MEK/ERK pathway mediates cytoprotection of salvianolic acid B against oxidative stress-induced apoptosis in rat bone marrow stem cells

Cell Biology International

Volumn 34, Issue 11, 2010, Pages 1063-1068

  Lu, Biyan ^a   Ye, Zhizhong ^b   Deng, Yubin ^a   Wu, Hongfu ^a,b   Feng, Jianqiang ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGDONG MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; Bone marrow stem cell; MEK ERK; Oxidative stress; Salvianolic acid B

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CASPASE 3; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SALVIANOLIC ACID B;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL PROTECTION; CELL SURVIVAL; CELL VIABILITY; CONTROLLED STUDY; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HEMATOPOIETIC STEM CELL; IMMUNOFLUORESCENCE; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; APOPTOSIS; BENZOFURANS; BONE MARROW CELLS; CYTOPROTECTION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; OXIDATIVE STRESS; PROTEIN KINASE INHIBITORS; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; STEM CELLS;

RATTUS; SALVIA MILTIORRHIZA;

EID: 77957325263     PISSN: 10656995     EISSN: 10958355     Source Type: Journal    
DOI: 10.1042/CBI20090126     Document Type: Article

References (30)

1. Akiyama Y, Radtke C, Kocsis JD. Remyelination of the rat spinal cord by transplantation of identified bone marrow stromal cells. J Neurosci 2002;22:6623-30.
2. Alexeyev MF. Is there more to aging than mitochondrial DNA and reactive oxygen species? FEBS J 2009;276:5768-87.
3. Barzilai A, Yamamoto K. DNA damage responses to oxidative stress. DNA Repair (Amst) 2004;3:1109-15.
4. Bhat NR, Zhang P. Hydrogen peroxide activation of multiple mitogenactivated protein kinases in an oligodendrocyte cell line: role of extracellular signal-regulated kinase in hydrogen peroxide-induced cell death. J Neurochem 1999;72:11229.
5. Chen YL, Hu CS, Lin FY, Chen YH, Sheu LM, Ku HH et al. Salvianolic acid B attenuates cyclooxygenase-2 expression in vitro in LPStreated human aortic smooth muscle cells and in vivo in the apolipoprotein-E-deficient mouse aorta. J Cell Biochem 2006;98:618231.
6. Dasari VR, Spomar DG, Cady C, Gujrati M, Rao JS, Dinh DH. Mesenchymal stem cells from rat bone marrow downregulate caspase-3-mediated apoptotic pathway after spinal cord injury in rats. Neurochem Res 2007;32:2080293.
7. Ditor DS, Bao F, Chen Y, Dekaban GA, Weaver LC. A therapeutic time window for anti-CD 11d monoclonal antibody treatment yielding reduced secondary tissue damage and enhanced behavioral recovery following severe spinal cord injury. J Neurosurg Spine 2006;5:343252.
8. Ebert R, Ulmer M, Zeck S, Meissner-Weigl J, Schneider D, Stopper H et al. Selenium supplementation restores the antioxidative capacity and prevents cell damage in bone marrow stromal cells in vitro. Stem Cells 2006;24:1226235.
9. Grasbon-Frodl EM, Nakao N, Brundin P. The lazaroid U-83836E improves the survival of rat embryonic mesencephalic tissue stored at 4 degrees C and subsequently used for cultures or intracerebral transplantation. Brain Res Bull 1996;39:34127.
10. Hansson O, Castilho RF, Kaminski Schierle GS, Karlsson J, Nicotera P, Leist M et al. Additive effects of caspase inhibitor and lazaroid on the survival of transplanted rat and human embryonic dopamine neurons. Exp Neurol 2000;164:102211.
11. Hardy SA, Maltman DJ, Przyborski SA. Mesenchymal stem cells as mediators of neural differentiation. Curr Stem Cell Res Ther 2008;3:43252.
