.1774
    • Glassman AH, Bigger JT. Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. Am J Psychiatry 2001;158:1774-82. DOI 10.1176/appi.ajp.158.11.1774
    • (2001) Am J Psychiatry , vol.158 , pp. 1774-1782
    • Glassman, A.H.1    Bigger, J.T.2
  • 34
    • 0842348094 scopus 로고    scopus 로고
    • Consensus development conference on antipsychotic drugs and obesity and diabetes
    • DOI 10.2337/diacare.27.8.2089
    • Barrett E, Blonde L, Clement S, et al. Consensus development conference on antipsychotic drugs and obesity and diabetes. Diabetes Care 2004;27:596-601. DOI 10.2337/diacare.27.8.2089
    • (2004) Diabetes Care , vol.27 , pp. 596-601
    • Barrett, E.1    Blonde, L.2    Clement, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.