Immunolabeling pattern of podoplanin (D2-40) may distinguish basal cell carcinomas from trichoepitheliomas: A clinicopathologic and immunohistochemical study of 49 cases

American Journal of Dermatopathology

Volumn 32, Issue 7, 2010, Pages 683-687

  Plaza, Jose A ^a   Ortega, Pablo F ^a   Bengana, Chafik ^a   Stockman, David L ^a   Suster, Saul ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

basal cell carcinomas; D2 40; podoplanin; trichoepitheliomas

Indexed keywords

PODOPLANIN;

ANTIBODY LABELING; ARTICLE; BASAL CELL CARCINOMA; CLINICAL ARTICLE; CONTROLLED STUDY; HAIR FOLLICLE; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENSITIVITY AND SPECIFICITY; TRICHOEPITHELIOMA;

ANTIBODIES, MONOCLONAL; CARCINOMA, BASAL CELL; DIAGNOSIS, DIFFERENTIAL; HUMANS; IMMUNOHISTOCHEMISTRY; MEMBRANE GLYCOPROTEINS; NEOPLASMS, BASAL CELL; PREDICTIVE VALUE OF TESTS; SKIN NEOPLASMS; TUMOR MARKERS, BIOLOGICAL;

EID: 77957341202     PISSN: 01931091     EISSN: None     Source Type: Journal    
DOI: 10.1097/DAD.0b013e3181cf8fb4     Document Type: Article

References (29)

