A proposal for calculating occupational exposure limits for volatile organic compounds acting as sensory irritants on the basis of their physicochemical properties

Journal of Occupational and Environmental Hygiene

Volumn 7, Issue 7, 2010, Pages 429-434

  Jakubowski, Marek ^a   Czerczak, Sławomir ^a  

^a NOFER INSTITUTE OF OCCUPATIONAL MEDICINE   (Poland)

Author keywords

Occupational exposure limits; Sensory irritants; Volatile organic compounds

Indexed keywords

IRRITANT AGENT; VOLATILE ORGANIC COMPOUND;

ARTICLE; DRUG EFFECT; HUMAN; MAXIMUM ALLOWABLE CONCENTRATION; NOSE; NOSE MUCOSA; OCCUPATIONAL EXPOSURE; ODOR; PERCEPTIVE THRESHOLD; REGRESSION ANALYSIS; STATISTICAL MODEL;

HUMANS; IRRITANTS; LINEAR MODELS; NASAL MUCOSA; NOSE; OCCUPATIONAL EXPOSURE; REGRESSION ANALYSIS; SENSORY THRESHOLDS; SMELL; THRESHOLD LIMIT VALUES; VOLATILE ORGANIC COMPOUNDS;

EID: 77957356194     PISSN: 15459624     EISSN: 15459632     Source Type: Journal    
DOI: 10.1080/15459624.2010.483983     Document Type: Article

References (16)

1. ACGIH: Documentation of the TLVs and BEIs, 7th ed. Cincinnati, Ohio: ACGIH, 2009.
2. Abraham, M.H., R. Sanchez-Moreno, J.E. Cometto-Munez, and W. Cain: A quantitative structure-activity analysis on the relative sensitivity of the olfactory and nasal trigeminal chemosensory systems. Chem. Senses 32:711–719 (2007).
3. Schwarzenbacher, K., J. Fleischer, and H. Breer: Formation and maturation of olfactory cilia monitored by odorant-specific antibodies. Histochem. Cell. Biol. 123:419–428 (2005).
4. Flannery, R.J., D.A. French, and S.J. Kleene: Clustering of cyclicnucleotide- gated channels in olfactory cilia. Biophys. J. 91:179–188 (2006).
5. Niimura, Y., and M. Nei: Evolutionary dynamics of olfactory and other chemosensory receptor genes in vertebrates. J. Hum. Genet. 51(6):505–517 (2006).
6. Malnic, B., J. Hirono, T. Sato, and L.B. Buck: Combinational receptor codes for odors. Cell 96:713–723 (1999).
7. Doly, R.L., J.E. Cometto-Muniz, A.A. Jalowaysky, P. Dalon, M. Kendal-Reed, and M. Hodgson: Assessment of upper respiratory tract and ocular irritative effects of volatile chemicals in humans. Crit. Rev. Toxicol. 34:85–142 (2004).
8. Alarie, Y., M. Schaper, G.D. Nielsen, and M.H. Abraham: Structureactivity relationships of volatile organic chemicals as sensory irritants. Arch. Toxicol. 72:125–140 (1998).
9. Abraham, M.H., R. Kumarsingh, J.E. Cometto-Muniz, and W.S. Cain: An algorithm for nasal pungency thresholds in man. Arch. Toxicol. 72:227–232 (1998).
10. Schaper, M.: Development of a database for sensory irritants and its use in establishing occupational exposure limits. Am. Ind. Hyg. Assoc. J. 54:488–544 (1993).
11. Leung, H-W., and D.M. Paustenbach: Setting occupational exposure limits for irritant organic acids and bases based on their equilibrium dissociation constants. Appl. Ind. Hyg. 3:115–118 (1988).
12. Abraham, M.H: Scales of solute hydrogen-bonding: Their construction and application of physicochemical and biochemical processes. Chem. Soc. Rev. 22:73–83 (1993).
13. Abraham, M.H., J.M.R. Gola, J.E. Cometto-Muniz, and W.S. Cain: The correlation and prediction of VOC thresholds for nasal pungency, eye irritation and odour in humans. Indoor Built Environ. 10:252–257 (2001).
14. Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency. Luxembourg: General Secretariat, European Parliament, Council of the EU, 2006.
15. Cometto-Muniz, J.E., W.S. Cain, and M.H. Abraham: Nasal pungency and odor of homologous aldehydes and carboxylic acids. Exp. Brain Res. 118:180–188 (1998).
16. Böhme, A., D. Thaens, A. Paschke, and G. Schüürmann: Kinetic glutathione chemoassay to quantify thiol reactivity of organic electrophiles— Application to α, β—unsaturated ketones, acrylates, and propiolates. Chem. Res. Toxicol. 22:742–750 (2009).