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Volumn 50, Issue 5, 2006, Pages 1731-1737

Antimalarial activity of allicin, a biologically active compound from garlic cloves

Author keywords

[No Author keywords available]

Indexed keywords

ALLICIN; ANTIMALARIAL AGENT; CIRCUMSPOROZOITE PROTEIN; CYSTEINE PROTEINASE; CYSTEINE PROTEINASE INHIBITOR; GREEN FLUORESCENT PROTEIN; N [N (3 CARBOXYOXIRANE 2 CARBONYL)LEUCYL]AGMATINE; RNA 18S;

EID: 33646447331     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.50.5.1731-1737.2006     Document Type: Article
Times cited : (121)

References (46)
  • 1
    • 0032715514 scopus 로고    scopus 로고
    • Antimicrobial properties of allicin from garlic
    • Ankri, S., and D. Mirelman. 1999. Antimicrobial properties of allicin from garlic. Microbes Infect. 1:125-129.
    • (1999) Microbes Infect. , vol.1 , pp. 125-129
    • Ankri, S.1    Mirelman, D.2
  • 2
    • 0030765775 scopus 로고    scopus 로고
    • Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica
    • Ankri, S., T. Miron, A. Rabinkov, M. Wilchek, and D. Mirelman. 1997. Allicin from garlic strongly inhibits cysteine proteinases and cytopathic effects of Entamoeba histolytica. Antimicrob. Agents Chemother. 41:2286-2288.
    • (1997) Antimicrob. Agents Chemother. , vol.41 , pp. 2286-2288
    • Ankri, S.1    Miron, T.2    Rabinkov, A.3    Wilchek, M.4    Mirelman, D.5
  • 3
    • 0034232515 scopus 로고    scopus 로고
    • Proteases involved in erythrocyte invasion by the malaria parasite: Function and potential as chemotherapeutic targets
    • Blackman, M. J. 2000. Proteases involved in erythrocyte invasion by the malaria parasite: function and potential as chemotherapeutic targets. Curr. Drug Targets 1:59-83.
    • (2000) Curr. Drug Targets , vol.1 , pp. 59-83
    • Blackman, M.J.1
  • 4
    • 0034795312 scopus 로고    scopus 로고
    • Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR
    • Bruna-Romero, O., J. C. R. Hafalla, G. Gonzalez-Aseguinolaza, G. Sano, M. Tsuji, and F. Zavala. 2001. Detection of malaria liver-stages in mice infected through the bite of a single Anopheles mosquito using a highly sensitive real-time PCR. Int. J. Parasitol. 31:1499-1502.
    • (2001) Int. J. Parasitol. , vol.31 , pp. 1499-1502
    • Bruna-Romero, O.1    Hafalla, J.C.R.2    Gonzalez-Aseguinolaza, G.3    Sano, G.4    Tsuji, M.5    Zavala, F.6
  • 5
    • 0026084864 scopus 로고
    • Efficacy of aqueous extract of garlic and allicin in experimental shigellosis in rabbits
    • Chowdhury, A. K., M. Ahsan, S. N. Islam, and Z. U. Ahed. 1991. Efficacy of aqueous extract of garlic and allicin in experimental shigellosis in rabbits. Indian J. Med. Res. 93:33-36.
    • (1991) Indian J. Med. Res. , vol.93 , pp. 33-36
    • Chowdhury, A.K.1    Ahsan, M.2    Islam, S.N.3    Ahed, Z.U.4
  • 6
    • 12344299732 scopus 로고    scopus 로고
    • The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion
    • Coppi, A., C. Pinzon-Ortiz, C. Hutter, and P. Sinnis. 2004. The Plasmodium circumsporozoite protein is proteolytically processed during cell invasion. J. Exp. Med. 201:27-33.
    • (2004) J. Exp. Med. , vol.201 , pp. 27-33
    • Coppi, A.1    Pinzon-Ortiz, C.2    Hutter, C.3    Sinnis, P.4
  • 9
    • 0000817158 scopus 로고
    • Garlic chemistry: Stability of S-(2-propenyl)2-propene-1-sulfinothionate (allicin) in blood, solvents, and simulated physiological fluids
    • Freeman, F., and Y. Kodera. 1995. Garlic chemistry: stability of S-(2-propenyl)2-propene-1-sulfinothionate (allicin) in blood, solvents, and simulated physiological fluids. J. Agric. Food Chem. 43:2332-2338.
