Activity of a trisubstituted pyrrole in inhibiting sporozoite invasion and blocking malaria infection

Antimicrobial Agents and Chemotherapy

Volumn 54, Issue 10, 2010, Pages 4269-4274

  Panchal, Dhruv ^a   Bhanot, Purnima ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 [2 (4 FLUOROPHENYL) 5 (1 METHYLPIPERIDINE 4 YL) 1H PYRROL 3 YL] PYRIDINE; PROTEIN KINASE; PYRROLE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CELL INVASION; CELL STRAIN HEPG2; CONTROLLED STUDY; FEMALE; IN VIVO STUDY; MALARIA; MALARIA CONTROL; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM BERGHEI; PLASMODIUM BERGHEI INFECTION; PLASMODIUM YOELII; PLASMODIUM YOELII INFECTION; PRIORITY JOURNAL; SPOROZOITE; TISSUE CULTURE;

ANIMALS; ANTIMALARIALS; FEMALE; HEP G2 CELLS; HUMANS; MALARIA; MICE; PLASMODIUM BERGHEI; PLASMODIUM YOELII; POLYMERASE CHAIN REACTION; PYRROLES; SPOROZOITES;

EID: 77957337175     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00420-10     Document Type: Article

References (25)

1. Alonso, P. L., J. Sacarlal, J. J. Aponte, A. Leach, E. Macete, P. Aide, B. Sigauque, J. Milman, I. Mandomando, Q. Bassat, C. Guinovart, M. Espasa, S. Corachan, M. Lievens, M. M. Navia, M. C. Dubois, C. Menendez, F. Dubovsky, J. Cohen, R. Thompson, and W. R. Ballou. 2005. Duration of protection with RTS,S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: single-blind extended follow-up of a randomised controlled trial. Lancet 366:2012-2018.
2. Beier, J. C., M. S. Beier, J. A. Vaughan, C. B. Pumpuni, J. R. Davis, and B. H. Noden. 1992. Sporozoite transmission by Anopheles freeborni and Anopheles gambiae experimentally infected with Plasmodium falciparum. J. Am. Mosq. Control Assoc. 8:404-408.
3. Bruna-Romero, O., J. C. Hafalla, G. Gonzalez-Aseguinolaza, G. Sano, M. Tsuji, and F. Zavala. 2001. Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR. Int. J. Parasitol. 31:1499-1502.
4. Carraz, M., A. Jossang, J. F. Franetich, A. Siau, L. Ciceron, L. Hannoun, R. Sauerwein, F. Frappier, P. Rasoanaivo, G. Snounou, and D. Mazier. 2006. A plant-derived morphinan as a novel lead compound active against malaria liver stages. PLoS Med. 3:e513.
5. Coppi, A., M. Cabinian, D. Mirelman, and P. Sinnis. 2006. Antimalarial activity of allicin, a biologically active compound from garlic cloves. Antimicrob. Agents Chemother. 50:1731-1737.
6. Cunha-Rodrigues, M., S. Portugal, M. Prudencio, L. A. Goncalves, C. Casalou, D. Buger, R. Sauerwein, W. Haas, and M. M. Mota. 2008. Genistein-supplemented diet decreases malaria liver infection in mice and constitutes a potential prophylactic strategy. PLoS One 3:e2732.
7. Davies, C. S., M. Pudney, J. C. Nicholas, and R. E. Sinden. 1993. The novel hydroxynaphthoquinone 566C80 inhibits the development of liver stages of Plasmodium berghei cultured in vitro. Parasitology 106(Pt. 1):1-6.
8. Diaz, C. A., J. Allocco, M. A. Powles, L. Yeung, R. G. Donald, J. W. Anderson, and P. A. Liberator. 2006. Characterization of Plasmodium falciparum cGMP-dependent protein kinase (PfPKG): antiparasitic activity of a PKG inhibitor. Mol. Biochem. Parasitol. 146:78-88.
9. Falae, A., A. Combe, A. Anburaj, T. G. Carvalho, R. Menard, and P. Bhanot. 2009. The role of Plasmodium berghei cGMP dependent protein kinase in late liver stage development. J. Biol. Chem. 285:3282-3288.
10. Gantt, S. M., J. M. Myung, M. R. Briones, W. D. Li, E. J. Corey, S. Omura, V. Nussenzweig, and P. Sinnis. 1998. Proteasome inhibitors block development of Plasmodium spp. Antimicrob. Agents Chemother. 42:2731-2738.
