The free radical scavengers edaravone and tempol suppress experimental dextran sulfate sodium-induced colitis in mice

International Journal of Molecular Medicine

Volumn 17, Issue 2, 2006, Pages 331-334

  Araki, Yoshio ^a   Sugihara, Hiroyuki ^b   Hattori, Takanori ^b  

^a Biwako Youikuin Hospital   (Japan)

^b SHIGA UNIVERSITY OF MEDICAL SCIENCE   (Japan)

Author keywords

Dextran sulfate sodium induced colitis; Free radical scavenger; Reactive oxygen species

Indexed keywords

AMINE OXIDE; DEXTRAN SULFATE; DRUG DERIVATIVE; INTERLEUKIN 6; PEROXIDASE; PHENAZONE; PHENYLMETHYLPYRAZOLONE; SCAVENGER; TEMPOL;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; BLOOD; CHEMICALLY INDUCED DISORDER; COLITIS; DISEASE MODEL; DRUG ANTAGONISM; MALE; MOUSE; PATHOLOGY; SPIN LABELING;

ANIMALS; ANTIPYRINE; COLITIS; CYCLIC N-OXIDES; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; FREE RADICAL SCAVENGERS; INTERLEUKIN-6; MALE; MICE; MICE, INBRED BALB C; PEROXIDASE; SPIN LABELS;

EID: 33644863531     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.17.2.331     Document Type: Article

References (25)

