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Volumn 54, Issue 10, 2010, Pages 4522-4523

Role of mutations in dihydrofolate reductase DfrA (Rv2763c) and thymidylate synthase ThyA (Rv2764c) in Mycobacterium tuberculosis drug resistance

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; COTRIMOXAZOLE; DIHYDROFOLATE REDUCTASE; ETHIONAMIDE; ISONIAZID; METHOTREXATE; THYMIDYLATE SYNTHASE;

EID: 77957328041     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00422-10     Document Type: Letter
Times cited : (7)

References (20)
  • 1
    • 33745094315 scopus 로고    scopus 로고
    • Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid
    • Argyrou, A., M. Vetting, B. Aladegbami, and J. Blanchard. 2006. Mycobacterium tuberculosis dihydrofolate reductase is a target for isoniazid. Nat. Struct. Mol. Biol. 13:408-413.
    • (2006) Nat. Struct. Mol. Biol. , vol.13 , pp. 408-413
    • Argyrou, A.1    Vetting, M.2    Aladegbami, B.3    Blanchard, J.4
  • 2
    • 0034613029 scopus 로고    scopus 로고
    • Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: New insight into the enzymatic mechanism and sulfa-drug action
    • Baca, A., R. Sirawaraporn, S. Turley, W. Sirawaraporn, and W. Hol. 2000. Crystal structure of Mycobacterium tuberculosis 7,8-dihydropteroate synthase in complex with pterin monophosphate: new insight into the enzymatic mechanism and sulfa-drug action. J. Mol. Biol. 302:1193-1212.
    • (2000) J. Mol. Biol. , vol.302 , pp. 1193-1212
    • Baca, A.1    Sirawaraporn, R.2    Turley, S.3    Sirawaraporn, W.4    Hol, W.5
  • 3
    • 34249654136 scopus 로고    scopus 로고
    • Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aureus
    • Besier, S., A. Ludwig, K. Ohlsen, V. Brade, and T. Wichelhaus. 2007. Molecular analysis of the thymidine-auxotrophic small colony variant phenotype of Staphylococcus aureus. Int. J. Med. Microbiol. 297:217-225.
    • (2007) Int. J. Med. Microbiol. , vol.297 , pp. 217-225
    • Besier, S.1    Ludwig, A.2    Ohlsen, K.3    Brade, V.4    Wichelhaus, T.5
  • 4
    • 44449104965 scopus 로고    scopus 로고
    • The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates
    • Besier, S., J. Zander, B. C. Kahl, P. Kraiczy, V. Brade, and T. A. Wichelhaus. 2008. The thymidine-dependent small-colony-variant phenotype is associated with hypermutability and antibiotic resistance in clinical Staphylococcus aureus isolates. Antimicrob. Agents Chemother. 52:2183-2189.
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 2183-2189
    • Besier, S.1    Zander, J.2    Kahl, B.C.3    Kraiczy, P.4    Brade, V.5    Wichelhaus, T.A.6
  • 5
    • 38649119459 scopus 로고    scopus 로고
    • Mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureus
    • Chatterjee, I., A. Kriegeskorte, A. Fischer, S. Deiwick, N. Theimann, R. Proctor, G. Peters, M. Herrmann, and B. Kahl. 2008. In vivo mutations of thymidylate synthase (encoded by thyA) are responsible for thymidine dependency in clinical small-colony variants of Staphylococcus aureus. J. Bacteriol. 190:834-842.
    • (2008) J. Bacteriol. , vol.190 , pp. 834-842
    • Chatterjee, I.1    Kriegeskorte, A.2    Fischer, A.3    Deiwick, S.4    Theimann, N.5    Proctor, R.6    Peters, G.7    Herrmann, M.8    Kahl, B.9
  • 7
    • 50949123930 scopus 로고    scopus 로고
    • Biochemical and structural characterization of the putative dihydropteroate synthase ortholog Rv1207 of Mycobacterium tuberculosis
    • Gengenbacher, M., T. Xu, P. Niyomrattanakit, G. Spraggon, and T. Dick. 2008. Biochemical and structural characterization of the putative dihydropteroate synthase ortholog Rv1207 of Mycobacterium tuberculosis. FEMS Microbiol. Lett. 287:128-135.
    • (2008) FEMS Microbiol. Lett. , vol.287 , pp. 128-135
    • Gengenbacher, M.1    Xu, T.2    Niyomrattanakit, P.3    Spraggon, G.4    Dick, T.5
  • 8
    • 70349138844 scopus 로고    scopus 로고
    • Contribution of dfrA and inhA mutations to the detection of isoniazid-resistant Mycobacterium tuberculosis isolates
    • Ho, Y., Y. Sun, S. Wong, and A. Lee. 2009. Contribution of dfrA and inhA mutations to the detection of isoniazid-resistant Mycobacterium tuberculosis isolates. Antimicrob. Agents Chemother. 53:4010-4012.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 4010-4012
    • Ho, Y.1    Sun, Y.2    Wong, S.3    Lee, A.4
  • 9