    • (1995) J. Agric. Food Chem. , vol.43 , pp. 2332-2338
    • Freeman, F.1    Kodera, Y.2
  • 10
    • 0022508114 scopus 로고
    • L3T4+ T lymphocytes play a major role in the pathogenesis of murine cerebral malaria
    • Grau, G. E., P.-F. Piguet, J. D. Engers, J. A. Louis, P. Vassali, and P.-H. Lambert. 1986. L3T4+ T lymphocytes play a major role in the pathogenesis of murine cerebral malaria. J. Immunol. 137:2348-2354.
    • (1986) J. Immunol. , vol.137 , pp. 2348-2354
    • Grau, G.E.1    Piguet, P.-F.2    Engers, J.D.3    Louis, J.A.4    Vassali, P.5    Lambert, P.-H.6
  • 12
    • 84960955720 scopus 로고
    • Combined action of streptomycin and chloramphenicol with plant antibiotics against tubercle bacilli. 1. Streptomycin and chloramphenicol with cepharanthine. II. Streptomycin and allicin
    • Gupta, K. C., and R. Viswanathan. 1955. Combined action of streptomycin and chloramphenicol with plant antibiotics against tubercle bacilli. 1. Streptomycin and chloramphenicol with cepharanthine. II. Streptomycin and allicin. Antibiot. Chemother. 5:24-27.
    • (1955) Antibiot. Chemother. , vol.5 , pp. 24-27
    • Gupta, K.C.1    Viswanathan, R.2
  • 13
    • 3042752369 scopus 로고    scopus 로고
    • History, folk medicine and legendary uses of garlic
    • H. P. Koch and L. D. Lawson (ed.). Williams & Wilkins, Baltimore, Md.
    • Hahn, G. 1996. History, folk medicine and legendary uses of garlic, p. 1-24. In H. P. Koch and L. D. Lawson (ed.), Garlic: the science and therapeutic application of Allium sativum L. and related species. Williams & Wilkins, Baltimore, Md.
    • (1996) Garlic: The Science and Therapeutic Application of Allium Sativum L. and Related Species , pp. 1-24
    • Hahn, G.1
  • 17
    • 0003990404 scopus 로고    scopus 로고
    • Toxicity, side effects, and the unwanted effects of garlic
    • H. P. Koch and L. D. Lawson (ed.). Williams & Wilkins, Baltimore, Md.
    • Koch, H. P. 1996. Toxicity, side effects, and the unwanted effects of garlic, p. 221-228. In H. P. Koch and L. D. Lawson (ed.), Garlic: the science and therapeutic application of Allium sativum L. and related species. Williams & Wilkins, Baltimore, Md.
    • (1996) Garlic: The Science and Therapeutic Application of Allium Sativum L. and Related Species , pp. 221-228
    • Koch, H.P.1
  • 19
    • 0034761722 scopus 로고    scopus 로고
    • Pathogenesis of cerebral malaria: Recent experimental data and possible applications for humans
    • Lou, J., R. Lucas, and G. E. Grau. 2001. Pathogenesis of cerebral malaria: recent experimental data and possible applications for humans. Clin. Microbiol. Rev. 14:810-820.
    • (2001) Clin. Microbiol. Rev. , vol.14 , pp. 810-820
    • Lou, J.1    Lucas, R.2    Grau, G.E.3
  • 20
    • 0033058811 scopus 로고    scopus 로고
    • Cysteine protease inhibitors as chemotherapy for parasitic infections
    • McKerrow, J. H. 1999. Cysteine protease inhibitors as chemotherapy for parasitic infections. Bioorg. Med. Chem. 7:639-644.
    • (1999) Bioorg. Med. Chem. , vol.7 , pp. 639-644
    • McKerrow, J.H.1
  • 21
    • 0032781317 scopus 로고    scopus 로고
    • Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: Insights on safety, target validation, and mechanism of action
    • McKerrow, J. H. 1999. Development of cysteine protease inhibitors as chemotherapy for parasitic diseases: insights on safety, target validation, and mechanism of action. Int. J. Parasitol. 29:833-837.
    • (1999) Int. J. Parasitol. , vol.29 , pp. 833-837
    • McKerrow, J.H.1
  • 23
    • 0023178834 scopus 로고