1. Abdelsayed RA, Guijarro-Rojas M, Ibrahim NA, et al. Immunohisto-chemical evaluation of basal cell carcinoma and trichepithelioma using Bcl-2, Ki67, PCNA and P53. J Cutan Pathol. 2000;27:169-175.
2. Smoller BR, Van de Rijn M, Lebrun D, et al. bcl-2 expression reliably distinguishes trichoepitheliomas from basal cell carcinomas. Br J Dermatol. 1994;131:28-31.
3. Kirchmann TT, Prieto VG, Smoller BR. CD34 staining pattern distinguishes basal cell carcinoma from trichoepithelioma. Arch Dermatol. 1994;130:589-592.
4. Swanson PE, Fitzpatrick MM, Ritter JH, et al. Immunohistologic differential diagnosis of basal cell carcinoma, squamous cell carcinoma, and trichoepithelioma in small cutaneous biopsy specimens. J Cutan Pathol. 1998;25:153-159.
5. Kurzen H, Esposito L, Langbein L, et al. Cytokeratins as markers of follicular differentiation: an immunohistochemical study of trichoblastoma and basal cell carcinoma. Am J Dermatopathol. 2001;23:501-509.
6. Yamamoto O, Asahi M. Cytokeratin expression in trichoblastic fibroma (small nodular type trichoblastoma), trichoepithelioma and basal cell carcinoma. Br J Dermatol. 1999;140:8-16.
7. Lum CA, Binder SW. Proliferative characterization of basal-cell carcinoma and trichoepithelioma in small biopsy specimens. J Cutan Pathol. 2004;31:550-554.
8. Liang H, Wu H, Giorgadze TA, et al. Podoplanin is a highly sensitive and specific marker to distinguish primary skin adnexal carcinomas from adenocarcinomas metastatic to skin. Am J Surg Pathol. 2007;31:304-310.
9. Gombos Z, Xu X, Chu CS, et al. Peritumoral lymphatic vessel density and vascular endothelial growth factor C expression in early-stage squamous cell carcinoma of the uterine cervix. Clin Cancer Res. 2005;11:8364-8371.
10. Giorgadze TA, Zhang PJ, Pasha T, et al. Lymphatic vessel density is significantly increased in melanoma. J Cutan Pathol. 2004;31:672-677.
11. Dumoff KL, Chu C, Xu X, et al. Low D2-40 immunoreactivity correlates with lymphatic invasion and nodal metastasis in early-stage squamous cell carcinoma of the uterine cervix. Mod Pathol. 2005;18:97-104.
12. Fukunaga M. Expression of D2-40 in lymphatic endothelium of normal tissues and in vascular tumours. Histopathology. 2005;46:396-402.
13. Kahn HJ, Bailey D, Marks A. Monoclonal antibody D2-40, a new marker of lymphatic endothelium, reacts with Kaposi's sarcoma and a subset of angiosarcomas. Mod Pathol. 2002;15:434-440.
14. Roy S, Chu A, Trojanowski JQ, et al. D2-40, a novel monoclonal antibody against the M2A antigen as a marker to distinguish hemangioblastomas from renal cell carcinomas. Acta Neuropathol. 2005;109:497-502.
15. Debelenko LV, Perez-Atayde AR, Mulliken JB, et al. D2-40 immuno-histochemical analysis of pediatric vascular tumors reveals positivity in kaposiform hemangioendothelioma. Mod Pathol. 2005;18:1454-1460.
16. Dadras SS, Lange-Asschenfeldt B, Velasco P, et al. Tumor lymphangio-genesis predicts melanoma metastasis to sentinel lymph nodes. Mod Pathol. 2005;18:1232-1242.
17. Breiteneder-Geleff S, Soleiman A, Kowalski H, et al. Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium. Am J Pathol. 1999;154:385-394.
18. Marks A, Sutherland DR, Bailey D, et al. Characterization and distribution of an oncofetal antigen (M2A antigen) expressed on testicular germ cell tumours. Br J Cancer. 1999;80:569-578.
19. Chu AY, Litzky LA, Pasha TL, et al. Utility of D2-40, a novel mesothelial marker, in the diagnosis of malignant mesothelioma. Mod Pathol. 2005; 18:105-110.
20. Schacht V, Dadras SS, Johnson LA, et al. Up-regulation of the lymphatic marker podoplanin, a mucin-type transmembrane glycoprotein, in human squamous cell carcinomas and germ cell tumors. Am J Pathol. 2005;166: 913-921.
21. Gomaa AH, Yaar M, Bhawan J. Cutaneous immunoreactivity of D2-40 antibody beyond the lymphatics. Am J Dermatopathol. 2007;29: 18-21.
22. Yang HM, Cabral E, Dadras SS, et al. Immunohistochemical expression of D2-40 in benign and malignant sebaceous tumors and comparison to basal and squamous cell carcinomas. Am J Dermatopathol. 2008;30:549-554.
23. Basarab T, Orchard G, Russell-Jones R. The use of immunostaining for bcl-2 and CD34 and the lectin peanut agglutinin in differentiating between basal cell carcinomas and trichoepitheliomas. Am J Dermatopathol. 1998; 20:448-452.
24. Ackerman A, Mendonca AMN, Guo Y. Trichoepithelioma vs. basal cell carcinoma, nodular type. In: Differential Diagnosis in Dermatopathology I 1992. 2nd ed. Philadelphia, PA: Lea and Febiger; 1992:130-133.
25. Izikson L, Bhan A, Zembowicz A. Androgen receptor expression helps to differentiate basal cell carcinoma from benign trichoblastic tumors. Am J Dermatopathol. 2005;27:91-95.
26. Katona TM, Perkins SM, Billings SD. Does the panel of cytokeratin 20 and androgen receptor antibodies differentiate desmoplastic trichoepithelioma from morpheaform/infiltrative basal cell carcinoma? J Cutan Pathol. 2008;35:174-179.
27. Liubskaia OG, Papadiuk VI. [A rare case of malignant trichoepithelioma of the external acoustic meatus]. Vestn Otorinolaringol. 1995:50-51.
28. Johnson SC, Bennett RG. Occurrence of basal cell carcinoma among multiple trichoepitheliomas. J Am Acad Dermatol. 1993;28:322-326.
29. Ishida M, Kushima R, Okabe H. Immunohistochemical demonstration of D2-40 in basal cell carcinomas of the skin. J Cutan Pathol. 2008;35: 926-930.