T-type calcium channel antagonism decreases motivation for nicotine and blocks nicotine- and cue-induced reinstatement for a response previously reinforced with nicotine

Biological Psychiatry

Volumn 68, Issue 8, 2010, Pages 712-718

  Uslaner, Jason M ^a   Vardigan, Joshua D ^a   Drott, Jason M ^a   Uebele, Victor N ^a   Renger, John J ^a   Lee, Ariel ^a   Li, Zhaoxia ^b   Le A D ^b   Hutson, Pete H ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

Author keywords

Addiction; drug abuse; incentive salience; progressive ratio; relapse; self administration

Indexed keywords

(2 (4 CYCLOPROPYLPHENYL)N ((1R) 1 (5 [2,2,2 TRIFLUOROETHYL]OXO)PYRIDINE 2 YL)ETHYL])ACETAMIDE); CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL T TYPE; NICOTINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; AVERSION; CALCIUM ANTAGONISM; DRUG EFFECT; FEEDING; MALE; MOTIVATION; NONHUMAN; PERFORMANCE; PRIORITY JOURNAL; RAT; REINFORCEMENT;

ANIMALS; BENZENEACETAMIDES; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, T-TYPE; CONDITIONING, OPERANT; CUES; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTINCTION, PSYCHOLOGICAL; FOOD; MALE; MOTIVATION; NICOTINE; PYRIDINES; RATS; RATS, LONG-EVANS; RATS, WISTAR; REINFORCEMENT (PSYCHOLOGY); REINFORCEMENT SCHEDULE; SELF ADMINISTRATION;

EID: 77957342873     PISSN: 00063223     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biopsych.2010.05.004     Document Type: Article

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