    • Inhibition of growth of Entamoeba histolytica by allicin, the active principle of garlic (Allium sativum)
    • Mirelman, D., D. Monheit, and S. Varon. 1987. Inhibition of growth of Entamoeba histolytica by allicin, the active principle of garlic (Allium sativum). J. Infect. Dis. 156:243-244.
    • (1987) J. Infect. Dis. , vol.156 , pp. 243-244
    • Mirelman, D.1    Monheit, D.2    Varon, S.3
  • 25
    • 0036667914 scopus 로고    scopus 로고
    • A spectrophotometric assay for allicin, alliin, and alliinase (alliin lyase) with a chromogenic thiol: Reaction of 4-mercaptopyridine with thiosulfinates
    • Miron, T., I. Shin, G. Feigenblat, L. Weiner, D. Mirelman, M. Wilchek, and A. Rabinkov. 2002. A spectrophotometric assay for allicin, alliin, and alliinase (alliin lyase) with a chromogenic thiol: reaction of 4-mercaptopyridine with thiosulfinates. Anal. Biochem. 307:76-83.
    • (2002) Anal. Biochem. , vol.307 , pp. 76-83
    • Miron, T.1    Shin, I.2    Feigenblat, G.3    Weiner, L.4    Mirelman, D.5    Wilchek, M.6    Rabinkov, A.7
  • 26
    • 0344234336 scopus 로고    scopus 로고
    • The Plasmodium circumsporozoite protein is involved in mosquito salivary gland invasion by sporozoites
    • Myung, J. M., P. Marshall, and P. Sinnis. 2004. The Plasmodium circumsporozoite protein is involved in mosquito salivary gland invasion by sporozoites. Mol. Biochem. Parasitol. 133:53-59.
    • (2004) Mol. Biochem. Parasitol. , vol.133 , pp. 53-59
    • Myung, J.M.1    Marshall, P.2    Sinnis, P.3
  • 27
  • 28
    • 0033057631 scopus 로고    scopus 로고
    • Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors
    • Olson, J. E., G. K. Lee, A. Semenov, and P. J. Rosenthal. 1999. Antimalarial effects in mice of orally administered peptidyl cysteine protease inhibitors. Bioorg. Med. Chem. 7:633-638.
    • (1999) Bioorg. Med. Chem. , vol.7 , pp. 633-638
    • Olson, J.E.1    Lee, G.K.2    Semenov, A.3    Rosenthal, P.J.4
  • 29
    • 0016810019 scopus 로고
    • The chemotherapy of rodent malaria. XXII. The value of drug-resistant strains of P. berghei in screening for blood schizontocidal activity
    • Peters, W. 1975. The chemotherapy of rodent malaria. XXII. The value of drug-resistant strains of P. berghei in screening for blood schizontocidal activity. Ann. Trop. Med. Parasitol. 69:155-171.
    • (1975) Ann. Trop. Med. Parasitol. , vol.69 , pp. 155-171
    • Peters, W.1
  • 31
    • 0035920237 scopus 로고    scopus 로고
    • The binding of the circumsporozoite protein to cell surface heparan sulfate proteoglycans is required for Plasmodium sporozoite attachment to target cells
    • Pinzon-Ortiz, C., J. Friedman, J. Esko, and P. Sinnis. 2001. The binding of the circumsporozoite protein to cell surface heparan sulfate proteoglycans is required for Plasmodium sporozoite attachment to target cells. J. Biol. Chem. 276:26784-26791.
    • (2001) J. Biol. Chem. , vol.276 , pp. 26784-26791
    • Pinzon-Ortiz, C.1    Friedman, J.2    Esko, J.3    Sinnis, P.4
  • 35
    • 0027512171 scopus 로고
    • Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria
    • Rosenthal, P. J., G. K. Lee, and R. E. Smith. 1993. Inhibition of a Plasmodium vinckei cysteine proteinase cures murine malaria. J. Clin. Investig. 91:1052-1056.
    • (1993) J. Clin. Investig. , vol.91 , pp. 1052-1056
    • Rosenthal, P.J.1    Lee, G.K.2    Smith, R.E.3
  • 36
    • 0035986688 scopus 로고    scopus 로고
    • Cysteine proteases of malaria parasites: Targets for chemotherapy
    • Rosenthal, P. J., P. S. Sijwali, A. Singh, and B. R. Shenai. 2002. Cysteine proteases of malaria parasites: targets for chemotherapy. Curr. Pharm. Des. 8:1659-1672.