1. Fiocchi C: Inflammatory bowel disease: etiology and pathogenesis. Gastroenterology 115: 182-205, 1998. (Pubitemid 28307304)
2. Stephen BH, Samuel M and David BS: The pharmacology of anti-inflammatory drugs in inflammatory bowel disease. In: Inflammatory Bowel Disease. 4th edition. Joseph BK and Roy GS (eds). Williams and Wilkins, Baltimore, pp664-694, 1995.
3. Stephen BH, Samuel M and David BS: The pharmacology of anti-inflammatory drugs in inflammatory bowel disease. In: Inflammatory Bowel Disease. 4th edition. Joseph BK and Roy GS (eds). Williams and Wilkins, Baltimore, pp643-663, 1995.
4. Ricketts CR: Dextran sulphate-a synthetic analogue of heparin. Biochem J 51: 129-133, 1952.
5. Blackburn AC, Doe WF and Buffinton GD: Salicylate hydroxylation as an indicator of hydroxyl radical generation in dextran sulfate-induced colitis. Free Radic Biol Med 25: 305-313, 1998.
6. Dykens JA and Baginski TJ: Urinary 8-hydroxydeoxyguanosine excretion as a non-invasive marker of neutrophil activation in animal models of inflammatory bowel disease. Scand J Gastroenterol 3: 628-636, 1998.
7. Cuzzocrea S, Mazzon E, Serraino I, Lepore V, Terranova ML, Ciccolo A and Caputi AP: Melatonin reduces dinitrobenzene sulfonic acid-induced colitis. J Pineal Res 30: 1-12, 2001. (Pubitemid 32056605)
8. Pentney PT and Bubenik GA: Melatonin reduces the severity of dextran-induced colitis in mice. J Pineal Res 19: 31-39, 1995.
9. Ademoglu E, Erbil Y, Tam B, Barbaros U, Ilhan E, Olgac V and Mutlu-Turkoglu U: Do vitamin E and selenium have beneficial effects on trinitrobenzenesulfonic acid-induced experimental colitis? Dig Dis Sci 49: 102-108, 2004.
10. Carrier J, Aghdassi E, Cullen J and Allard JP: Iron supplementation increases disease activity and vitamin E ameliorates the effect in rats with dextran sulfate sodium-induced colitis. J Nutr 132: 3146-3150, 2002.
11. Cuzzocrea S, Mazzon E, Dugo L, Caputi AP, Riley DP and Salvemini D: Protective effects of M40403, a superoxide dismutase mimetic, in a rodent model of colitis. Eur J Pharmacol 432: 79-89, 2001. (Pubitemid 33153136)
12. Ogawa Y, Kanatsu K, Iino T, Kato S, Jeong YI, Shibata N, Takada K and Takeuchi K: Protection against dextran sulfate sodium-induced colitis by microspheres of ellagic acid in rats. Life Sci 71: 827-839, 2002.
13. Araki Y, Andoh A and Fujiyama Y: The free radical scavenger edaravone suppresses experimental dextran sulfate sodium-induced colitis in rats. Int J Mol Med 12: 125-129, 2003.
14. Cuzzocrea S, McDonald MC, Mazzon E, Dugo L, Lepore V, Fonti MT, Ciccolo A, Terranova ML, Caputi AP and Thiemermann C: Tempol, a membrane-permeable radical scavenger, reduces dinitrobenzene sulfonic acid-induced colitis. Eur J Pharmacol 406: 127-137, 2000.
15. Laight DW, Berthelon JJ, Andrews TJ, Carrier MJ and Anggord EE: Assessment of superoxide anion scavenging activity of some common spin traps at physiological temperature and pH by microassay. Br J Pharmacol 122: 130-135, 1997.
16. Watanabe T, Yuki S, Egawa M and Nishi H: Protective effects of MCI-186 on cerebral ischemia: possible involvement of free radical scavenging and antioxidant actions. J Pharmacol Exp Ther 268: 1597-1604, 1994.
17. Watanabe T and Egawa M: Effects of antistroke agent MCI-186 on cerebral arachidonate cascade. J Pharmacol Exp Ther 271: 1624-1629, 1994. (Pubitemid 24382679)
18. Araki Y, Andoh A, Takizawa J, Takizawa W and Fujiyama Y: Clostridium butyricum, a probiotic derivative, suppresses dextran sulfate sodium-induced experimental colitis in rats. Int J Mol Med 13: 577-580, 2004.
19. Kanauchi O, Serizawa I, Matsumura T, Fukuda Y and Satomi M: Evaluation of antigenicity of germinated barley foodstuff for the treatment of ulcerative colitis in a chronic murine colitis model. Int J Mol Med 7: 143-147, 2001.
20. Oda T: Role of mast cells in dextran sulfate sodium-induced experimental colitis in rats. J Kyoto Pref Univ Med 104: 1069-1082, 1995.
21. Suzuki A, Hanada T, Mitsuyama K, Yoshida T, Kamizono S, Hoshino T, Kubo M, Yamashita A, Okabe M, Takeda K, Akira S, Matsumoto S, Toyonaga A, Sata M and Yoshimura A: CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J Exp Med 193: 471-481, 2001.
22. Araki Y, Fujiyama Y, Andoh A, Koyama S, Kanauchi O and Bamba T: The dietary combination of germinated barley foodstuff plus Clostridium butyricum suppresses the dextran sulfate sodium-induced experimental colitis in rats. Scand J Gastroenterol 35: 1060-1067, 2000.
23. Hanai H, Kanauchi O, Mitsuyama K, Andoh A, Takeuchi K, Takayuki I, Araki Y, Fujiyama Y, Toyonaga A, Sata M, Kojima A, Fukuda M and Bamba T: Germinated barley foodstuff prolongs remission in patients with ulcerative colitis. Int J Mol Med 13: 643-647, 2004.
24. Kanauchi O, Mitsuyama K, Homma T, Takahama K, Fujiyama Y, Andoh A, Araki Y, Suga T, Hibi T, Naganuma M, Asakura H, Nakano H, Shimoyama T, Hida N, Haruma K, Koga H, Sata M, Tomiyasu N, Toyonaga A, Fukuda M, Kojima A and Bamba T: Treatment of ulcerative colitis patients by long-term administration of germinated barley foodstuff: Multi-center open trial. Int J Mol Med 12: 701-704, 2003.
25. Fukuda M, Kanauchi O, Araki Y, Andoh A, Mitsuyama K, Takagi K, Toyonaga A, Sata M, Fujiyama Y, Fukuoka M, Matsumoto Y and Bamba T: Prebiotic treatment of experimental colitis with germinated barley foodstuff: A comparison with probiotic or antibiotic treatment. Int J Mol Med 9: 65-70, 2002.