12. Hung SC, Pochampally RR, Chen SC, Hsu SC, Prockop DJ. Angiogenic effects of human multipotent stromal cell conditioned medium activate the PI3K-Akt pathway in hypoxic endothelial cells to inhibit apoptosis, increase survival, and stimulate angiogenesis. Stem Cells 2007;25:2363-70.
13. Kan S, Li J, Huang W, Shao L, Chen D. Microsphere resin chromatography combined with microbial biotransformation for the separation and purification of salvianolic acid B in aqueous extract of roots of Salvia multiorrihza Bunge. J Chromatogr A 2009;1216:3881-6.
14. Kim YK, Kim HJ, Kwon CH, Kim JH, Woo JS, Jung JS et al. Role of ERK activation in cisplatin-induced apoptosis in OK renal epithelial cells. J Appl Toxicol 2005;25:374-82.
15. Li M, Zhao MQ, Kumar Durairajan SS, Xie LX, Zhang HX, Kum WF et al. Protective effect of tetramethylpyrazine and salvianolic acid B on apoptosis of rat cerebral microvascular endothelial cell under high shear stress. Clin Hemorheol Microcirc 2008;38:177-87.
16. Liu CL, Xie LX, Li M, Durairajan SS, Goto S, Huang JD. Salvianolic acid B inhibits hydrogen peroxide-induced endothelial cell apoptosis through regulating PI3K/Akt signaling. PLoS ONE 2007;2:e1321.
17. Liu CS, Chen NH, Zhang JT. Protection of PC12 cells from hydrogen peroxide-induced cytotoxicity by salvianolic acid B, a new compound isolated from Radix Salviae miltiorrhizae. Phytomedicine 2007b;14:492-7.
18. Mias C, Trouche E, Seguelas MH, Calcagno F, Dignat-George F, Sabatier F et al. Ex vivo pretreatment with melatonin improves survival, proangiogenic/mitogenic activity, and efficiency of mesenchymal stem cells injected into ischemic kidney. Stem Cells 2008;26:1749-57.
19. Muller-Ehmsen J, Whittaker P, Kloner RA, Dow JS, Sakoda T, Long TI et al. Survival and development of neonatal rat cardiomyocytes transplanted into adult myocardium. J Mol Cell Cardiol 2002;34:107-16.
20. Nagaya N, Fujii T, Iwase T, Ohgushi H, Itoh T, Uematsu M et al. Intravenous administration of mesenchymal stem cells improves cardiac function in rats with acute myocardial infarction through angiogenesis and myogenesis. Am J Physiol Heart Circ Physiol 2004;287:H2670-6.
21. Phinney DG. Biochemical heterogeneity of mesenchymal stem cell populations: clues to their therapeutic efficacy. Cell Cycle 2007;6:2884-9.
22. Phinney DG, Prockop DJ. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair-current views. Stem Cells 2007;25: 2896-902.
23. Stolzing A, Scutt A. Effect of reduced culture temperature on antioxidant defences of mesenchymal stem cells. Free Radical Biol Med 2006;41:326-38.
24. Tian LL, Wang XJ, Sun YN, Li CR, Xing YL, Zhao HB et al. Salvianolic acid B, an antioxidant from Salvia miltiorrhiza, prevents 6-hydroxydopamine induced apoptosis in SH-SY5Y cells. Int J Biochem Cell Biol 2008;40:409-22.
25. Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 2002;105:93-8.
26. Wang X, Martindale JL, Holbrook NJ. Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem 2000;275:39435-43.
27. Weinberg F, Chandel NS. Reactive oxygen species-dependent signaling regulates cancer. Cell Mol Life Sci 2009;66:3663-73.
28. Wu HL, Li YH, Lin YH, Wang R, Li YB, Tie L et al. Salvianolic acid B protects human endothelial cells from oxidative stress damage: a possible protective role of glucose-regulated protein 78 induction. Cardiovasc Res 2009;81:148-58.
29. Zhang H, Yu C, Jia JY, Leung SW, Siow YL, Man RY et al. Contents of four active components in different commercial crude drugs and preparations of danshen (Salvia miltiorrhiza). Acta Pharmacol Sin 2002;23:1163-8.
30. Zhu W, Chen J, Cong X, Hu S, Chen X. Hypoxia and serum deprivationinduced apoptosis in mesenchymal stem cells. Stem Cells 2006;24:416-25.