    • (2002) Curr. Pharm. Des. , vol.8 , pp. 1659-1672
    • Rosenthal, P.J.1    Sijwali, P.S.2    Singh, A.3    Shenai, B.R.4
  • 37
    • 0035793051 scopus 로고    scopus 로고
    • Malaria parasite exit from the host erythrocyte: A two-step process requiring extraerythrocytic proteolysis
    • Salmon, B. L., A. Oksman, and D. E. Goldberg. 2001. Malaria parasite exit from the host erythrocyte: a two-step process requiring extraerythrocytic proteolysis. Proc. Natl. Acad. Sci. USA 98:271-276.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 271-276
    • Salmon, B.L.1    Oksman, A.2    Goldberg, D.E.3
  • 38
    • 2442654043 scopus 로고    scopus 로고
    • Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis
    • Shadkchan, Y., E. Shemesh, D. Mirelman, T. Miron, A. Rabinkov, M. Wilchek, and N. Osherov. 2004. Efficacy of allicin, the reactive molecule of garlic, in inhibiting Aspergillus spp. in vitro, and in a murine model of disseminated aspergillosis. J. Antimicrob. Chemother. 53:832-836.
    • (2004) J. Antimicrob. Chemother. , vol.53 , pp. 832-836
    • Shadkchan, Y.1    Shemesh, E.2    Mirelman, D.3    Miron, T.4    Rabinkov, A.5    Wilchek, M.6    Osherov, N.7
  • 39
    • 0034666133 scopus 로고    scopus 로고
    • Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase
    • Shenai, B. R., P. S. Sijwali, A. Singh, and P. J. Rosenthal. 2000. Characterization of native and recombinant falcipain-2, a principal trophozoite cysteine protease and essential hemoglobinase. J. Biol. Chem. 275:29000-29010.
    • (2000) J. Biol. Chem. , vol.275 , pp. 29000-29010
    • Shenai, B.R.1    Sijwali, P.S.2    Singh, A.3    Rosenthal, P.J.4
  • 40
    • 0035644195 scopus 로고    scopus 로고
    • Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3
    • Sijwali, P. S., B. R. Shenai, J. Gut, A. Singh, and P. J. Rosenthal. 2001. Expression and characterization of the Plasmodium falciparum haemoglobinase falcipain-3. Biochem. J. 360:481-489.
    • (2001) Biochem. J. , vol.360 , pp. 481-489
    • Sijwali, P.S.1    Shenai, B.R.2    Gut, J.3    Singh, A.4    Rosenthal, P.J.5
  • 41
    • 74049134817 scopus 로고
    • Chemical investigations on alliin, the specific principle of garlic
    • Stoll, A., and E. Seebeck. 1951. Chemical investigations on alliin, the specific principle of garlic. Adv. Enzymol. 11:377-400.
    • (1951) Adv. Enzymol. , vol.11 , pp. 377-400
    • Stoll, A.1    Seebeck, E.2
  • 43
    • 0016541036 scopus 로고
    • The characteristics of the antibacterial activity of garlic
    • Uchida, Y., T. Takahashi, and N. Sate. 1975. The characteristics of the antibacterial activity of garlic. Jpn. J. Antibiot. 28:638-642.
    • (1975) Jpn. J. Antibiot. , vol.28 , pp. 638-642
    • Uchida, Y.1    Takahashi, T.2    Sate, N.3
  • 45
    • 0001404835 scopus 로고
    • Enzyme inhibition by allicin, the active principle of garlic
    • Willis, E. 1956. Enzyme inhibition by allicin, the active principle of garlic. Biochem. J. 63:514-520.
    • (1956) Biochem. J. , vol.63 , pp. 514-520
    • Willis, E.1
  • 46
    • 0019410116 scopus 로고
    • Biosynthesis of Pb44, the protective antigen of sporozoites of Plasmodium berghei
    • Yoshida, N., P. Potocnjak, V. Nussenzweig, and R. S. Nussenzweig. 1981. Biosynthesis of Pb44, the protective antigen of sporozoites of Plasmodium berghei. J. Exp. Med. 154:1225-1236.
    • (1981) J. Exp. Med. , vol.154 , pp. 1225-1236
    • Yoshida, N.1    Potocnjak, P.2    Nussenzweig, V.3    Nussenzweig, R.S.4


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