    • 0035370341 scopus 로고    scopus 로고
    • Resistance to trimethoprim-sulfamethoxazole
    • Huovinen, P. 2001. Resistance to trimethoprim-sulfamethoxazole. Clin. Infect. Dis. 32:1608-1614.
    • (2001) Clin. Infect. Dis. , vol.32 , pp. 1608-1614
    • Huovinen, P.1
  • 11
    • 0034645774 scopus 로고    scopus 로고
    • Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs
    • Li, R., R. Sirawaraporn, P. Chitnumsub, W. Sirawaraporn, J. Wooden, F. Athappilly, S. Turley, and W. G. J. Hol. 2000. Three-dimensional structure of M. tuberculosis dihydrofolate reductase reveals opportunities for the design of novel tuberculosis drugs. J. Mol. Biol. 295:307-323.
    • (2000) J. Mol. Biol. , vol.295 , pp. 307-323
    • Li, R.1    Sirawaraporn, R.2    Chitnumsub, P.3    Sirawaraporn, W.4    Wooden, J.5    Athappilly, F.6    Turley, S.7    Hol, W.G.J.8
  • 13
    • 3142583521 scopus 로고    scopus 로고
    • The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria
    • Rengarajan, J., C. M. Sassetti, V. Naroditskaya, A. Sloutsky, B. R. Bloom, and E. J. Rubin. 2004. The folate pathway is a target for resistance to the drug para-aminosalicylic acid (PAS) in mycobacteria. Mol. Microbiol. 53:275-282.
    • (2004) Mol. Microbiol. , vol.53 , pp. 275-282
    • Rengarajan, J.1    Sassetti, C.M.2    Naroditskaya, V.3    Sloutsky, A.4    Bloom, B.R.5    Rubin, E.J.6
  • 14
    • 60349114577 scopus 로고    scopus 로고
    • Staphylococcus aureus as an intracellular pathogen: The role of small colony variants
    • Sendi, P., and R. Proctor. 2009. Staphylococcus aureus as an intracellular pathogen: the role of small colony variants. Trends Microbiol. 17:54-58.
    • (2009) Trends Microbiol. , vol.17 , pp. 54-58
    • Sendi, P.1    Proctor, R.2
  • 15
    • 0032444693 scopus 로고    scopus 로고
    • Susceptibilities of Mycobacterium tuberculosis and Mycobacterium avium complex to lipophilic deazapteridine derivatives, inhibitors of dihydrofolate reductase
    • Suling, W., R. Reynolds, E. Barrow, L. Wilson, J. Piper, and W. Barrow. 1998. Susceptibilities of Mycobacterium tuberculosis and Mycobacterium avium complex to lipophilic deazapteridine derivatives, inhibitors of dihydrofolate reductase. J. Antimicrob. Chemother. 42:811-815.
    • (1998) J. Antimicrob. Chemother. , vol.42 , pp. 811-815
    • Suling, W.1    Reynolds, R.2    Barrow, E.3    Wilson, L.4    Piper, J.5    Barrow, W.6
  • 16
    • 65749109291 scopus 로고    scopus 로고
    • Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques
    • Vickers, A., N. Potter, C. Fishwick, I. Chopra, and A. O'Neill. 2009. Analysis of mutational resistance to trimethoprim in Staphylococcus aureus by genetic and structural modelling techniques. J. Antimicrob. Chemother. 63:1112-1117.
    • (2009) J. Antimicrob. Chemother. , vol.63 , pp. 1112-1117
    • Vickers, A.1    Potter, N.2    Fishwick, C.3    Chopra, I.4    O'Neill, A.5
  • 17
    • 35848935866 scopus 로고    scopus 로고
    • The mechanism of isoniazid killing: Clarity through the scope of genetics
    • Vilchèze, C., and W. J. Jacobs. 2007. The mechanism of isoniazid killing: clarity through the scope of genetics. Annu. Rev. Microbiol. 61:35-50.
    • (2007) Annu. Rev. Microbiol. , vol.61 , pp. 35-50
    • Vilchèze, C.1    Jacobs, W.J.2
  • 18
    • 70350329241 scopus 로고    scopus 로고
    • Reconsidering some approved antimicrobial agents for tuberculosis
    • Young, L. 2009. Reconsidering some approved antimicrobial agents for tuberculosis. Antimicrob. Agents Chemother. 53:4577-4579.
    • (2009) Antimicrob. Agents Chemother. , vol.53 , pp. 4577-4579
    • Young, L.1
  • 20
    • 77955865485 scopus 로고    scopus 로고
    • Mutations in the thymidylate synthase gene is a major mechanism in the para-aminosalicylic acid resistance of M. tuberculosis
    • In Chinese
    • Zhang, Z., Y. Zhao, Z. Li, H. Jia, Y. Liu, X. Chen, Z. Liu, B. Du, A. Xing, and Y. Ma. 2007. Mutations in the thymidylate synthase gene is a major mechanism in the para-aminosalicylic acid resistance of M. tuberculosis. Zhonghua Jie He He Hu Xi Za Zhi 30:683-685. (In Chinese.)
    • (2007) Zhonghua Jie He He Hu Xi Za Zhi , vol.30 , pp. 683-685
    • Zhang, Z.1    Zhao, Y.2    Li, Z.3    Jia, H.4    Liu, Y.5    Chen, X.6    Liu, Z.7    Du, B.8    Xing, A.9    Ma, Y.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.