11. Gurnett, A. M., P. A. Liberator, P. M. Dulski, S. P. Salowe, R. G. Donald, J. W. Anderson, J. Wiltsie, C. A. Diaz, G. Harris, B. Chang, S. J. Darkin-Rattray, B. Nare, T. Crumley, P. S. Blum, A. S. Misura, T. Tamas, M. K. Sardana, J. Yuan, T. Biftu, and D. M. Schmatz. 2002. Purification and molecular characterization of cGMP-dependent protein kinase from apicomplexan parasites. A novel chemotherapeutic target. J. Biol. Chem. 277:15913-15922.
12. Mahmoudi, N., R. Garcia-Domenech, J. Galvez, K. Farhati, J. F. Franetich, R. Sauerwein, L. Hannoun, F. Derouin, M. Danis, and D. Mazier. 2008. New active drugs against liver stages of Plasmodium predicted by molecular topology. Antimicrob. Agents Chemother. 52:1215-1220.
13. Mazier, D., L. Renia, and G. Snounou. 2009. A pre-emptive strike against malaria's stealthy hepatic forms. Nat. Rev. Drug Discov. 8:854-864.
14. McRobert, L., C. J. Taylor, W. Deng, Q. L. Fivelman, R. M. Cummings, S. D. Polley, O. Billker, and D. A. Baker. 2008. Gametogenesis in malaria parasites is mediated by the cGMP-dependent protein kinase. PLoS Biol. 6:e139.
15. Medica, D. L., and P. Sinnis. 2005. Quantitative dynamics of Plasmodium yoelii sporozoite transmission by infected anopheline mosquitoes. Infect. Immun. 73:4363-4369.
16. Moon, R. W., C. J. Taylor, C. Bex, R. Schepers, D. Goulding, C. J. Janse, A. P. Waters, D. A. Baker, and O. Billker. 2009. A cyclic GMP signalling module that regulates gliding motility in a malaria parasite. PLoS Pathog. 5:e1000599.
17. Nare, B., J. J. Allocco, P. A. Liberator, and R. G. Donald. 2002. Evaluation of a cyclic GMP-dependent protein kinase inhibitor in treatment of murine toxoplasmosis: gamma interferon is required for efficacy. Antimicrob. Agents Chemother. 46:300-307.
18. Parvanova, I., S. Epiphanio, A. Fauq, T. E. Golde, M. Prudencio, and M. M. Mota. 2009. A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity. PLoS One 4:e5078.
19. Ponnudurai, T., A. H. Lensen, G. J. van Gemert, M. G. Bolmer, and J. H. Meuwissen. 1991. Feeding behaviour and sporozoite ejection by infected Anopheles stephensi. Trans. R. Soc. Trop. Med. Hyg. 85:175-180.
20. Radke, J. R., R. G. Donald, A. Eibs, M. E. Jerome, M. S. Behnke, P. Liberator, and M. W. White. 2006. Changes in the expression of human cell division autoantigen-1 influence Toxoplasma gondii growth and development. PLoS Pathog. 2:e105.
21. Renia, L., F. Miltgen, Y. Charoenvit, T. Ponnudurai, J. P. Verhave, W. E. Collins, and D. Mazier. 1988. Malaria sporozoite penetration. A new approach by double staining. J. Immunol. Methods 112:201-205.
22. Schwartz, A. L., and M. R. Hollingdale. 1985. Primaquine and lysosomotropic amines inhibit malaria sporozoite entry into human liver cells. Mol. Biochem. Parasitol. 14:305-311.
23. Taylor, H. M., L. McRobert, M. Grainger, A. Sicard, A. R. Dluzewski, C. S. Hopp, A. A. Holder, and D. A. Baker. 2010. The malaria parasite cyclic GMP-dependent protein kinase plays a central role in blood-stage schizogony. Eukaryot. Cell 9:37-45.
24. Tsuji, M., D. Mattei, R. S. Nussenzweig, D. Eichinger, and F. Zavala. 1994. Demonstration of heat-shock protein 70 in the sporozoite stage of malaria parasites. Parasitol. Res. 80:16-21.
25. Yoshida, N., P. Potocnjak, V. Nussenzweig, and R. S. Nussenzweig. 1981. Biosynthesis of Pb44, the protective antigen of sporozoites of Plasmodium berghei. J. Exp. Med. 154:1225-1236.