An algorithm for nasal pungency thresholds in man

Archives of Toxicology

Volumn 72, Issue 4, 1998, Pages 227-232

  Abraham, Michael H ^a   Kumarsingh, Rachel ^a   Cometto Muniz, J Enrique ^b   Cain, William S ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Hydrogen bonding; Linear free energy equation; Nasal pungency; Sensory irritation; Volatile organic compounds

Indexed keywords

ACETIC ACID; ACETIC ACID ETHYL ESTER; ACETONE; ALCOHOL; ALDEHYDE; ALLYL COMPOUND; AROMATIC HYDROCARBON; BUTYRALDEHYDE; BUTYRIC ACID; CARBOXYLIC ACID; CHLOROBENZENE; CYCLOALKANE; ETHYLBENZENE; FORMIC ACID; HEPTANE; HEXADECANE; HEXANOIC ACID; IRRITANT AGENT; ISOCYANIC ACID DERIVATIVE; METHANOL; OCTANOIC ACID; ORGANIC SOLVENT; PENTYL ACETATE; PROPANE; TOLUENE; VOLATILE ORGANIC COMPOUND;

ALGORITHM; ARTICLE; ENERGY; HYDROGEN BOND; NOSE MUCOSA; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; SOLUBILITY; VAPOR; WORKPLACE;

AIR POLLUTANTS; ALGORITHMS; HUMANS; SENSORY THRESHOLDS; SMELL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031957834     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050493     Document Type: Article

References (27)

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7. Abraham MH, Andonian-Haftvan J, Cometto-Muniz JE, Cain WS (1996) An analysis of nasal irritation thresholds using a new solvation equation. Fundam Appl Toxicol 31: 71-76
8. Alarie Y (1966) Irritating properties of airborne materials to the upper respiratory tract. Arch Environ Health 13: 433-449
9. Alarie Y (1981) Dose-response analysis in animal studies: prediction of human responses. Environ Health Perspect 42: 9-13
10. Alarie Y, Schaper M, Nielsen GD, Abraham MH (1997) Structure-activity relationships of volatile organic chemicals. Arch Toxicol (in press)
11. ASTM (1984) Standard test method for estimating sensory irritation of airborne chemicals designation E981-84. American Society for Testing and Materials, Philadelphia
12. Berglund B, Berglund U, Lindvall R (1986) Assessment of discomfort and irritation from the indoor air. Proceedings of the ASHRAE Conference IAQ '86, Atlanta, Georgia, pp 138-149, April 20-23rd, 1986
13. Brown SK, Sim MR, Abramson MJ, Gray CN (1994) Concentrations of volatile organic compounds in indoor air a review. Indoor Air 4: 123-124
14. Cometto-Muniz JE, Cain WS (1984) Temporal integration of pungency. Chem Senses 8: 315-327
15. Cometto-Muniz JE, Cain WS (1990) Thresholds for odor and nasal pungency. Physiol Behav 48: 719-725
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23. Garcia-Medina MR, Cain WS (1982) Bilateral integration in the common chemical senses. Physiol Behav 29: 349-353
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27. Schaper M (1993) Development of a data base for sensory irritants and its use in establishing occupational exposure limits. Am Ind Hyg Assoc J 54: 488-544